Abstract:
BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangements may also contribute to leukemogenesis but are less summarized. CASE PRESENTATION:Here we reported rare fusion genes ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15 in a 47-year-old AML-M4 patient with FLT3 internal tandem duplication (ITD) discovered by whole genome sequencing (WGS) using the patient's healthy sibling as a sequencing control. CONCLUSION:This is, to our knowledge, the first case of AML with fusion gene ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wang L,Sun Y,Sun Y,Meng L,Xu Xdoi
10.1186/s12885-018-4396-4subject
Has Abstractpub_date
2018-04-23 00:00:00pages
458issue
1issn
1471-2407pii
10.1186/s12885-018-4396-4journal_volume
18pub_type
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