Abstract:
BACKGROUND:Plenty of studies have demonstrated the prognostic value of various inflammation-based indexes in cancer. This study was designed to investigate the prognostic value of the C-reactive protein/albumin (CRP/Alb) ratio in esophageal squamous cell carcinoma. METHODS:A retrospective study of 423 cases with newly diagnosed esophageal squamous cell carcinoma was conducted. We analyzed the association of the CRP/Alb ratio with clinicopathologic characteristics. The prognostic value was explored by univariate and multivariate survival analysis. In addition, we compared the discriminatory ability of the CRP/Alb ratio with other inflammation-based prognostic scores by evaluating the area under the receiver operating characteristics curves (AUC), including the modified Glasgow Prognostic Score (mGPS), neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR). RESULTS:The optimal cut-off value was identified to be 0.095 for the CRP/Alb ratio. A higher level of the CRP/Alb ratio was associated with larger tumor size (P < 0.001), poorer differentiation (P = 0.019), deeper tumor invasion (P = 0.003), more lymph node metastasis (P = 0.015), more distant metastasis (P < .001) and later TNM stage (P < 0.001). The CRP/Alb ratio was identified to be the only inflammation-based prognostic score with independent association with overall survival by multivariate analysis (P = 0.031). The AUC value of the CRP/Alb ratio was higher compared with the NLR and PLR, but not mGPS at 6, 12 and 24 months of follow-up. In addition, the CRP/Alb ratio could identify a group of patients with mGPS score of 0 who had comparable overall survival with those with mGPS score of 1. CONCLUSIONS:The CRP/Alb ratio is a novel but promising inflammation-based prognostic score in esophageal squamous cell carcinoma. It is a valuable coadjutant for the mGPS to further identify patients' survival differences.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wei XL,Wang FH,Zhang DS,Qiu MZ,Ren C,Jin Y,Zhou YX,Wang DS,He MM,Bai L,Wang F,Luo HY,Li YH,Xu RHdoi
10.1186/s12885-015-1379-6subject
Has Abstractpub_date
2015-05-02 00:00:00pages
350issn
1471-2407pii
10.1186/s12885-015-1379-6journal_volume
15pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, many of these methods are limited in their ability to achieve reproducible, quantitative results th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-198
更新日期:2008-07-14 00:00:00
abstract:BACKGROUND:Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4349-y
更新日期:2018-04-13 00:00:00
abstract:BACKGROUND:Aberrant methylation is a frequent event in oral cancer. METHODS:In order to better characterize these alterations, a search for genes downregulated by aberrant methylation in oral squamous cell carcinoma (OSCC) was conducted through the mining of ORESTES dataset. Findings were further validated in OSCC cel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4077-3
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-200
更新日期:2007-10-24 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4965-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-341
更新日期:2010-06-30 00:00:00
abstract:BACKGROUND:The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinical practice three-year project to increase breast cancer screening among young breast cancer survivor...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-13-97
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Patients with unresectable malignant biliary obstruction have limited life expectancy because of limited stent patency and tumor progression. The aim of our study was to retrospectively evaluate the safety and efficacy of combining intraductal RFA with biliary metal stent placement for patients with malignan...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3278-5
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3120-0
更新日期:2017-02-16 00:00:00
abstract:BACKGROUND:Although adjuvant chemotherapy with S-1 after curative gastrectomy has been performed as a standard treatment for Stage II and III gastric cancer (GC) in Japan, patients with Stage III GC still have a high incidence of recurrence and a poor prognostic outcome. The aim of this study was to investigate risk fa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4052-z
更新日期:2018-01-30 00:00:00
abstract:BACKGROUND:Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs) play a role in the regulation of the tumor cell response to hypoxia, however, not much is known ab...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-429
更新日期:2014-06-13 00:00:00
abstract:BACKGROUND:The standard therapy regimen of conventional osteosarcoma includes neoadjuvant chemotherapy followed by surgical resection and postoperative chemotherapy. The percentage of necrotic tissue following induction chemotherapy is assessed by using the Huvos grading system, which classifies patients as "poor respo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-606
更新日期:2014-08-20 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) shows a 5-year survival rate below 10%, demonstrating the urgency in improving its treatment. Alterations in epidermal growth factor receptors are closely related to malignancy transformation in a number of tumors and recent successful targeted therapies have been di...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-569
更新日期:2012-12-04 00:00:00
abstract:BACKGROUND:Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug mostly concern Triple Negative Breast Cancer (TNBC) murine models. Here, we explored the therapeutic...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1540-2
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:The purpose of our study was to investigate the immunohistochemical expression of TGF-beta1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We also aimed to evaluate the expression of TGF-beta1 and p27 in the context of other cell cycle an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-98
更新日期:2005-08-08 00:00:00
abstract:BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1512-6
更新日期:2015-07-04 00:00:00
abstract:BACKGROUND:Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD). METHODS:In this study, we evaluated DPYD promoter methylation through quantitative methylation-specific PCR a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-470
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6211-2
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. METHODS:Here, additi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-63
更新日期:2012-02-08 00:00:00
abstract:BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-018-4992-3
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) are both expressed by a number of malignant tumors, including those of the breast. In the latter, both behave as potent inhibitors of invasion. Nevertheless, the signaling pathways whereby the activated GnRH/GnRHR system exerts this effect have n...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-550
更新日期:2012-11-23 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) is a type of breast cancer with a high degree of malignancy. Because of the remarkable biological characteristics of high invasion, metastasis and recurrence, TNBC is often accompanied by a poor prognosis. As a molecular characteristic of TNBC, high expression of CD147 ha...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5796-9
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is k...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5476-9
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2957-y
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells. METHODS:The growth inhibition of U251 cells induced by resveratrol was assessed with methyl thiazolyl tetrazoli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-215
更新日期:2009-06-30 00:00:00
abstract:BACKGROUND:In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-250
更新日期:2008-08-29 00:00:00
abstract:BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5439-1
更新日期:2019-03-18 00:00:00
abstract:BACKGROUND:The differentiation of pancreatic ductal adenocarcinoma (PDAC) could be associated with prognosis and may influence the choices of clinical management. No applicable methods could reliably predict the tumor differentiation preoperatively. Thus, the aim of this study was to compare the metabonomic profiling o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3703-9
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct molecular features compared to metastases of known origin. METHODS:Employing genome wide transcripto...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1128-x
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07676-6
更新日期:2020-12-01 00:00:00