Abstract:
BACKGROUND:This paper describes the development of a Cancer Awareness Measure for colorectal (CRC) cancer (Bowel/Colorectal CAMa) (study 1) and presents key results from a population-representative survey using the measure (study 2). METHODS:STUDY 1: Items were taken from the literature and reviewed by expert groups. A series of three validation studies assessed reliability and validity of the measure. To establish test-retest reliability, 49 people over 50 years of age completed the Bowel/Colorectal CAM on two occasions (range 9-14 days, mean 13.5 days). Construct validity was assessed by comparing responses from bowel cancer experts (n = 16) and the lay public (n = 35). Lastly, a brief intervention study tested sensitivity to change with participants (n = 70) randomly allocated to be given a control leaflet or an intervention leaflet and their responses were compared. STUDY 2: 1520 respondents completed the Bowel/Colorectal CAM in a population survey carried out by TNS-British Market Research Bureau International (TNS-BMRB) in March 2010. RESULTS:STUDY 1: Internal reliability (Cronbach's alpha = 0.84) was high. Test-retest reliability was over r = 0.7 for warning signs, risk factors and age people are first invited for screening, but lower (between 0.6 and 0.7) for other items (lifetime risk, awareness of bowel cancer screening, age at risk). Bowel cancer experts achieved higher scores than equally educated controls (54.7 [4.3] vs. 42.9 [5.7]; P < 0.001) demonstrating the measure has construct validity and intervention participants showed higher knowledge than controls (51.4 [5.9] vs. 42.9 [5.7]; P < 0.001) suggesting the measure is sensitive to change. STUDY 2: Respondents recalled on average, one CRC sign and one risk factor. There was particularly low prompted awareness of the signs 'lump in the abdomen' (64%) and 'tiredness' (50%) and several lifestyle risk factors for CRC, e.g. exercise (37%).Respondents from more affluent groups had consistently higher knowledge of signs and risk factors compared to those from more deprived groups. CONCLUSIONS:The Bowel/Colorectal CAM meets accepted psychometric criteria for reliability and construct validity and should therefore provide a useful tool for assessment of CRC awareness. The population survey revealed low awareness of several CRC signs and risk factors and emphasises the importance of continuing public education, particularly about the link between lifestyle behaviours and CRC.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Power E,Simon A,Juszczyk D,Hiom S,Wardle Jdoi
10.1186/1471-2407-11-366subject
Has Abstractpub_date
2011-08-23 00:00:00pages
366issn
1471-2407pii
1471-2407-11-366journal_volume
11pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2. METHODS:ATC were generated from PBMC activated for 14 days with anti-CD3 monoclonal antibody in th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-83
更新日期:2013-02-22 00:00:00
abstract:BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-432
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Previous studies suggested the association of certain cytokines with the invasion and metastatic propert...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-574
更新日期:2010-10-22 00:00:00
abstract:BACKGROUND:Increased level of serum S100B can serve as a marker of metastatic spread in patients with cutaneous melanoma (CM). In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and planning treatment.The aims of this study were to det...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-328
更新日期:2011-08-02 00:00:00
abstract:BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangemen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4396-4
更新日期:2018-04-23 00:00:00
abstract:BACKGROUND:This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially young patients. The flatness filter has been described as main source of photon scatter. MATERIAL ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6535-y
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3539-3
更新日期:2017-08-17 00:00:00
abstract:BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-167
更新日期:2008-06-09 00:00:00
abstract:BACKGROUND:Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. METHODS:To compare the functional role of E-cadherin and P-cadherin in inva...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-74
更新日期:2009-03-03 00:00:00
abstract:BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-5579-3
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:Aberrant methylation is a frequent event in oral cancer. METHODS:In order to better characterize these alterations, a search for genes downregulated by aberrant methylation in oral squamous cell carcinoma (OSCC) was conducted through the mining of ORESTES dataset. Findings were further validated in OSCC cel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4077-3
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbidity on treatment choice. This study aimed to assess the impact of comorbidity on colon cancer patien...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-116
更新日期:2009-04-20 00:00:00
abstract:BACKGROUND:Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor-specific manner. Rec...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-103
更新日期:2010-03-18 00:00:00
abstract:BACKGROUND:To assess the diagnostic value of retrospective PET-MRI fusion and to compare the results with side-by-side analysis and single modality use of PET and of MRI alone for locoregional tumour and nodal staging of head-and-neck cancer. METHODS:Thirty-three patients with head-and-neck cancer underwent preoperati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-846
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:Recruitment of cofactors in the interaction of the androgen receptor (AR) and AR ligands plays a critical role in determining androgenic/antiandrogenic effects of the AR ligand on signaling, but the functions of key cofactors, including nuclear receptor coactivator (NCOA), remain poorly understood in prostat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2378-y
更新日期:2016-05-25 00:00:00
abstract:BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-245
更新日期:2006-10-13 00:00:00
abstract:BACKGROUND:About 85% of breast cancer patients attending Komfo Anokye Teaching Hospital (KATH), Ghana, present with stage III/IV disease. In spite of great investments into the early diagnosis and management of breast cancer, late presentation persists and poses a barrier to realising the possible benefits of the gains...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07520-x
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07413-z
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:Young age remains a controversial issue as a prognostic factor in breast cancer. Debate includes patients from different parts of the world. Almost 50% of patients with breast cancer seen at the American University of Beirut Medical Center (AUBMC) are below age 50. METHODS:We reviewed 1320 patients seen at ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-194
更新日期:2006-07-20 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-90
更新日期:2012-03-19 00:00:00
abstract:BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-164
更新日期:2006-06-23 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4639-4
更新日期:2018-07-20 00:00:00
abstract:BACKGROUND:Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4180-5
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1007-5
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive. METHODS:We developed a pathway based classifier approach to predict pr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-37
更新日期:2008-01-31 00:00:00
abstract:PURPOSE:Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practitioners is not well known. METHODS:Two nationwide observational telephone surveys were conducted in early ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-104
更新日期:2008-04-15 00:00:00
abstract:BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-566
更新日期:2010-10-19 00:00:00
abstract:BACKGROUND:Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-218
更新日期:2012-06-06 00:00:00
abstract:BACKGROUND:Renal cell carcinoma (RCC) is a seventh ranked malignancy with poor prognosis. RCC is lethal at metastatic stage as it does not respond to conventional systemic treatments, and there is an urgent need to find out promising novel biomarkers for effective treatment. The goal of this study was to evaluate the b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2775-2
更新日期:2016-09-30 00:00:00
abstract:BACKGROUND:The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise training in prescribed programs; 2) the reporting of the components of the exercise prescription; and 3)...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5520-9
更新日期:2019-04-05 00:00:00