Non-invasively predicting differentiation of pancreatic cancer through comparative serum metabonomic profiling.

abstract：BACKGROUND:Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual's susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development. METHO...

journal_title：BMC cancer

authors： Zhao P,Zou P,Zhao L,Yan W,Kang C,Jiang T,You Y

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield higher BED, shorten the total treatmen...

journal_title：BMC cancer

authors： Ren XC,Wang QY,Zhang R,Chen XJ,Wang N,Liu YE,Zong J,Guo ZJ,Wang DY,Lin Q

更新日期：2016-04-23 00:00:00

abstract：BACKGROUND:Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney cancer is rising across the sexes in some of these countries, a trend which may possibly reflect the ...

journal_title：BMC cancer

authors： López-Abente G,Aragonés N,Pérez-Gómez B,Ramis R,Vidal E,García-Pérez J,Fernández-Navarro P,Pollán M

更新日期：2008-10-09 00:00:00

abstract：BACKGROUND:Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors. We consider this case of interest as treatment with catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect in a patient w...

journal_title：BMC cancer

authors： Bezan A,Hohla F,Meissnitzer T,Greil R

更新日期：2013-12-31 00:00:00

abstract：BACKGROUND:Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants. Positive correlation between the degree of AhR overexpression and states ...

journal_title：BMC cancer

authors： Wong PS,Li W,Vogel CF,Matsumura F

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:To evaluate the effect of Recurrence Score® results (RS; Oncotype DX® multigene assay ODX) on treatment recommendations by Swiss multidisciplinary tumor boards (TB). METHODS:SAKK 26/10 is a multicenter, prospective cohort study of early breast cancer patients: Eligibility: R0-resection, ≥10% ER+ malignant c...

journal_title：BMC cancer

authors： Pestalozzi BC,Tausch C,Dedes KJ,Rochlitz C,Zimmermann S,von Moos R,Winterhalder R,Ruhstaller T,Mueller A,Buser K,Borner M,Novak U,Nussbaum CU,Seifert B,Bigler M,Bize V,Vilei SB,Rageth C,Aebi S,Swiss Group for Clinic

更新日期：2017-04-13 00:00:00

abstract：BACKGROUND:Soft tissue metastases, in particular intraneural metastasis, from any carcinomas seldom occur. To our knowledge, no case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma is reported in the literature. CASE PRESENTATION:A case is reported of a 82-year old woman with sciatic nerve pa...

journal_title：BMC cancer

authors： Ichikawa J,Matsumoto S,Shimoji T,Tanizawa T,Gokita T,Hayakawa K,Aoki K,Ina S,Kanda H

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neoplasia in symptomatic patients in fast-track programs. METHODS:All patients referred for fast-track...

journal_title：BMC cancer

authors： Fernández-Bañares F,Clèries R,Boadas J,Ribes J,Oliva JC,Alsius A,Sanz X,Martínez-Bauer E,Galter S,Pujals M,Pujol M,Del Pozo P,Campo R

更新日期：2019-07-25 00:00:00

abstract：BACKGROUND:Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that...

journal_title：BMC cancer

authors： Hayashi T,Yamashita T,Terashima T,Suda T,Okada H,Asahina Y,Hayashi T,Hara Y,Nio K,Sunagozaka H,Takatori H,Arai K,Sakai Y,Yamashita T,Mizukoshi E,Honda M,Kaneko S

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Uterine carcinosarcoma (UCS) represents a true example of cancer associated with epithelial-mesenchymal transition (EMT), which exhibits cancer stem cell (CSC)-like traits. Both Sox and β-catenin signal transductions play key roles in the regulation of EMT/CSC properties, but little is known about their invo...

journal_title：BMC cancer

authors： Inoue H,Takahashi H,Hashimura M,Eshima K,Akiya M,Matsumoto T,Saegusa M

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...

journal_title：BMC cancer

authors： Schmidt JW,Wehde BL,Sakamoto K,Triplett AA,West WW,Wagner KU

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response ...

journal_title：BMC cancer

authors： McNamara MA,George DJ

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following error is the article. ...

journal_title：BMC cancer

authors： Ye S,Hao X,Zhou T,Wu M,Wei J,Wang Y,Zhou L,Jiang X,Ji L,Chen Y,You L,Zhang Y,Xu G,Zhou J,Ma D,Wang S

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial r...

journal_title：BMC cancer

authors： Stava C,Beck M,Weiss LT,Lopez A,Vassilopoulou-Sellin R

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer in women worldwide, with a great diversity in outcomes among individual patients. The ability to accurately predict a breast cancer outcome is important to patients, physicians, researchers, and policy makers. Many models have been developed and tested in different set...

journal_title：BMC cancer

authors： Phung MT,Tin Tin S,Elwood JM

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:Being the most common cancer among women worldwide, it is vital to be well-aware of breast cancer risk factors, symptoms and curability. However, few studies have reported breast cancer literacy in students using a validated instrument. METHODS:A cross-sectional study was conducted among students of grades ...

journal_title：BMC cancer

authors： Bhandari PM,Thapa K,Dhakal S,Bhochhibhoya S,Deuja R,Acharya P,Mishra SR

更新日期：2016-02-18 00:00:00

abstract：BACKGROUND:According to the very limited cancer registry, incidence and mortality rates for female breast cancer in China are regarded to be increasing especially in the metropolitan areas. Representative data on the breast cancer profile of Chinese women and its time trend over years are relatively rare. The aims of t...

journal_title：BMC cancer

authors： Li J,Zhang BN,Fan JH,Pang Y,Zhang P,Wang SL,Zheng S,Zhang B,Yang HJ,Xie XM,Tang ZH,Li H,Li JY,He JJ,Qiao YL

更新日期：2011-08-22 00:00:00

abstract：:... ...

journal_title：BMC cancer

authors： Knoerl R,Weller E,Halpenny B,Berry D

更新日期：2019-05-13 00:00:00

abstract：BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...

journal_title：BMC cancer

authors： Yang GF,He WP,Cai MY,He LR,Luo JH,Deng HX,Guan XY,Zeng MS,Zeng YX,Xie D

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:Most staging systems for soft tissue sarcoma are based on histologic malignancy-grade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth per se should influence a tumor's metastatic capability. Therefore we hypothesized that the unf...

journal_title：BMC cancer

authors： Rydholm A,Gustafson P

更新日期：2003-05-26 00:00:00

abstract：BACKGROUND:Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed ...

journal_title：BMC cancer

authors： Batista LI,Lu KH,Beahm EK,Arun BK,Bodurka DC,Meric-Bernstam F

更新日期：2008-04-14 00:00:00

abstract：BACKGROUND:Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women. CASE PRESENTATION:We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors. CONCLUSION...

journal_title：BMC cancer

authors： Mendez LC,Hsieh E,Earle CC,Wong S

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. Here, to determine the relationship of LAD1 with colorectal cancer progression, we explored the effec...

journal_title：BMC cancer

authors： Moon B,Yang SJ,Park SM,Lee SH,Song KS,Jeong EJ,Park M,Kim JS,Yeom YI,Kim JA

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is supported by the short PR isofor...

journal_title：BMC cancer

authors： Rosati R,Oppat K,Huang Y,Kim S,Ratnam M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-oral carbohydrate load and their influence on tumor characteristics and survival. METHODS:The study...

journal_title：BMC cancer

authors： Lende TH,Austdal M,Bathen TF,Varhaugvik AE,Skaland I,Gudlaugsson E,Egeland NG,Lunde S,Akslen LA,Jonsdottir K,Janssen EAM,Søiland H,Baak JPA

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet data about their collective behavior in hepatocellular carcinoma (HCC) is missing. Hence, we qua...

journal_title：BMC cancer

authors： Avci ME,Konu O,Yagci T

更新日期：2008-12-29 00:00:00

abstract：BACKGROUND:Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone receptor statu...

journal_title：BMC cancer

authors： Mandel J,Avula R,Prochownik EV

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS:Comparative...

journal_title：BMC cancer

authors： Huang XY,Gan RH,Xie J,She L,Zhao Y,Ding LC,Su BH,Zheng DL,Lu YG

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00