Minocycline prevents and repairs the skin disorder associated with afatinib, one of the epidermal growth factor receptor-tyrosine kinase inhibitors for non-small cell lung cancer.

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unkno...

journal_title：BMC cancer

authors： Niavarani SR,Lawson C,Bakos O,Boudaud M,Batenchuk C,Rouleau S,Tai LH

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Cancer services are inaccessible in many low-income countries, and few published examples describe oncology programs within the public sector. In 2011, the Rwanda Ministry of Health (RMOH) established Butaro Cancer Center of Excellence (BCCOE) to expand cancer services nationally. In hopes of informing cance...

journal_title：BMC cancer

authors： Tapela NM,Mpunga T,Hedt-Gauthier B,Moore M,Mpanumusingo E,Xu MJ,Nzayisenga I,Hategekimana V,Umuhizi DG,Pace LE,Bigirimana JB,Wang J,Driscoll C,Uwizeye FR,Drobac PC,Ngoga G,Shyirambere C,Muhayimana C,Lehmann L,Shulma

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment of metastatic colorectal cancer. METHODS:This trial was a randomized, two-armed, non-inferiority p...

journal_title：BMC cancer

authors： Kim ST,Hong YS,Lim HY,Lee J,Kim TW,Kim KP,Kim SY,Baek JY,Kim JH,Lee KW,Chung IJ,Cho SH,Lee KH,Shin SJ,Kang HJ,Shin DB,Lee JW,Jo SJ,Park YS

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression. The aim of this study was to...

journal_title：BMC cancer

authors： Eppenberger M,Zlobec I,Baumhoer D,Terracciano L,Lugli A

更新日期：2010-03-11 00:00:00

abstract：BACKGROUND:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. METHODS:We reviewed our database of ER-positiv...

journal_title：BMC cancer

authors： Lee ES,Han W,Kim MK,Kim J,Yoo TK,Lee MH,Lee KH,Kim TY,Moon HG,Im SA,Noh DY,Lee ES

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas ...

journal_title：BMC cancer

authors： Pelizzo G,Veschi V,Mantelli M,Croce S,Di Benedetto V,D'Angelo P,Maltese A,Catenacci L,Apuzzo T,Scavo E,Moretta A,Todaro M,Stassi G,Avanzini MA,Calcaterra V

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS:In a candid...

journal_title：BMC cancer

authors： Desjardins S,Beauparlant JC,Labrie Y,Ouellette G,Durocher F,INHERIT BRCAs.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the research group, 80% of the patients with breast cancer reported a high level of stress symptoms close t...

journal_title：BMC cancer

authors： Nordin K,Rissanen R,Ahlgren J,Burell G,Fjällskog ML,Börjesson S,Arving C

更新日期：2012-05-04 00:00:00

abstract：BACKGROUND:Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer. METHODS:To further understand Herceptin resistance mechanisms at the molecular level, we used comparative proteome approaches to analyze two human ...

journal_title：BMC cancer

authors： Kang SH,Kang KW,Kim KH,Kwon B,Kim SK,Lee HY,Kong SY,Lee ES,Jang SG,Yoo BC

更新日期：2008-10-04 00:00:00

abstract：BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...

journal_title：BMC cancer

authors： Liu YJ,Zhang Q,Hu SY,Zhao FH

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. Here we followed-up on our previous observation that inhibition of ...

journal_title：BMC cancer

authors： Hackl C,Lang SA,Moser C,Mori A,Fichtner-Feigl S,Hellerbrand C,Dietmeier W,Schlitt HJ,Geissler EK,Stoeltzing O

更新日期：2010-12-03 00:00:00

abstract：BACKGROUND:Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study was to establish whether platinum-based combination chemotherapy may by beneficial in this patient ...

journal_title：BMC cancer

authors： Huang L,Liao LM,Liu AW,Wu JB,Cheng XL,Lin JX,Zheng M

更新日期：2014-02-27 00:00:00

abstract：BACKGROUND:New Zealand and Australia have the highest incidence and mortality rates from cutaneous melanoma in the world. The predominantly fair-skinned New Zealanders and Australians both enjoy sun, tanned skin and the outdoors, and differences in these activities among generations have been important determinants of ...

journal_title：BMC cancer

authors： Sneyd MJ,Cox B

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance. METHODS:Tumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF ...

journal_title：BMC cancer

authors： Wheler J,Yelensky R,Falchook G,Kim KB,Hwu P,Tsimberidou AM,Stephens PJ,Hong D,Cronin MT,Kurzrock R

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate...

journal_title：BMC cancer

authors： Grant DJ,Chen Z,Howard LE,Wiggins E,De Hoedt A,Vidal AC,Carney ST,Squires J,Magyar CE,Huang J,Freedland SJ

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). METHODS:All eligible studies were found by searching PubMed, Web of Science and EMBASE, and survival resu...

journal_title：BMC cancer

authors： Chen YL,Liu XL,Li L

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, particularly in Asian melanoma. METHODS:We retrospectively reviewed 49 melanoma patients undergoing...

journal_title：BMC cancer

authors： Wu CE,Yang CK,Peng MT,Huang PW,Chang CF,Yeh KY,Chen CB,Wang CL,Hsu CW,Chen IW,Lin CT,Ueng SH,Lin G,Lin YF,Cheng CY,Chang JW

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...

journal_title：BMC cancer

authors： Hwang-Bo J,Bae MG,Park JH,Chung IS

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as tho...

journal_title：BMC cancer

authors： Kothandaraman N,Bajic VB,Brendan PN,Huak CY,Keow PB,Razvi K,Salto-Tellez M,Choolani M

更新日期：2010-02-24 00:00:00

abstract：BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in s...

journal_title：BMC cancer

authors： Patel T

更新日期：2002-05-03 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in cancer invasion, metastasis, and chemoresistance. Additionally, EMT is partially responsible for che...

journal_title：BMC cancer

authors： Zhang Z,Zheng S,Lin Y,Sun J,Ding N,Chen J,Zhong J,Shi L,Xue M

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinical trial cohort that has been treated with a uniform approach. ...

journal_title：BMC cancer

authors： Yoon HH,Catalano PJ,Murphy KM,Skaar TC,Philips S,Powell M,Montgomery EA,Hafez MJ,Offer SM,Liu G,Meltzer SJ,Wu X,Forastiere AA,Benson AB,Kleinberg LR,Gibson MK

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:The bone scan index (BSI) using a computer-aided diagnosis system for bone scans is expected to be an objective and quantitative clinical tool for evaluating bone metastatic prostate cancer. This study aimed to evaluate the pretreatment BSI as a prognostic factor in hormone-naive prostate cancer patients wit...

journal_title：BMC cancer

authors： Miyoshi Y,Yoneyama S,Kawahara T,Hattori Y,Teranishi J,Kondo K,Moriyama M,Takebayashi S,Yokomizo Y,Yao M,Uemura H,Noguchi K

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and postoperative chemotherapy. However, these reg...

journal_title：BMC cancer

authors： Slagter AE,Jansen EPM,van Laarhoven HWM,van Sandick JW,van Grieken NCT,Sikorska K,Cats A,Muller-Timmermans P,Hulshof MCCM,Boot H,Los M,Beerepoot LV,Peters FPJ,Hospers GAP,van Etten B,Hartgrink HH,van Berge Henegouwen MI,

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Analysis of the clinical response of extramedullary lesions in leukemic patients treated with radiation therapy (RT) and defining the optimal dose of radiation. METHODS:Forty-two extramedullary lesions found in 24 leukemic patients treated with RT were reviewed. The radiation was delivered usually 2 Gy/day,...

journal_title：BMC cancer

authors： Song JH,Son SH,Lee JH,Chung SM,Jang HS,Choi BO

更新日期：2011-10-06 00:00:00

abstract：BACKGROUND:The development of non-small cell lung carcinoma proceeds through a series of well-defined pathological steps before the appearance of invasive lung carcinoma. The molecular changes that correspond with pathology changes are not well defined and identification of the molecular events may provide clues on the...

journal_title：BMC cancer

authors： Tichelaar JW,Zhang Y,leRiche JC,Biddinger PW,Lam S,Anderson MW

更新日期：2005-12-06 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...

journal_title：BMC cancer

authors： Itoh A,Sadamori H,Yabushita K,Monden K,Tatsukawa M,Hioki M,Hyodo T,Omonishi K,Ueki T,Ohno S,Sakaguchi K,Takakura N

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a recurrence despite adjuvant tamoxifen treatment. Factors that predict tamoxifen efficacy would be hel...

journal_title：BMC cancer

authors： Jager NG,Koornstra RH,Vincent AD,van Schaik RH,Huitema AD,Korse TM,Schellens JH,Linn SC,Beijnen JH

更新日期：2013-12-28 00:00:00