Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells.

abstract：BACKGROUND:Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib. Here, we report the successful treatment with alternating chemotherapy and TKIs of two cases of advanced NSCLC...

journal_title：BMC cancer

authors： Guo R,Chen X,Wang T,Zhang Z,Sun J,Shu Y

更新日期：2011-03-02 00:00:00

abstract：BACKGROUND:FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apoptotic cell death, an...

journal_title：BMC cancer

authors： Suter SE,Small GW,Seiser EL,Thomas R,Breen M,Richards KL

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA1/BRCA2 inactivation during cancer development will be helpful for more effective treatments. ME...

journal_title：BMC cancer

authors： Zhang J,Shi Y,Lalonde E,Li L,Cavallone L,Ferenczy A,Gotlieb WH,Foulkes WD,Majewski J

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associated with the real-world mortality risk. METHODS:This was a retrospective German claims data analys...

journal_title：BMC cancer

authors： Hardtstock F,Myers D,Li T,Cizova D,Maywald U,Wilke T,Griesinger F

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progression of hormone-naïve, organ-confined tumors. In localized prostate c...

journal_title：BMC cancer

authors： Hsiao JJ,Ng BH,Smits MM,Wang J,Jasavala RJ,Martinez HD,Lee J,Alston JJ,Misonou H,Trimmer JS,Wright ME

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...

journal_title：BMC cancer

authors： Lu R,Wu C,Guo L,Liu Y,Mo W,Wang H,Ding J,Wong ET,Yu M

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:The relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported that NSAID consumption protected against breast cancer, while most cohort studies did not find this ef...

journal_title：BMC cancer

authors： Dierssen-Sotos T,Gómez-Acebo I,de Pedro M,Pérez-Gómez B,Servitja S,Moreno V,Amiano P,Fernandez-Villa T,Barricarte A,Tardon A,Diaz-Santos M,Peiro-Perez R,Marcos-Gragera R,Lope V,Gracia-Lavedan E,Alonso MH,Michelena-Echeves

更新日期：2016-08-20 00:00:00

abstract：BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...

journal_title：BMC cancer

authors： Morita M,Tamiya M,Fujimoto D,Tamiya A,Suzuki H,Hirano K,Fukuda Y,Yokoyama T,Kominami R,Kanazu M,Uchida J,Hara S,Yamashita S,Tomioka H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer. METHODS:We sought to inves...

journal_title：BMC cancer

authors： James FR,Jiminez-Linan M,Alsop J,Mack M,Song H,Brenton JD,Pharoah PDP,Ali HR

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Rhabdoid tumors are rare cancers of early childhood arising in the kidney, central nervous system and other organs. The majority are caused by somatic inactivating mutations or deletions affecting the tumor suppressor locus SMARCB1 [OMIM 601607]. Germ-line SMARCB1 inactivation has been reported in associatio...

journal_title：BMC cancer

authors： Dagar V,Chow CW,Ashley DM,Algar EM

更新日期：2009-12-13 00:00:00

abstract：BACKGROUND:Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal carcinoma in situ (DCIS), because cases of undetected invasive foci and nodal metastases occasionally...

journal_title：BMC cancer

authors： Zavagno G,Carcoforo P,Marconato R,Franchini Z,Scalco G,Burelli P,Pietrarota P,Lise M,Mencarelli R,Capitanio G,Ballarin A,Pierobon ME,Marconato G,Nitti D

更新日期：2005-03-11 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) is the most malignant brain tumor. Many abnormal secretion and expression of cytokines have been found in GBM, initially speculated that the occurrence of GBM may be involved in these abnormal secretion of cytokines. This study aims to detect the association of cytokine genes with GBM. ME...

journal_title：BMC cancer

authors： Jin T,Li X,Zhang J,Wang H,Geng T,Li G,Gao G,Chen C

更新日期：2013-05-12 00:00:00

abstract：BACKGROUND:Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of recurrent glioblastoma, too. In both cases, adjuvant treatment, mostly using temozolomide, can improve...

journal_title：BMC cancer

authors： Straube C,Scherb H,Gempt J,Kirschke J,Zimmer C,Schmidt-Graf F,Meyer B,Combs SE

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...

journal_title：BMC cancer

authors： Qu N,Qin S,Zhang X,Bo X,Liu Z,Tan C,Wen G,Jiang H

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as first-line palliative combination chemotherapy. We also analyzed the predictive or prognostic value of...

journal_title：BMC cancer

authors： Keam B,Im SA,Han SW,Ham HS,Kim MA,Oh DY,Lee SH,Kim JH,Kim DW,Kim TY,Heo DS,Kim WH,Bang YJ

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet delivery, but self-guided interventions have shown limited efficacy. The aim of this study is to test t...

journal_title：BMC cancer

authors： Lyhne JD,Smith A'B,Frostholm L,Fink P,Jensen LH

更新日期：2020-03-16 00:00:00

abstract：BACKGROUND:Staging of B-cell non Hodgkin's lymphoma (NHL) routinely involves bone marrow (BM) examination by trephine biopsy (BM-TB). The evidence of disease in the BM-TB results in a clinical stage IV classification affecting therapeutic strategies for NHL patients. BM immunophenotyping by flow cytometry (FC) is also ...

journal_title：BMC cancer

authors： Mancuso P,Calleri A,Antoniotti P,Quarna J,Pruneri G,Bertolini F

更新日期：2010-11-24 00:00:00

abstract：BACKGROUND:Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining an individual's susceptibility to bladder cancer in particular when in combination with specific envi...

journal_title：BMC cancer

authors： McGrath M,Michaud D,De Vivo I

更新日期：2006-10-06 00:00:00

abstract：BACKGROUND:There are large ethnic differences in cervical cancer survival in New Zealand that are only partly explained by stage at diagnosis. We investigated the association of comorbidity with cervical cancer survival, and whether comorbidity accounted for the previously observed ethnic differences in survival. METH...

journal_title：BMC cancer

authors： Brewer N,Borman B,Sarfati D,Jeffreys M,Fleming ST,Cheng S,Pearce N

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). METHODS:Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a ...

journal_title：BMC cancer

authors： Gremel G,Djureinovic D,Niinivirta M,Laird A,Ljungqvist O,Johannesson H,Bergman J,Edqvist PH,Navani S,Khan N,Patil T,Sivertsson Å,Uhlén M,Harrison DJ,Ullenhag GJ,Stewart GD,Pontén F

更新日期：2017-01-04 00:00:00

abstract：BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...

journal_title：BMC cancer

authors： Wu S,Zhou Y,Hua HY,Zhang Y,Zhu WY,Wang ZQ,Li J,Gao HQ,Wu XH,Lu TX,Hua D

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...

journal_title：BMC cancer

authors： Yanes T,Meiser B,Young MA,Kaur R,Mitchell G,Barlow-Stewart K,Roscioli T,Halliday J,James P

更新日期：2017-07-18 00:00:00

abstract：:... ...

journal_title：BMC cancer

authors： Knoerl R,Weller E,Halpenny B,Berry D

更新日期：2019-05-13 00:00:00

abstract：BACKGROUND:Despite long-term or permanent health problems, cancer survivors are often motivated to return to work. For cancer survivors who have lost their job, return to work can be more challenging compared to employed survivors, as they generally find themselves in a more vulnerable social and financial position. Ca...

journal_title：BMC cancer

authors： van Egmond MP,Duijts SF,Vermeulen SJ,van der Beek AJ,Anema JR

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...

journal_title：BMC cancer

authors： Siva S,Callahan J,Kron T,Martin OA,MacManus MP,Ball DL,Hicks RJ,Hofman MS

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence suggests that the expression level of histamine receptor H4 (HRH4) is abnormal in colorectal cancer tissu...

journal_title：BMC cancer

authors： Fang Z,Yao W,Xiong Y,Li J,Liu L,Shi L,Zhang W,Zhang C,Nie L,Wan J

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:In Australia, associations between geographic remoteness, socioeconomic disadvantage, and colorectal cancer (CRC) survival show that survival rates are lowest among residents of geographically remote regions and those living in disadvantaged areas. At present we know very little about the reasons for these i...

journal_title：BMC cancer

authors： Baade PD,Turrell G,Aitken JF

更新日期：2010-01-28 00:00:00

abstract：BACKGROUND:Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation, inhibition of apoptosis, increased invasion and metastasis, and chemoresista...

journal_title：BMC cancer

authors： McEvoy LM,O'Toole SA,Spillane CD,Martin CM,Gallagher MF,Stordal B,Blackshields G,Sheils O,O'Leary JJ

更新日期：2015-07-25 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This stu...

journal_title：BMC cancer

authors： Zhu Q,Gong L,Wang J,Tu Q,Yao L,Zhang JR,Han XJ,Zhu SJ,Wang SM,Li YH,Zhang W

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K ...

journal_title：BMC cancer

authors： Krone B,Kölmel KF,Grange JM

更新日期：2014-08-16 00:00:00