Specific genomic aberrations in primary colorectal cancer are associated with liver metastases.


BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases. METHODS:Array Comparative Genomic Hybridization (aCGH) was employed to asses DNA copy number changes in primary colorectal tumors of three distinctive patient groups. This included formalin-fixed, paraffin-embedded tissue of patients who developed liver metastases (LM; n = 36), metastases (PM; n = 37) and a group that remained metastases-free (M0; n = 25).A novel statistical method for identifying recurrent copy number changes, KC-SMART, was used to find specific locations of genomic aberrations specific for various groups. We created a classifier for organ specific metastases based on the aCGH data using Prediction Analysis for Microarrays (PAM). RESULTS:Specifically in the tumors of primary CRC patients who subsequently developed liver metastasis, KC-SMART analysis identified genomic aberrations on chromosome 20q. LM-PAM, a shrunken centroids classifier for liver metastases occurrence, was able to distinguish the LM group from the other groups (M0&PM) with 80% accuracy (78% sensitivity and 86% specificity). The classification is predominantly based on chromosome 20q aberrations. CONCLUSION:Liver specific CRC metastases may be predicted with a high accuracy based on specific genomic aberrations in the primary CRC tumor. The ability to predict the site of metastases is important for improvement of personalized patient management.


BMC Cancer


BMC cancer


Bruin SC,Klijn C,Liefers GJ,Braaf LM,Joosse SA,van Beers EH,Verwaal VJ,Morreau H,Wessels LF,van Velthuysen ML,Tollenaar RA,Van't Veer LJ




Has Abstract


2010-12-02 00:00:00










  • Identification of novel signaling components in N,N'-dinitrosopiperazine-mediated metastasis of nasopharyngeal carcinoma by quantitative phosphoproteomics.

    abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer. N,N'-dinitrosopiperazine (DNP), a carcinogen with specificity for nasopharyngeal epithelium, facilitates NPC metastasis. However, the underlying mechanism is not known. METHODS:Quantitative phosphoproteomics, using stable isotope lab...

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  • Efficacy of bevacizumab combined with chemotherapy in the treatment of HER2-negative metastatic breast cancer: a network meta-analysis.

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    pub_type: 杂志文章,meta分析


    authors: Sun Z,Lan X,Xu S,Li S,Xi Y

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    pub_type: 杂志文章


    authors: Zitron IM,Thakur A,Norkina O,Barger GR,Lum LG,Mittal S

    更新日期:2013-02-22 00:00:00

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    authors: Wouters A,Pauwels B,Lardon F,Pattyn GG,Lambrechts HA,Baay M,Meijnders P,Vermorken JB

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    authors: Sribenja S,Sawanyawisuth K,Kraiklang R,Wongkham C,Vaeteewoottacharn K,Obchoei S,Yao Q,Wongkham S,Chen C

    更新日期:2013-09-23 00:00:00

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    pub_type: 杂志文章


    authors: Di Nicolantonio F,Mercer SJ,Knight LA,Gabriel FG,Whitehouse PA,Sharma S,Fernando A,Glaysher S,Di Palma S,Johnson P,Somers SS,Toh S,Higgins B,Lamont A,Gulliford T,Hurren J,Yiangou C,Cree IA

    更新日期:2005-07-18 00:00:00

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    authors: McBride ML,Groome PA,Decker K,Kendell C,Jiang L,Whitehead M,Li D,Grunfeld E,CanIMPACT Team.

    更新日期:2019-07-04 00:00:00

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    authors: Ravi M,Tentu S,Baskar G,Rohan Prasad S,Raghavan S,Jayaprakash P,Jeyakanthan J,Rayala SK,Venkatraman G

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    authors: Eidukevicius R,Characiejus D,Janavicius R,Kazlauskaite N,Pasukoniene V,Mauricas M,Den Otter W

    更新日期:2005-09-22 00:00:00

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    pub_type: 杂志文章


    authors: Takuwa H,Tsuji W,Shintaku M,Yotsumoto F

    更新日期:2018-12-22 00:00:00

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    pub_type: 杂志文章


    authors: Dozmorov MG,Azzarello JT,Wren JD,Fung KM,Yang Q,Davis JS,Hurst RE,Culkin DJ,Penning TM,Lin HK

    更新日期:2010-12-06 00:00:00

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    journal_title:BMC cancer

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Liu XH,Liu ZL,Sun M,Liu J,Wang ZX,De W

    更新日期:2013-10-08 00:00:00

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Mogensen MB,Rossing M,Østrup O,Larsen PN,Heiberg Engel PJ,Jørgensen LN,Hogdall EV,Eriksen J,Ibsen P,Jess P,Grauslund M,Nielsen HJ,Nielsen FC,Vainer B,Osterlind K

    更新日期:2018-07-20 00:00:00

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    pub_type: 杂志文章


    authors: Moelans CB,de Weger RA,Ezendam C,van Diest PJ

    更新日期:2009-01-05 00:00:00

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Senchenko VN,Anedchenko EA,Kondratieva TT,Krasnov GS,Dmitriev AA,Zabarovska VI,Pavlova TV,Kashuba VI,Lerman MI,Zabarovsky ER

    更新日期:2010-03-01 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Luo J,Liu P,Wang L,Huang Y,Wang Y,Geng W,Chen D,Bai Y,Yang Z

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Melnychuk M,Vindrola-Padros C,Aitchison M,Clarke CS,Fulop NJ,Levermore C,Maddineni SB,Moore CM,Mughal MM,Perry C,Pritchard-Jones K,Ramsay AIG,Shackley D,Vickers J,Morris S

    更新日期:2018-02-27 00:00:00

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    pub_type: 杂志文章


    authors: Voels B,Wang L,Sens DA,Garrett SH,Zhang K,Somji S

    更新日期:2017-05-25 00:00:00

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    pub_type: 杂志文章


    authors: Jeong S,Lee K,Wen X,Kim Y,Cho NY,Jang JJ,Kang GH

    更新日期:2017-08-29 00:00:00

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    journal_title:BMC cancer

    pub_type: 杂志文章,meta分析


    authors: Marinovich ML,Macaskill P,Irwig L,Sardanelli F,Mamounas E,von Minckwitz G,Guarneri V,Partridge SC,Wright FC,Choi JH,Bhattacharyya M,Martincich L,Yeh E,Londero V,Houssami N

    更新日期:2015-10-08 00:00:00

  • The feasibility and advantage of uniportal video-assisted thoracoscopic surgery (VATS) in pulmonary lobectomy.

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Wang L,Liu D,Lu J,Zhang S,Yang X

    更新日期:2017-01-25 00:00:00

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Langton JM,Pesa N,Rushton S,Ward RL,Pearson SA

    更新日期:2013-03-12 00:00:00

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Jami MS,Hou J,Liu M,Varney ML,Hassan H,Dong J,Geng L,Wang J,Yu F,Huang X,Peng H,Fu K,Li Y,Singh RK,Ding SJ

    更新日期:2014-03-15 00:00:00

  • Systematic validation of predicted microRNAs for cyclin D1.

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Jiang Q,Feng MG,Mo YY

    更新日期:2009-06-18 00:00:00

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    abstract:BACKGROUND:The cholesterol biosynthesis pathway is typically upregulated in breast cancer. The role of NAD(P)-dependent steroid dehydrogenase-like (NSDHL) gene, which is involved in cholesterol biosynthesis, in breast cancer remains unknown. This study aimed to uncover the role of NSDHL in the growth and metastasis of ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Yoon SH,Kim HS,Kim RN,Jung SY,Hong BS,Kang EJ,Lee HB,Moon HG,Noh DY,Han W

    更新日期:2020-05-04 00:00:00

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    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Quaife SL,Vrinten C,Ruparel M,Janes SM,Beeken RJ,Waller J,McEwen A

    更新日期:2018-05-02 00:00:00

  • Impact of chromosomal instability on colorectal cancer progression and outcome.

    abstract:BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Orsetti B,Selves J,Bascoul-Mollevi C,Lasorsa L,Gordien K,Bibeau F,Massemin B,Paraf F,Soubeyran I,Hostein I,Dapremont V,Guimbaud R,Cazaux C,Longy M,Theillet C

    更新日期:2014-02-22 00:00:00