Long-term efficacy of crizotinib in a metastatic papillary renal carcinoma with MET amplification: a case report and literature review.

abstract：BACKGROUND:Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinoma and poorly differentiated, less treatable non-adenocarcinoma including small cell carcinoma, and t...

journal_title：BMC cancer

authors： Kanan AD,Corey E,Vêncio RZN,Ishwar A,Liu AY

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic significance in patients with breast cancer. METHODS:PubMed,...

journal_title：BMC cancer

authors： Jiang D,Gao Z,Cai Z,Wang M,He J

更新日期：2015-10-17 00:00:00

abstract：BACKGROUND:Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to induce oncolytic cell death in a variety of cancer cells of diverse origins. However, whether oncolyti...

journal_title：BMC cancer

authors： Jiang K,Song C,Kong L,Hu L,Lin G,Ye T,Yao G,Wang Y,Chen H,Cheng W,Barr MP,Liu Q,Zhang G,Ding C,Meng S

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin ...

journal_title：BMC cancer

authors： Bifulco G,Mandato VD,Piccoli R,Giampaolino P,Mignogna C,Mignogna MD,Costagliola L,Nappi C

更新日期：2010-06-23 00:00:00

abstract：BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...

journal_title：BMC cancer

authors： Maciel-Silva P,Caldeira I,de Assis Santos I,Carreira ACO,Siqueira FR,Antonioli E,Goldberg AC,Belizário JE,Garay-Malpartida HM

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...

journal_title：BMC cancer

authors： Bruin SC,Klijn C,Liefers GJ,Braaf LM,Joosse SA,van Beers EH,Verwaal VJ,Morreau H,Wessels LF,van Velthuysen ML,Tollenaar RA,Van't Veer LJ

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery. METHODS:567 patients who were performed curative intent between 1980 and 2003 were enrolled. 187 ...

journal_title：BMC cancer

authors： Zhang H,Liu C,Wu D,Meng Y,Song R,Lu P,Wang S

更新日期：2010-06-20 00:00:00

abstract：BACKGROUND:Glioblastoma is the most common and most aggressive form of malignant glioma and is very difficult to treat. Controlling tumour cell invasion and angiogenesis is essential to improve the prognosis of glioblastoma patients. Since constitutive activation of nuclear factor-κB (NF-κB) is necessary for tumour pro...

journal_title：BMC cancer

authors： Nakabayashi H,Shimizu K

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:There is no biological or epidemiological data on the association between NOS3 promoter polymorphisms and prostate cancer. The polymorphisms in the promoter region of NOS3 gene may be responsible for variations in the plasma NO, which may promote cancer progression by providing a selective growth advantage t...

journal_title：BMC cancer

authors： Marangoni K,Araújo TG,Neves AF,Goulart LR

更新日期：2008-09-29 00:00:00

abstract：BACKGROUND:Conditional survival (CS) measures the probability that patients will survive an additional number of years given that they have already survived for a certain period of time. METHODS:In total, 2935 gastric cancer patients who had undergone curative gastrectomy between 1995 and 2011 were enrolled. The Cox p...

journal_title：BMC cancer

authors： Lee JW,Ali B,Yoo HM,Park CH,Song KY

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment regimen, overall survival could be extended significantly however, median overall survival is still onl...

journal_title：BMC cancer

authors： Combs SE,Kieser M,Rieken S,Habermehl D,Jäkel O,Haberer T,Nikoghosyan A,Haselmann R,Unterberg A,Wick W,Debus J

更新日期：2010-09-06 00:00:00

abstract：BACKGROUND:Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In present study, we explored the mechanism of how TG2 may be involved in cell migration. METHODS:To study t...

journal_title：BMC cancer

authors： Kumar A,Hu J,LaVoie HA,Walsh KB,DiPette DJ,Singh US

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...

journal_title：BMC cancer

authors： Wu Z,Zhao J,Gao P,Song Y,Sun J,Chen X,Ma B,Wang Z

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Neoadjuvant Chemotherapy (NC) including trastuzumab induces a high rate of pathological Complete Responses (pCR) in patients with locally advanced HER2-overexpressing Breast Cancer (BC), but is penalized by a severe cardiotoxicity when combined with anthracyclines. A phase II study was designed to assess whe...

journal_title：BMC cancer

authors： Miolo G,Muraro E,Martorelli D,Lombardi D,Scalone S,Spazzapan S,Massarut S,Perin T,Viel E,Comaro E,Talamini R,Bidoli E,Turchet E,Crivellari D,Dolcetti R

更新日期：2014-12-15 00:00:00

abstract：BACKGROUND:Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immunotherapy plays an important auxiliary role in the treatment of advanced OV patient, so it is of gre...

journal_title：BMC cancer

authors： Yan S,Fang J,Chen Y,Xie Y,Zhang S,Zhu X,Fang F

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results. METHODS:We conducted a nested case-control study to assess the association between incident lung cancer o...

journal_title：BMC cancer

authors： Colombara DV,Manhart LE,Carter JJ,Hawes SE,Weiss NS,Hughes JP,Qiao YL,Taylor PR,Smith JS,Galloway DA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...

journal_title：BMC cancer

authors： Bischel LL,Beebe DJ,Sung KE

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. METHODS:Eleven LS hereditary cancer registrie...

journal_title：BMC cancer

authors： Rossi BM,Palmero EI,López-Kostner F,Sarroca C,Vaccaro CA,Spirandelli F,Ashton-Prolla P,Rodriguez Y,de Campos Reis Galvão H,Reis RM,Escremim de Paula A,Capochin Romagnolo LG,Alvarez K,Della Valle A,Neffa F,Kalfayan PG,Spir

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer in women worldwide, with a great diversity in outcomes among individual patients. The ability to accurately predict a breast cancer outcome is important to patients, physicians, researchers, and policy makers. Many models have been developed and tested in different set...

journal_title：BMC cancer

authors： Phung MT,Tin Tin S,Elwood JM

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attractive drug candidates for the targeted therapy of this malignancy. However, the ...

journal_title：BMC cancer

authors： Voisin L,Julien C,Duhamel S,Gopalbhai K,Claveau I,Saba-El-Leil MK,Rodrigue-Gervais IG,Gaboury L,Lamarre D,Basik M,Meloche S

更新日期：2008-11-17 00:00:00

abstract：BACKGROUND:Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammogr...

journal_title：BMC cancer

authors： Tehranifar P,Cohn BA,Flom JD,Protacio A,Cirillo P,Lumey LH,Michels KB,Terry MB

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostat...

journal_title：BMC cancer

authors： Rui X,Shao S,Wang L,Leng J

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells. METHODS:The growth inhibition of U251 cells induced by resveratrol was assessed with methyl thiazolyl tetrazoli...

journal_title：BMC cancer

authors： Li J,Qin Z,Liang Z

更新日期：2009-06-30 00:00:00

abstract：BACKGROUND:Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve t...

journal_title：BMC cancer

authors： Caponigro F,Di Gennaro E,Ionna F,Longo F,Aversa C,Pavone E,Maglione MG,Di Marzo M,Muto P,Cavalcanti E,Petrillo A,Sandomenico F,Maiolino P,D'Aniello R,Botti G,De Cecio R,Losito NS,Scala S,Trotta A,Zotti AI,Bruzzese

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of recurrent glioblastoma, too. In both cases, adjuvant treatment, mostly using temozolomide, can improve...

journal_title：BMC cancer

authors： Straube C,Scherb H,Gempt J,Kirschke J,Zimmer C,Schmidt-Graf F,Meyer B,Combs SE

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also ...

journal_title：BMC cancer

authors： Zhou L,Yu L,Zhu B,Wu S,Song W,Gong X,Wang D

更新日期：2016-11-10 00:00:00

abstract：BACKGROUND:Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence...

journal_title：BMC cancer

authors： Pfirrmann D,Tug S,Brosteanu O,Mehdorn M,Busse M,Grimminger PP,Lordick F,Glatz T,Hoeppner J,Lang H,Simon P,Gockel I

更新日期：2017-06-14 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the text boxes and the different areas in the map: Navarra, neighbouring communities and other Spanish communiti...

journal_title：BMC cancer

authors： de Sabando AR,Lafuente EU,García-Amigot F,Sánchez AA,Garofalo LM,Moreno S,Ardanaz E,Ramos-Arroyo MA

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT. METHODS:Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patie...

journal_title：BMC cancer

authors： Quero L,Mongiat-Artus P,Ravery V,Maylin C,Desgrandchamps F,Hennequin C

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00