Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway.

abstract：BACKGROUND:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS:We here investigated a represent...

journal_title：BMC cancer

authors： Deichmann M,Thome M,Benner A,Kirschner M,Hassanzadeh J,Kurzen H

更新日期：2005-06-03 00:00:00

abstract：BACKGROUND:Cell-free DNA's (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy for improving the detection of tumor variants in cfDNA. Using this app...

journal_title：BMC cancer

authors： Cario CL,Chen E,Leong L,Emami NC,Lopez K,Tenggara I,Simko JP,Friedlander TW,Li PS,Paris PL,Carroll PR,Witte JS

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their metastatic disease. MET...

journal_title：BMC cancer

authors： Hu X,Cao J,Hu W,Wu C,Pan Y,Cai L,Tong Z,Wang S,Li J,Wang Z,Wang B,Chen X,Yu H

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...

journal_title：BMC cancer

authors： Borch KB,Braaten T,Lund E,Weiderpass E

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...

journal_title：BMC cancer

authors： Zhao L,Zhao H,Yan H

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:The present study evaluates the outcome of 19 children with rhabdomyosarcoma of the head-and-neck region treated with Intensity Modulated Radiotherapy (IMRT) or Fractionated Stereotactic Radiotherapy (FSRT) between August 1995 and November 2005. METHODS:We treated 19 children with head-and-neck rhabdomyosar...

journal_title：BMC cancer

authors： Combs SE,Behnisch W,Kulozik AE,Huber PE,Debus J,Schulz-Ertner D

更新日期：2007-09-13 00:00:00

abstract：BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...

journal_title：BMC cancer

authors： Pignochino Y,Sarotto I,Peraldo-Neia C,Penachioni JY,Cavalloni G,Migliardi G,Casorzo L,Chiorino G,Risio M,Bardelli A,Aglietta M,Leone F

更新日期：2010-11-18 00:00:00

abstract：BACKGROUND:Germline mutations in the DNA mismatch repair genes predispose to Lynch syndrome, thus conferring a high relative risk of colorectal and endometrial cancer. The MLH1, MSH2 and MSH6 mutational spectrum reported so far involves minor alterations scattered throughout their coding regions as well as large genomi...

journal_title：BMC cancer

authors： Thodi G,Fostira F,Sandaltzopoulos R,Nasioulas G,Grivas A,Boukovinas I,Mylonaki M,Panopoulos C,Magic MB,Fountzilas G,Yannoukakos D

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas ...

journal_title：BMC cancer

authors： Pelizzo G,Veschi V,Mantelli M,Croce S,Di Benedetto V,D'Angelo P,Maltese A,Catenacci L,Apuzzo T,Scavo E,Moretta A,Todaro M,Stassi G,Avanzini MA,Calcaterra V

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor that contributes to tumour aggressiveness and correlates with poor prognosis and resistance to conventional therapy. Therefore, identifying hypoxic environments within tumours is extremely useful for understanding cancer biology and developing novel therapeutic strategies. Seve...

journal_title：BMC cancer

authors： Takei N,Yoneda A,Kosaka M,Sakai-Sawada K,Tamura Y

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been reported in a variety of human tumour entities. FOXM1 is a gene of interest because recently chemical in...

journal_title：BMC cancer

authors： Bektas N,Haaf At,Veeck J,Wild PJ,Lüscher-Firzlaff J,Hartmann A,Knüchel R,Dahl E

更新日期：2008-02-06 00:00:00

abstract：BACKGROUND:To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. METHODS:We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. T...

journal_title：BMC cancer

authors： Yang J,Yang Y,Xia M,Wang L,Zhou W,Yang Y,Jiang Y,Wang H,Qian J,Jin L,Wang X

更新日期：2016-03-12 00:00:00

abstract：BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...

journal_title：BMC cancer

authors： Matsumoto M,Seike M,Noro R,Soeno C,Sugano T,Takeuchi S,Miyanaga A,Kitamura K,Kubota K,Gemma A

更新日期：2015-04-09 00:00:00

abstract：BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...

journal_title：BMC cancer

authors： Gerlier L,Lamotte M,Awada A,Bosly A,Bries G,Cocquyt V,Focan C,Henry S,Lalami Y,Machiels JP,Mebis J,Straetmans N,Verhoeven D,Somers L

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether early tumor shrinkage (ETS) at 6 weeks after treatment correlates with progression-free survival (PFS) and overall survival (OS) in advanced biliary tract cancer (BTC) patients receiving gemcitabine plus oxaliplatin (GEMOX), with or without erlotinib. METHODS:T...

journal_title：BMC cancer

authors： Kim ST,Jang KT,Lee SJ,Jang HL,Lee J,Park SH,Park YS,Lim HY,Kang WK,Park JO

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...

journal_title：BMC cancer

authors： Adam Y,van Gelderen CJ,de Bruyn G,McIntyre JA,Turton DA,Martinson NA

更新日期：2008-07-25 00:00:00

abstract：BACKGROUND:The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic th...

journal_title：BMC cancer

authors： Paiva TF Jr,de Jesus VH,Marques RA,da Costa AA,de Macedo MP,Peresi PM,Damascena A,Rossi BM,Begnami MD,de Lima VC

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...

journal_title：BMC cancer

authors： Letessier A,Sircoulomb F,Ginestier C,Cervera N,Monville F,Gelsi-Boyer V,Esterni B,Geneix J,Finetti P,Zemmour C,Viens P,Charafe-Jauffret E,Jacquemier J,Birnbaum D,Chaffanet M

更新日期：2006-10-13 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. METHODS:The in vitro antineoplastic effect and mechanism of action of Casiopei...

journal_title：BMC cancer

authors： Trejo-Solís C,Jimenez-Farfan D,Rodriguez-Enriquez S,Fernandez-Valverde F,Cruz-Salgado A,Ruiz-Azuara L,Sotelo J

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:The standard therapy regimen of conventional osteosarcoma includes neoadjuvant chemotherapy followed by surgical resection and postoperative chemotherapy. The percentage of necrotic tissue following induction chemotherapy is assessed by using the Huvos grading system, which classifies patients as "poor respo...

journal_title：BMC cancer

authors： Salas S,Jiguet-Jiglaire C,Campion L,Bartoli C,Frassineti F,Deville JL,Maues De Paula A,Forest F,Jézéquel P,Gentet JC,Bouvier C

更新日期：2014-08-20 00:00:00

abstract：BACKGROUND:Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism. METHODS:The expre...

journal_title：BMC cancer

authors： Tu XP,Li H,Chen LS,Luo XN,Lu ZM,Zhang SY,Chen SH

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases...

journal_title：BMC cancer

authors： Henkens R,Delvenne P,Arafa M,Moutschen M,Zeddou M,Tautz L,Boniver J,Mustelin T,Rahmouni S

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age. METHODS:This single-center retrospective study included 39 infants (42 eyes) aged ≤3 months who were diagnosed with unilat...

journal_title：BMC cancer

authors： Chen Q,Zhang B,Dong Y,Mo X,Zhang L,Xia J,Zhang J,Zhang S

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Preclinical evidence suggests that aspirin may inhibit lung cancer progression. In a large cohort of lung cancer patients, we investigated whether low-dose aspirin use was associated with a reduction in the risk of lung cancer-specific mortality. METHODS:We identified lung cancer patients from English cance...

journal_title：BMC cancer

authors： Mc Menamin ÚC,Cardwell CR,Hughes CM,Murray LM

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity an...

journal_title：BMC cancer

authors： Eskew JD,Sadikot T,Morales P,Duren A,Dunwiddie I,Swink M,Zhang X,Hembruff S,Donnelly A,Rajewski RA,Blagg BS,Manjarrez JR,Matts RL,Holzbeierlein JM,Vielhauer GA

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a contr...

journal_title：BMC cancer

authors： Dorn J,Spatz H,Schmieder M,Barth TF,Blatz A,Henne-Bruns D,Knippschild U,Kramer K

更新日期：2010-07-02 00:00:00

abstract：BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...

journal_title：BMC cancer

authors： Stücker I,Loriot MA,N'koutchou G,Cénée S,Bodin L,Mulot C,Gelu-Simeon M,Pelletier L,Bronowicki JP,Degos F,Beaune P,Laurent-Puig P,Hémon D,Trinchet JC,Pelletier G

更新日期：2007-11-19 00:00:00

abstract：:Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published. ...

journal_title：BMC cancer

authors： Doma V,Kárpáti S,Rásó E,Barbai T,Tímár J

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Given their frequency of occurrence in the United States, cancer and heart disease often coexist. For patients requiring open-heart surgery, this raises concern that the use of cardiopulmonary bypass (CPB) may cause a transient immunosuppression with the potential to promote the spread and growth of coexisti...

journal_title：BMC cancer

authors： Pinto CA,Marcella S,August DA,Holland B,Kostis JB,Demissie K

更新日期：2013-11-03 00:00:00

abstract：BACKGROUND:The high complication rates of surgically implanted port catheter systems (SIPCS) represents a major drawback in the treatment of isolated liver neoplasms by hepatic arterial infusion (HAI) of chemotherapy. Interventionally implanted port catheter systems (IIPCS) have evolved into a promising alternative tha...

journal_title：BMC cancer

authors： Hildebrandt B,Pech M,Nicolaou A,Langrehr JM,Kurcz J,Bartels B,Miersch A,Felix R,Neuhaus P,Riess H,Dörken B,Ricke J

更新日期：2007-04-24 00:00:00