Abstract:
BACKGROUND:There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer. METHODS:We sought to investigate the prognostic significance of TILs in a study of 953 invasive epithelial ovarian cancer tumour samples, both primary and metastatic, from 707 patients from the prospective population-based SEARCH study. TILs were analysed using a standardised method based on H&E staining producing a percentage score for stromal and intratumoral compartments. We used Cox regression to estimate hazard ratios of the association between TILs and survival. RESULTS:The extent of stromal and intra-tumoral TILs were correlated in the primary tumours (n = 679, Spearman's rank correlation = 0.60, P < 0.001) with a similar correlation in secondary tumours (n = 224, Spearman's rank correlation = 0.62, P < 0.001). There was a weak correlation between stromal TIL levels in primary and secondary tumour samples (Spearman's rank correlation = 0.29, P < 0.001) and intra-tumoral TIL levels in primary and secondary tumour samples (Spearman's rank correlation = 0.19, P = 0.0094). The extent of stromal TILs differed between histotypes (Pearson chi2 (12d.f.) 54.1, P < 0.0001) with higher levels of stromal infiltration in the high-grade serous and endometriod cases. A significant association was observed for higher intratumoral TIL levels and a favourable prognosis (HR 0.74 95% CI 0.55-1.00 p = 0.047). CONCLUSION:This study is the largest collection of epithelial ovarian tumour samples evaluated for TILs. We have shown that stromal and intratumoral TIL levels are correlated and that their levels correlate with clinical variables such as tumour histological subtype. We have also shown that increased levels of both intratumoral and stromal TILs are associated with a better prognosis; however, this is only statistically significant for intratumoral TILs. This study suggests that a clinically useful immune prognostic indicator in epithelial ovarian cancer could be developed using this technique.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
James FR,Jiminez-Linan M,Alsop J,Mack M,Song H,Brenton JD,Pharoah PDP,Ali HRdoi
10.1186/s12885-017-3585-xsubject
Has Abstractpub_date
2017-09-20 00:00:00pages
657issue
1issn
1471-2407pii
10.1186/s12885-017-3585-xjournal_volume
17pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The increasing number of individuals living with cancer has led to a focus on the quality of life of survivors, and their families. Sexual wellbeing is a central component of quality of life, with a growing body of research demonstrating the association between cancer and changes to sexuality and intimacy. H...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-270
更新日期:2013-05-31 00:00:00
abstract:BACKGROUND:While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients' quality of life. This study aimed to develop a treatment for inflammatory ulcers as one of the side effects of afat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06797-2
更新日期:2020-04-06 00:00:00
abstract:BACKGROUND:Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-857
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangiogenic polypeptide. Sustained enhanced expression of Vastatin was shown to inhibit tumour growth and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3125-8
更新日期:2017-02-13 00:00:00
abstract:BACKGROUND:For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3844-x
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:UroVysion fluorescence in situ hybridization (uFISH) was reported to have superior sensitivity to urine cytology. However uFISH studies are limited by varying definitions of what is considered a positive result, absence of histopathology and small sample size. The aim of our study was to better determine the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3227-3
更新日期:2017-04-07 00:00:00
abstract:BACKGROUND:Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions of miRNAs have been shown to affect miRNA expression. Therefore, we aimed to analyze the effect of m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5641-1
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:The treatment of the primary tumor in advanced metastatic colorectal cancer (CRC) is still a matter of discussion. Little attention has thus far been paid to the endoscopically observable changes of the primary in non-curatively resectable stage IV disease. METHODS:20 patients [14 men, 6 women, median age 6...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-218
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-55
更新日期:2008-02-20 00:00:00
abstract:CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-017-3767-6
更新日期:2018-01-11 00:00:00
abstract:INTRODUCTION:Metastasis represents a major adverse step in the progression of breast carcinoma. Lymph node invasion is the most relevant prognostic factor; however little is known on the molecular events associated with lymph node metastasis process. This study is to investigate the status and role of methylation in ly...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-378
更新日期:2010-07-20 00:00:00
abstract:BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5439-1
更新日期:2019-03-18 00:00:00
abstract:BACKGROUND:The incidence of thyroid cancer and the number of patients who die from this disease are increasing globally. Differentiated thyroid cancer (DTC) is the histologic subtype present in most patients and is primarily responsible for the increased overall incidence of thyroid cancer. Sorafenib is a multikinase i...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-11-349
更新日期:2011-08-11 00:00:00
abstract:BACKGROUND:cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and pro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-99
更新日期:2007-06-14 00:00:00
abstract::Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the text boxes and the different areas in the map: Navarra, neighbouring communities and other Spanish communiti...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-6458-7
更新日期:2019-12-17 00:00:00
abstract:BACKGROUND:In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival. METHODS:Analysis was car...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-487
更新日期:2012-10-22 00:00:00
abstract:BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5327-8
更新日期:2019-02-15 00:00:00
abstract::Chimeric antigen receptor T (CAR-T) cells are a promising new treatment for patients with relapsed or refractory hematologic malignancies, including lymphoma. Given the success of CAR-T cells directed against CD19, new targets are being developed and tested, since not all lymphomas express CD19. CD30 is promising targ...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-5415-9
更新日期:2019-03-06 00:00:00
abstract:BACKGROUND:Cervical cancer is the most common cancer and the leading cause of cancer death among women in Tanzania. Knowledge of and willingness to receive a cervical cancer screening are important determinants of prevention. This study aimed to describe women's awareness of cervical cancer and to explore the attitudes...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6528-x
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:Cytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has not been well investigated. The aim of the present study was to d...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1951-0
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. METHODS:This phase I study evaluated dose limiting toxicity (DLT...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-12-587
更新日期:2012-12-10 00:00:00
abstract:BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07534-5
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Despite the excellent results obtained with hormone therapy, the long treatment period and the side effects associated with its use make patient adherence difficult. Moreover, certain aspects of health care can mitigate or exacerbate non-adherence. This study aimed to identify the factors associated with adh...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-397
更新日期:2014-06-03 00:00:00
abstract:BACKGROUND:We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery. METHODS:567 patients who were performed curative intent between 1980 and 2003 were enrolled. 187 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-308
更新日期:2010-06-20 00:00:00
abstract:BACKGROUND:The phase 3 MPACT trial in patients with metastatic pancreatic cancer demonstrated superior efficacy of nab-paclitaxel (nab-P) + gemcitabine (Gem) vs Gem monotherapy for all endpoints examined including overall survival, the primary endpoint. In the MPACT trial, patients were treated until progressive diseas...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-016-2798-8
更新日期:2016-10-21 00:00:00
abstract:BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-85
更新日期:2008-03-31 00:00:00
abstract:BACKGROUND:Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION:We report the case of a 51 year old ma...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-5049-3
更新日期:2018-11-22 00:00:00
abstract:BACKGROUND:The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSCC and, although useful for predicting risk, manual assessment of histopathology is subjective and la...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1380-0
更新日期:2015-05-15 00:00:00
abstract:BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-168
更新日期:2012-05-06 00:00:00
abstract:BACKGROUND:Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging has been reported for evaluating irradiated parotid damage. However, the changes of IVIM p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2900-2
更新日期:2016-11-08 00:00:00