Differences in predictions of ODE models of tumor growth: a cautionary example.

abstract：BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VE...

journal_title：BMC cancer

authors： Ding C,Li L,Yang T,Fan X,Wu G

更新日期：2016-10-12 00:00:00

abstract：BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...

journal_title：BMC cancer

authors： Wolf B,Goebel G,Hackl H,Fiegl H

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a novel target for breast cancer treatment. The aim of this study is t...

journal_title：BMC cancer

authors： Johnston SJ,Ahmad D,Aleskandarany MA,Kurozumi S,Nolan CC,Diez-Rodriguez M,Green AR,Rakha EA

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for overall survival (OS), are not well captured by the World Health Organization (WHO) and Response Evaluat...

journal_title：BMC cancer

authors： Noguchi M,Moriya F,Suekane S,Ohnishi R,Matsueda S,Sasada T,Yamada A,Itoh K

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival rates of only 50-60%. Neo-adjuvant and adjuvant chemotherapy (CTX) has been applied to achieve pre-...

journal_title：BMC cancer

authors： Schmitt T,Lehner B,Kasper B,Bischof M,Roeder F,Dietrich S,Dimitrakopoulou-Strauss A,Strauss LG,Mechtersheimer G,Wuchter P,Ho AD,Egerer G

更新日期：2011-12-07 00:00:00

abstract：BACKGROUND:Fos-related antigen 1 (FRA-1) is an immediate early gene encoding a member of AP-1 family of transcription factors involved in cell proliferation, differentiation, apoptosis, and other biological processes. fra-1 gene overexpression has an important role in the process of cellular transformation, and our pre...

journal_title：BMC cancer

authors： Chiappetta G,Ferraro A,Botti G,Monaco M,Pasquinelli R,Vuttariello E,Arnaldi L,Di Bonito M,D'Aiuto G,Pierantoni GM,Fusco A

更新日期：2007-01-25 00:00:00

abstract：:Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...

journal_title：BMC cancer

authors： Jiann BP

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...

journal_title：BMC cancer

authors： Rouissi K,Bahria IB,Bougatef K,Marrakchi R,Stambouli N,Hamdi K,Cherif M,Ben Slama MR,Sfaxi M,Othman FB,Chebil M,Elgaaied AB,Ouerhani S

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...

journal_title：BMC cancer

authors： Zhang XH,Huang DP,Guo GL,Chen GR,Zhang HX,Wan L,Chen SY

更新日期：2008-01-13 00:00:00

abstract：BACKGROUND:Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. It is related to the overexpression of a membrane protein, P-glycoprotein (Pgp-170), thereby reducing drug cytotoxicity. A variety o...

journal_title：BMC cancer

authors： Limtrakul P,Anuchapreeda S,Buddhasukh D

更新日期：2004-04-17 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia a...

journal_title：BMC cancer

authors： Schilling D,Bayer C,Geurts-Moespot A,Sweep FC,Pruschy M,Mengele K,Sprague LD,Molls M

更新日期：2007-07-30 00:00:00

abstract：BACKGROUND:The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity an...

journal_title：BMC cancer

authors： Eskew JD,Sadikot T,Morales P,Duren A,Dunwiddie I,Swink M,Zhang X,Hembruff S,Donnelly A,Rajewski RA,Blagg BS,Manjarrez JR,Matts RL,Holzbeierlein JM,Vielhauer GA

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. We therefore tested the activity of the combination of Trastuzumab with metronomic, low dose chemotherapy with cyclophosphamide (CTX) and methotrexate (MTX) in metastatic breast cancer (MBC). METHODS:Between April 2002 and June...

journal_title：BMC cancer

authors： Orlando L,Cardillo A,Ghisini R,Rocca A,Balduzzi A,Torrisi R,Peruzzotti G,Goldhirsch A,Pietri E,Colleoni M

更新日期：2006-09-15 00:00:00

abstract：BACKGROUND:Growing evidence has indicated that some inflammatory markers, including lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI), can be used as indicators in the prognosis of colorectal cancer (CRC). However, there ...

journal_title：BMC cancer

authors： Song Y,Yang Y,Gao P,Chen X,Yu D,Xu Y,Zhao J,Wang Z

更新日期：2017-11-10 00:00:00

abstract：BACKGROUND:Analysis of the clinical response of extramedullary lesions in leukemic patients treated with radiation therapy (RT) and defining the optimal dose of radiation. METHODS:Forty-two extramedullary lesions found in 24 leukemic patients treated with RT were reviewed. The radiation was delivered usually 2 Gy/day,...

journal_title：BMC cancer

authors： Song JH,Son SH,Lee JH,Chung SM,Jang HS,Choi BO

更新日期：2011-10-06 00:00:00

abstract：BACKGROUND:Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim of the present work was to study the growth inhibition of tumor cells by butanol extract of Bifidobac...

journal_title：BMC cancer

authors： Lee DK,Jang S,Kim MJ,Kim JH,Chung MJ,Kim KJ,Ha NJ

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:EndoPredict (EP) is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE) tissue by reverse tra...

journal_title：BMC cancer

authors： Kronenwett R,Bohmann K,Prinzler J,Sinn BV,Haufe F,Roth C,Averdick M,Ropers T,Windbergs C,Brase JC,Weber KE,Fisch K,Müller BM,Schmidt M,Filipits M,Dubsky P,Petry C,Dietel M,Denkert C

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal ch...

journal_title：BMC cancer

authors： Wang Y,Gong C,Yang L,Wu Q,Shi S,Shi H,Qian Z,Wei Y

更新日期：2010-08-02 00:00:00

abstract：BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...

journal_title：BMC cancer

authors： Schmidt JW,Wehde BL,Sakamoto K,Triplett AA,West WW,Wagner KU

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC. METHODS:We investigated SMAD4 status in PDAC by immunohistochemical methods to explore the relationshi...

journal_title：BMC cancer

authors： Wang Z,Li Y,Zhan S,Zhang L,Zhang S,Tang Q,Li M,Tan Z,Liu S,Xing X

更新日期：2019-11-04 00:00:00

abstract：BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...

journal_title：BMC cancer

authors： Nakayama T,Ling ZQ,Mukaisho K,Hattori T,Sugihara H

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significanc...

journal_title：BMC cancer

authors： Song Y,Song S,Zhang D,Zhang Y,Chen L,Qian L,Shi M,Zhao H,Jiang Z,Guo N

更新日期：2006-12-28 00:00:00

abstract：BACKGROUND:Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily ...

journal_title：BMC cancer

authors： Chu D,Wei L

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. METHODS:This study included ...

journal_title：BMC cancer

authors： Girardi DM,de Lima MA,Pereira GCB,Negrão MV,López RVM,Capareli FC,Sabbaga J,Hoff PMG

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of smoking on breast cancer characteristics is limited. We evaluated the impact of smoking on breast ca...

journal_title：BMC cancer

authors： Goldvaser H,Gal O,Rizel S,Hendler D,Neiman V,Shochat T,Sulkes A,Brenner B,Yerushalmi R

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism o...

journal_title：BMC cancer

authors： Kong X,Xu P,Cai WJ,Wang HG,Li BB,Huang GL,He ZW,Chen G,Ye CG

更新日期：2018-04-13 00:00:00

abstract：BACKGROUND:To the best of our knowledge, no study has reported mediastinal shift accompanied with obstructive atelectasis due to bulky primary esophageal tumor components treated with adaptive radiotherapy and concurrent chemotherapy. CASE PRESENTATION:Here we report the case of a 65-year-old male patient diagnosed wi...

journal_title：BMC cancer

authors： Sakanaka K,Fujii K,Mizowaki T

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progression of hormone-naïve, organ-confined tumors. In localized prostate c...

journal_title：BMC cancer

authors： Hsiao JJ,Ng BH,Smits MM,Wang J,Jasavala RJ,Martinez HD,Lee J,Alston JJ,Misonou H,Trimmer JS,Wright ME

更新日期：2015-03-31 00:00:00