Abstract:
BACKGROUND:According to the very limited cancer registry, incidence and mortality rates for female breast cancer in China are regarded to be increasing especially in the metropolitan areas. Representative data on the breast cancer profile of Chinese women and its time trend over years are relatively rare. The aims of the current study are to illustrate the breast cancer profile of Chinese women in time span and to explore the current treatment approaches to female breast cancer. METHODS:This was a hospital-based nation-wide and multi-center retrospective study of female primary breast cancer cases. China was divided into 7 regions according to the geographic distribution; from each region, one tertiary hospital was selected. With the exception of January and February, one month was randomly selected to represent each year from year 1999 to 2008 at every hospital. All inpatient cases within the selected month were reviewed and related information was collected based on the designed case report form (CRF). The Cancer Hospital/Institute, Chinese Academy of Medical Sciences (CICAMS) was the leading hospital in this study. RESULTS:Four-thousand two-hundred and eleven cases were randomly selected from the total pool of 45,200 patients and were included in the analysis. The mean age at diagnosis was 48.7 years (s.d. = 10.5 yrs) and breast cancer peaked in age group 40-49 yrs (38.6%). The most common subtype was infiltrating ductal carcinoma (86.5%). Clinical stage I & II accounted for 60.6% of 4,211 patients. Three-thousand five-hundred and thirty-four cases had estrogen receptor (ER) and progestin receptor (PR) tests, among them, 47.9% were positive for both. Two-thousand eight-hundred and forty-nine cases had human epidermal growth factor receptor 2(HER-2) tests, 25.8% of them were HER-2 positive. Among all treatment options, surgery (96.9% (4,078/4,211)) was predominant, followed by chemotherapy (81.4% (3,428/4,211). Much less patients underwent radiotherapy (22.6% (952/4,211)) and endocrine therapy (38.0% (1,599/4,211)). CONCLUSIONS:The younger age of breast cancer onset among Chinese women and more advanced tumor stages pose a great challenge. Adjuvant therapy, especially radiotherapy and endocrine therapy are of great unmet needs.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Li J,Zhang BN,Fan JH,Pang Y,Zhang P,Wang SL,Zheng S,Zhang B,Yang HJ,Xie XM,Tang ZH,Li H,Li JY,He JJ,Qiao YLdoi
10.1186/1471-2407-11-364subject
Has Abstractpub_date
2011-08-22 00:00:00pages
364issn
1471-2407pii
1471-2407-11-364journal_volume
11pub_type
杂志文章,多中心研究相关文献
BMC CANCER文献大全abstract:BACKGROUND:Germline mutations in the DNA mismatch repair genes predispose to Lynch syndrome, thus conferring a high relative risk of colorectal and endometrial cancer. The MLH1, MSH2 and MSH6 mutational spectrum reported so far involves minor alterations scattered throughout their coding regions as well as large genomi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-544
更新日期:2010-10-11 00:00:00
abstract:BACKGROUND:Extramural tumor deposits (TDs) and extracapsular lymph node involvement (ECLNI) are considered to be poor prognostic factors in patients with T3-4, N0-2, M0 colorectal cancer (CRC). Although TDs are known to have multiple origins and pleomorphic features, the prognostic significances of the different type o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1885-6
更新日期:2015-11-06 00:00:00
abstract:BACKGROUND:Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-261
更新日期:2012-06-21 00:00:00
abstract:BACKGROUND:Isothiocyanates are natural compounds found in consumable cruciferous vegetables. They have been shown to inhibit chemical carcinogenesis by a wide variety of chemical carcinogens in animal models. Recent studies have also shown that isothiocyanates have antitumor activity, inhibiting the growth of several t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-269
更新日期:2010-06-09 00:00:00
abstract:BACKGROUND:The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist surgical pathways for several cancers including prostate, bladder, kidney, and oesophago-gastric ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4137-8
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5820-0
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). METHODS:Between 2002 and 2007, a population-based case-contro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-344
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study its expression at protein level in HCC and its biological function for HCC cell growth. METHOD:Weste...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-109
更新日期:2006-04-29 00:00:00
abstract:BACKGROUND:The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-oral carbohydrate load and their influence on tumor characteristics and survival. METHODS:The study...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-019-6393-7
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4585-1
更新日期:2018-06-18 00:00:00
abstract:BACKGROUND:Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen rec...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1699-6
更新日期:2015-10-15 00:00:00
abstract:BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-365
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:The prevalence of patients with gastrointestinal stromal tumourgst (GIST) who fail currently available treatments imatinib and sunitinib (third-line treatment-eligible GIST) is unknown, but is expected to be below an ultra-orphan disease threshold of 2/100,000 population used in England and Wales. Our study ...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/1471-2407-14-364
更新日期:2014-05-24 00:00:00
abstract:BACKGROUND:Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected luminal, post-EMT and basal-like breast carcinoma cell lines. METHODS:Migration was assessed in luminal (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-158
更新日期:2011-05-02 00:00:00
abstract:BACKGROUND:In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, particularly in health promotion and prevention. There are no randomized controlled trials in Latin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3870-8
更新日期:2017-12-13 00:00:00
abstract:BACKGROUND:High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood stem cell (PBSC) grafts can be challenging, and the question arises whether reinfusion of low-dose gra...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06873-7
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:Disorders of cell adhesion are critical steps in cancer progression in which varieties of markers including cadherins are involved in.Btbd7 was found to inhibit E-cadherin expression in MDCK cells and play important roles during branching morphogenesis of embryonic salivary glands and lungs. However its func...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-704
更新日期:2014-09-24 00:00:00
abstract:BACKGROUNDS:Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows phenotypic changes (population changes) upon differentiation of CSC during culture and can be used for s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1297-7
更新日期:2015-04-11 00:00:00
abstract:BACKGROUND:RNA from exosomes and other microvesicles contain transcripts of tumour origin. In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients. METHODS:Microvesicle RNA from serum from patients with de-novo primary glioblastoma multiforme (N = 9...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-22
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) is one of the standard care regimens for patients with resectable early-stage breast cancer. It would be advantageous to determine the chemosensitivity of tumors before initiating NAC. One of the parameters potentially compromising such chemosensitivity would be a hypoxic micro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-400
更新日期:2014-06-04 00:00:00
abstract:CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-017-3767-6
更新日期:2018-01-11 00:00:00
abstract:BACKGROUND:Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-29
更新日期:2014-01-17 00:00:00
abstract:BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3874-4
更新日期:2017-12-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-020-07245-x
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to identify the magnitude of delayed diagnosis and its associated factors in women with breast cancer in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-141
更新日期:2011-04-17 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4965-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quanti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5888-6
更新日期:2019-07-12 00:00:00
abstract:BACKGROUND:The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively little research has been conducted into disclosure in cancer care. Studies have been mainly undertaken i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5895-7
更新日期:2019-07-10 00:00:00
abstract:BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-251
更新日期:2006-10-23 00:00:00
abstract:BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-807
更新日期:2014-11-04 00:00:00