Abstract:
BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases. METHODS:Array Comparative Genomic Hybridization (aCGH) was employed to asses DNA copy number changes in primary colorectal tumors of three distinctive patient groups. This included formalin-fixed, paraffin-embedded tissue of patients who developed liver metastases (LM; n = 36), metastases (PM; n = 37) and a group that remained metastases-free (M0; n = 25).A novel statistical method for identifying recurrent copy number changes, KC-SMART, was used to find specific locations of genomic aberrations specific for various groups. We created a classifier for organ specific metastases based on the aCGH data using Prediction Analysis for Microarrays (PAM). RESULTS:Specifically in the tumors of primary CRC patients who subsequently developed liver metastasis, KC-SMART analysis identified genomic aberrations on chromosome 20q. LM-PAM, a shrunken centroids classifier for liver metastases occurrence, was able to distinguish the LM group from the other groups (M0&PM) with 80% accuracy (78% sensitivity and 86% specificity). The classification is predominantly based on chromosome 20q aberrations. CONCLUSION:Liver specific CRC metastases may be predicted with a high accuracy based on specific genomic aberrations in the primary CRC tumor. The ability to predict the site of metastases is important for improvement of personalized patient management.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Bruin SC,Klijn C,Liefers GJ,Braaf LM,Joosse SA,van Beers EH,Verwaal VJ,Morreau H,Wessels LF,van Velthuysen ML,Tollenaar RA,Van't Veer LJdoi
10.1186/1471-2407-10-662subject
Has Abstractpub_date
2010-12-02 00:00:00pages
662issn
1471-2407pii
1471-2407-10-662journal_volume
10pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-018-4699-5
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-259
更新日期:2010-06-04 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5820-0
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this disease. However, the mechanism of miRNA-induced mRNA cleavage remains to be investigated. METHOD:In...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06717-4
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of contention. METHODS:A database of 386 patients, enrolled in a randomized clinical trial on the effect of a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-702
更新日期:2014-09-24 00:00:00
abstract:BACKGROUND:Survival rates of lung cancer remains poor and the impact of comorbidities on the prognosis is discussed. The objective of this study was to assess if the Charlson Comorbidity Index (CCI) was associated with 8-year survival rates by histological type. METHODS:A cohort study was conducted using randomly sele...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5000-7
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2712-4
更新日期:2016-08-19 00:00:00
abstract:BACKGROUND:Smoking is by far the most important cause of cancer that can be modified at the individual level. Cancer incidence and mortality rates in Korea are the highest among all Asian countries, and smoking prevalence in Korean men is one of the highest in developed countries. The purpose of the current study was t...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-406
更新日期:2014-06-06 00:00:00
abstract:BACKGROUND:As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of cancer-related pain in the outpatient setting. METHODS:We conducted a prospective study to compare rein...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07270-w
更新日期:2020-09-04 00:00:00
abstract:BACKGROUND:Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lentivirus-mediated cytosine deaminase-thymidine kinase (CDglyTK) gene in transplanted breast cancer deli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6111-5
更新日期:2019-09-14 00:00:00
abstract:BACKGROUND:Febrile neutropenia (FN) is common in breast cancer patients undergoing chemotherapy. Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This study aimed to evaluate the predictive value of patient-related, chemotherapy-related, and genetic risk...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-201
更新日期:2014-03-19 00:00:00
abstract:BACKGROUND:Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-29
更新日期:2014-01-17 00:00:00
abstract:BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic si...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07121-8
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07766-5
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:The associations between microRNAs and lung cancer have received increasing attention. This study assess the association between polymorphisms in miR-135a-2, miR-219-2 and miR-211 genes and the risk of lung cancer, as well as the gene-environment interaction between these polymorphisms and cooking oil fume e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2784-1
更新日期:2016-09-23 00:00:00
abstract:BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-5086-y
更新日期:2018-12-05 00:00:00
abstract:BACKGROUND:Pneumatosis cystoides intestinalis (PCI) is a rare self-limiting condition characterized by air-filled cysts within intestinal walls. Diagnosis should be prudent because it can mimic pneumoperitoneum leading to unnecessary treatment such as surgical exploration. Although various drugs including anti-neoplast...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-017-3744-0
更新日期:2017-11-09 00:00:00
abstract:BACKGROUND:Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2033-z
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:A substantial number of patients will develop further biochemical progression after radical prostatectomy (RP) and salvage radiotherapy (sRT). Recently published data using prostate-specific membrane antigen ligand positron emission tomography (PSMA - PET) for re-staging suggest that those recurrences are of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06883-5
更新日期:2020-04-29 00:00:00
abstract:BACKGROUND:The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinical practice three-year project to increase breast cancer screening among young breast cancer survivor...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-13-97
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively radioresistant tumors such as malignant melanoma, renal cell carcinoma, and colorectal cancer. Additionally, a potential benefit from escalating the radiation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-582
更新日期:2010-10-26 00:00:00
abstract:BACKGROUND:Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to evaluate tumor response simulating different conditions of administration of antiangiogenic treatment (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-403
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND:H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there is also an overexpression of CXCR4 and an obvious involvement in gastric cancer metastasis. The aim o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-419
更新日期:2010-08-11 00:00:00
abstract:BACKGROUND:Increased level of serum S100B can serve as a marker of metastatic spread in patients with cutaneous melanoma (CM). In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and planning treatment.The aims of this study were to det...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-328
更新日期:2011-08-02 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2749-4
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Angiogenesis is a proliferative process resulting in the development of new blood vessels from existing endothelial cells and is considered crucial for tumor growth and metastasis. Tumor angiogenesis can be quantified by microvascular density (MVD), which is evaluated in highly vascularized tumor areas (hot ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-72
更新日期:2014-02-07 00:00:00
abstract:BACKGROUND:Territorial differences in the access to innovative anticancer drugs have been reported from many countries. The objectives of this study were to evaluate access to innovative treatments for metastatic lung cancer in France, and to assess whether socioeconomic indicators were predictors of access at the leve...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4958-5
更新日期:2018-10-22 00:00:00
abstract:BACKGROUND:Bevacizumab, a humanized antibody to vascular endothelial growth factor (VEGF), shows clinical activity against human cancer, with its addition to standard chemotherapy having been found to improve outcome in patients with advanced nonsquamous non-small cell lung cancer (NSCLC). However, there have been no e...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-12-327
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake as compare...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2133-4
更新日期:2016-02-13 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide, and CD133 is a popular cancer stem cell (CSC) marker for HCC. CD133(+) CSCs have been reported to resist conventional chemo- and radiotherapy, but little is known about their response to immune surveillance. Interferon-gamma (IFN...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2050-6
更新日期:2016-01-13 00:00:00