Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?

abstract：BACKGROUND:In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and no evidence of its effectiveness in Japanese adult women in particular. This study aims to evaluate t...

journal_title：BMC cancer

authors： Kurokawa T,Yamamoto M,Onuma T,Tsuyoshi H,Shinagawa A,Chino Y,Yoshida Y

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsi...

journal_title：BMC cancer

authors： Yu Y,Wang Q,Sun J,Zhao J,Chen S,Li Y

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction and increased physical activity may suppress hormonal, energy-sensing, and inflammatory factor...

journal_title：BMC cancer

authors： Demark-Wahnefried W,Nix JW,Hunter GR,Rais-Bahrami S,Desmond RA,Chacko B,Morrow CD,Azrad M,Frugé AD,Tsuruta Y,Ptacek T,Tully SA,Segal R,Grizzle WE

更新日期：2016-02-05 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...

journal_title：BMC cancer

authors： Siva S,Callahan J,Kron T,Martin OA,MacManus MP,Ball DL,Hicks RJ,Hofman MS

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...

journal_title：BMC cancer

authors： Orsetti B,Selves J,Bascoul-Mollevi C,Lasorsa L,Gordien K,Bibeau F,Massemin B,Paraf F,Soubeyran I,Hostein I,Dapremont V,Guimbaud R,Cazaux C,Longy M,Theillet C

更新日期：2014-02-22 00:00:00

abstract：BACKGROUND:We compared the outcome of patients who received non-image-guided intensity-modulated radiotherapy (IMRT) with those who received helical tomotherapy (HT), a daily image-guided radiotherapy (IGRT), after surgery for oral cavity cancer (OCC). METHODS:During the period November 2006 to December 2013, a total ...

journal_title：BMC cancer

authors： Hsieh CH,Shueng PW,Wang LY,Huang YC,Liao LJ,Lo WC,Lin YC,Wu LJ,Tien HJ

更新日期：2016-02-23 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, risk stratification and prognostication. However, the genetic mechanisms that give rise to ALL remain p...

journal_title：BMC cancer

authors： Zhang H,Wang H,Qian X,Gao S,Xia J,Liu J,Cheng Y,Man J,Zhai X

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...

journal_title：BMC cancer

authors： Zhang L,Li Z,Liu Y,Xu S,Tandon M,Appelboom B,LaValle CR,Chiosea SI,Wang L,Sen M,Lui VWY,Grandis JR,Wang QJ

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone. METHO...

journal_title：BMC cancer

authors： Douglas S,Huttenlocher S,Bajrovic A,Rudat V,Schild SE,Rades D

更新日期：2012-06-21 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). The cardiotoxic effects of sorafenib and sunitinib may cause hypertension, left ventricular ejection fraction (LVEF) dysfunction and/or congestive heart failure (CHF), and arterial thrombo-em...

journal_title：BMC cancer

authors： Pantaleo MA,Mandrioli A,Saponara M,Nannini M,Erente G,Lolli C,Biasco G

更新日期：2012-06-11 00:00:00

abstract：BACKGROUND:To compare the value of two dynamic contrast-enhanced Magnetic Resonance Images (DCE-MRI) reconstruction approaches, namely golden-angle radial sparse parallel (GRASP) and view-sharing with golden-angle radial profile (VS-GR) reconstruction, and evaluate their values in assessing response to neoadjuvant chem...

journal_title：BMC cancer

authors： Lu Y,Ma L,Qin J,Wang Z,Guo J,Zhao Y,Zhang H,Yan X,Liu H,Li H,Kamel IR,Qu J

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily ...

journal_title：BMC cancer

authors： Chu D,Wei L

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...

journal_title：BMC cancer

authors： Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JH

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Humans are exposed to an array of both harmful and beneficial hormonally active compounds in the environment and through diet. Two such chemicals are Bisphenol A (BPA), a plasticizer, and genistein, a component of soy. Prepubertal exposure to BPA increased mammary carcinogenesis, while genistein suppressed c...

journal_title：BMC cancer

authors： Wang J,Jenkins S,Lamartiniere CA

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant cells is still controversial, and the cell subsets and the mechanisms involved are poorly investiga...

journal_title：BMC cancer

authors： Estrela-Lima A,Araújo MS,Costa-Neto JM,Teixeira-Carvalho A,Barrouin-Melo SM,Cardoso SV,Martins-Filho OA,Serakides R,Cassali GD

更新日期：2010-06-04 00:00:00

abstract：BACKGROUND:Axonal sensory peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Omega-3 fatty acids have beneficial effects on neurological disorders from their effects on neurons cells and inhibition of the formation of proinflammatory cytokines involved in peripheral neuropathy. METHODS:This stu...

journal_title：BMC cancer

authors： Ghoreishi Z,Esfahani A,Djazayeri A,Djalali M,Golestan B,Ayromlou H,Hashemzade S,Asghari Jafarabadi M,Montazeri V,Keshavarz SA,Darabi M

更新日期：2012-08-15 00:00:00

abstract：BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...

journal_title：BMC cancer

authors： Lapin M,Tjensvoll K,Oltedal S,Javle M,Smaaland R,Gilje B,Nordgård O

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to date. Broadly speaking, the CTAs can be divided into two groups: the CTX antigens that are encoded ...

journal_title：BMC cancer

authors： Kim R,Kulkarni P,Hannenhalli S

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

journal_title：BMC cancer

authors： Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastrointestinal (GI) NETs with 177Lu-Dotatate resulted in a significant improvement in progression-free su...

journal_title：BMC cancer

authors： Smith-Palmer J,Leeuwenkamp OR,Virk J,Reed N

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:The effect of current therapies in improving the survival of lung cancer patients remains far from satisfactory. It is consequently desirable to find more appropriate therapeutic opportunities based on informed insights. A molecular pharmacological analysis was undertaken to design an improved chemotherapeut...

journal_title：BMC cancer

authors： Gemma A,Li C,Sugiyama Y,Matsuda K,Seike Y,Kosaihira S,Minegishi Y,Noro R,Nara M,Seike M,Yoshimura A,Shionoya A,Kawakami A,Ogawa N,Uesaka H,Kudoh S

更新日期：2006-06-30 00:00:00

abstract：BACKGROUND:Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/...

journal_title：BMC cancer

authors： Sinilnikova OM,Dondon MG,Eon-Marchais S,Damiola F,Barjhoux L,Marcou M,Verny-Pierre C,Sornin V,Toulemonde L,Beauvallet J,Le Gal D,Mebirouk N,Belotti M,Caron O,Gauthier-Villars M,Coupier I,Buecher B,Lortholary A,Dugast

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:To determine the effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy. METHODS:PubMed, Web of Science, ProQuest and Medline were searched using the key words "cervical cancer", "locally advanced disease", "radiotherapy" and "surgery ...

journal_title：BMC cancer

authors： Shi D,Liang Z,Zhang C,Zhang H,Liu X

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey. METHODS:A qualitative interview study with thematic analysis, conducted with 36 patients. RESULTS:There is no clear patte...

journal_title：BMC cancer

authors： Ng CWQ,Lim JNW,Liu J,Hartman M

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...

journal_title：BMC cancer

authors： Flamant L,Roegiers E,Pierre M,Hayez A,Sterpin C,De Backer O,Arnould T,Poumay Y,Michiels C

更新日期：2012-09-06 00:00:00

abstract：BACKGROUND:Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2. METHODS:ATC were generated from PBMC activated for 14 days with anti-CD3 monoclonal antibody in th...

journal_title：BMC cancer

authors： Zitron IM,Thakur A,Norkina O,Barger GR,Lum LG,Mittal S

更新日期：2013-02-22 00:00:00

abstract：BACKGROUND:Resilience has been linked to psychological adaptation to many challenging life events. The present study aims to explore the level of resilience in oral cancer patients and the key factors associated with resilience, and to evaluate the relationship between resilience and anxiety. METHODS:A multiple center...

journal_title：BMC cancer

authors： Gao Y,Yuan L,Pan B,Wang L

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:To evaluate efficacy in patients with brain metastasis (BM) on entry into the lapatinib expanded access program (LEAP). METHODS:LEAP is a worldwide, single-arm, open-label study. HER2-positive, locally-advanced or metastatic breast cancer patients with progression after an anthracycline, taxane, and trastuz...

journal_title：BMC cancer

authors： Ro J,Park S,Kim S,Kim TY,Im YH,Rha SY,Chung JS,Moon H,Santillana S

更新日期：2012-07-28 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor that contributes to tumour aggressiveness and correlates with poor prognosis and resistance to conventional therapy. Therefore, identifying hypoxic environments within tumours is extremely useful for understanding cancer biology and developing novel therapeutic strategies. Seve...

journal_title：BMC cancer

authors： Takei N,Yoneda A,Kosaka M,Sakai-Sawada K,Tamura Y

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is a plausible candidate. CHEK2 encodes a checkpoint...

journal_title：BMC cancer

authors： Rashid MU,Muhammad N,Faisal S,Amin A,Hamann U

更新日期：2013-06-27 00:00:00