Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis.

abstract：BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...

journal_title：BMC cancer

authors： Choi MH,Mejlænder-Andersen E,Manueldas S,El Jellas K,Steine SJ,Tjensvoll K,Sætran HA,Knappskog S,Hoem D,Nordgård O,Hovland R,Molven A

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. METHODS:Eleven LS hereditary cancer registrie...

journal_title：BMC cancer

authors： Rossi BM,Palmero EI,López-Kostner F,Sarroca C,Vaccaro CA,Spirandelli F,Ashton-Prolla P,Rodriguez Y,de Campos Reis Galvão H,Reis RM,Escremim de Paula A,Capochin Romagnolo LG,Alvarez K,Della Valle A,Neffa F,Kalfayan PG,Spir

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer. N,N'-dinitrosopiperazine (DNP), a carcinogen with specificity for nasopharyngeal epithelium, facilitates NPC metastasis. However, the underlying mechanism is not known. METHODS:Quantitative phosphoproteomics, using stable isotope lab...

journal_title：BMC cancer

authors： Huang D,Li Y,Liu N,Zhang Z,Peng Z,Duan C,Tang X,Tan G,Yan G,Tang F

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...

journal_title：BMC cancer

authors： Yasuta S,Kobayashi T,Aizawa H,Takahashi S,Ikeda M,Konishi M,Kojima M,Kuno H,Uesaka K,Morinaga S,Miyamoto A,Toyama H,Takakura N,Sugimachi K,Takayama W

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS:We systematically analyzed the smoking-related DNA methylation sites reported ...

journal_title：BMC cancer

authors： Chen Z,Wen W,Cai Q,Long J,Wang Y,Lin W,Shu XO,Zheng W,Guo X

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study its expression at protein level in HCC and its biological function for HCC cell growth. METHOD:Weste...

journal_title：BMC cancer

authors： Guo M,Li J,Wan D,Gu J

更新日期：2006-04-29 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...

journal_title：BMC cancer

authors： Nakayama T,Ling ZQ,Mukaisho K,Hattori T,Sugihara H

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased express...

journal_title：BMC cancer

authors： Veltman JD,Lambers ME,van Nimwegen M,Hendriks RW,Hoogsteden HC,Aerts JG,Hegmans JP

更新日期：2010-08-30 00:00:00

abstract：BACKGROUND:The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expressi...

journal_title：BMC cancer

authors： Huang Y,Dong W,Li J,Zhang H,Shan Z,Teng W

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine strategy that integrates genomic profiling and preclinical drug-screening platforms, in order to persona...

journal_title：BMC cancer

authors： Oh DY,Jung K,Song JY,Kim S,Shin S,Kwon YJ,Oh E,Park WY,Song SY,Choi YL

更新日期：2017-08-10 00:00:00

abstract：BACKGROUND:Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unkno...

journal_title：BMC cancer

authors： Niavarani SR,Lawson C,Bakos O,Boudaud M,Batenchuk C,Rouleau S,Tai LH

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these int...

journal_title：BMC cancer

authors： Vilaprinyo E,Rué M,Marcos-Gragera R,Martínez-Alonso M

更新日期：2009-03-30 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...

journal_title：BMC cancer

authors： Zhao L,Zhao H,Yan H

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine stated practice across UK breast units, in terms of indications for use, radiological monitoring, patho...

journal_title：BMC cancer

authors： Whitehead I,Irwin GW,Bannon F,Coles CE,Copson E,Cutress RI,Dave RV,Gardiner MD,Grayson M,Holcombe C,Irshad S,O'Brien C,O'Connell RL,Palmieri C,Shaaban AM,Sharma N,Singh JK,Potter S,McIntosh SA,NeST Study Research Co

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological v...

journal_title：BMC cancer

authors： Jia N,Cormack FC,Xie B,Shiue Z,Najafian B,Gralow JR

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer. METHODS:Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review...

journal_title：BMC cancer

authors： Mazzone PJ,Rai H,Beukemann M,Xu M,Jain A,Sasidhar M

更新日期：2012-09-14 00:00:00

abstract：BACKGROUND:Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a subset of breast cancer with different biologic behaviour. We investigated the clinicopathologic charac...

journal_title：BMC cancer

authors： Rhee J,Han SW,Oh DY,Kim JH,Im SA,Han W,Park IA,Noh DY,Bang YJ,Kim TY

更新日期：2008-10-23 00:00:00

abstract：BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...

journal_title：BMC cancer

authors： von Bergwelt-Baildon M,Hallek MJ,Shimabukuro-Vornhagen AA,Kochanek M

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...

journal_title：BMC cancer

authors： Miele E,Abballe L,Spinelli GP,Besharat ZM,Catanzaro G,Chiacchiarini M,Vacca A,Po A,Capalbo C,Ferretti E

更新日期：2020-02-17 00:00:00

abstract：BACKGROUND:Smoking is by far the most important cause of cancer that can be modified at the individual level. Cancer incidence and mortality rates in Korea are the highest among all Asian countries, and smoking prevalence in Korean men is one of the highest in developed countries. The purpose of the current study was t...

journal_title：BMC cancer

authors： Park S,Jee SH,Shin HR,Park EH,Shin A,Jung KW,Hwang SS,Cha ES,Yun YH,Park SK,Boniol M,Boffetta P

更新日期：2014-06-06 00:00:00

abstract：BACKGROUND:Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, metastasis, and angioge...

journal_title：BMC cancer

authors： Chang AY,Wang M

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:To compare the value of two dynamic contrast-enhanced Magnetic Resonance Images (DCE-MRI) reconstruction approaches, namely golden-angle radial sparse parallel (GRASP) and view-sharing with golden-angle radial profile (VS-GR) reconstruction, and evaluate their values in assessing response to neoadjuvant chem...

journal_title：BMC cancer

authors： Lu Y,Ma L,Qin J,Wang Z,Guo J,Zhao Y,Zhang H,Yan X,Liu H,Li H,Kamel IR,Qu J

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between...

journal_title：BMC cancer

authors： Kim Y,Franke AA,Shvetsov YB,Wilkens LR,Cooney RV,Lurie G,Maskarinec G,Hernandez BY,Le Marchand L,Henderson BE,Kolonel LN,Goodman MT

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Breast cancer in women is increasingly frequent, and care is complex, onerous and expensive, all of which lend urgency to improvements in care. Quality measurement is essential to monitor effectiveness and to guide improvements in healthcare. METHODS:Ten databases, including Medline, were searched electroni...

journal_title：BMC cancer

authors： Schachter HM,Mamaladze V,Lewin G,Graham ID,Brouwers M,Sampson M,Morrison A,Zhang L,O'Blenis P,Garritty C

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escalation trea...

journal_title：BMC cancer

authors： Nopmaneepaisarn T,Tangjaturonrasme N,Rawangban W,Vinayanuwattikun C,Keelawat S,Bychkov A

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:The prognosis for patients with recurrent glioblastoma is still poor with a median survival between 3 and 6 months. Reports about the application of carmustine (BCNU), one of the standard chemotherapeutic drugs in the treatment of newly diagnosed glioblastoma, in the recurrent situation are rare. METHODS:We...

journal_title：BMC cancer

authors： Reithmeier T,Graf E,Piroth T,Trippel M,Pinsker MO,Nikkhah G

更新日期：2010-02-02 00:00:00

abstract：BACKGROUND:It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and...

journal_title：BMC cancer

authors： Olsson Möller U,Rydén L,Malmström M

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KC...

journal_title：BMC cancer

authors： Barbirou M,Woldu HG,Sghaier I,Bedoui SA,Mokrani A,Aami R,Mezlini A,Yacoubi-Loueslati B,Tonellato PJ,Bouhaouala-Zahar B

更新日期：2020-11-10 00:00:00