Identification of dissociation factors in pancreatic Cancer using a mass spectrometry-based proteomic approach.

abstract：BACKGROUND:In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival. METHODS:Analysis was car...

journal_title：BMC cancer

authors： Lakha F,Theodoratou E,Farrington SM,Tenesa A,Cetnarskyj R,Din FV,Porteous ME,Dunlop MG,Campbell H

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...

journal_title：BMC cancer

authors： Hanf M,Chiron D,de Visme S,Touzeau C,Maisonneuve H,Jardel H,Pellat-Deceunynck C,Amiot M,le Gouill S

更新日期：2016-10-14 00:00:00

abstract：BACKGROUND:The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain. METHODS:Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, num...

journal_title：BMC cancer

authors： Ritte R,Tikk K,Lukanova A,Tjønneland A,Olsen A,Overvad K,Dossus L,Fournier A,Clavel-Chapelon F,Grote V,Boeing H,Aleksandrova K,Trichopoulou A,Lagiou P,Trichopoulos D,Palli D,Berrino F,Mattiello A,Tumino R,Sacerdote

更新日期：2013-12-09 00:00:00

abstract：BACKGROUND:Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quality of life and thus to identify those patients who need and can benefit most from specific intervent...

journal_title：BMC cancer

authors： Peters E,Mendoza Schulz L,Reuss-Borst M

更新日期：2016-10-10 00:00:00

abstract：BACKGROUND:The increasing number of individuals living with cancer has led to a focus on the quality of life of survivors, and their families. Sexual wellbeing is a central component of quality of life, with a growing body of research demonstrating the association between cancer and changes to sexuality and intimacy. H...

journal_title：BMC cancer

authors： Perz J,Ussher JM,Gilbert E

更新日期：2013-05-31 00:00:00

abstract：BACKGROUND:Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earl...

journal_title：BMC cancer

authors： Sullivan FM,Farmer E,Mair FS,Treweek S,Kendrick D,Jackson C,Robertson C,Briggs A,McCowan C,Bedford L,Young B,Vedhara K,Gallant S,Littleford R,Robertson J,Sewell H,Dorward A,Sarvesvaran J,Schembri S

更新日期：2017-03-11 00:00:00

abstract：BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...

journal_title：BMC cancer

authors： Seymour JF,Döhner H,Butrym A,Wierzbowska A,Selleslag D,Jang JH,Kumar R,Cavenagh J,Schuh AC,Candoni A,Récher C,Sandhu I,Del Castillo TB,Al-Ali HK,Falantes J,Stone RM,Minden MD,Weaver J,Songer S,Beach CL,Dombret H

更新日期：2017-12-14 00:00:00

abstract：BACKGROUND:Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. It is related to the overexpression of a membrane protein, P-glycoprotein (Pgp-170), thereby reducing drug cytotoxicity. A variety o...

journal_title：BMC cancer

authors： Limtrakul P,Anuchapreeda S,Buddhasukh D

更新日期：2004-04-17 00:00:00

abstract：BACKGROUND:The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous polyposis coli (APC) gene has been reported to have a "gatekeeper" function in the colonic muc...

journal_title：BMC cancer

authors： Sarebø M,Skjelbred CF,Breistein R,Lothe IM,Hagen PC,Bock G,Hansteen IL,Kure EH

更新日期：2006-03-17 00:00:00

abstract：BACKGROUND:The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations. This study investigated genomic differences betwee...

journal_title：BMC cancer

authors： Mealey NE,O'Sullivan DE,Pader J,Ruan Y,Wang E,Quan ML,Brenner DR

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of 18F-FDOPA PET and PET/CT in patients with gli...

journal_title：BMC cancer

authors： Xiao J,Jin Y,Nie J,Chen F,Ma X

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS:Comparative...

journal_title：BMC cancer

authors： Huang XY,Gan RH,Xie J,She L,Zhao Y,Ding LC,Su BH,Zheng DL,Lu YG

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Protein secretion by mammary cells results in autocrine and paracrine signaling that defines cell growth, migration and the extracellular environment. Even so, we have a limited understanding of the cellular processes that regulate protein secretion. METHODS:In this study, we utilize human epithelial mammar...

journal_title：BMC cancer

authors： Zhang Y,Gonzalez RM,Zangar RC

更新日期：2011-02-14 00:00:00

abstract：BACKGROUND:Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/F...

journal_title：BMC cancer

authors： Jiang K,Li Y,Zhu Q,Xu J,Wang Y,Deng W,Liu Q,Zhang G,Meng S

更新日期：2014-07-30 00:00:00

abstract：BACKGROUND:Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for overall survival (OS), are not well captured by the World Health Organization (WHO) and Response Evaluat...

journal_title：BMC cancer

authors： Noguchi M,Moriya F,Suekane S,Ohnishi R,Matsueda S,Sasada T,Yamada A,Itoh K

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:There is no consensus regarding resection of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastatic colorectal cancer (CRC). A potential benefit of resection of the primary tumour is to prevent complications of the primary tumour in later stages of the disease. We...

journal_title：BMC cancer

authors： 't Lam-Boer J,Mol L,Verhoef C,de Haan AF,Yilmaz M,Punt CJ,de Wilt JH,Koopman M

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostat...

journal_title：BMC cancer

authors： Rui X,Shao S,Wang L,Leng J

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...

journal_title：BMC cancer

authors： Martarelli D,Catalano A,Procopio A,Orecchia S,Libener R,Santoni G

更新日期：2006-05-17 00:00:00

abstract：BACKGROUND:The length of interval between successive childbirths (birth interval) might influence the incidence of breast cancer, either by stimulating or by inhibiting the factors that are responsible for the initiation of breast cancer or its early development. METHODS:This is a case-control study nested in a cohort...

journal_title：BMC cancer

authors： Katuwal S,Tapanainen JS,Pukkala E,Kauppila A

更新日期：2019-03-04 00:00:00

abstract：BACKGROUND:Smoking is by far the most important cause of cancer that can be modified at the individual level. Cancer incidence and mortality rates in Korea are the highest among all Asian countries, and smoking prevalence in Korean men is one of the highest in developed countries. The purpose of the current study was t...

journal_title：BMC cancer

authors： Park S,Jee SH,Shin HR,Park EH,Shin A,Jung KW,Hwang SS,Cha ES,Yun YH,Park SK,Boniol M,Boffetta P

更新日期：2014-06-06 00:00:00

abstract：BACKGROUND:Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study were to see if the national target of 70% of all cancer patients being included in a CPP was met, and ...

journal_title：BMC cancer

authors： Nilssen Y,Brustugun OT,Eriksen MT,Haug ES,Naume B,Møller B

更新日期：2020-05-30 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a cohort of lymph node-negative breast cancer patients not treated in the adjuvant setting. METHODS:COX...

journal_title：BMC cancer

authors： Sicking I,Rommens K,Battista MJ,Böhm D,Gebhard S,Lebrecht A,Cotarelo C,Hoffmann G,Hengstler JG,Schmidt M

更新日期：2014-12-15 00:00:00

abstract：BACKGROUND:Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expressed. Therefore these proteins are potential targets for immunotherapy and a possible basis for vaccine...

journal_title：BMC cancer

authors： Gentschev I,Fensterle J,Schmidt A,Potapenko T,Troppmair J,Goebel W,Rapp UR

更新日期：2005-02-09 00:00:00

abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...

journal_title：BMC cancer

authors： Borch KB,Braaten T,Lund E,Weiderpass E

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...

journal_title：BMC cancer

authors： Park MH,Jo M,Won D,Song HS,Han SB,Song MJ,Hong JT

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...

journal_title：BMC cancer

authors： Fang W,Huang Y,Hong S,Zhang Z,Wang M,Gan J,Wang W,Guo H,Wang K,Zhang L

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. Th...

journal_title：BMC cancer

authors： Ye F,Zhou C,Cheng Q,Shen J,Chen H

更新日期：2008-04-18 00:00:00

abstract：BACKGROUND:Rhabdoid tumors are rare cancers of early childhood arising in the kidney, central nervous system and other organs. The majority are caused by somatic inactivating mutations or deletions affecting the tumor suppressor locus SMARCB1 [OMIM 601607]. Germ-line SMARCB1 inactivation has been reported in associatio...

journal_title：BMC cancer

authors： Dagar V,Chow CW,Ashley DM,Algar EM

更新日期：2009-12-13 00:00:00

abstract：BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...

journal_title：BMC cancer

authors： Ventrucci G,de Mello MA,Gomes-Marcondes MC

更新日期：2002-04-15 00:00:00