Oligodendroglioma of the ciliary body: a unique case report and the review of literature.

abstract：BACKGROUND:New therapeutic principles in clinical oncology require the adjustment of response criteria to govern therapy decisions. For advanced hepatocellular carcinoma (HCC) a new era has recently begun by the approval of the multikinase inhibitor sorafenib. As a unique feature, HCC usually develops in a diseased liv...

journal_title：BMC cancer

authors： Horger M,Lauer UM,Schraml C,Berg CP,Koppenhöfer U,Claussen CD,Gregor M,Bitzer M

更新日期：2009-06-28 00:00:00

abstract：BACKGROUND:Traditional beliefs of androgen's stimulating effects on the growth of prostate cancer (PCa) have been challenged in recent years. Our previous in vitro study indicated that physiological normal levels of androgens inhibited the proliferation of PCa cells. In this in vivo study, the ability of testosterone (...

journal_title：BMC cancer

authors： Song W,Soni V,Soni S,Khera M

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Translationally controlled tumor protein (TCTP), alternatively called fortilin, is believed to be involved in the development of the chemoresistance of tumor cells against anticancer drugs such as etoposide, taxol, and oxaliplatin, the underlying mechanisms of which still remain elusive. METHODS:Cell death ...

journal_title：BMC cancer

authors： Jung J,Kim HY,Maeng J,Kim M,Shin DH,Lee K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...

journal_title：BMC cancer

authors： Xia B,Hou L,Kang H,Chang W,Liu Y,Zhang Y,Ding Y

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy. METHOD...

journal_title：BMC cancer

authors： Riedlinger G,Adams J,Stehle JR Jr,Blanks MJ,Sanders AM,Hicks AM,Willingham MC,Cui Z

更新日期：2010-05-03 00:00:00

abstract：BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...

journal_title：BMC cancer

authors： Yanes T,Meiser B,Young MA,Kaur R,Mitchell G,Barlow-Stewart K,Roscioli T,Halliday J,James P

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:Increasing evidence revealed that high expression level of lncRNA SNHG1 was associated with the unfavorable prognosis of cancer and maybe used as a valuable biomarker for cancer patients. The present meta->analysis is to analyze existing data to reveal potential clinical application of SNHG1 on cancer progno...

journal_title：BMC cancer

authors： Dong B,Chen X,Zhang Y,Zhu C,Dong Q

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone metastasis was investigated in a cohort of patients. We have tried to draw the criteria to use adjuvant bisphosphonate. METHODS:Consecutive breast cancer patients undergoing surgery between 19...

journal_title：BMC cancer

authors： Koizumi M,Yoshimoto M,Kasumi F,Iwase T

更新日期：2010-07-21 00:00:00

abstract：BACKGROUND:Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript. METHO...

journal_title：BMC cancer

authors： Harries LW,Perry JR,McCullagh P,Crundwell M

更新日期：2010-06-22 00:00:00

abstract：BACKGROUND:The effect of current therapies in improving the survival of lung cancer patients remains far from satisfactory. It is consequently desirable to find more appropriate therapeutic opportunities based on informed insights. A molecular pharmacological analysis was undertaken to design an improved chemotherapeut...

journal_title：BMC cancer

authors： Gemma A,Li C,Sugiyama Y,Matsuda K,Seike Y,Kosaihira S,Minegishi Y,Noro R,Nara M,Seike M,Yoshimura A,Shionoya A,Kawakami A,Ogawa N,Uesaka H,Kudoh S

更新日期：2006-06-30 00:00:00

abstract：BACKGROUND:Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to determine the correlation of AREG and EREG expression between primary colorectal cancer and corresp...

journal_title：BMC cancer

authors： Kuramochi H,Nakajima G,Kaneko Y,Nakamura A,Inoue Y,Yamamoto M,Hayashi K

更新日期：2012-03-13 00:00:00

abstract：BACKGROUND:Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to canc...

journal_title：BMC cancer

authors： Chong Y,Thakur N,Paik KY,Lee EJ,Kang CS

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance in esophageal squamous cell carcinoma (ESCC) remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes. METHODS:We retrospect...

journal_title：BMC cancer

authors： Chen JW,Xie JD,Ling YH,Li P,Yan SM,Xi SY,Luo RZ,Yun JP,Xie D,Cai MY

更新日期：2014-05-05 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. H...

journal_title：BMC cancer

authors： Sureda A,André M,Borchmann P,da Silva MG,Gisselbrecht C,Vassilakopoulos TP,Zinzani PL,Walewski J

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast cancer is a highly heterogeneous disease, the responses of different patients to everolimus may ...

journal_title：BMC cancer

authors： Yi Z,Ma F,Liu B,Guan X,Li L,Li C,Qian H,Xu B

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the p...

journal_title：BMC cancer

authors： Yang Y,Im SA,Keam B,Lee KH,Kim TY,Suh KJ,Ryu HS,Moon HG,Han SW,Oh DY,Han W,Kim TY,Park IA,Noh DY

更新日期：2016-07-21 00:00:00

abstract：BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...

journal_title：BMC cancer

authors： Ravi M,Tentu S,Baskar G,Rohan Prasad S,Raghavan S,Jayaprakash P,Jeyakanthan J,Rayala SK,Venkatraman G

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...

journal_title：BMC cancer

authors： Harrer DC,Simon B,Fujii SI,Shimizu K,Uslu U,Schuler G,Gerer KF,Hoyer S,Dörrie J,Schaft N

更新日期：2017-08-17 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cells are a promising new treatment for patients with relapsed or refractory hematologic malignancies, including lymphoma. Given the success of CAR-T cells directed against CD19, new targets are being developed and tested, since not all lymphomas express CD19. CD30 is promising targ...

journal_title：BMC cancer

authors： Grover NS,Savoldo B

更新日期：2019-03-06 00:00:00

abstract：BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...

journal_title：BMC cancer

authors： Lovitt CJ,Shelper TB,Avery VM

更新日期：2018-01-06 00:00:00

abstract：BACKGROUND:UroVysion fluorescence in situ hybridization (uFISH) was reported to have superior sensitivity to urine cytology. However uFISH studies are limited by varying definitions of what is considered a positive result, absence of histopathology and small sample size. The aim of our study was to better determine the...

journal_title：BMC cancer

authors： Lavery HJ,Zaharieva B,McFaddin A,Heerema N,Pohar KS

更新日期：2017-04-07 00:00:00

abstract：BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...

journal_title：BMC cancer

authors： Dankner R,Balicer R,Boffetta P,Boker LK,Wallenstein S,Freedman L,Goldfracht M,Roth J,Tamler R,LeRoith D

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for M2 ...

journal_title：BMC cancer

authors： Medrek C,Pontén F,Jirström K,Leandersson K

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a cohort of lymph node-negative breast cancer patients not treated in the adjuvant setting. METHODS:COX...

journal_title：BMC cancer

authors： Sicking I,Rommens K,Battista MJ,Böhm D,Gebhard S,Lebrecht A,Cotarelo C,Hoffmann G,Hengstler JG,Schmidt M

更新日期：2014-12-15 00:00:00

abstract：BACKGROUND:The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its...

journal_title：BMC cancer

authors： Liu XH,Liu ZL,Sun M,Liu J,Wang ZX,De W

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Thymosin β10 (Tβ10) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of Tβ10 in liver fluke-associated cholangiocarcinoma (CCA) are not fully understood. In this study, we investigated the expression of Tβ10 in CCA tumor tissues and cell lines as well as mo...

journal_title：BMC cancer

authors： Sribenja S,Sawanyawisuth K,Kraiklang R,Wongkham C,Vaeteewoottacharn K,Obchoei S,Yao Q,Wongkham S,Chen C

更新日期：2013-09-23 00:00:00

abstract：BACKGROUND:To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age. METHODS:This single-center retrospective study included 39 infants (42 eyes) aged ≤3 months who were diagnosed with unilat...

journal_title：BMC cancer

authors： Chen Q,Zhang B,Dong Y,Mo X,Zhang L,Xia J,Zhang J,Zhang S

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield higher BED, shorten the total treatmen...

journal_title：BMC cancer

authors： Ren XC,Wang QY,Zhang R,Chen XJ,Wang N,Liu YE,Zong J,Guo ZJ,Wang DY,Lin Q

更新日期：2016-04-23 00:00:00

abstract：BACKGROUND:MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators of gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and are deregulated in the pathogenesis of breast cancer and function to inhibit tumor suppressors. Routine blood monitoring of these circu...

journal_title：BMC cancer

authors： Sochor M,Basova P,Pesta M,Dusilkova N,Bartos J,Burda P,Pospisil V,Stopka T

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curative intent, frequently undergo neoadjuvant chemoradiotherapy. Unfortunately, ~ 70% of patients have li...

journal_title：BMC cancer

authors： Bibby BAS,Miranda CS,Reynolds JV,Cawthorne CJ,Maher SG

更新日期：2019-08-07 00:00:00