Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori.

abstract：BACKGROUND:Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity and resistance. In dividing cells, traditional metrics derived from dose-response curves such as IC...

journal_title：BMC cancer

authors： Clark NA,Hafner M,Kouril M,Williams EH,Muhlich JL,Pilarczyk M,Niepel M,Sorger PK,Medvedovic M

更新日期：2017-10-24 00:00:00

abstract：BACKGROUND:Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and postoperative chemotherapy. However, these reg...

journal_title：BMC cancer

authors： Slagter AE,Jansen EPM,van Laarhoven HWM,van Sandick JW,van Grieken NCT,Sikorska K,Cats A,Muller-Timmermans P,Hulshof MCCM,Boot H,Los M,Beerepoot LV,Peters FPJ,Hospers GAP,van Etten B,Hartgrink HH,van Berge Henegouwen MI,

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected luminal, post-EMT and basal-like breast carcinoma cell lines. METHODS:Migration was assessed in luminal (...

journal_title：BMC cancer

authors： Voss MJ,Möller MF,Powe DG,Niggemann B,Zänker KS,Entschladen F

更新日期：2011-05-02 00:00:00

abstract：BACKGROUND:Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody used in association with chemotherapy in met...

journal_title：BMC cancer

authors： Lereclus E,Tout M,Girault A,Baroukh N,Caulet M,Borg C,Bouché O,Ternant D,Paintaud G,Lecomte T,Raoul W

更新日期：2017-03-27 00:00:00

abstract：:Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...

journal_title：BMC cancer

authors： Jiann BP

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Breast cancer places a heavy burden on the Australian healthcare system, but information about the actual number of women living with breast cancer and their current or future health service needs is limited. We used existing population-based data and innovative statistical methods to address this critical r...

journal_title：BMC cancer

authors： Yu XQ,De Angelis R,Luo Q,Kahn C,Houssami N,O'Connell DL

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemot...

journal_title：BMC cancer

authors： Kim B,Stephen SL,Hanby AM,Horgan K,Perry SL,Richardson J,Roundhill EA,Valleley EM,Verghese ET,Williams BJ,Thorne JL,Hughes TA

更新日期：2015-09-11 00:00:00

abstract：BACKGROUD:Pancreatic cancer is a highly malignant tumor of the digestive system. This secretome of pancreatic cancer is key to its progression and metastasis. But different methods of protein extraction affect the final results. In other words, the real secretion of proteins in cancer cells has been changed. Based on m...

journal_title：BMC cancer

authors： Liu P,Kong L,Liang K,Wu Y,Jin H,Song B,Tan X

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Salivary gland cancer (SGC) is one of the common malignancies of the head and neck area. It develops in the minor and major salivary glands and sometimes metastasizes to other organs, particularly to the lungs. Inhibitors of differentiation (Id) proteins are negative regulators of basic helix-loop-helix tran...

journal_title：BMC cancer

authors： Sumida T,Murase R,Onishi-Ishikawa A,McAllister SD,Hamakawa H,Desprez PY

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor tr...

journal_title：BMC cancer

authors： Bathe OF,Dalyot-Herman N,Malek TR

更新日期：2003-07-28 00:00:00

abstract：BACKGROUND:NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported ...

journal_title：BMC cancer

authors： Shang L,Fang Z,Liu J,Du F,Jing H,Xu Y,Dong K,Zhang X,Wu H,Jing C,Li L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investig...

journal_title：BMC cancer

authors： Deng L,Ren Z,Jia Q,Wu W,Shen H,Wang Y

更新日期：2013-07-29 00:00:00

abstract：BACKGROUND:Leukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. KillerRed is a genetically encoded red fluorescent protein photosensitizer (PS). In this study, we aimed to investigate the...

journal_title：BMC cancer

authors： Yuan M,Liu C,Li J,Ma W,Yu X,Zhang P,Ji Y

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....

journal_title：BMC cancer

authors： Stensman H,Larsson C

更新日期：2008-12-11 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following error is the article. ...

journal_title：BMC cancer

authors： Ye S,Hao X,Zhou T,Wu M,Wei J,Wang Y,Zhou L,Jiang X,Ji L,Chen Y,You L,Zhang Y,Xu G,Zhou J,Ma D,Wang S

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their metastatic disease. MET...

journal_title：BMC cancer

authors： Hu X,Cao J,Hu W,Wu C,Pan Y,Cai L,Tong Z,Wang S,Li J,Wang Z,Wang B,Chen X,Yu H

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of the CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 gene polymorphisms and tobacco smok...

journal_title：BMC cancer

authors： Ezzeldin N,El-Lebedy D,Darwish A,El Bastawisy A,Abd Elaziz SH,Hassan MM,Saad-Hussein A

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play role in tumor dissemination and are an independent survival predictor in breast cancer (BC) patients. The aim of this study was to assess correlation between CTCs and tumor MMP1 in BC. METHOD...

journal_title：BMC cancer

authors： Cierna Z,Mego M,Janega P,Karaba M,Minarik G,Benca J,Sedlácková T,Cingelova S,Gronesova P,Manasova D,Pindak D,Sufliarsky J,Danihel L,Reuben JM,Mardiak J

更新日期：2014-06-28 00:00:00

abstract：BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...

journal_title：BMC cancer

authors： Osipov V,Ho KC,Krouwer HG,Meyer G,Shidham VB

更新日期：2002-12-03 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have shown evidence that tight junction (TJ) components were correlated with carcinogenesis and tumor deve...

journal_title：BMC cancer

authors： Ram AK,Pottakat B,Vairappan B

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:Afaitnib has shown anti-tumor activity against metastatic EGFR-mutated NSCLC after prior failure to first generation EGFR-TKI and chemotherapy. We prospectively evaluated the efficacy and safety of afatinib in Chinese patients who previously failed first-generation TKI and chemotherapy under a compassionate ...

journal_title：BMC cancer

authors： Lee VH,Leung DK,Choy TS,Lam KO,Lam PM,Leung TW,Kwong DL

更新日期：2016-02-24 00:00:00

abstract：BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...

journal_title：BMC cancer

authors： Choi MH,Mejlænder-Andersen E,Manueldas S,El Jellas K,Steine SJ,Tjensvoll K,Sætran HA,Knappskog S,Hoem D,Nordgård O,Hovland R,Molven A

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:Various efforts to understand the relationship between biological information and disease have been done using many different types of highthroughput data such as genomics and metabolomics. However, information obtained from previous studies was not satisfactory, implying that new direction of studies is in ...

journal_title：BMC cancer

authors： Jeong J,Seo K,Kim ES

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Reprogramming energy metabolism has been an emerging hallmark of cancer cells. MicroRNAs play important roles in glucose metabolism. METHODS:The targets of microRNA-26a (miR-26a) were predicted by bioinformatics tools. The efficacy of miR-26a binding the 3'-untranslated region (UTR) of pyruvate dehydrogenas...

journal_title：BMC cancer

authors： Chen B,Liu Y,Jin X,Lu W,Liu J,Xia Z,Yuan Q,Zhao X,Xu N,Liang S

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the popu...

journal_title：BMC cancer

authors： Yoshimura A,Yamada T,Okura N,Takeda T,Furutani W,Kubota Y,Shiotsu S,Hiranuma O,Nishioka N,Chihara Y,Tamiya N,Kaneko Y,Uchino J,Takayama K

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Com...

journal_title：BMC cancer

authors： Zhang B,Song Y,Fu Y,Zhu B,Wang B,Wang J

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of ...

journal_title：BMC cancer

authors： Oo KK,Kamolhan T,Soni A,Thongchot S,Mitrpant C,O-Charoenrat P,Thuwajit C,Thuwajit P

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were de...

journal_title：BMC cancer

authors： Gan L,He J,Zhang X,Zhang YJ,Yu GZ,Chen Y,Pan J,Wang JJ,Wang X

更新日期：2012-12-02 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of breast cancer, without tumor-specific treatment options and accounts for 15% of all types of breast ca...

journal_title：BMC cancer

authors： Kaur P,Nagaraja GM,Zheng H,Gizachew D,Galukande M,Krishnan S,Asea A

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...

journal_title：BMC cancer

authors： Lu R,Wu C,Guo L,Liu Y,Mo W,Wang H,Ding J,Wong ET,Yu M

更新日期：2012-12-19 00:00:00