Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates.

abstract：BACKGROUND:Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake as compare...

journal_title：BMC cancer

authors： Chambers JA,Callander AS,Grangeret R,O'Carroll RE

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...

journal_title：BMC cancer

authors： Hwang-Bo J,Bae MG,Park JH,Chung IS

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:A substantial number of patients will develop further biochemical progression after radical prostatectomy (RP) and salvage radiotherapy (sRT). Recently published data using prostate-specific membrane antigen ligand positron emission tomography (PSMA - PET) for re-staging suggest that those recurrences are of...

journal_title：BMC cancer

authors： Oehus AK,Kroeze SGC,Schmidt-Hegemann NS,Vogel MME,Kirste S,Becker J,Burger IA,Derlin T,Bartenstein P,Eiber M,Mix M,la Fougère C,Belka C,Combs SE,Grosu AL,Müller AC,Guckenberger M,Christiansen H,Henkenberens C

更新日期：2020-04-29 00:00:00

abstract：BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...

journal_title：BMC cancer

authors： Jiang Q,Feng MG,Mo YY

更新日期：2009-06-18 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer. METHODS:Circulating cells were identified by reverse transcription-polymerase chain reaction (RT-PCR) to detect p503S, p504S and p510...

journal_title：BMC cancer

authors： Cardillo MR,Gentile V,Ceccariello A,Giacomelli L,Messinetti S,Di Silverio F

更新日期：2005-09-05 00:00:00

abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...

journal_title：BMC cancer

authors： Ryan AV,Wilson S,Wakelam MJ,Warmington SA,Dunn JA,Hobbs RF,Martin A,Ismail T

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...

journal_title：BMC cancer

authors： Liu YJ,Zhang Q,Hu SY,Zhao FH

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imagi...

journal_title：BMC cancer

authors： Qiu C,Bai Y,Yin T,Miao X,Gao R,Zhou H,Ren J,Song L,Liu C,Zheng H,Zheng R

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:The human pancreatic cancer cell line A818-6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benign, highly differentiated, duct-like pancreatic epithelial structure. This characteristic allowing A8...

journal_title：BMC cancer

authors： Tawfik D,Zaccagnino A,Bernt A,Szczepanowski M,Klapper W,Schwab A,Kalthoff H,Trauzold A

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast cancer is a highly heterogeneous disease, the responses of different patients to everolimus may ...

journal_title：BMC cancer

authors： Yi Z,Ma F,Liu B,Guan X,Li L,Li C,Qian H,Xu B

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Cytokines are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play key role in tumor dissemination and are an independent survival predictor in breast cancer patients. The aim of this study was to assess correlation between CTCs and plasma cytokines in primary breast cancer (PBC) p...

journal_title：BMC cancer

authors： Mego M,Cholujova D,Minarik G,Sedlackova T,Gronesova P,Karaba M,Benca J,Cingelova S,Cierna Z,Manasova D,Pindak D,Sufliarsky J,Cristofanilli M,Reuben JM,Mardiak J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. Here, to determine the relationship of LAD1 with colorectal cancer progression, we explored the effec...

journal_title：BMC cancer

authors： Moon B,Yang SJ,Park SM,Lee SH,Song KS,Jeong EJ,Park M,Kim JS,Yeom YI,Kim JA

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported ...

journal_title：BMC cancer

authors： Shang L,Fang Z,Liu J,Du F,Jing H,Xu Y,Dong K,Zhang X,Wu H,Jing C,Li L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival rates of only 50-60%. Neo-adjuvant and adjuvant chemotherapy (CTX) has been applied to achieve pre-...

journal_title：BMC cancer

authors： Schmitt T,Lehner B,Kasper B,Bischof M,Roeder F,Dietrich S,Dimitrakopoulou-Strauss A,Strauss LG,Mechtersheimer G,Wuchter P,Ho AD,Egerer G

更新日期：2011-12-07 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their metastatic disease. MET...

journal_title：BMC cancer

authors： Hu X,Cao J,Hu W,Wu C,Pan Y,Cai L,Tong Z,Wang S,Li J,Wang Z,Wang B,Chen X,Yu H

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript. METHO...

journal_title：BMC cancer

authors： Harries LW,Perry JR,McCullagh P,Crundwell M

更新日期：2010-06-22 00:00:00

abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...

journal_title：BMC cancer

authors： Nielsen K,Binderup T,Langer SW,Kjaer A,Knigge P,Grøndahl V,Melchior L,Federspiel B,Knigge U

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:The prognostic value of histone γ-H2AX and 53BP1 proteins to predict the radiotherapy (RT) outcome of patients with rectal carcinoma (RC) was evaluated in a prospective study. High expression of the constitutive histone γ-H2AX is indicative of defective DNA repair pathway and/or genomic instability, whereas ...

journal_title：BMC cancer

authors： Djuzenova CS,Zimmermann M,Katzer A,Fiedler V,Distel LV,Gasser M,Waaga-Gasser AM,Flentje M,Polat B

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate processes such as replication, transcription, DNA repair and maintenance of epigeneti...

journal_title：BMC cancer

authors： Patel M,Patel D,Datta S,Singh U

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 protein overexpression, a second line gene amplification test is generally deemed necessary for cases ...

journal_title：BMC cancer

authors： Moelans CB,de Weger RA,Ezendam C,van Diest PJ

更新日期：2009-01-05 00:00:00

abstract：BACKGROUND:According to the very limited cancer registry, incidence and mortality rates for female breast cancer in China are regarded to be increasing especially in the metropolitan areas. Representative data on the breast cancer profile of Chinese women and its time trend over years are relatively rare. The aims of t...

journal_title：BMC cancer

authors： Li J,Zhang BN,Fan JH,Pang Y,Zhang P,Wang SL,Zheng S,Zhang B,Yang HJ,Xie XM,Tang ZH,Li H,Li JY,He JJ,Qiao YL

更新日期：2011-08-22 00:00:00

abstract：BACKGROUND:Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS:We systematically analyzed the smoking-related DNA methylation sites reported ...

journal_title：BMC cancer

authors： Chen Z,Wen W,Cai Q,Long J,Wang Y,Lin W,Shu XO,Zheng W,Guo X

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC) is a partnership among two research institutions and a network of safety net clinics to promote...

journal_title：BMC cancer

authors： Coronado GD,Vollmer WM,Petrik A,Aguirre J,Kapka T,Devoe J,Puro J,Miers T,Lembach J,Turner A,Sanchez J,Retecki S,Nelson C,Green B

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). METHODS:Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a ...

journal_title：BMC cancer

authors： Gremel G,Djureinovic D,Niinivirta M,Laird A,Ljungqvist O,Johannesson H,Bergman J,Edqvist PH,Navani S,Khan N,Patil T,Sivertsson Å,Uhlén M,Harrison DJ,Ullenhag GJ,Stewart GD,Pontén F

更新日期：2017-01-04 00:00:00

abstract：BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...

journal_title：BMC cancer

authors： Yasuta S,Kobayashi T,Aizawa H,Takahashi S,Ikeda M,Konishi M,Kojima M,Kuno H,Uesaka K,Morinaga S,Miyamoto A,Toyama H,Takakura N,Sugimachi K,Takayama W

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expressed. Therefore these proteins are potential targets for immunotherapy and a possible basis for vaccine...

journal_title：BMC cancer

authors： Gentschev I,Fensterle J,Schmidt A,Potapenko T,Troppmair J,Goebel W,Rapp UR

更新日期：2005-02-09 00:00:00

abstract：BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...

journal_title：BMC cancer

authors： Lu R,Wu C,Guo L,Liu Y,Mo W,Wang H,Ding J,Wong ET,Yu M

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resi...

journal_title：BMC cancer

authors： He D,Xu Q,Yan M,Zhang P,Zhou X,Zhang Z,Duan W,Zhong L,Ye D,Chen W

更新日期：2009-09-25 00:00:00

abstract：BACKGROUND:Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment regimen, overall survival could be extended significantly however, median overall survival is still onl...

journal_title：BMC cancer

authors： Combs SE,Kieser M,Rieken S,Habermehl D,Jäkel O,Haberer T,Nikoghosyan A,Haselmann R,Unterberg A,Wick W,Debus J

更新日期：2010-09-06 00:00:00