Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway.

abstract：BACKGROUND:Understanding the complex, multistep process of metastasis remains a major challenge in cancer research. Metastasis models can reveal insights in tumor development and progression and provide tools to test new intervention strategies. METHODS:To develop a new cancer metastasis model, we used DU145 human pro...

journal_title：BMC cancer

authors： Banyard J,Chung I,Migliozzi M,Phan DT,Wilson AM,Zetter BR,Bielenberg DR

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer. N,N'-dinitrosopiperazine (DNP), a carcinogen with specificity for nasopharyngeal epithelium, facilitates NPC metastasis. However, the underlying mechanism is not known. METHODS:Quantitative phosphoproteomics, using stable isotope lab...

journal_title：BMC cancer

authors： Huang D,Li Y,Liu N,Zhang Z,Peng Z,Duan C,Tang X,Tan G,Yan G,Tang F

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:This paper describes the development of a Cancer Awareness Measure for colorectal (CRC) cancer (Bowel/Colorectal CAMa) (study 1) and presents key results from a population-representative survey using the measure (study 2). METHODS:STUDY 1: Items were taken from the literature and reviewed by expert groups. ...

journal_title：BMC cancer

authors： Power E,Simon A,Juszczyk D,Hiom S,Wardle J

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...

journal_title：BMC cancer

authors： Wells M,Aitchison P,Harris F,Ozakinci G,Radley A,Bauld L,Entwistle V,Munro A,Haw S,Culbard B,Williams B

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis. The arginine-lowering agent PEGylated arginine deiminase (ADI-PEG 20) has shown efficacy as a monot...

journal_title：BMC cancer

authors： McAlpine JA,Lu HT,Wu KC,Knowles SK,Thomson JA

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...

journal_title：BMC cancer

authors： Jiang Q,Feng MG,Mo YY

更新日期：2009-06-18 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials, including co-administration...

journal_title：BMC cancer

authors： Li L,Huang Y,Gao Y,Shi T,Xu Y,Li H,Hyytiäinen M,Keski-Oja J,Jiang Q,Hu Y,Du Z

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. METHODS:We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. T...

journal_title：BMC cancer

authors： Yang J,Yang Y,Xia M,Wang L,Zhou W,Yang Y,Jiang Y,Wang H,Qian J,Jin L,Wang X

更新日期：2016-03-12 00:00:00

abstract：BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VE...

journal_title：BMC cancer

authors： Ding C,Li L,Yang T,Fan X,Wu G

更新日期：2016-10-12 00:00:00

abstract：BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...

journal_title：BMC cancer

authors： Cleary CM,White KM,Young RM,Hawkes AL,Leske S,Starfelt LC,Wihardjo K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...

journal_title：BMC cancer

authors： Policht FA,Song M,Sitailo S,O'Hare A,Ashfaq R,Muller CY,Morrison LE,King W,Sokolova IA

更新日期：2010-08-16 00:00:00

abstract：BACKGROUND:The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen). Inter-individual variations of the activity of these ...

journal_title：BMC cancer

authors： Gjerde J,Geisler J,Lundgren S,Ekse D,Varhaug JE,Mellgren G,Steen VM,Lien EA

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...

journal_title：BMC cancer

authors： Rief H,Omlor G,Akbar M,Welzel T,Bruckner T,Rieken S,Haefner MF,Schlampp I,Gioules A,Habermehl D,von Nettelbladt F,Debus J

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Metastatic melanoma is an incurable disease with an average survival of less than one year. Talabostat is a novel dipeptidyl peptidase inhibitor with immunostimulatory properties. METHODS:This phase II, open label, single arm study was conducted to evaluate the safety and efficacy of 75-100 mg/m2 cisplatin ...

journal_title：BMC cancer

authors： Eager RM,Cunningham CC,Senzer NN,Stephenson J Jr,Anthony SP,O'Day SJ,Frenette G,Pavlick AC,Jones B,Uprichard M,Nemunaitis J

更新日期：2009-07-30 00:00:00

abstract：BACKGROUND:For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the preferred surgical approach worldwide. However, this procedure is associated with considerable morbidity. Several meta-analyses have shown an advantage in ...

journal_title：BMC cancer

authors： Haverkamp L,Brenkman HJ,Seesing MF,Gisbertz SS,van Berge Henegouwen MI,Luyer MD,Nieuwenhuijzen GA,Wijnhoven BP,van Lanschot JJ,de Steur WO,Hartgrink HH,Stoot JH,Hulsewé KW,Spillenaar Bilgen EJ,Rütter JE,Kouwenhoven EA,van

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...

journal_title：BMC cancer

authors： Seymour JF,Döhner H,Butrym A,Wierzbowska A,Selleslag D,Jang JH,Kumar R,Cavenagh J,Schuh AC,Candoni A,Récher C,Sandhu I,Del Castillo TB,Al-Ali HK,Falantes J,Stone RM,Minden MD,Weaver J,Songer S,Beach CL,Dombret H

更新日期：2017-12-14 00:00:00

abstract：BACKGROUND:Gynecologic cancer is one of the most common malignant diseases in working-age women. This study investigated whether several characteristics influence return to work after treatment of gynecologic cancer. METHODS:We investigated the correlations between return to work and several other characteristics in 1...

journal_title：BMC cancer

authors： Nakamura K,Masuyama H,Nishida T,Haraga J,Ida N,Saijo M,Haruma T,Kusumoto T,Seki N,Hiramatsu Y

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib. Here, we report the successful treatment with alternating chemotherapy and TKIs of two cases of advanced NSCLC...

journal_title：BMC cancer

authors： Guo R,Chen X,Wang T,Zhang Z,Sun J,Shu Y

更新日期：2011-03-02 00:00:00

abstract：BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...

journal_title：BMC cancer

authors： Ma Q,Shilkrut M,Zhao Z,Li M,Batty N,Barber B

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinical trial cohort that has been treated with a uniform approach. ...

journal_title：BMC cancer

authors： Yoon HH,Catalano PJ,Murphy KM,Skaar TC,Philips S,Powell M,Montgomery EA,Hafez MJ,Offer SM,Liu G,Meltzer SJ,Wu X,Forastiere AA,Benson AB,Kleinberg LR,Gibson MK

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important determinant factors for tumor susceptibility. In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor...

journal_title：BMC cancer

authors： Liu GC,Zhou YF,Su XC,Zhang J

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...

journal_title：BMC cancer

authors： Elkiran ET,Mar N,Aygen B,Gursu F,Karaoglu A,Koca S

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Extramural tumor deposits (TDs) and extracapsular lymph node involvement (ECLNI) are considered to be poor prognostic factors in patients with T3-4, N0-2, M0 colorectal cancer (CRC). Although TDs are known to have multiple origins and pleomorphic features, the prognostic significances of the different type o...

journal_title：BMC cancer

authors： Yamano T,Semba S,Noda M,Yoshimura M,Kobayashi M,Hamanaka M,Beppu N,Yano A,Tsukamoto K,Matsubara N,Tomita N

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in t...

journal_title：BMC cancer

authors： Bonde AK,Tischler V,Kumar S,Soltermann A,Schwendener RA

更新日期：2012-01-24 00:00:00

abstract：BACKGROUND:The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005. METHODS:Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS wa...

journal_title：BMC cancer

authors： Hamidou Z,Causeret S,Dabakuyo TS,Gentil J,Arnould L,Roignot P,Altwegg T,Poillot ML,Bonnetain F,Arveux P

更新日期：2010-11-10 00:00:00

abstract：BACKGROUND:Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. Interleukin-6 (IL-6) and interleukin-8 (IL-8) may i...

journal_title：BMC cancer

authors： Schillace RV,Skinner AM,Pommier RF,O'Neill S,Muller PJ,Naik AM,Hansen JE,Pommier SJ

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targeted therapy for ALL is urgently needed. In the present study, we initially found that the level of S...

journal_title：BMC cancer

authors： Jin Y,Cao Q,Chen C,Du X,Jin B,Pan J

更新日期：2015-04-07 00:00:00

abstract：BACKGROUND:Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression of hepatocellular carcinoma. METHODS:In the present study, the e...

journal_title：BMC cancer

authors： An J,Zhang Z,Liu Z,Wang R,Hui D,Jin Y

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells...

journal_title：BMC cancer

authors： Quentmeier H,Eberth S,Romani J,Weich HA,Zaborski M,Drexler HG

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Neoadjuvant Chemotherapy (NC) including trastuzumab induces a high rate of pathological Complete Responses (pCR) in patients with locally advanced HER2-overexpressing Breast Cancer (BC), but is penalized by a severe cardiotoxicity when combined with anthracyclines. A phase II study was designed to assess whe...

journal_title：BMC cancer

authors： Miolo G,Muraro E,Martorelli D,Lombardi D,Scalone S,Spazzapan S,Massarut S,Perin T,Viel E,Comaro E,Talamini R,Bidoli E,Turchet E,Crivellari D,Dolcetti R

更新日期：2014-12-15 00:00:00