Prognostic value of low microRNA-34a expression in human gastrointestinal cancer: a systematic review and meta-analysis.

abstract：BACKGROUND:S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the cancer. Here, we sought to identify a molecular signature based on S100A8 expression and to assess ...

journal_title：BMC cancer

authors： Kim SK,Kim EJ,Leem SH,Ha YS,Kim YJ,Kim WJ

更新日期：2010-01-25 00:00:00

abstract：BACKGROUND:Selection of patients with local failure of nasopharyngeal carcinoma (NPC) for appropriate type of salvage treatment can be difficult due to the lack of data on comparative efficacy of different salvage treatments. The purpose of the present study was to validate a previously published prognostic scoring sys...

journal_title：BMC cancer

authors： Chua DT,Hung KN,Lee V,Ng SC,Tsang J

更新日期：2009-04-29 00:00:00

abstract：BACKGROUND:cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and pro...

journal_title：BMC cancer

authors： Figueiredo JC,Knight JA,Cho S,Savas S,Onay UV,Briollais L,Goodwin PJ,McLaughlin JR,Andrulis IL,Ozcelik H

更新日期：2007-06-14 00:00:00

abstract：BACKGROUND:Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of contention. METHODS:A database of 386 patients, enrolled in a randomized clinical trial on the effect of a...

journal_title：BMC cancer

authors： Demicheli R,Ambrogi F

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and pharmacological actions have been reported. Yet we know little on the initial pathway involved in a...

journal_title：BMC cancer

authors： Kurkalang S,Banerjee A,Ghoshal N,Dkhar H,Chatterjee A

更新日期：2013-06-28 00:00:00

abstract：BACKGROUND:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell surv...

journal_title：BMC cancer

authors： Koschny R,Brost S,Hinz U,Sykora J,Batke EM,Singer S,Breuhahn K,Stremmel W,Walczak H,Schemmer P,Schirmacher P,Ganten TM

更新日期：2013-11-09 00:00:00

abstract：OBJECTIVES:The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the investigated data from patient charts and patient-reported outcome (PRO) up to 14 years after therap...

journal_title：BMC cancer

authors： Kessel KA,Grosser RCE,Kraus KM,Hoffmann H,Oechsner M,Combs SE

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Pro...

journal_title：BMC cancer

authors： Udeh EI,Ofoha CG,Adewole DA,Nnabugwu II

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS:PRAF2 mRNA expression was determined in 77 frozen ESCC samples by quantitati...

journal_title：BMC cancer

authors： Qian Z,Wei B,Zhou Y,Wang Q,Wang J,Sun Y,Gao Y,Chen X

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Most staging systems for soft tissue sarcoma are based on histologic malignancy-grade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth per se should influence a tumor's metastatic capability. Therefore we hypothesized that the unf...

journal_title：BMC cancer

authors： Rydholm A,Gustafson P

更新日期：2003-05-26 00:00:00

abstract：BACKGROUND:The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether th...

journal_title：BMC cancer

authors： Liu C,Lu P,Lu Y,Xu H,Wang S,Chen J

更新日期：2007-10-24 00:00:00

abstract：BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...

journal_title：BMC cancer

authors： Fan C,Jin M,Chen K,Zhang Y,Zhang S,Liu B

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:SUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the development of HCC and has been reported to be SUMOylated by exogenous small ubiquitin-related modifier 3 (...

journal_title：BMC cancer

authors： Liu J,Sha M,Wang Q,Ma Y,Geng X,Gao Y,Feng L,Shen Y,Shen Y

更新日期：2015-10-12 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. METHODS:FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancre...

journal_title：BMC cancer

authors： Zhang J,Jia G,Zuo C,Jia N,Wang H

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Humans are exposed to an array of both harmful and beneficial hormonally active compounds in the environment and through diet. Two such chemicals are Bisphenol A (BPA), a plasticizer, and genistein, a component of soy. Prepubertal exposure to BPA increased mammary carcinogenesis, while genistein suppressed c...

journal_title：BMC cancer

authors： Wang J,Jenkins S,Lamartiniere CA

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study were to see if the national target of 70% of all cancer patients being included in a CPP was met, and ...

journal_title：BMC cancer

authors： Nilssen Y,Brustugun OT,Eriksen MT,Haug ES,Naume B,Møller B

更新日期：2020-05-30 00:00:00

abstract：BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...

journal_title：BMC cancer

authors： Chen X,Li WL,Zhang YL,Wu Q,Guo YM,Bai ZL

更新日期：2010-12-29 00:00:00

abstract：BACKGROUND:Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expr...

journal_title：BMC cancer

authors： Stenzinger A,Endris V,Klauschen F,Sinn B,Lorenz K,Warth A,Goeppert B,Ehemann V,Muckenhuber A,Kamphues C,Bahra M,Neuhaus P,Weichert W

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:Clinical trials where cancer patients were treated with protease inhibitors have suggested that the serine protease, prostasin, may act as a tumour suppressor. Prostasin is proteolytically activated by the serine protease, matriptase, which has a very high oncogenic potential. Prostasin is inhibited by prote...

journal_title：BMC cancer

authors： Selzer-Plon J,Bornholdt J,Friis S,Bisgaard HC,Lothe IM,Tveit KM,Kure EH,Vogel U,Vogel LK

更新日期：2009-06-25 00:00:00

abstract：BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...

journal_title：BMC cancer

authors： Saban MR,Hellmich HL,Simpson C,Davis CA,Lang ML,Ihnat MA,O'Donnell MA,Wu XR,Saban R

更新日期：2007-11-02 00:00:00

abstract：BACKGROUND:Reprogramming energy metabolism has been an emerging hallmark of cancer cells. MicroRNAs play important roles in glucose metabolism. METHODS:The targets of microRNA-26a (miR-26a) were predicted by bioinformatics tools. The efficacy of miR-26a binding the 3'-untranslated region (UTR) of pyruvate dehydrogenas...

journal_title：BMC cancer

authors： Chen B,Liu Y,Jin X,Lu W,Liu J,Xia Z,Yuan Q,Zhao X,Xu N,Liang S

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:Preclinical evidence suggests that aspirin may inhibit lung cancer progression. In a large cohort of lung cancer patients, we investigated whether low-dose aspirin use was associated with a reduction in the risk of lung cancer-specific mortality. METHODS:We identified lung cancer patients from English cance...

journal_title：BMC cancer

authors： Mc Menamin ÚC,Cardwell CR,Hughes CM,Murray LM

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determi...

journal_title：BMC cancer

authors： Lou H,Gharzouzi E,Guerra SP,Fokom Domgue J,Sawitzke J,Villagran G,Garland L,Boland JF,Wagner S,Rosas H,Troxler J,McMillen H,Kessing B,Alvirez E,Castillo M,Morales H,Argueta V,Rosingh A,van Aerde-van Nunen FJHB,Lopez

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...

journal_title：BMC cancer

authors： Dai SD,Wang Y,Miao Y,Zhao Y,Zhang Y,Jiang GY,Zhang PX,Yang ZQ,Wang EH

更新日期：2009-06-09 00:00:00

abstract：BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...

journal_title：BMC cancer

authors： Hsieh CY,Lein MY,Yang SN,Wang YC,Lin YJ,Lin CY,Hua CH,Tsai MH,Lin CC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated oligometastasized PC patients receiving stereotactic body radiotherapy (SBRT) to bone metastases. METHODS:In this retrospective study, 15 oligometastasized...

journal_title：BMC cancer

authors： Habl G,Straube C,Schiller K,Duma MN,Oechsner M,Kessel KA,Eiber M,Schwaiger M,Kübler H,Gschwend JE,Combs SE

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the clinical significance of HNSCC molecular subtypes is uncertain therefore personalisation of HNSCC t...

journal_title：BMC cancer

authors： Qadir F,Lalli A,Dar HH,Hwang S,Aldehlawi H,Ma H,Dai H,Waseem A,Teh MT

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non-small cell lung cancer (NSCLC), especially in East Asian patients. We conducted this meta-analysis to compare their efficacy and safety in treatin...

journal_title：BMC cancer

authors： Zhang W,Wei Y,Yu D,Xu J,Peng J

更新日期：2018-08-02 00:00:00

abstract：BACKGROUND:The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associated with the real-world mortality risk. METHODS:This was a retrospective German claims data analys...

journal_title：BMC cancer

authors： Hardtstock F,Myers D,Li T,Cizova D,Maywald U,Wilke T,Griesinger F

更新日期：2020-03-30 00:00:00

abstract：BACKGROUNDS:Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows phenotypic changes (population changes) upon differentiation of CSC during culture and can be used for s...

journal_title：BMC cancer

authors： Yamada T,Abei M,Danjoh I,Shirota R,Yamashita T,Hyodo I,Nakamura Y

更新日期：2015-04-11 00:00:00