MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells.

abstract：BACKGROUND:Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA1/BRCA2 inactivation during cancer development will be helpful for more effective treatments. ME...

journal_title：BMC cancer

authors： Zhang J,Shi Y,Lalonde E,Li L,Cavallone L,Ferenczy A,Gotlieb WH,Foulkes WD,Majewski J

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...

journal_title：BMC cancer

authors： Wu Z,Zhao J,Gao P,Song Y,Sun J,Chen X,Ma B,Wang Z

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease. ...

journal_title：BMC cancer

authors： Wang X,Yang W,Yang J

更新日期：2010-08-04 00:00:00

abstract：BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...

journal_title：BMC cancer

authors： Tanimoto K,Sekiguchi N,Yokota Y,Kaneko A,Watanabe T,Maeshima AM,Matsuno Y,Harada M,Tobinai K,Kobayashi Y

更新日期：2006-10-20 00:00:00

abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

journal_title：BMC cancer

authors： Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms f...

journal_title：BMC cancer

authors： Blank S,Rachakonda S,Keller G,Weichert W,Lordick F,Langer R,Springfeld C,Bruckner T,Becker K,Kumar R,Ott K

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor. This study investiga...

journal_title：BMC cancer

authors： Nguyen L,Fifis T,Christophi C

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Androgen deprivation therapy (ADT) is a cornerstone in the treatment of advanced prostate cancer. Adverse musculoskeletal and cardiovascular effects of ADT are widely reported and investigations into the potential of exercise to ameliorate the effects of treatment are warranted. The 'Football Club (FC) Prost...

journal_title：BMC cancer

authors： Uth J,Schmidt JF,Christensen JF,Hornstrup T,Andersen LJ,Hansen PR,Christensen KB,Andersen LL,Helge EW,Brasso K,Rørth M,Krustrup P,Midtgaard J

更新日期：2013-12-13 00:00:00

abstract：BACKGROUND:Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR tyrosine kinase inhibitor. Few studies have analyzed population-level testing. METHODS:We identif...

journal_title：BMC cancer

authors： Lynch JA,Berse B,Rabb M,Mosquin P,Chew R,West SL,Coomer N,Becker D,Kautter J

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...

journal_title：BMC cancer

authors： Lapin M,Tjensvoll K,Oltedal S,Javle M,Smaaland R,Gilje B,Nordgård O

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results. METHODS:We conducted a nested case-control study to assess the association between incident lung cancer o...

journal_title：BMC cancer

authors： Colombara DV,Manhart LE,Carter JJ,Hawes SE,Weiss NS,Hughes JP,Qiao YL,Taylor PR,Smith JS,Galloway DA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:In Europe, gastric cancer remains diagnosed at advanced stage (serosal and/or lymph node involvement). Despite curative management combining perioperative systemic chemotherapy and gastrectomy with D1-D2 lymph node dissection, 5-year survival rates of T3 and/or N + patients remain under 30%. More than 50% of...

journal_title：BMC cancer

authors： Glehen O,Passot G,Villeneuve L,Vaudoyer D,Bin-Dorel S,Boschetti G,Piaton E,Garofalo A

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS:We used cell death assays, size exclusion chromatography, Co-Immunoprecipitation, shRNA lentivectors and glioma neural stem cells ...

journal_title：BMC cancer

authors： Selmi T,Alecci C,dell' Aquila M,Montorsi L,Martello A,Guizzetti F,Volpi N,Parenti S,Ferrari S,Salomoni P,Grande A,Zanocco-Marani T

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Pro...

journal_title：BMC cancer

authors： Udeh EI,Ofoha CG,Adewole DA,Nnabugwu II

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:Mucosal melanomas represent about 1% of all melanoma cases and classically have a worse prognosis than cutaneous melanomas. Due to the rarity of mucosal melanomas, only limited clinical studies with metastatic mucosal melanoma are available. Mucosal melanomas most commonly contain mutations in the gene CKIT,...

journal_title：BMC cancer

authors： Kim CY,Kim DW,Kim K,Curry J,Torres-Cabala C,Patel S

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen rec...

journal_title：BMC cancer

authors： Zekas E,Prossnitz ER

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer. METHODS:A total of 301 consecutive patients (mean age, 49.8 ± 11.0 years; range, 29-86 years) with breast cancer confirmed by patho...

journal_title：BMC cancer

authors： Ni-Jia-Ti MY,Ai-Hai-Ti DL,Huo-Jia AS,Wu-Mai-Er PL,A-Bu-Li-Zi AB,Shi Y,Rou-Zi NE,Su WJ,Dai GZ,Da-Mo-la MH

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...

journal_title：BMC cancer

authors： Zhao L,Zhao H,Yan H

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated oligometastasized PC patients receiving stereotactic body radiotherapy (SBRT) to bone metastases. METHODS:In this retrospective study, 15 oligometastasized...

journal_title：BMC cancer

authors： Habl G,Straube C,Schiller K,Duma MN,Oechsner M,Kessel KA,Eiber M,Schwaiger M,Kübler H,Gschwend JE,Combs SE

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS:PRAF2 mRNA expression was determined in 77 frozen ESCC samples by quantitati...

journal_title：BMC cancer

authors： Qian Z,Wei B,Zhou Y,Wang Q,Wang J,Sun Y,Gao Y,Chen X

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...

journal_title：BMC cancer

authors： Mikhitarian K,Martin RH,Ruppel MB,Gillanders WE,Hoda R,Schutte del H,Callahan K,Mitas M,Cole DJ

更新日期：2008-02-20 00:00:00

abstract：BACKGROUND:It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and...

journal_title：BMC cancer

authors： Olsson Möller U,Rydén L,Malmström M

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua),...

journal_title：BMC cancer

authors： Nyaga SG,Lohani A,Jaruga P,Trzeciak AR,Dizdaroglu M,Evans MK

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:The purpose of this case report is to describe a conjunctiva and eyelid Kaposi's sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection. CAS...

journal_title：BMC cancer

authors： Sousa Neves F,Braga J,Cardoso da Costa J,Sequeira J,Prazeres S

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:pressurized intraperitoneal aerosol chemotherapy (PIPAC), with or without electrostatic precipitation (ePIPAC), was recently introduced in the treatment of peritoneal metastases (PM) from ovarian cancer (OC). Preliminary clinical data are promising, but several methodological issues as well the anticancer ef...

journal_title：BMC cancer

authors： Van de Sande L,Willaert W,Cosyns S,De Clercq K,Shariati M,Remaut K,Ceelen W

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the research group, 80% of the patients with breast cancer reported a high level of stress symptoms close t...

journal_title：BMC cancer

authors： Nordin K,Rissanen R,Ahlgren J,Burell G,Fjällskog ML,Börjesson S,Arving C

更新日期：2012-05-04 00:00:00

abstract：BACKGROUND:Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations. METHODS:From a multi-institutiona...

journal_title：BMC cancer

authors： Redana S,Donadio M,Nolè F,Jacomuzzi ME,Beano A,Martinello R,Sapino A,Viale G,Aglietta M,Montemurro F

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need for repeat surgery. This individual patient data (IPD) meta-analysis examines MRI's agreement with pa...

journal_title：BMC cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,Mamounas E,von Minckwitz G,Guarneri V,Partridge SC,Wright FC,Choi JH,Bhattacharyya M,Martincich L,Yeh E,Londero V,Houssami N

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor tr...

journal_title：BMC cancer

authors： Bathe OF,Dalyot-Herman N,Malek TR

更新日期：2003-07-28 00:00:00

abstract：BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...

journal_title：BMC cancer

authors： Dankner R,Balicer R,Boffetta P,Boker LK,Wallenstein S,Freedman L,Goldfracht M,Roth J,Tamler R,LeRoith D

更新日期：2012-08-23 00:00:00