Impact of diabetes mellitus on epithelial ovarian cancer survival.

abstract：BACKGROUND:Treatment of locally advanced non-small-cell lung cancer is based on a combined approach. To study the impact of trimodal therapy for stage III-N2 NSCLC a single centre retrospective evaluation focusing on survival and therapy-related toxicity was performed. METHODS:71 patients diagnosed between March 2001 ...

journal_title：BMC cancer

authors： Askoxylakis V,Tanner J,Kappes J,Hoffmann H,Nicolay NH,Rief H,Debus J,Thomas M,Bischof M

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and relationship with survival in patients with PDAC to establish the significance of GOLPH3 in the dev...

journal_title：BMC cancer

authors： Zhang LJ,Wang KB,Liu LS,Chen LZ,Peng BG,Liang LJ,Li Z,Xue L,Li W,Xia JT

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, in recent years there has been a progressive increase in the use of robot-assisted laparoscopic radic...

journal_title：BMC cancer

authors： Porreca A,Palmer K,Artibani W,Antonelli A,Bianchi L,Brunocilla E,Bocciardi AM,Brausi M,Busetto GM,Carini M,Carrieri G,Celia A,Cindolo L,Cochetti G,Colombo R,De Berardinis E,De Cobelli O,Di Maida F,Ercolino A,Gaboard

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVE:Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this study was to explore the efficacy of crizotinib in advanced non-small-cell lung cancer (NSCLC) with c...

journal_title：BMC cancer

authors： Chen RL,Zhao J,Zhang XC,Lou NN,Chen HJ,Yang X,Su J,Xie Z,Zhou Q,Tu HY,Zhong WZ,Yan HH,Guo WB,Wu YL,Yang JJ

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Genetically engineered mouse models of mammary gland cancer enable the in vivo study of molecular mechanisms and signaling during development and cancer pathophysiology. However, traditional whole mount and histological imaging modalities are only applicable to non-viable tissue. METHODS:We evaluated three ...

journal_title：BMC cancer

authors： Tilli MT,Parrish AR,Cotarla I,Jones LP,Johnson MD,Furth PA

更新日期：2008-01-23 00:00:00

abstract：BACKGROUND:To assess the safety and efficacy of simultaneous integrated boost (SIB) or late course accelerated boost (LCAB) with external beam radiotherapy (EBRT) to the vaginal cuff for high risk cervical cancer patients after radical hysterectomy. METHODS:Between October 2009 and January 2012, patients with high ris...

journal_title：BMC cancer

authors： Wang X,Zhao Y,Shen Y,Shu P,Li Z,Bai S,Xu F

更新日期：2015-04-11 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. METHODS:The in vitro antineoplastic effect and mechanism of action of Casiopei...

journal_title：BMC cancer

authors： Trejo-Solís C,Jimenez-Farfan D,Rodriguez-Enriquez S,Fernandez-Valverde F,Cruz-Salgado A,Ruiz-Azuara L,Sotelo J

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment. METHODS:We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionn...

journal_title：BMC cancer

authors： Yun YH,Kim YA,Sim JA,Shin AS,Chang YJ,Lee J,Kim MS,Shim YM,Zo JL

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:In order to maximize later health, there are established components and guidelines for quality follow-up care of breast cancer survivors. However, adherence to quality follow-up in Canada may not be optimal, and may vary by province. We determined and compared the proportion of patients in each province who ...

journal_title：BMC cancer

authors： McBride ML,Groome PA,Decker K,Kendell C,Jiang L,Whitehead M,Li D,Grunfeld E,CanIMPACT Team.

更新日期：2019-07-04 00:00:00

abstract：BACKGROUND:The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these b...

journal_title：BMC cancer

authors： Rud AK,Lund-Iversen M,Berge G,Brustugun OT,Solberg SK,Mælandsmo GM,Boye K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear. METHODS:With the goal of revealing the underlying mechanism, three data sets with accession numbers GSE8401, GSE46517 ...

journal_title：BMC cancer

authors： Su W,Guan Y,Huang B,Wang J,Wei Y,Zhao Y,Jiao Q,Ji J,Yu D,Xu L

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Territorial differences in the access to innovative anticancer drugs have been reported from many countries. The objectives of this study were to evaluate access to innovative treatments for metastatic lung cancer in France, and to assess whether socioeconomic indicators were predictors of access at the leve...

journal_title：BMC cancer

authors： Scherpereel A,Durand-Zaleski I,Cotté FE,Fernandes J,Debieuvre D,Blein C,Gaudin AF,Tournier C,Vainchtock A,Chauvin P,Souquet PJ,Westeel V,Chouaïd C

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Liver resection had been regarded as a standard treatment for primary hepatocellular carcinoma (HCC). However, early mortality and recurrence after surgery were still of major concern. RAM (Risk Assessment for early Mortality) scoring system is a newly developed tool for assessing early mortality after hepat...

journal_title：BMC cancer

authors： Hsu HY,Yu MC,Lee CW,Tsai HI,Sung CM,Chen CW,Huang SW,Lin CY,Jeng WJ,Lee WC,Chen MF

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in cancer invasion, metastasis, and chemoresistance. Additionally, EMT is partially responsible for che...

journal_title：BMC cancer

authors： Zhang Z,Zheng S,Lin Y,Sun J,Ding N,Chen J,Zhong J,Shi L,Xue M

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells. METHODS:The growth inhibition of U251 cells induced by resveratrol was assessed with methyl thiazolyl tetrazoli...

journal_title：BMC cancer

authors： Li J,Qin Z,Liang Z

更新日期：2009-06-30 00:00:00

abstract：BACKGROUND:We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival (OS) in an expanded access cohort of trastuzumab-treated HER2-positive patients with metastatic brea...

journal_title：BMC cancer

authors： Toi M,Sperinde J,Huang W,Saji S,Winslow J,Jin X,Tan Y,Ohno S,Nakamura S,Iwata H,Masuda N,Aogi K,Morita S,Petropoulos C,Bates M

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health. This paper reports on trends in the geographical mortality patterns of the most frequent cancers in Spain, over a period of 2...

journal_title：BMC cancer

authors： López-Abente G,Aragonés N,Pérez-Gómez B,Pollán M,García-Pérez J,Ramis R,Fernández-Navarro P

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...

journal_title：BMC cancer

authors： Wang L,Wang R,Pan Y,Sun Y,Zhang J,Chen H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...

journal_title：BMC cancer

authors： Ehteda A,Galettis P,Pillai K,Morris DL

更新日期：2013-02-23 00:00:00

abstract：BACKGROUND:RhoC is a small G protein/GTPase and involved in tumor mobility, invasion and metastasis. Previously, up-regulated RhoC expression is found to play an important role in ovarian carcinogenesis and subsequent progression by modulating proliferation, apoptosis, migration and invasion. METHODS:We transfected Rh...

journal_title：BMC cancer

authors： Gou WF,Zhao Y,Lu H,Yang XF,Xiu YL,Zhao S,Liu JM,Zhu ZT,Sun HZ,Liu YP,Xu F,Takano Y,Zheng HC

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the func...

journal_title：BMC cancer

authors： Jami MS,Hou J,Liu M,Varney ML,Hassan H,Dong J,Geng L,Wang J,Yu F,Huang X,Peng H,Fu K,Li Y,Singh RK,Ding SJ

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that independently arising neoplasms in an individual patient would exhibit measurable genomic variation, en...

journal_title：BMC cancer

authors： Shen C,Xu H,Liu L,Zhou Y,Chen D,Du H,Han Z,Che G

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening outcomes within a lung cancer screening program (LCSP) at our urban academic medical center includi...

journal_title：BMC cancer

authors： Lake M,Shusted CS,Juon HS,McIntire RK,Zeigler-Johnson C,Evans NR,Kane GC,Barta JA

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Modeling the relationship between age and mortality for breast cancer patients may have important prognostic and therapeutic implications. METHODS:Data from 9 registries of the Surveillance, Epidemiology, and End Results Program (SEER) of the United States were used. This study employed proportional hazards...

journal_title：BMC cancer

authors： Tai P,Cserni G,Van De Steene J,Vlastos G,Voordeckers M,Royce M,Lee SJ,Vinh-Hung V,Storme G

更新日期：2005-10-08 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer. METHODS:Circulating cells were identified by reverse transcription-polymerase chain reaction (RT-PCR) to detect p503S, p504S and p510...

journal_title：BMC cancer

authors： Cardillo MR,Gentile V,Ceccariello A,Giacomelli L,Messinetti S,Di Silverio F

更新日期：2005-09-05 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies. This study aimed to identify the key prognosis impacting genes and relevant subtypes for LUAD. ME...

journal_title：BMC cancer

authors： Lv Z,Lei T

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistance. Thus, novel therapeutic approaches are required. Statins and amino-bisphosp...

journal_title：BMC cancer

authors： Göbel A,Zinna VM,Dell'Endice S,Jaschke N,Kuhlmann JD,Wimberger P,Rachner TD

更新日期：2020-07-29 00:00:00

abstract：BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...

journal_title：BMC cancer

authors： Inari H,Teruya N,Kishi M,Horii R,Akiyama F,Takahashi S,Ito Y,Ueno T,Iwase T,Ohno S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This in vitro study, for the first ti...

journal_title：BMC cancer

authors： Wouters A,Pauwels B,Lardon F,Pattyn GG,Lambrechts HA,Baay M,Meijnders P,Vermorken JB

更新日期：2010-08-19 00:00:00

abstract：BACKGROUND:Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quality of life and thus to identify those patients who need and can benefit most from specific intervent...

journal_title：BMC cancer

authors： Peters E,Mendoza Schulz L,Reuss-Borst M

更新日期：2016-10-10 00:00:00