Post-radiation dedifferentiation of meningioma into osteosarcoma.


BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years old, presented with a pituitary macroadenoma. He underwent a subtotal resection of the tumor and did well until 1990 when a recurrent tumor was diagnosed. This was treated with subtotal resection of the tumor, followed by radiation therapy for six weeks to a total of 54 Gy. He was considered "disease-free" for nearly ten years. However, most recently in July 2000, he presented with a visual field deficit due to a second recurrence of his pituitary macroadenoma, now with suprasellar extension. At this time, as an incidental finding, a mass attached to the dura was noted in the left parietal hemisphere. This dura-based mass had grown rapidly by January 2001 and was excised. It showed histological, immunohistochemical, and electron microscopic features of malignant meningioma and osteosarcoma with a sharp demarcation between the two components. CONCLUSIONS:We report a rare case of a radiation induced dedifferentiation of meningioma into osteosarcoma, which has not been reported previously.


BMC Cancer


BMC cancer


Osipov V,Ho KC,Krouwer HG,Meyer G,Shidham VB





Has Abstract


2002-12-03 00:00:00








  • Influence of mTOR-inhibitors and mycophenolic acid on human cholangiocellular carcinoma and cancer associated fibroblasts.

    abstract:BACKGROUND:The incidence of Cholangiocellular Carcinoma (CCA) is increasing in the western world. The tumour has a high proportion of desmoplastic stroma and is correlated with a worse prognosis when cancer associated myofibroblasts (CAFs) are present. Recent studies showed promising results after liver transplantation...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Heits N,Heinze T,Bernsmeier A,Kerber J,Hauser C,Becker T,Kalthoff H,Egberts JH,Braun F

    更新日期:2016-05-20 00:00:00

  • Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis.

    abstract:BACKGROUND:Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERC...

    journal_title:BMC cancer

    pub_type: 杂志文章,meta分析


    authors: Zhang E,Cui Z,Xu Z,Duan W,Huang S,Tan X,Yin Z,Sun C,Lu L

    更新日期:2013-12-12 00:00:00

  • Prognostic significance of stem cell/ epithelial-mesenchymal transition markers in periampullary/pancreatic cancers: FGFR1 is a promising prognostic marker.

    abstract:BACKGROUND:Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to canc...

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    pub_type: 杂志文章


    authors: Chong Y,Thakur N,Paik KY,Lee EJ,Kang CS

    更新日期:2020-03-14 00:00:00

  • High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells.

    abstract:BACKGROUND:Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism is not fully elucidate...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Sato Y,Kubo T,Morimoto K,Yanagihara K,Seyama T

    更新日期:2016-02-06 00:00:00

  • Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma.

    abstract:BACKGROUND:This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. METHODS:In this retrospective case series, intravitreal chemotherapy-assisted en...

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    pub_type: 杂志文章


    authors: Yu X,Li X,Xing Y,Lu S,Tanumiharjo S,Ma J

    更新日期:2020-08-26 00:00:00

  • The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription.

    abstract:BACKGROUND:Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvir...

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    pub_type: 杂志文章


    authors: Simon PS,Sharman SK,Lu C,Yang D,Paschall AV,Tulachan SS,Liu K

    更新日期:2015-10-23 00:00:00

  • Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy.

    abstract:BACKGROUND:Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer p...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Vidlickova I,Dequiedt F,Jelenska L,Sedlakova O,Pastorek M,Stuchlik S,Pastorek J,Zatovicova M,Pastorekova S

    更新日期:2016-03-19 00:00:00

  • MiR-890 inhibits proliferation and invasion and induces apoptosis in triple-negative breast cancer cells by targeting CD147.

    abstract:BACKGROUND:Triple-negative breast cancer (TNBC) is a type of breast cancer with a high degree of malignancy. Because of the remarkable biological characteristics of high invasion, metastasis and recurrence, TNBC is often accompanied by a poor prognosis. As a molecular characteristic of TNBC, high expression of CD147 ha...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Wang C,Xu C,Niu R,Hu G,Gu Z,Zhuang Z

    更新日期:2019-06-13 00:00:00

  • Correction to: Functional and clinical significance of ROR1 in lung adenocarcinoma.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:BMC cancer

    pub_type: 已发布勘误


    authors: Schiavone G,Epistolio S,Martin V,Molinari F,Barizzi J,Mazzucchelli L,Frattini M,Wannesson L

    更新日期:2020-12-07 00:00:00

  • Prognostic impact of mRNA levels of osteopontin splice variants in soft tissue sarcoma patients.

    abstract:BACKGROUND:It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, little is known about the prognostic relevance of the OPN mRNA splice variants. METHODS:We analyzed ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Hahnel A,Wichmann H,Greither T,Kappler M,Würl P,Kotzsch M,Taubert H,Vordermark D,Bache M

    更新日期:2012-04-02 00:00:00

  • Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan.

    abstract:BACKGROUND:In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. METHODS:Taiwan Cancer Registry records of 9039 subjects diagnos...

    journal_title:BMC cancer

    pub_type: 杂志文章,多中心研究


    authors: Chen PH,Shieh TY,Ho PS,Tsai CC,Yang YH,Lin YC,Ko MS,Tsai PC,Chiang SL,Tu HP,Ko YC

    更新日期:2007-06-15 00:00:00

  • Resolution of severe hyponatraemia is associated with improved survival in patients with cancer.

    abstract:BACKGROUND:Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with cancer. METHODS:A retrospective review of all patients admitted to a specialist cancer hospital with ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Balachandran K,Okines A,Gunapala R,Morganstein D,Popat S

    更新日期:2015-03-22 00:00:00

  • MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5.

    abstract:BACKGROUND:MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated in several other cancers, its role in non-small cell lung cancer (NSCLC) is unknown. The aim of the present st...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Liu XH,Lu KH,Wang KM,Sun M,Zhang EB,Yang JS,Yin DD,Liu ZL,Zhou J,Liu ZJ,De W,Wang ZX

    更新日期:2012-08-09 00:00:00

  • The acceptability of high resolution anoscopy examination in patients attending a tertiary referral centre.

    abstract:BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: De-Masi A,Davis E,Cuming T,Chindawi N,Pesola F,Cappello C,Chambers S,Bowring J,Rosenthal AN,Sasieni P,Nathan M

    更新日期:2018-05-11 00:00:00

  • Expression of Bmi-1 is a prognostic marker in bladder cancer.

    abstract:BACKGROUND:The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in human bladder cancer. METHODS:We examined the expression of Bmi-1 mRNA and Bmi-1 protein by RT-PCR ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Qin ZK,Yang JA,Ye YL,Zhang X,Xu LH,Zhou FJ,Han H,Liu ZW,Song LB,Zeng MS

    更新日期:2009-02-19 00:00:00

  • Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcoma.

    abstract:BACKGROUND:The present study evaluates the outcome of 19 children with rhabdomyosarcoma of the head-and-neck region treated with Intensity Modulated Radiotherapy (IMRT) or Fractionated Stereotactic Radiotherapy (FSRT) between August 1995 and November 2005. METHODS:We treated 19 children with head-and-neck rhabdomyosar...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Combs SE,Behnisch W,Kulozik AE,Huber PE,Debus J,Schulz-Ertner D

    更新日期:2007-09-13 00:00:00

  • Expression profile and prognostic role of sex hormone receptors in gastric cancer.

    abstract:BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were de...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Gan L,He J,Zhang X,Zhang YJ,Yu GZ,Chen Y,Pan J,Wang JJ,Wang X

    更新日期:2012-12-02 00:00:00

  • Impact of chromosomal instability on colorectal cancer progression and outcome.

    abstract:BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Orsetti B,Selves J,Bascoul-Mollevi C,Lasorsa L,Gordien K,Bibeau F,Massemin B,Paraf F,Soubeyran I,Hostein I,Dapremont V,Guimbaud R,Cazaux C,Longy M,Theillet C

    更新日期:2014-02-22 00:00:00

  • Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis.

    abstract:BACKGROUND:Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear. METHODS:With the goal of revealing the underlying mechanism, three data sets with accession numbers GSE8401, GSE46517 ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Su W,Guan Y,Huang B,Wang J,Wei Y,Zhao Y,Jiao Q,Ji J,Yu D,Xu L

    更新日期:2020-09-07 00:00:00

  • A prospective clinical trial on sorafenib treatment of hepatocellular carcinoma before liver transplantation.

    abstract:BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

    journal_title:BMC cancer

    pub_type: 临床试验,杂志文章


    authors: Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

    更新日期:2019-06-11 00:00:00

  • Different protein expression associated with chemotherapy response in oropharyngeal cancer according to HPV status.

    abstract:BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Kim MJ,Ki MS,Kim K,Shim HJ,Hwang JE,Bae WK,Chung IJ,Lee DH,Lee JK,Yoon TM,Lim SC,Chung WK,Jeong JU,Lim HS,Choi YD,Cho SH

    更新日期:2014-11-07 00:00:00

  • Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen.

    abstract:BACKGROUND:Recruitment of cofactors in the interaction of the androgen receptor (AR) and AR ligands plays a critical role in determining androgenic/antiandrogenic effects of the AR ligand on signaling, but the functions of key cofactors, including nuclear receptor coactivator (NCOA), remain poorly understood in prostat...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Takeda K,Hara N,Nishiyama T,Tasaki M,Ishizaki F,Tomita Y

    更新日期:2016-05-25 00:00:00

  • Protein kinase Cepsilon is important for migration of neuroblastoma cells.

    abstract:BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Stensman H,Larsson C

    更新日期:2008-12-11 00:00:00

  • EnROL: a multicentre randomised trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme.

    abstract:BACKGROUND:During the last two decades the use of laparoscopic resection and a multimodal approach known as an enhanced recovery programme, have been major changes in colorectal perioperative care. Clinical outcome improves using laparoscopic surgery to resect colorectal cancer but until recently no multicentre trial e...

    journal_title:BMC cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kennedy RH,Francis A,Dutton S,Love S,Pearson S,Blazeby JM,Quirke P,Franks PJ,Kerr DJ

    更新日期:2012-05-16 00:00:00

  • The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females.

    abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Isakova J,Talaibekova E,Aldasheva N,Vinnikov D,Aldashev A

    更新日期:2017-11-13 00:00:00

  • Satisfaction with care among patients with non-metastatic breast cancer: development and first steps of validation of the REPERES-60 questionnaire.

    abstract:BACKGROUND:The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid instrument measuring satisfaction among patients with breast cancer and exploring their care itiner...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Defossez G,Mathoulin-Pelissier S,Ingrand I,Gasquet I,Sifer-Riviere L,Ingrand P,Salamon R,Migeot V,REPERES research network.

    更新日期:2007-07-16 00:00:00

  • Promotion of the occurrence of endometrioid carcinoma by S100 calcium binding protein P.

    abstract:BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Zhang D,Chen X,Xia H,Wang L,Zhao H,Xu B,Zhang A,Zhang W

    更新日期:2020-09-03 00:00:00

  • Replicase-based plasmid DNA shows anti-tumor activity.

    abstract:BACKGROUND:Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsR...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Rodriguez BL,Yu Z,Chung WG,Weiss R,Cui Z

    更新日期:2011-03-28 00:00:00

  • Value of peri-operative chemotherapy in patients with CINSARC high-risk localized grade 1 or 2 soft tissue sarcoma: study protocol of the target selection phase III CHIC-STS trial.

    abstract:BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

    更新日期:2020-07-31 00:00:00

  • Variation in the initial assessment and investigation for ovarian cancer in symptomatic women: a systematic review of international guidelines.

    abstract:BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Funston G,Van Melle M,Baun ML,Jensen H,Helsper C,Emery J,Crosbie EJ,Thompson M,Hamilton W,Walter FM

    更新日期:2019-11-01 00:00:00