Linc01234 promotes cell proliferation and metastasis in oral squamous cell carcinoma via miR-433/PAK4 axis.

abstract：BACKGROUND:The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX). METHODS:Genomic DNA was isolated from who...

journal_title：BMC cancer

authors： Oh SY,Kwon HC,Kim SH,Lee S,Lee JH,Hwang JA,Hong SH,Graves CA,Camphausen K,Kim HJ,Lee YS

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a cohort of lymph node-negative breast cancer patients not treated in the adjuvant setting. METHODS:COX...

journal_title：BMC cancer

authors： Sicking I,Rommens K,Battista MJ,Böhm D,Gebhard S,Lebrecht A,Cotarelo C,Hoffmann G,Hengstler JG,Schmidt M

更新日期：2014-12-15 00:00:00

abstract：BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in s...

journal_title：BMC cancer

authors： Patel T

更新日期：2002-05-03 00:00:00

abstract：BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...

journal_title：BMC cancer

authors： Chen X,Li WL,Zhang YL,Wu Q,Guo YM,Bai ZL

更新日期：2010-12-29 00:00:00

abstract：BACKGROUND:MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The p...

journal_title：BMC cancer

authors： Wang W,Li J,Zhu W,Gao C,Jiang R,Li W,Hu Q,Zhang B

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...

journal_title：BMC cancer

authors： Zhao H,Agazie YM

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based compara...

journal_title：BMC cancer

authors： Carneiro A,Isinger A,Karlsson A,Johansson J,Jönsson G,Bendahl PO,Falkenback D,Halvarsson B,Nilbert M

更新日期：2008-04-11 00:00:00

abstract：BACKGROUND:This study was performed to design a predictive tool that allows the estimation of overall survival (OS) of elderly myeloma patients (aged ≥ 65 years) presenting with myeloma-induced spinal cord compression (SCC). METHODS:One-hundred-and-sixteen patients irradiated for motor deficits of the legs due to myel...

journal_title：BMC cancer

authors： Rades D,Conde-Moreno AJ,Cacicedo J,Veninga T,Gebauer N,Bartscht T,Schild SE

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. METHODS:This study included ...

journal_title：BMC cancer

authors： Girardi DM,de Lima MA,Pereira GCB,Negrão MV,López RVM,Capareli FC,Sabbaga J,Hoff PMG

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen in white males above the age of 40 years. Here we report a case of paraneoplastic acrokeratosis in a...

journal_title：BMC cancer

authors： Hempen A,Samartzis EP,Kamarachev J,Fink D,Dedes KJ

更新日期：2015-07-08 00:00:00

abstract：BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...

journal_title：BMC cancer

authors： Jassim GA,Whitford DL

更新日期：2013-04-28 00:00:00

abstract：OBJECTIVE:C-reactive protein (CRP) is considered a useful serum marker for patients with RCC. However, its clinical utility in advanced metastatic renal cell carcinoma (AM-RCC), particularly in deciding whether to perform nephrectomy at the onset, is not well studied. PATIENTS AND METHODS:We retrospectively evaluated ...

journal_title：BMC cancer

authors： Ito H,Shioi K,Murakami T,Takizawa A,Sano F,Kawahara T,Mizuno N,Makiyama K,Nakaigawa N,Kishida T,Miura T,Kubota Y,Yao M

更新日期：2012-08-02 00:00:00

abstract：BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...

journal_title：BMC cancer

authors： Hjortland GO,Meza-Zepeda LA,Beiske K,Ree AH,Tveito S,Hoifodt H,Bohler PJ,Hole KH,Myklebost O,Fodstad O,Smeland S,Hovig E

更新日期：2011-10-20 00:00:00

abstract：BACKGROUND:SUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the development of HCC and has been reported to be SUMOylated by exogenous small ubiquitin-related modifier 3 (...

journal_title：BMC cancer

authors： Liu J,Sha M,Wang Q,Ma Y,Geng X,Gao Y,Feng L,Shen Y,Shen Y

更新日期：2015-10-12 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...

journal_title：BMC cancer

authors： Itoh A,Sadamori H,Yabushita K,Monden K,Tatsukawa M,Hioki M,Hyodo T,Omonishi K,Ueki T,Ohno S,Sakaguchi K,Takakura N

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective cohort study of 215 patie...

journal_title：BMC cancer

authors： Akhavan S,Ghahghaei-Nezamabadi A,Modaresgilani M,Mousavi AS,Sepidarkish M,Tehranian A,Rezayof E

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. ...

journal_title：BMC cancer

authors： O'Connor D,Brown M,Eatock M,Turkington RC,Prue G

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publicatio...

journal_title：BMC cancer

authors： Wang L,Yu X,Li J,Zhang Z,Hou J,Li F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...

journal_title：BMC cancer

authors： Flamant L,Roegiers E,Pierre M,Hayez A,Sterpin C,De Backer O,Arnould T,Poumay Y,Michiels C

更新日期：2012-09-06 00:00:00

abstract：BACKGROUND:Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and a good prognostic indicator for lung adenocarcinoma. However, its good prognostic ability might be due to epidermal growth factor receptor (EGFR)-sensitizing mutations as shown by the positive correlation between TTF-1 expression and ...

journal_title：BMC cancer

authors： Park JY,Jang SH,Kim HI,Kim JH,Park S,Hwang YI,Jung KS,Seo J,Lee CY,Ko Y,Park YB

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...

journal_title：BMC cancer

authors： Jiang H,Xu S,Chen C

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS:We systematically analyzed the smoking-related DNA methylation sites reported ...

journal_title：BMC cancer

authors： Chen Z,Wen W,Cai Q,Long J,Wang Y,Lin W,Shu XO,Zheng W,Guo X

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet data about their collective behavior in hepatocellular carcinoma (HCC) is missing. Hence, we qua...

journal_title：BMC cancer

authors： Avci ME,Konu O,Yagci T

更新日期：2008-12-29 00:00:00

abstract：BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...

journal_title：BMC cancer

authors： Jiang Q,Wei H,Tian Z

更新日期：2008-01-17 00:00:00

abstract：BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...

journal_title：BMC cancer

authors： Yasuta S,Kobayashi T,Aizawa H,Takahashi S,Ikeda M,Konishi M,Kojima M,Kuno H,Uesaka K,Morinaga S,Miyamoto A,Toyama H,Takakura N,Sugimachi K,Takayama W

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...

journal_title：BMC cancer

authors： Obrzut B,Kusy M,Semczuk A,Obrzut M,Kluska J

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...

journal_title：BMC cancer

authors： Netland IA,Førde HE,Sleire L,Leiss L,Rahman MA,Skeie BS,Gjerde CH,Enger PØ,Goplen D

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physician factors impact treatment decisions. The purpose of this study was to examine patient and physic...

journal_title：BMC cancer

authors： Schwedhelm TM,Rees JR,Onega T,Zipkin RJ,Schaefer A,Celaya MO,Moen EL

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:Disorders of cell adhesion are critical steps in cancer progression in which varieties of markers including cadherins are involved in.Btbd7 was found to inhibit E-cadherin expression in MDCK cells and play important roles during branching morphogenesis of embryonic salivary glands and lungs. However its func...

journal_title：BMC cancer

authors： Fan C,Miao Y,Zhang X,Liu D,Jiang G,Lin X,Han Q,Luan L,Xu Z,Wang E

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is impo...

journal_title：BMC cancer

authors： Gil-Kulik P,Dudzińska E,Radzikowska-Büchner E,Wawer J,Jojczuk M,Nogalski A,Wawer GA,Feldo M,Kocki W,Cioch M,Bogucka-Kocka A,Rahnama M,Kocki J

更新日期：2020-05-18 00:00:00