当前位置： SCI文献检索 > BMC CANCER期刊下所有文献 > Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases.

Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases.

Abstract：

BACKGROUND:Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to determine the correlation of AREG and EREG expression between primary colorectal cancer and corresponding liver metastases. METHODS:One hundred twenty colorectal cancer patients with liver metastases (100 with synchronous metastases, 20 with metachronous) were evaluated. No patients had ever received anti-EGFR antibody agents. AREG and EREG mRNA expression from both the primary tumor and liver metastases were measured using real-time RT-PCR. KRAS codon 12, 13 mutation status was analyzed by direct sequencing. RESULTS:Modest, but significant, correlations were observed between primary tumor and corresponding liver metastases in both AREG mRNA expression (Rs = 0.54, p < 0.0001) and EREG mRNA expression (Rs = 0.58, p < 0.0001). AREG and EREG mRNA expression was strongly correlated in both the primary tumor (Rs = 0.81, p < 0.0001) and the liver metastases (Rs = 0.87, p < 0.0001). No significant survival difference was observed between low and high AREG or EREG patients when all 120 patients were analyzed. However, when divided by KRAS status, KRAS wild-type patients with low EREG mRNA levels in the primary site showed significantly better overall survival rates than those with high levels (p = 0.018). In multivariate analysis, low EREG expression was significantly associated with better overall survival (p = 0.006). CONCLUSIONS:AREG and EREG expression showed a modest correlation between primary tumor and liver metastases. As EREG mRNA expression was associated with decreased survival, it is appeared to be a useful prognostic marker in KRAS wild-type patients who never received anti-EGFR therapy.

journal_name

BMC Cancer

journal_title

BMC cancer

authors

Kuramochi H,Nakajima G,Kaneko Y,Nakamura A,Inoue Y,Yamamoto M,Hayashi K

doi

10.1186/1471-2407-12-88

subject

Has Abstract

pub_date

2012-03-13 00:00:00

pages

88

issn

1471-2407

pii

1471-2407-12-88

journal_volume

12

pub_type

杂志文章

相关文献

BMC CANCER文献大全
  • Accuracy of detecting residual disease after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma (preSINO trial): a prospective multicenter diagnostic cohort study.

    abstract：BACKGROUND:After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surveillance strategy has been proposed for SCC patients with clinically complete response (cCR) after nC...

    journal_title：BMC cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1186/s12885-020-6669-y

    authors： Zhang X,Eyck BM,Yang Y,Liu J,Chao YK,Hou MM,Hung TM,Pang Q,Yu ZT,Jiang H,Law S,Wong I,Lam KO,van der Wilk BJ,van der Gaast A,Spaander MCW,Valkema R,Lagarde SM,Wijnhoven BPL,van Lanschot JJB,Li Z

    更新日期：2020-03-06 00:00:00

  • The role of major duct excision and microdochectomy in the detection of breast carcinoma.

    abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-6-164

    authors： Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

    更新日期：2006-06-23 00:00:00

  • Synchronous anal canal carcinoma in a heterosexual couple.

    abstract：BACKGROUND:Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women. CASE PRESENTATION:We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors. CONCLUSION...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-018-4785-8

    authors： Mendez LC,Hsieh E,Earle CC,Wong S

    更新日期：2018-09-10 00:00:00

  • Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.

    abstract：BACKGROUND:Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and induction of an...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-015-1994-2

    authors： Weijer R,Broekgaarden M,van Golen RF,Bulle E,Nieuwenhuis E,Jongejan A,Moerland PD,van Kampen AH,van Gulik TM,Heger M

    更新日期：2015-12-26 00:00:00

  • Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial.

    abstract：BACKGROUND:Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment regimen, overall survival could be extended significantly however, median overall survival is still onl...

    journal_title：BMC cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2407-10-478

    authors： Combs SE,Kieser M,Rieken S,Habermehl D,Jäkel O,Haberer T,Nikoghosyan A,Haselmann R,Unterberg A,Wick W,Debus J

    更新日期：2010-09-06 00:00:00

  • Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs : a systematic review and meta-analysis.

    abstract：BACKGROUND:Forkhead box P3(FOXP3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity. However, the research on the prognostic significance of tumor-infiltrating FOXP3+ Tregs in breast cancer is still limited and the ...

    journal_title：BMC cancer

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/s12885-016-2732-0

    authors： Shou J,Zhang Z,Lai Y,Chen Z,Huang J

    更新日期：2016-08-26 00:00:00

  • The association of alcohol consumption with mammographic density in a multiethnic urban population.

    abstract：BACKGROUND:Alcohol consumption is associated with higher breast cancer risk. While studies suggest a modest association between alcohol intake and mammographic density, few studies have examined the association in racial/ethnic minority populations. METHODS:We assessed dense breast area and total breast area from digi...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-015-1094-3

    authors： Quandt Z,Flom JD,Tehranifar P,Reynolds D,Terry MB,McDonald JA

    更新日期：2015-01-01 00:00:00

  • Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma.

    abstract：BACKGROUND:Thyroid cancer is among the fastest growing malignancies; almost fifty-percent of these rapidly increasing incidence tumors are less than or equal to 1cm in size, termed papillary thyroid microcarcinoma (PTMC). The management of PTMC remains a controversy due to differing natural history of these patients. E...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-12-523

    authors： Kunavisarut T,Kak I,Macmillan C,Ralhan R,Walfish PG

    更新日期：2012-11-15 00:00:00

  • Agreement between MRI and pathologic breast tumor size after neoadjuvant chemotherapy, and comparison with alternative tests: individual patient data meta-analysis.

    abstract：BACKGROUND:Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need for repeat surgery. This individual patient data (IPD) meta-analysis examines MRI's agreement with pa...

    journal_title：BMC cancer

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12885-015-1664-4

    authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,Mamounas E,von Minckwitz G,Guarneri V,Partridge SC,Wright FC,Choi JH,Bhattacharyya M,Martincich L,Yeh E,Londero V,Houssami N

    更新日期：2015-10-08 00:00:00

  • Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma.

    abstract：BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-018-4300-2

    authors： Wu C,Gupta N,Huang YH,Zhang HF,Alshareef A,Chow A,Lai R

    更新日期：2018-04-02 00:00:00

  • Rechallenge and maintenance therapy using cetuximab and chemotherapy administered to a patient with metastatic colorectal cancer.

    abstract：BACKGROUND:Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-based regimens may be beneficial, particularly for patients with wild-type (WT) KRAS. CASE PRESENTAT...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-017-3133-8

    authors： Ma J,Yang QL,Ling Y

    更新日期：2017-02-14 00:00:00

  • Isolation and genomic analysis of circulating tumor cells from castration resistant metastatic prostate cancer.

    abstract：BACKGROUND:The number of circulating tumor cells (CTCs) in metastatic prostate cancer patients provides prognostic and predictive information. However, it is the molecular characterization of CTCs that offers insight into the biology of these tumor cells in the context of personalized treatment. METHODS:We developed a...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-12-78

    authors： Magbanua MJ,Sosa EV,Scott JH,Simko J,Collins C,Pinkel D,Ryan CJ,Park JW

    更新日期：2012-02-28 00:00:00

  • The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women.

    abstract：BACKGROUND:The length of interval between successive childbirths (birth interval) might influence the incidence of breast cancer, either by stimulating or by inhibiting the factors that are responsible for the initiation of breast cancer or its early development. METHODS:This is a case-control study nested in a cohort...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-019-5404-z

    authors： Katuwal S,Tapanainen JS,Pukkala E,Kauppila A

    更新日期：2019-03-04 00:00:00

  • Linc01234 promotes cell proliferation and metastasis in oral squamous cell carcinoma via miR-433/PAK4 axis.

    abstract：BACKGROUND:Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral squamous cell carcinoma (OSCC) remain unclear. METHODS:We evaluated the expression profile and progno...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-020-6541-0

    authors： Liu D,Jian X,Xu P,Zhu R,Wang Y

    更新日期：2020-02-10 00:00:00

  • Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis.

    abstract：BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publicatio...

    journal_title：BMC cancer

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12885-016-2427-6

    authors： Wang L,Yu X,Li J,Zhang Z,Hou J,Li F

    更新日期：2016-07-01 00:00:00

  • Cancer incidence in Ghana, 2012: evidence from a population-based cancer registry.

    abstract：BACKGROUND:Data on cancers is a challenge in most developing countries. Population-based cancer registries are also not common in developing countries despite the usefulness of such registries in informing cancer prevention and control programmes. The availability of population-based data on cancers in Africa varies ac...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-14-362

    authors： Laryea DO,Awuah B,Amoako YA,Osei-Bonsu E,Dogbe J,Larsen-Reindorf R,Ansong D,Yeboah-Awudzi K,Oppong JK,Konney TO,Boadu KO,Nguah SB,Titiloye NA,Frimpong NO,Awittor FK,Martin IK

    更新日期：2014-05-23 00:00:00

  • Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma.

    abstract：BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-017-3595-8

    authors： Jeong S,Lee K,Wen X,Kim Y,Cho NY,Jang JJ,Kang GH

    更新日期：2017-08-29 00:00:00

  • A prospective observational study of Gallium-68 ventilation and perfusion PET/CT during and after radiotherapy in patients with non-small cell lung cancer.

    abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...

    journal_title：BMC cancer

    pub_type： 临床试验,杂志文章

    doi：10.1186/1471-2407-14-740

    authors： Siva S,Callahan J,Kron T,Martin OA,MacManus MP,Ball DL,Hicks RJ,Hofman MS

    更新日期：2014-10-02 00:00:00

  • Early life socioeconomic environment and mammographic breast density.

    abstract：BACKGROUND:Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammogr...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-016-3010-x

    authors： Tehranifar P,Cohn BA,Flom JD,Protacio A,Cirillo P,Lumey LH,Michels KB,Terry MB

    更新日期：2017-01-10 00:00:00

  • Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study.

    abstract：BACKGROUND:Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quanti...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-019-5888-6

    authors： Guinan EM,Bennett AE,Doyle SL,O'Neill L,Gannon J,Foley G,Elliott JA,O'Sullivan J,Reynolds JV,Hussey J

    更新日期：2019-07-12 00:00:00

  • ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286).

    abstract：BACKGROUND:Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of n...

    journal_title：BMC cancer

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s12885-016-2564-y

    authors： Hoeppner J,Lordick F,Brunner T,Glatz T,Bronsert P,Röthling N,Schmoor C,Lorenz D,Ell C,Hopt UT,Siewert JR

    更新日期：2016-07-19 00:00:00

  • Correction to: A systematic comparison of copy number alterations in four types of female cancer.

    abstract：:After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article. ...

    journal_title：BMC cancer

    pub_type： 杂志文章,已发布勘误

    doi：10.1186/s12885-017-3766-7

    authors： Kaveh F,Baumbusch LO,Nebdal D,Børresen-Dale AL,Lingjærde OC,Edvardsen H,Kristensen VN,Solvang HK

    更新日期：2018-01-16 00:00:00

  • The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma.

    abstract：BACKGROUND:In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. METHODS:The clinicopatholo...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-020-07495-9

    authors： An YZ,Cho E,Ling J,Zhang X

    更新日期：2020-10-12 00:00:00

  • Acral vascular necrosis associated with immune-check point inhibitors: case report with literature review.

    abstract：BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...

    journal_title：BMC cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12885-019-5661-x

    authors： Khaddour K,Singh V,Shayuk M

    更新日期：2019-05-14 00:00:00

  • Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression.

    abstract：BACKGROUND:Protein secretion by mammary cells results in autocrine and paracrine signaling that defines cell growth, migration and the extracellular environment. Even so, we have a limited understanding of the cellular processes that regulate protein secretion. METHODS:In this study, we utilize human epithelial mammar...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-11-69

    authors： Zhang Y,Gonzalez RM,Zangar RC

    更新日期：2011-02-14 00:00:00

  • Minocycline prevents and repairs the skin disorder associated with afatinib, one of the epidermal growth factor receptor-tyrosine kinase inhibitors for non-small cell lung cancer.

    abstract：BACKGROUND:While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients' quality of life. This study aimed to develop a treatment for inflammatory ulcers as one of the side effects of afat...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-020-06797-2

    authors： Sano K,Nakadate K,Hanada K

    更新日期：2020-04-06 00:00:00

  • HAX-1 overexpression, splicing and cellular localization in tumors.

    abstract：BACKGROUND:HAX-1 has been described as a protein potentially involved in carcinogenesis and especially metastasis. Its involvement in regulation of apoptosis and cell migration along with some data indicating its overexpression in cancer cell lines and tumors suggests that HAX-1 may play a role in neoplastic transforma...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-10-76

    authors： Trebinska A,Rembiszewska A,Ciosek K,Ptaszynski K,Rowinski S,Kupryjanczyk J,Siedlecki JA,Grzybowska EA

    更新日期：2010-03-02 00:00:00

  • Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses.

    abstract：BACKGROUND:Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the p...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-016-2500-1

    authors： Yang Y,Im SA,Keam B,Lee KH,Kim TY,Suh KJ,Ryu HS,Moon HG,Han SW,Oh DY,Han W,Kim TY,Park IA,Noh DY

    更新日期：2016-07-21 00:00:00

  • MiR-200c and HuR in ovarian cancer.

    abstract：BACKGROUND:MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal transition and have been reported to act as both oncogenes and tumor suppressors. This study assessed...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-13-72

    authors： Prislei S,Martinelli E,Mariani M,Raspaglio G,Sieber S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

    更新日期：2013-02-08 00:00:00

  • Improved nutrition in adolescents and young adults after childhood cancer - INAYA study.

    abstract：BACKGROUND:Multimodality treatment improves the chance of survival but increases the risk for long-term side effects in young cancer survivors, so-called" Adolescents and Young Adults"(AYAs). Compared to the general population AYAs have a 5 to 15-fold increased risk of cardiovascular morbidity. Thus, improving modifiab...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-016-2896-7

    authors： Quidde J,von Grundherr J,Koch B,Bokemeyer C,Escherich G,Valentini L,Buchholz D,Schilling G,Stein A

    更新日期：2016-11-08 00:00:00