Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism.

abstract：BACKGROUND:Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This study aims to assess knowledge and attitude towards cervical cancer and its prevention, as well as prac...

journal_title：BMC cancer

authors： Ruddies F,Gizaw M,Teka B,Thies S,Wienke A,Kaufmann AM,Abebe T,Addissie A,Kantelhardt EJ

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is a type of breast cancer with a high degree of malignancy. Because of the remarkable biological characteristics of high invasion, metastasis and recurrence, TNBC is often accompanied by a poor prognosis. As a molecular characteristic of TNBC, high expression of CD147 ha...

journal_title：BMC cancer

authors： Wang C,Xu C,Niu R,Hu G,Gu Z,Zhuang Z

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy. METHODS:Medical notes of 174 NPC patients a...

journal_title：BMC cancer

authors： Luo R,Wu VWC,He B,Gao X,Xu Z,Wang D,Yang Z,Li M,Lin Z

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as effective antineoplastic drugs for several malignant tumors. We hypothesized that Selumetinib might be ...

journal_title：BMC cancer

authors： Zhou Y,Lin S,Tseng KF,Han K,Wang Y,Gan ZH,Min DL,Hu HY

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance between portal venous inflow and a diminished hepatic volume. Finding a reversible, non-invasive metho...

journal_title：BMC cancer

authors： Mohkam K,Rayar M,Adam JP,Muscari F,Rode A,Merle P,Pradat P,Bauler S,Delfour I,Chiche L,Ducerf C,Boudjema K,Lesurtel M,Laurent C,Mabrut JY

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (M...

journal_title：BMC cancer

authors： Zarzour AH,Selim M,Abd-Elsayed AA,Hameed DA,Abdelaziz MA

更新日期：2008-08-29 00:00:00

abstract：BACKGROUND:We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival (OS) in an expanded access cohort of trastuzumab-treated HER2-positive patients with metastatic brea...

journal_title：BMC cancer

authors： Toi M,Sperinde J,Huang W,Saji S,Winslow J,Jin X,Tan Y,Ohno S,Nakamura S,Iwata H,Masuda N,Aogi K,Morita S,Petropoulos C,Bates M

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION:We report the case of a 51 year old ma...

journal_title：BMC cancer

authors： Rochigneux P,Thomassin-Piana J,Laibe S,Brunelle S,Salem N,Escudier B,Vassal G,Gravis G

更新日期：2018-11-22 00:00:00

abstract：BACKGROUND:The origin and development of breast cancer remain complex and obscure. Recently, microRNA (miRNA) has been identified as an important regulator of the initiation and progression of breast cancer, and some studies have shown the essential role of miR-124-3p as a tumor suppressor in breast tumorigenesis. Howe...

journal_title：BMC cancer

authors： Wang Y,Chen L,Wu Z,Wang M,Jin F,Wang N,Hu X,Liu Z,Zhang CY,Zen K,Chen J,Liang H,Zhang Y,Chen X

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...

journal_title：BMC cancer

authors： Ryan AV,Wilson S,Wakelam MJ,Warmington SA,Dunn JA,Hobbs RF,Martin A,Ismail T

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers. In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and ...

journal_title：BMC cancer

authors： Sasi W,Jiang WG,Sharma A,Mokbel K

更新日期：2010-04-30 00:00:00

abstract：BACKGROUND:Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs. CASE PRES...

journal_title：BMC cancer

authors： Abe M,Watanabe K,Shinozaki-Ushiku A,Ushiku T,Abe T,Fujihara Y,Amano Y,Zong L,Wang CP,Kubo E,Inaki R,Kinoshita N,Yamashita S,Takai D,Ushijima T,Nagase T,Hoshi K

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs) play a role in the regulation of the tumor cell response to hypoxia, however, not much is known ab...

journal_title：BMC cancer

authors： Gits CM,van Kuijk PF,de Rijck JC,Muskens N,Jonkers MB,van IJcken WF,Mathijssen RH,Verweij J,Sleijfer S,Wiemer EA

更新日期：2014-06-13 00:00:00

abstract：BACKGROUND:Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model's lack of cellular components of the tumor's microenvironment. In this study, we aim to determine if the intact lung micr...

journal_title：BMC cancer

authors： Mishra DK,Miller RA,Pence KA,Kim MP

更新日期：2018-04-18 00:00:00

abstract：BACKGROUND:Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a recurrence despite adjuvant tamoxifen treatment. Factors that predict tamoxifen efficacy would be hel...

journal_title：BMC cancer

authors： Jager NG,Koornstra RH,Vincent AD,van Schaik RH,Huitema AD,Korse TM,Schellens JH,Linn SC,Beijnen JH

更新日期：2013-12-28 00:00:00

abstract：BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...

journal_title：BMC cancer

authors： Fan C,Jin M,Chen K,Zhang Y,Zhang S,Liu B

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:Selection of patients with local failure of nasopharyngeal carcinoma (NPC) for appropriate type of salvage treatment can be difficult due to the lack of data on comparative efficacy of different salvage treatments. The purpose of the present study was to validate a previously published prognostic scoring sys...

journal_title：BMC cancer

authors： Chua DT,Hung KN,Lee V,Ng SC,Tsang J

更新日期：2009-04-29 00:00:00

abstract：BACKGROUND:Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its u...

journal_title：BMC cancer

authors： Song Q,Chen Q,Wang Q,Yang L,Lv D,Jin G,Liu J,Li B,Fei X

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with cancer. METHODS:A retrospective review of all patients admitted to a specialist cancer hospital with ...

journal_title：BMC cancer

authors： Balachandran K,Okines A,Gunapala R,Morganstein D,Popat S

更新日期：2015-03-22 00:00:00

abstract：BACKGROUND:Multimodality treatment improves the chance of survival but increases the risk for long-term side effects in young cancer survivors, so-called" Adolescents and Young Adults"(AYAs). Compared to the general population AYAs have a 5 to 15-fold increased risk of cardiovascular morbidity. Thus, improving modifiab...

journal_title：BMC cancer

authors： Quidde J,von Grundherr J,Koch B,Bokemeyer C,Escherich G,Valentini L,Buchholz D,Schilling G,Stein A

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how...

journal_title：BMC cancer

authors： Liu LN,Lin YC,Miaskowski C,Chen SC,Chen ML

更新日期：2017-12-18 00:00:00

abstract：BACKGROUND:Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second ...

journal_title：BMC cancer

authors： Brasseur M,Heurgué-Berlot A,Barbe C,Brami C,Rey JB,Vella-Boucaud J,Dabouz F,Deslée G,Grange F,Volet J,Bouché O

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For metastatic prostate cancer (PCa), the bone marrow microenvironment influences metastasis, drug response, and possibly drug resistance. METHODS:Using a nov...

journal_title：BMC cancer

authors： Mosaad E,Chambers K,Futrega K,Clements J,Doran MR

更新日期：2018-05-24 00:00:00

abstract：CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Wang X,Chen J,Wang J,Yu F,Zhao S,Zhang Y,Tang H,Peng Z

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes. This stud...

journal_title：BMC cancer

authors： Kawai S,Fukuda N,Yamamoto S,Mitani S,Omae K,Wakatsuki T,Kato K,Kadowaki S,Takahari D,Boku N,Muro K,Machida N

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans. METHODS:Medical records of African Americans,...

journal_title：BMC cancer

authors： Brim H,Zahaf M,Laiyemo AO,Nouraie M,Pérez-Pérez GI,Smoot DT,Lee E,Razjouyan H,Ashktorab H

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer. METHODS:qRT-PCR was performed to detect miR-21 levels in plasma of 127 healthy controls, 82 benign breast ...

journal_title：BMC cancer

authors： Wang H,Tan Z,Hu H,Liu H,Wu T,Zheng C,Wang X,Luo Z,Wang J,Liu S,Lu Z,Tu J

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Ectopic TSH-secreting pituitary adenoma (TSH-oma) is a very unusual disorder. To date, there are only four cases reported. It is difficult to distinguish ectopic cases from both regular TSH-omas and resistance to thyroid hormone (RTH). CASE PRESENTATION:A newly identified case of ectopic TSH-oma arising fro...

journal_title：BMC cancer

authors： Song M,Wang H,Song L,Tian H,Ge Q,Li J,Zhu Y,Li J,Zhao R,Ji HL

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion. METHODS:Nine hundred nine women undergoing second level ...

journal_title：BMC cancer

authors： Bruno MT,Scalia G,Cassaro N,Boemi S

更新日期：2020-05-19 00:00:00