Post-radiation dedifferentiation of meningioma into osteosarcoma.

Abstract:

BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years old, presented with a pituitary macroadenoma. He underwent a subtotal resection of the tumor and did well until 1990 when a recurrent tumor was diagnosed. This was treated with subtotal resection of the tumor, followed by radiation therapy for six weeks to a total of 54 Gy. He was considered "disease-free" for nearly ten years. However, most recently in July 2000, he presented with a visual field deficit due to a second recurrence of his pituitary macroadenoma, now with suprasellar extension. At this time, as an incidental finding, a mass attached to the dura was noted in the left parietal hemisphere. This dura-based mass had grown rapidly by January 2001 and was excised. It showed histological, immunohistochemical, and electron microscopic features of malignant meningioma and osteosarcoma with a sharp demarcation between the two components. CONCLUSIONS:We report a rare case of a radiation induced dedifferentiation of meningioma into osteosarcoma, which has not been reported previously.

journal_name

BMC Cancer

journal_title

BMC cancer

authors

Osipov V,Ho KC,Krouwer HG,Meyer G,Shidham VB

doi

10.1186/1471-2407-2-34

keywords:

subject

Has Abstract

pub_date

2002-12-03 00:00:00

pages

34

issn

1471-2407

journal_volume

2

pub_type

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