Abstract：
BACKGROUND:To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. METHODS:We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. Then, we performed association analyses of suggestively significant SNPs with HBV infection in 1075 controls, 1936 PSs and 639 PSEs. RESULTS:In total, 109 rare variants (74 novel) and 38 single nucleotide polymorphisms (SNPs, one novel) were screened. Of the seven non-synonymous rare variants, six were singletons and one was a double hit. All three damaging rare singletons presented exclusively in the PSE group. Of the five SNPs validated in all 3650 subjects, the T allele of rs4646287 was significantly decreased (p = 0.002) in the PS group (10.1%) and PSE group (8.1%) compared to the controls (10.9%) and was decreased to 7.4% in the PSE hepatocellular carcinoma (HCC) subgroup. Additionally, rs4646287-T was associated with a 0.68-fold (95% CI = 0.51-0.89, p = 0.006) decreased risk of PSE compared with the controls. The NTCP mRNA level was lower in HCC tissues in "CT + TT" carriers than in "CC" carriers. CONCLUSIONS:We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Yang J,Yang Y,Xia M,Wang L,Zhou W,Yang Y,Jiang Y,Wang H,Qian J,Jin L,Wang Xdoi
10.1186/s12885-016-2257-6subject
Has Abstractpub_date
2016-03-12 00:00:00pages
211issn
1471-2407pii
10.1186/s12885-016-2257-6journal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are use...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-193
更新日期：2010-05-11 00:00:00
abstract：BACKGROUND:There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding stron...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4094-2
更新日期：2018-02-13 00:00:00
abstract：BACKGROUND:In Ethiopia, the incidence of new cases of breast cancer is currently increasing resulting to high rates of morbidity and mortality. Breast cancer is by far the most common cancer accounting for more than one out of three cancer cases in women and one out of every five in the general population. The study wa...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5612-6
更新日期：2019-04-25 00:00:00
abstract：BACKGROUND:Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor signaling cascades are kn...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1363-1
更新日期：2015-05-08 00:00:00
abstract：BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-311
更新日期：2010-06-21 00:00:00
abstract：BACKGROUND:Treatment of locally advanced non-small-cell lung cancer is based on a combined approach. To study the impact of trimodal therapy for stage III-N2 NSCLC a single centre retrospective evaluation focusing on survival and therapy-related toxicity was performed. METHODS:71 patients diagnosed between March 2001 ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-572
更新日期：2014-08-07 00:00:00
abstract：BACKGROUND:Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because many patients have multiple co-morbidities and would not fulfill the eligibility criteria of clinical...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-610
更新日期：2013-12-27 00:00:00
abstract：BACKGROUND:Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. CASE PRESENTATION:We describe a pat...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-5-94
更新日期：2005-08-04 00:00:00
abstract：BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-391
更新日期：2012-09-06 00:00:00
abstract：BACKGROUND:While mathematical models are often used to predict progression of cancer and treatment outcomes, there is still uncertainty over how to best model tumor growth. Seven ordinary differential equation (ODE) models of tumor growth (exponential, Mendelsohn, logistic, linear, surface, Gompertz, and Bertalanffy) h...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2164-x
更新日期：2016-02-26 00:00:00
abstract：BACKGROUND:Alcohol consumption is associated with higher breast cancer risk. While studies suggest a modest association between alcohol intake and mammographic density, few studies have examined the association in racial/ethnic minority populations. METHODS:We assessed dense breast area and total breast area from digi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1094-3
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thy...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3120-0
更新日期：2017-02-16 00:00:00
abstract：BACKGROUND:Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor. This study investiga...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2568-7
更新日期：2016-07-26 00:00:00
abstract：BACKGROUND:Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma (PMBCL). However, their CNA-based profile and clinical impact still remain unc...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07293-3
更新日期：2020-08-27 00:00:00
abstract：BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-6-235
更新日期：2006-10-03 00:00:00
abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4731-9
更新日期：2018-08-20 00:00:00
abstract：BACKGROUND:Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine strategy that integrates genomic profiling and preclinical drug-screening platforms, in order to persona...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3525-9
更新日期：2017-08-10 00:00:00
abstract：BACKGROUND:Venous thromboembolic events (VTE) are common in cancer patients and associated with higher mortality. In vivo thrombosis and anticoagulation might be involved in tumor growth and progression. We studied the association of warfarin and other anticoagulant use as antithrombotic medication and prostate cancer ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3579-8
更新日期：2017-08-29 00:00:00
abstract：BACKGROUND:Ovarian tissue cryopreservation has a wide range of cancerous indications. Avoiding relapse becomes a specific concern that clinicians frequently encounter. The data about the comparative viability of cancer cells after cryopreservation are limited. This study aimed to evaluate the effect of cryopreservation...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07227-z
更新日期：2020-08-12 00:00:00
abstract：BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-90
更新日期：2012-03-19 00:00:00
abstract：BACKGROUND:Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet delivery, but self-guided interventions have shown limited efficacy. The aim of this study is to test t...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-06731-6
更新日期：2020-03-16 00:00:00
abstract：BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4300-2
更新日期：2018-04-02 00:00:00
abstract：BACKGROUND:To the best of our knowledge, no study has reported mediastinal shift accompanied with obstructive atelectasis due to bulky primary esophageal tumor components treated with adaptive radiotherapy and concurrent chemotherapy. CASE PRESENTATION:Here we report the case of a 65-year-old male patient diagnosed wi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6505-4
更新日期：2020-01-06 00:00:00
abstract：BACKGROUND:Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-5115-x
更新日期：2018-12-07 00:00:00
abstract：BACKGROUND:Mammographic breast density and parenchymal patterns are well-established risk factors for breast cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic density and parenchymal pattern, and secondarily to examine what potential impact reproducibility ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1256-3
更新日期：2015-04-12 00:00:00
abstract：BACKGROUND:Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to sex, genetic background and lifestyle. Here, we compute the individual phase of the Circadian Timing...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2319-9
更新日期：2016-04-21 00:00:00
abstract：BACKGROUND:To assess metastatic breast cancer (MBC) patient psychological factors, perceptions, and comprehension of tumor genomic testing. METHODS:In a prospective, single institution, single-arm trial, patients with MBC underwent next-generation sequencing at study entry with sequencing results released at progressi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-06905-2
更新日期：2020-05-06 00:00:00
abstract：BACKGROUND:Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. METHODS:This study included ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4305-x
更新日期：2018-04-03 00:00:00
abstract：BACKGROUND:Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2903-z
更新日期：2016-11-10 00:00:00
abstract：BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-509
更新日期：2013-10-30 00:00:00
