Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression.

abstract：BACKGROUND:The transient receptor potential, subfamily V, member 6 (TRPV6) is a Ca(2+) selective cation channel. Several studies have shown that TRPV6 transcripts are expressed in locally advanced prostatic adenocarcinoma, metastatic and androgen-insensitive prostatic lesions but are undetectable in healthy prostate ti...

journal_title：BMC cancer

authors： Kessler T,Wissenbach U,Grobholz R,Flockerzi V

更新日期：2009-10-26 00:00:00

abstract：BACKGROUND:The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablating metastatic lesions and may play a synergistic role with immunotherapy. The purpose of this study ...

journal_title：BMC cancer

authors： Bahig H,Aubin F,Stagg J,Gologan O,Ballivy O,Bissada E,Nguyen-Tan FP,Soulières D,Guertin L,Filion E,Christopoulos A,Lambert L,Tehfe M,Ayad T,Charpentier D,Jamal R,Wong P

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...

journal_title：BMC cancer

authors： Nielsen K,Binderup T,Langer SW,Kjaer A,Knigge P,Grøndahl V,Melchior L,Federspiel B,Knigge U

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...

journal_title：BMC cancer

authors： Sáenz-López P,Carretero R,Cózar JM,Romero JM,Canton J,Vilchez JR,Tallada M,Garrido F,Ruiz-Cabello F

更新日期：2008-12-19 00:00:00

abstract：BACKGROUND:Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. ...

journal_title：BMC cancer

authors： Radoï L,Menvielle G,Cyr D,Lapôtre-Ledoux B,Stücker I,Luce D,ICARE Study Group.

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because many patients have multiple co-morbidities and would not fulfill the eligibility criteria of clinical...

journal_title：BMC cancer

authors： Schlumpf M,Fischer C,Naehrig D,Rochlitz C,Buess M

更新日期：2013-12-27 00:00:00

abstract：BACKGROUND:Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/...

journal_title：BMC cancer

authors： Sinilnikova OM,Dondon MG,Eon-Marchais S,Damiola F,Barjhoux L,Marcou M,Verny-Pierre C,Sornin V,Toulemonde L,Beauvallet J,Le Gal D,Mebirouk N,Belotti M,Caron O,Gauthier-Villars M,Coupier I,Buecher B,Lortholary A,Dugast

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, we evaluated the mechanism of cell death induced by ICRP in HeLa and MCF-7 cells. METHODS:Cell deat...

journal_title：BMC cancer

authors： Martínez-Torres AC,Reyes-Ruiz A,Calvillo-Rodriguez KM,Alvarez-Valadez KM,Uscanga-Palomeque AC,Tamez-Guerra RS,Rodríguez-Padilla C

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...

journal_title：BMC cancer

authors： Capdevila J,Sevilla I,Alonso V,Antón Aparicio L,Jiménez Fonseca P,Grande E,Reina JJ,Manzano JL,Alonso Lájara JD,Barriuso J,Castellano D,Medina J,López C,Segura Á,Carrera S,Crespo G,Fuster J,Munarriz J,García Alfonso P

更新日期：2015-07-04 00:00:00

abstract：BACKGROUND:Estimating the risk of malignancy is essential in the management of adnexal masses. An accurate differential diagnosis between benign and malignant masses will reduce morbidity and costs due to unnecessary operations, and will improve referral to a gynecologic oncologist for specialized cancer care, which im...

journal_title：BMC cancer

authors： Meys EM,Rutten IJ,Kruitwagen RF,Slangen BF,Bergmans MG,Mertens HJ,Nolting E,Boskamp D,Beets-Tan RG,van Gorp T

更新日期：2015-06-26 00:00:00

abstract：BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...

journal_title：BMC cancer

authors： Bond CE,Bettington ML,Pearson SA,McKeone DM,Leggett BA,Whitehall VL

更新日期：2015-01-23 00:00:00

abstract：BACKGROUND:Studies have consistently indicated that the majority of individuals meeting the US Prevention Services Task Force guidelines for genetic testing have not had genetic counseling or testing. Despite increased availability and lower costs of multiplex cancer gene panels, there remains a gap in genetics service...

journal_title：BMC cancer

authors： Rayes N,Bowen DJ,Coffin T,Nebgen D,Peterson C,Munsell MF,Gavin K,Lechner R,Crase J,Polinsky D,Romero I,Blank SV,Levine DA,Norquist BM,Swisher EM,Lu KH

更新日期：2019-07-02 00:00:00

abstract：:Following publication of the original article [1], the authors reported that during the production process, Table 1 was omitted. ...

journal_title：BMC cancer

authors： Boon SS,Chen Z,Li J,Lee KYC,Cai L,Zhong R,Chan PKS

更新日期：2019-12-29 00:00:00

abstract：BACKGROUND:Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms f...

journal_title：BMC cancer

authors： Blank S,Rachakonda S,Keller G,Weichert W,Lordick F,Langer R,Springfeld C,Bruckner T,Becker K,Kumar R,Ott K

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Being the most common cancer among women worldwide, it is vital to be well-aware of breast cancer risk factors, symptoms and curability. However, few studies have reported breast cancer literacy in students using a validated instrument. METHODS:A cross-sectional study was conducted among students of grades ...

journal_title：BMC cancer

authors： Bhandari PM,Thapa K,Dhakal S,Bhochhibhoya S,Deuja R,Acharya P,Mishra SR

更新日期：2016-02-18 00:00:00

abstract：BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...

journal_title：BMC cancer

authors： Hanf M,Chiron D,de Visme S,Touzeau C,Maisonneuve H,Jardel H,Pellat-Deceunynck C,Amiot M,le Gouill S

更新日期：2016-10-14 00:00:00

abstract：BACKGROUND:Although adjuvant chemotherapy with S-1 after curative gastrectomy has been performed as a standard treatment for Stage II and III gastric cancer (GC) in Japan, patients with Stage III GC still have a high incidence of recurrence and a poor prognostic outcome. The aim of this study was to investigate risk fa...

journal_title：BMC cancer

authors： Nishibeppu K,Komatsu S,Ichikawa D,Imamura T,Kosuga T,Okamoto K,Konishi H,Shiozaki A,Fujiwara H,Otsuji E

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:For most patients, pancreatic adenocarcinoma responds poorly to treatment, and novel therapeutic approaches are needed. Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of the apoptosis antagonist SMAC (second mitochondria-derived activator of caspases), exerts synergisti...

journal_title：BMC cancer

authors： Niu J,Wang X,Qu J,Mager DE,Straubinger RM

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Malignant melanoma is an aggressive type of skin cancer, and despite recent advances in treatment, the survival rate of the metastatic form remains low. Nifuroxazide analogues are drugs based on the substitution of the nitrofuran group by benzofuroxan, in view of the pharmacophore similarity of the nitro gro...

journal_title：BMC cancer

authors： Farias CF,Massaoka MH,Girola N,Azevedo RA,Ferreira AK,Jorge SD,Tavares LC,Figueiredo CR,Travassos LR

更新日期：2015-10-27 00:00:00

abstract：BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservat...

journal_title：BMC cancer

authors： Gu B,Fang Q,Wu Y,Du W,Zhang X,Chen D

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...

journal_title：BMC cancer

authors： Jensen H,Tørring ML,Olesen F,Overgaard J,Fenger-Grøn M,Vedsted P

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...

journal_title：BMC cancer

authors： Young JM,Walsh J,Butow PN,Solomon MJ,Shaw J

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:The "EMERGE" study, aimed to capture real-life management patterns and outcomes in metastatic breast cancer (MBC) in Greece, also accounting for hormone (HR) and human epidermal growth factor receptor 2 (HER2) status. METHODS:"EMERGE" was a multicenter, retrospective cohort study of adult MBC patients diagn...

journal_title：BMC cancer

authors： Kotsakis A,Ardavanis A,Koumakis G,Samantas E,Psyrri A,Papadimitriou C

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Local control in malignant salivary gland tumours is dose dependent. High local control rates in adenoid cystic carcinomas could be achieved by highly conformal radiotherapy techniques and particle (neutron/carbon ion) therapy. Considering high doses are needed to achieve local control, all malignant salivar...

journal_title：BMC cancer

authors： Jensen AD,Nikoghosyan A,Windemuth-Kieselbach C,Debus J,Münter MW

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...

journal_title：BMC cancer

authors： Hjortland GO,Meza-Zepeda LA,Beiske K,Ree AH,Tveito S,Hoifodt H,Bohler PJ,Hole KH,Myklebost O,Fodstad O,Smeland S,Hovig E

更新日期：2011-10-20 00:00:00

abstract：BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...

journal_title：BMC cancer

authors： Allen-Brady K,Camp NJ

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:Ongoing improvements in technique and instruments for video-assisted thoracoscopic surgery (VATS) have made minimally-invasive uniportal VATS lobectomy a reality. However, the outcomes of the procedure are still under investigation, and at present, uniportal VATS lobectomy is performed infrequently at most h...

journal_title：BMC cancer

authors： Wang L,Liu D,Lu J,Zhang S,Yang X

更新日期：2017-01-25 00:00:00

abstract：BACKGROUND:Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS:LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy...

journal_title：BMC cancer

authors： Takei K,Ikeda S,Arai T,Tanaka N,Muramatsu M,Sawabe M

更新日期：2008-08-13 00:00:00

abstract：BACKGROUND:Cancer stem cell (CSC) hypothesis has not been well demonstrated by the lack of the most convincing evidence concerning a single cell capable of giving rise to a tumor. The scarcity in quantity and improper approaches for isolation and purification of CSCs have become the major obstacles for great developmen...

journal_title：BMC cancer

authors： Li HZ,Yi TB,Wu ZY

更新日期：2008-05-14 00:00:00

abstract：BACKGROUND:Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. Interleukin-6 (IL-6) and interleukin-8 (IL-8) may i...

journal_title：BMC cancer

authors： Schillace RV,Skinner AM,Pommier RF,O'Neill S,Muller PJ,Naik AM,Hansen JE,Pommier SJ

更新日期：2014-09-30 00:00:00