Long-term follow-up results of simultaneous integrated or late course accelerated boost with external beam radiotherapy to vaginal cuff for high risk cervical cancer patients after radical hysterectomy.

abstract：BACKGROUND:Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluated a well-established hepatic tumor cell line, HepG2, and an adul...

journal_title：BMC cancer

authors： Rangwala F,Williams KP,Smith GR,Thomas Z,Allensworth JL,Lyerly HK,Diehl AM,Morse MA,Devi GR

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC) is a partnership among two research institutions and a network of safety net clinics to promote...

journal_title：BMC cancer

authors： Coronado GD,Vollmer WM,Petrik A,Aguirre J,Kapka T,Devoe J,Puro J,Miers T,Lembach J,Turner A,Sanchez J,Retecki S,Nelson C,Green B

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily ...

journal_title：BMC cancer

authors： Chu D,Wei L

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:Neuroendocrine tumors (NETs) of the esophagus are extremely rare, and few cases have been reported worldwide. Thus, a comprehensive nationwide study is needed to understand the characteristics of and treatment strategy for esophageal NETs. METHODS:We collected data on esophageal NET patients from 25 hospita...

journal_title：BMC cancer

authors： Lee CG,Lim YJ,Park SJ,Jang BI,Choi SR,Kim JK,Kim YT,Cho JY,Yang CH,Chun HJ,Song SY,Neuroendocrine tumor study group.

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate participation from high-risk groups poses a potential barrier to its effectiveness. The present study examin...

journal_title：BMC cancer

authors： Quaife SL,Vrinten C,Ruparel M,Janes SM,Beeken RJ,Waller J,McEwen A

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer. METHODS:A total of 301 consecutive patients (mean age, 49.8 ± 11.0 years; range, 29-86 years) with breast cancer confirmed by patho...

journal_title：BMC cancer

authors： Ni-Jia-Ti MY,Ai-Hai-Ti DL,Huo-Jia AS,Wu-Mai-Er PL,A-Bu-Li-Zi AB,Shi Y,Rou-Zi NE,Su WJ,Dai GZ,Da-Mo-la MH

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial r...

journal_title：BMC cancer

authors： Stava C,Beck M,Weiss LT,Lopez A,Vassilopoulou-Sellin R

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...

journal_title：BMC cancer

authors： Yasuta S,Kobayashi T,Aizawa H,Takahashi S,Ikeda M,Konishi M,Kojima M,Kuno H,Uesaka K,Morinaga S,Miyamoto A,Toyama H,Takakura N,Sugimachi K,Takayama W

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...

journal_title：BMC cancer

authors： Wells M,Aitchison P,Harris F,Ozakinci G,Radley A,Bauld L,Entwistle V,Munro A,Haw S,Culbard B,Williams B

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...

journal_title：BMC cancer

authors： Fang W,Huang Y,Hong S,Zhang Z,Wang M,Gan J,Wang W,Guo H,Wang K,Zhang L

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma (DLBCL) remains unconfirmed. This study aimed to identify the prognostic importance of H. pylori...

journal_title：BMC cancer

authors： Cheng Y,Xiao Y,Zhou R,Liao Y,Zhou J,Ma X

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Socioeconomic inequalities in cancer mortality in Britain have been shown to be present in the 1990s and early 2000s. Little is known about on-going patterns in such inequalities in cancer mortality. We examined time trends in socioeconomic inequalities in cancer mortality in Britain between 1978 and 2013. ...

journal_title：BMC cancer

authors： Ramsay SE,Morris RW,Whincup PH,Papacosta AO,Lennon LT,Wannamethee SG

更新日期：2014-06-30 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...

journal_title：BMC cancer

authors： Miwa K,Oki E,Enomoto M,Ihara K,Ando K,Fujita F,Tominaga M,Mori S,Nakayama G,Shimokawa M,Saeki H,Baba H,Mori M,Akagi Y

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. It is related to the overexpression of a membrane protein, P-glycoprotein (Pgp-170), thereby reducing drug cytotoxicity. A variety o...

journal_title：BMC cancer

authors： Limtrakul P,Anuchapreeda S,Buddhasukh D

更新日期：2004-04-17 00:00:00

abstract：BACKGROUND:Cancer cells exhibit increased glycolysis for ATP production (the Warburg effect) and macromolecular biosynthesis; it is also linked with therapeutic resistance that is generally associated with compromised respiratory metabolism. Molecular mechanisms underlying radio-resistance linked to elevated glycolysis...

journal_title：BMC cancer

authors： Bhatt AN,Chauhan A,Khanna S,Rai Y,Singh S,Soni R,Kalra N,Dwarakanath BS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in the breast cancer-associated chromosomal region 11q13. The EMSY gene encodes a BRCA2-interacting protein that has been implic...

journal_title：BMC cancer

authors： Määttä KM,Nurminen R,Kankuri-Tammilehto M,Kallioniemi A,Laasanen SL,Schleutker J

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...

journal_title：BMC cancer

authors： Netland IA,Førde HE,Sleire L,Leiss L,Rahman MA,Skeie BS,Gjerde CH,Enger PØ,Goplen D

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

journal_title：BMC cancer

authors： Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:Survival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world populations relatively straightforward. In resource-poor settings, given the deficiencies in a variety o...

journal_title：BMC cancer

authors： Freeman E,Semeere A,Wenger M,Bwana M,Asirwa FC,Busakhala N,Oga E,Jedy-Agba E,Kwaghe V,Iregbu K,Jaquet A,Dabis F,Yumo HA,Dusingize JC,Bangsberg D,Anastos K,Phiri S,Bohlius J,Egger M,Yiannoutsos C,Wools-Kaloustian K

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal carcinoma in situ (DCIS), because cases of undetected invasive foci and nodal metastases occasionally...

journal_title：BMC cancer

authors： Zavagno G,Carcoforo P,Marconato R,Franchini Z,Scalco G,Burelli P,Pietrarota P,Lise M,Mencarelli R,Capitanio G,Ballarin A,Pierobon ME,Marconato G,Nitti D

更新日期：2005-03-11 00:00:00

abstract：BACKGROUND:Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can ...

journal_title：BMC cancer

authors： Ellsworth RE,Ellsworth DL,Patney HL,Deyarmin B,Love B,Hooke JA,Shriver CD

更新日期：2008-10-14 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the short- and long-term outcomes after laparoscopic resection for low rectal cancer (LRC) compared with mid/high rectal cancer (M/HRC). METHODS:Patients with rectal cancer undergoing laparoscopic resection with curative intent were retrospectively reviewed between 2009 and 2015...

journal_title：BMC cancer

authors： Yang H,Yao Z,Cui M,Xing J,Zhang C,Zhang N,Liu M,Xu K,Tan F,Su X

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...

journal_title：BMC cancer

authors： Wolf B,Goebel G,Hackl H,Fiegl H

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associated with the real-world mortality risk. METHODS:This was a retrospective German claims data analys...

journal_title：BMC cancer

authors： Hardtstock F,Myers D,Li T,Cizova D,Maywald U,Wilke T,Griesinger F

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesized c-Met ...

journal_title：BMC cancer

authors： Park CH,Cho SY,Ha JD,Jung H,Kim HR,Lee CO,Jang IY,Chae CH,Lee HK,Choi SU

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...

journal_title：BMC cancer

authors： Stavik B,Skretting G,Aasheim HC,Tinholt M,Zernichow L,Sletten M,Sandset PM,Iversen N

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:About 85% of breast cancer patients attending Komfo Anokye Teaching Hospital (KATH), Ghana, present with stage III/IV disease. In spite of great investments into the early diagnosis and management of breast cancer, late presentation persists and poses a barrier to realising the possible benefits of the gains...

journal_title：BMC cancer

authors： Agbeko AE,Arthur J,Bayuo J,Kaburi BB,Kyei I

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress for cancer patients. However, objective assessment by medical staff makes it easy to underestimate ...

journal_title：BMC cancer

authors： Kanda K,Fujimoto K,Mochizuki R,Ishida K,Lee B

更新日期：2019-09-10 00:00:00