Abstract:
BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna sinensis K., has been reported to have potent anti-angiogenesis and anti-tumor activities. However, its effects on tumor-related lymphangiogenesis and lymph node metastasis are not yet understood. METHODS:The in vitro inhibitory effects of 3AOA on VEGF-A-induced lymphangiogenesis were investigated via in vitro experiments using mouse oral squamous cell carcinoma (SCCVII) cells and human lymphatic microvascular endothelial cells (HLMECs). The in vivo inhibitory effects of 3AOA on VEGF-A-induced lymphangiogenesis and sentinel lymph node metastasis were investigated in an oral cancer sentinel lymph node (OCSLN) animal model. RESULTS:3AOA inhibited tumor-induced lymphangiogenesis and sentinel lymph node metastasis in an OCSLN animal model, and reduced expression of VEGF-A, a lymphangiogenic factor in hypoxia mimetic agent CoCl2-treated SCCVII cells. 3AOA inhibited proliferation, tube formation, and migration of VEGF-A-treated HLMECs. The lymphatic vessel formation that was stimulated in vivo in a by VEGF-A Matrigel plug was reduced by 3AOA. 3AOA suppressed phosphorylation of vascular endothelial growth factor (VEGFR) -1 and - 2 receptors that was stimulated by VEGF-A. In addition, 3AOA suppressed phosphorylation of the lymphangiogenesis-related downstream signaling factors PI3K, FAK, AKT, and ERK1/2. 3AOA inhibited tumor growth, tumor-induced lymphangiogenesis, and sentinel lymph node metastasis in a VEGF-A-induced OCSLN animal model that was established using VEGF-A overexpressing SCCVII cells. CONCLUSION:3AOA inhibits VEGF-A-induced lymphangiogenesis and sentinel lymph node metastasis both in vitro and in vivo. The anti-lymphangiogenic effects of 3AOA are probably mediated via suppression of VEGF-A/VEGFR-1 and VEGFR-2 signaling in HLMECs, and can be a useful anti-tumor agent to restrict the metastatic spread of oral cancer.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Hwang-Bo J,Bae MG,Park JH,Chung ISdoi
10.1186/s12885-018-4630-0subject
Has Abstractpub_date
2018-07-05 00:00:00pages
714issue
1issn
1471-2407pii
10.1186/s12885-018-4630-0journal_volume
18pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. METHODS:The in vitro antineoplastic effect and mechanism of action of Casiopei...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-156
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker for lymphatic endothelium, provides powerful tools for studying tumor lymphangiogenesis. The purpose ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-64
更新日期:2009-02-21 00:00:00
abstract:BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4221-0
更新日期:2018-03-22 00:00:00
abstract:BACKGROUND:Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening outcomes within a lung cancer screening program (LCSP) at our urban academic medical center includi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06923-0
更新日期:2020-06-16 00:00:00
abstract:BACKGROUND:The preoperative prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patents with various carcinomas. However, the prognostic significance of the postoperative PNI is unknown. The aim of this study was to evaluate the prognostic significance of the postoperative PNI in pat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1537-x
更新日期:2015-07-16 00:00:00
abstract:BACKGROUND:Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear. METHODS:With the goal of revealing the underlying mechanism, three data sets with accession numbers GSE8401, GSE46517 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07372-5
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis. The arginine-lowering agent PEGylated arginine deiminase (ADI-PEG 20) has shown efficacy as a monot...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-621
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expressed. Therefore these proteins are potential targets for immunotherapy and a possible basis for vaccine...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-15
更新日期:2005-02-09 00:00:00
abstract:BACKGROUND:In Australia, associations between geographic remoteness, socioeconomic disadvantage, and colorectal cancer (CRC) survival show that survival rates are lowest among residents of geographically remote regions and those living in disadvantaged areas. At present we know very little about the reasons for these i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-24
更新日期:2010-01-28 00:00:00
abstract:BACKGROUND:Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification of responsive patients before the chemotherapy is initiated. We have demonstrated that doxorubicin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4724-8
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-195
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of n...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-016-2564-y
更新日期:2016-07-19 00:00:00
abstract:BACKGROUND:Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for overall survival (OS), are not well captured by the World Health Organization (WHO) and Response Evaluat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-613
更新日期:2013-12-30 00:00:00
abstract:BACKGROUND:The use of combined positron emission tomography/computerised tomography (PET/CT) scanners in oncology has been shown to improve the staging of tumours and the detection of relapses. However, mis-registration errors are increasingly recognised to be a common pitfall of PET/CT studies. CASE PRESENTATION:We r...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-147
更新日期:2007-08-03 00:00:00
abstract:BACKGROUND:It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifica...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-994
更新日期:2014-12-23 00:00:00
abstract:BACKGROUND:ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS:We used cell death assays, size exclusion chromatography, Co-Immunoprecipitation, shRNA lentivectors and glioma neural stem cells ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1388-5
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-14-740
更新日期:2014-10-02 00:00:00
abstract:BACKGROUND:CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and functional causality between CCR7 expression and lymph node metastasis in patients with esophageal squamous ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-291
更新日期:2014-04-26 00:00:00
abstract:BACKGROUND:NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6375-9
更新日期:2019-12-05 00:00:00
abstract:BACKGROUND:Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-101
更新日期:2008-04-14 00:00:00
abstract:BACKGROUND:The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). METHODS:A systematic search of the MEDLINE, EMBASE, and Web of Science databas...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-6668-z
更新日期:2020-03-04 00:00:00
abstract::Following publication of the original article [1], the authors reported the following error is the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-6367-9
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation, inhibition of apoptosis, increased invasion and metastasis, and chemoresista...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1539-8
更新日期:2015-07-25 00:00:00
abstract:BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3577-x
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-432
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Afaitnib has shown anti-tumor activity against metastatic EGFR-mutated NSCLC after prior failure to first generation EGFR-TKI and chemotherapy. We prospectively evaluated the efficacy and safety of afatinib in Chinese patients who previously failed first-generation TKI and chemotherapy under a compassionate ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-016-2201-9
更新日期:2016-02-24 00:00:00
abstract:BACKGROUND:MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators of gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and are deregulated in the pathogenesis of breast cancer and function to inhibit tumor suppressors. Routine blood monitoring of these circu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-448
更新日期:2014-06-18 00:00:00
abstract:BACKGROUND:It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, little is known about the prognostic relevance of the OPN mRNA splice variants. METHODS:We analyzed ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-131
更新日期:2012-04-02 00:00:00
abstract:BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-018-4992-3
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2033-z
更新日期:2015-12-23 00:00:00