Epidemiological characteristics, clinical outcomes and management patterns of metastatic breast cancer patients in routine clinical care settings of Greece: Results from the EMERGE multicenter retrospective chart review study.

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT. METHODS:Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patie...

journal_title：BMC cancer

authors： Quero L,Mongiat-Artus P,Ravery V,Maylin C,Desgrandchamps F,Hennequin C

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic si...

journal_title：BMC cancer

authors： Kloker LD,Berchtold S,Smirnow I,Beil J,Krieg A,Sipos B,Lauer UM

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity--however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may have contributed to disease control in a patient with acute undifferentiated leukemia. METHODS:To t...

journal_title：BMC cancer

authors： Kampa-Schittenhelm KM,Salitzky O,Akmut F,Illing B,Kanz L,Salih HR,Schittenhelm MM

更新日期：2016-01-16 00:00:00

abstract：BACKGROUND:Cancer cells exhibit increased glycolysis for ATP production (the Warburg effect) and macromolecular biosynthesis; it is also linked with therapeutic resistance that is generally associated with compromised respiratory metabolism. Molecular mechanisms underlying radio-resistance linked to elevated glycolysis...

journal_title：BMC cancer

authors： Bhatt AN,Chauhan A,Khanna S,Rai Y,Singh S,Soni R,Kalra N,Dwarakanath BS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Previous studies on bladder cancer have shown nodal involvement to be an independent indicator of prognosis and survival. This study aimed at developing an objective method for detection of nodal metastasis from molecular profiles of primary urothelial carcinoma tissues. METHODS:The study included primary b...

journal_title：BMC cancer

authors： Mitra AP,Almal AA,George B,Fry DW,Lenehan PF,Pagliarulo V,Cote RJ,Datar RH,Worzel WP

更新日期：2006-06-16 00:00:00

abstract：BACKGROUND:Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving peroxisome proliferator-activated receptor gamma (PPARγ) in a complex with peroxisome proliferator-ac...

journal_title：BMC cancer

authors： Kopp TI,Jensen DM,Ravn-Haren G,Cohen A,Sommer HM,Dragsted LO,Tjonneland A,Hougaard DM,Vogel U

更新日期：2016-04-21 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer. METHODS:qRT-PCR was performed to detect miR-21 levels in plasma of 127 healthy controls, 82 benign breast ...

journal_title：BMC cancer

authors： Wang H,Tan Z,Hu H,Liu H,Wu T,Zheng C,Wang X,Luo Z,Wang J,Liu S,Lu Z,Tu J

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing and analyzing data from large-scale projects, such as TCGA, is a demanding task. It is difficult to di...

journal_title：BMC cancer

authors： Lucchetta M,da Piedade I,Mounir M,Vabistsevits M,Terkelsen T,Papaleo E

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...

journal_title：BMC cancer

authors： Sáenz-López P,Carretero R,Cózar JM,Romero JM,Canton J,Vilchez JR,Tallada M,Garrido F,Ruiz-Cabello F

更新日期：2008-12-19 00:00:00

abstract：BACKGROUND:Programmed cell death 1 (PD1) inhibitors have recently shown promising anti-cancer effects in a number of solid tumor types. A predictive biomarker to this class of drugs has not been clearly identified; however, overexpression of the PD1 ligand (PD-L1) has shown particular promise in lung adenocarcinoma. In...

journal_title：BMC cancer

authors： Tessier-Cloutier B,Kalloger SE,Al-Kandari M,Milne K,Gao D,Nelson BH,Renouf DJ,Sheffield BS,Schaeffer DF

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. Here we followed-up on our previous observation that inhibition of ...

journal_title：BMC cancer

authors： Hackl C,Lang SA,Moser C,Mori A,Fichtner-Feigl S,Hellerbrand C,Dietmeier W,Schlitt HJ,Geissler EK,Stoeltzing O

更新日期：2010-12-03 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC cancer

authors： Schiavone G,Epistolio S,Martin V,Molinari F,Barizzi J,Mazzucchelli L,Frattini M,Wannesson L

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:The aim of this study was to examine the efficacy and safety of everolimus in patients with progressive unresectable adenoid cystic carcinoma (ACC). METHODS:Histologically confirmed ACC patients with documented disease progression within 12 months prior to the study entry were eligible. Everolimus was given...

journal_title：BMC cancer

authors： Kim DW,Oh DY,Shin SH,Kang JH,Cho BC,Chung JS,Kim H,Park KU,Kwon JH,Han JY,Kim MJ,Bang YJ

更新日期：2014-11-03 00:00:00

abstract：BACKGROUND:Cell-free DNA's (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy for improving the detection of tumor variants in cfDNA. Using this app...

journal_title：BMC cancer

authors： Cario CL,Chen E,Leong L,Emami NC,Lopez K,Tenggara I,Simko JP,Friedlander TW,Li PS,Paris PL,Carroll PR,Witte JS

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients' quality of life. This study aimed to develop a treatment for inflammatory ulcers as one of the side effects of afat...

journal_title：BMC cancer

authors： Sano K,Nakadate K,Hanada K

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. METHODS:This phase I study evaluated dose limiting toxicity (DLT...

journal_title：BMC cancer

authors： Mayr M,Becker K,Schulte N,Belle S,Hofheinz R,Krause A,Schmid RM,Röcken C,Ebert MP

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:In Ethiopia, the incidence of new cases of breast cancer is currently increasing resulting to high rates of morbidity and mortality. Breast cancer is by far the most common cancer accounting for more than one out of three cancer cases in women and one out of every five in the general population. The study wa...

journal_title：BMC cancer

authors： Deressa BT,Cihoric N,Badra EV,Tsikkinis A,Rauch D

更新日期：2019-04-25 00:00:00

abstract：BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...

journal_title：BMC cancer

authors： Choi MH,Mejlænder-Andersen E,Manueldas S,El Jellas K,Steine SJ,Tjensvoll K,Sætran HA,Knappskog S,Hoem D,Nordgård O,Hovland R,Molven A

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma patients, relatively little is known about brain-specific therapeutic response and adverse events in...

journal_title：BMC cancer

authors： McDonald MA,Sanghvi P,Bykowski J,Daniels GA

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...

journal_title：BMC cancer

authors： Bischel LL,Beebe DJ,Sung KE

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSCC and, although useful for predicting risk, manual assessment of histopathology is subjective and la...

journal_title：BMC cancer

authors： Bose P,Brockton NT,Guggisberg K,Nakoneshny SC,Kornaga E,Klimowicz AC,Tambasco M,Dort JC

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, including CAPRA-S, are currently used for disease prognostication. However, high...

journal_title：BMC cancer

authors： Kamdar S,Fleshner NE,Bapat B

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Mutations in the activation segment of the v-raf murine sarcoma viral oncogene homolog B (BRAF) gene are present in approximately 50% of melanomas. The selective BRAF inhibitor vemurafenib has demonstrated significant clinical benefits in patients with melanomas harboring the most common mutations (V600E, V6...

journal_title：BMC cancer

authors： Trudel S,Odolczyk N,Dremaux J,Toffin J,Regnier A,Sevestre H,Zielenkiewicz P,Arnault JP,Gubler B

更新日期：2014-09-29 00:00:00

abstract：BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...

journal_title：BMC cancer

authors： Schmidt JW,Wehde BL,Sakamoto K,Triplett AA,West WW,Wagner KU

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphom...

journal_title：BMC cancer

authors： Sernbo S,Gustavsson E,Brennan DJ,Gallagher WM,Rexhepaj E,Rydnert F,Jirström K,Borrebaeck CA,Ek S

更新日期：2011-09-24 00:00:00

abstract：BACKGROUND:In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechan...

journal_title：BMC cancer

authors： Wu F,Zhou J

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:Extramural tumor deposits (TDs) and extracapsular lymph node involvement (ECLNI) are considered to be poor prognostic factors in patients with T3-4, N0-2, M0 colorectal cancer (CRC). Although TDs are known to have multiple origins and pleomorphic features, the prognostic significances of the different type o...

journal_title：BMC cancer

authors： Yamano T,Semba S,Noda M,Yoshimura M,Kobayashi M,Hamanaka M,Beppu N,Yano A,Tsukamoto K,Matsubara N,Tomita N

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endome...

journal_title：BMC cancer

authors： Miura R,Yokoi A,Matsumoto T,Oguri Y,Hashimura M,Tochimoto M,Kajita S,Saegusa M

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women. CASE PRESENTATION:We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors. CONCLUSION...

journal_title：BMC cancer

authors： Mendez LC,Hsieh E,Earle CC,Wong S

更新日期：2018-09-10 00:00:00