Systematic validation of predicted microRNAs for cyclin D1.

abstract：BACKGROUND:To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use. METHODS:Pubmed and Embase were searched up the terms radiomics or radiogenomics and gliomas or glioblastomas until February 2019. From 189 articles, 51 ...

journal_title：BMC cancer

authors： Park JE,Kim HS,Kim D,Park SY,Kim JY,Cho SJ,Kim JH

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological v...

journal_title：BMC cancer

authors： Jia N,Cormack FC,Xie B,Shiue Z,Najafian B,Gralow JR

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...

journal_title：BMC cancer

authors： Nielsen K,Binderup T,Langer SW,Kjaer A,Knigge P,Grøndahl V,Melchior L,Federspiel B,Knigge U

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the incidence and prognostic value of disseminated tumor cells in bone marrow of breast carcinoma patients with early disease, and to analyze this finding in relation to lymph node involvement, determined by sentinel lymph node (SLN) biopsy analysis, and to prognostic...

journal_title：BMC cancer

authors： Solá M,Margelí M,Castellá E,Julian JF,Rull M,Gubern JM,Mariscal A,Barnadas A,Fraile M

更新日期：2011-06-16 00:00:00

abstract：BACKGROUND:As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy...

journal_title：BMC cancer

authors： Vuolukka K,Auvinen P,Palmgren JE,Aaltomaa S,Kataja V

更新日期：2020-05-20 00:00:00

abstract：BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...

journal_title：BMC cancer

authors： Bruin SC,Klijn C,Liefers GJ,Braaf LM,Joosse SA,van Beers EH,Verwaal VJ,Morreau H,Wessels LF,van Velthuysen ML,Tollenaar RA,Van't Veer LJ

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas ...

journal_title：BMC cancer

authors： Pelizzo G,Veschi V,Mantelli M,Croce S,Di Benedetto V,D'Angelo P,Maltese A,Catenacci L,Apuzzo T,Scavo E,Moretta A,Todaro M,Stassi G,Avanzini MA,Calcaterra V

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal tissues, and has a potential effect to protect tumors from anti-tumor immune responses. This case-c...

journal_title：BMC cancer

authors： Zhang J,Zhang M,Jiang W,Wang L,Fu Z,Li D,Pang D,Li D

更新日期：2009-11-11 00:00:00

abstract：BACKGROUND:Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-based regimens may be beneficial, particularly for patients with wild-type (WT) KRAS. CASE PRESENTAT...

journal_title：BMC cancer

authors： Ma J,Yang QL,Ling Y

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve t...

journal_title：BMC cancer

authors： Caponigro F,Di Gennaro E,Ionna F,Longo F,Aversa C,Pavone E,Maglione MG,Di Marzo M,Muto P,Cavalcanti E,Petrillo A,Sandomenico F,Maiolino P,D'Aniello R,Botti G,De Cecio R,Losito NS,Scala S,Trotta A,Zotti AI,Bruzzese

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...

journal_title：BMC cancer

authors： Zhang XH,Huang DP,Guo GL,Chen GR,Zhang HX,Wan L,Chen SY

更新日期：2008-01-13 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...

journal_title：BMC cancer

authors： Qu N,Qin S,Zhang X,Bo X,Liu Z,Tan C,Wen G,Jiang H

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myeloma (MM). METHODS:In exploration stage (stage I), circRNA expression profiles were detected by the mi...

journal_title：BMC cancer

authors： Zhou F,Wang D,Wei W,Chen H,Shi H,Zhou N,Wu L,Peng R

更新日期：2020-01-16 00:00:00

abstract：BACKGROUND:Outpatient autologous stem cell transplantations (ASCTs) in multiple myeloma and lymphoma patients have been shown to reduce the overall costs and improve the quality of life relative to inpatient ASCTs. This systematic review and meta-analysis was performed with the aim of comprehensively comparing the risk...

journal_title：BMC cancer

authors： Owattanapanich W,Suphadirekkul K,Kunacheewa C,Ungprasert P,Prayongratana K

更新日期：2018-11-16 00:00:00

abstract：BACKGROUND:The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly focused on their gene expressions. The activation and function of the RTKs in ccRCC have not been full...

journal_title：BMC cancer

authors： Zhang Q,Liu JH,Liu JL,Qi CT,Yan L,Chen Y,Yu Q

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...

journal_title：BMC cancer

authors： Wells M,Aitchison P,Harris F,Ozakinci G,Radley A,Bauld L,Entwistle V,Munro A,Haw S,Culbard B,Williams B

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were...

journal_title：BMC cancer

authors： Mizoo T,Taira N,Nishiyama K,Nogami T,Iwamoto T,Motoki T,Shien T,Matsuoka J,Doihara H,Ishihara S,Kawai H,Kawasaki K,Ishibe Y,Ogasawara Y,Komoike Y,Miyoshi S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness and perineural invas...

journal_title：BMC cancer

authors： Huang SF,Chien HT,Cheng SD,Chuang WY,Liao CT,Wang HM

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to canc...

journal_title：BMC cancer

authors： Chong Y,Thakur N,Paik KY,Lee EJ,Kang CS

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain cells and can kill human glioma cells. This study was further aimed ...

journal_title：BMC cancer

authors： Chio CC,Chen KY,Chang CK,Chuang JY,Liu CC,Liu SH,Chen RM

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion of lung cancer patients (~ 30%). Once diagnosed, patients have a poor prognosis surviving typically ...

journal_title：BMC cancer

authors： Shah N,Liu Z,Tallman RM,Mohammad A,Sprowls SA,Saralkar PA,Vickers SD,Pinti MV,Gao W,Lockman PR

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these b...

journal_title：BMC cancer

authors： Rud AK,Lund-Iversen M,Berge G,Brustugun OT,Solberg SK,Mælandsmo GM,Boye K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the research group, 80% of the patients with breast cancer reported a high level of stress symptoms close t...

journal_title：BMC cancer

authors： Nordin K,Rissanen R,Ahlgren J,Burell G,Fjällskog ML,Börjesson S,Arving C

更新日期：2012-05-04 00:00:00

abstract：BACKGROUND:Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods and beverages, while higher concentrations above 1 mg/l are regularly detected in only certain spir...

journal_title：BMC cancer

authors： Lachenmeier DW,Lima MC,Nóbrega IC,Pereira JA,Kerr-Corrêa F,Kanteres F,Rehm J

更新日期：2010-06-08 00:00:00

abstract：BACKGROUND:The aim of this study was to examine the efficacy and safety of everolimus in patients with progressive unresectable adenoid cystic carcinoma (ACC). METHODS:Histologically confirmed ACC patients with documented disease progression within 12 months prior to the study entry were eligible. Everolimus was given...

journal_title：BMC cancer

authors： Kim DW,Oh DY,Shin SH,Kang JH,Cho BC,Chung JS,Kim H,Park KU,Kwon JH,Han JY,Kim MJ,Bang YJ

更新日期：2014-11-03 00:00:00

abstract：BACKGROUND:With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. The aim of this study was to analyse EGFR express...

journal_title：BMC cancer

authors： Van Damme N,Deron P,Van Roy N,Demetter P,Bols A,Van Dorpe J,Baert F,Van Laethem JL,Speleman F,Pauwels P,Peeters M

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:To date, there is no report in the international literature of an oligodendroglioma of the ciliary body, nor is there an analysis of the possible origins of this lesion. CASE PRESENTATION:Here we report on a 52-year-old man admitted to our hospital with a ciliary body tumor revealed by clinical examination ...

journal_title：BMC cancer

authors： Guo Q,Hao J,Sun Sb,Xu Sp,Yang Q,Guo Ql,Cui Gd

更新日期：2010-10-23 00:00:00