Abstract:
BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservation in cT1-2 N0 buccal SCC. METHODS:This was a prospective, non-randomized cohort study. Patients with surgically treated cT1-2 N0 buccal SCC were prospectively enrolled and divided into two groups based on the management of the SMG. Level 1b lymph nodes were categorized into six groups based on the positional relationship between the lymph node and the SMG. The main study endpoints were locoregional control (LRC) and disease-specific survival (DSS). RESULTS:A total of 31 of the 137 included patients underwent SMG-sparing neck dissection. Patients with SMG preservation were likely to be young persons. Superior metastasis occurred in 11 patients with a prevalence of 8.0%, followed by an anterior metastasis rate of 5.1%, and no metastases developed deeply or within the SMG. The 5-year LRC rates in the SMG-sparing and SMG-excision groups were 74 and 75%, respectively, and the difference was not significant (p = 0.970). The 5-year DSS rates in the SMG-sparing and SMG-excision groups were 74 and 69%, respectively, and the difference was not significant (p = 0.709). CONCLUSIONS:SMG involvement was rare, and the superior group carried the highest risk for lymph node metastasis. SMG-sparing neck dissection is selectively suggested in cT1-2 N0 buccal SCC patients, and could avoid postoperative asymmetric appearance and dry mouth.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Gu B,Fang Q,Wu Y,Du W,Zhang X,Chen Ddoi
10.1186/s12885-020-07534-5subject
Has Abstractpub_date
2020-10-27 00:00:00pages
1034issue
1issn
1471-2407pii
10.1186/s12885-020-07534-5journal_volume
20pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia prom...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-108
更新日期:2013-03-09 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the feasibility and potential benefit of a brief psychosocial intervention based on cognitive-behavioral therapy performed in addition to early palliative care (PC) in the reduction of depressive symptoms among patients with advanced cancer. METHODS:An open-label randomiz...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-017-3560-6
更新日期:2017-08-23 00:00:00
abstract:BACKGROUND:Amplification of the 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify the endoplasmic reticulum (ER) lipid raft-associated 2 (ERLIN2) gene as one of the candidate oncogenes within the 8p11-12 ampl...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-225
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-14-67
更新日期:2014-02-05 00:00:00
abstract:BACKGROUND:Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS:All patients diagnosed with CRC be...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-339
更新日期:2009-09-24 00:00:00
abstract:BACKGROUND:To the best of our knowledge, no study has reported mediastinal shift accompanied with obstructive atelectasis due to bulky primary esophageal tumor components treated with adaptive radiotherapy and concurrent chemotherapy. CASE PRESENTATION:Here we report the case of a 65-year-old male patient diagnosed wi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6505-4
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:First-line treatment with FOLFOXIRI plus bevacizumab (BEV) is highly effective and regarded as one of the standards-of-care for patients with metastatic colorectal cancer (mCRC), despite the high incidence of neutropenia and diarrhea as side effects. AXEPT, an Asian phase III study, showed that modified CAPI...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07186-5
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). METHODS:Between 2002 and 2007, a population-based case-contro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-344
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorectal cancer (CRC) patients receiving cetuximab-based therapy. METHODS:Fifty-eight advanced CRC pat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-496
更新日期:2011-11-25 00:00:00
abstract:BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4630-0
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:The bone scan index (BSI) using a computer-aided diagnosis system for bone scans is expected to be an objective and quantitative clinical tool for evaluating bone metastatic prostate cancer. This study aimed to evaluate the pretreatment BSI as a prognostic factor in hormone-naive prostate cancer patients wit...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2176-6
更新日期:2016-02-19 00:00:00
abstract:BACKGROUND:Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent could be a promising approach to circumvent the limitations of previously attempted therapeutic inte...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-75
更新日期:2014-02-08 00:00:00
abstract:BACKGROUND:Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2701-7
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of breast cancer, without tumor-specific treatment options and accounts for 15% of all types of breast ca...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-120
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-178
更新日期:2009-06-09 00:00:00
abstract:BACKGROUND:The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations. METHODS:Subjects with biopsy confirmed untreated lung cancer, and others at risk for developing lung cancer, provided a urine sample. A colorimetric sens...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1996-0
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor tr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-3-21
更新日期:2003-07-28 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07235-z
更新日期:2020-08-20 00:00:00
abstract::Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-020-6552-x
更新日期:2020-01-23 00:00:00
abstract:BACKGROUND:Breast cancer survivors have an elevated risk of cognitive impairment compared to age-matched women without cancer. Causes of this impairment are complex, including both treatment and psychological factors. Mindfulness-based interventions, which have been shown to improve cognitive function in the general po...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5065-3
更新日期:2018-11-26 00:00:00
abstract:BACKGROUND:The incidence of Cholangiocellular Carcinoma (CCA) is increasing in the western world. The tumour has a high proportion of desmoplastic stroma and is correlated with a worse prognosis when cancer associated myofibroblasts (CAFs) are present. Recent studies showed promising results after liver transplantation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2360-8
更新日期:2016-05-20 00:00:00
abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3762-y
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Mammographic breast density and parenchymal patterns are well-established risk factors for breast cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic density and parenchymal pattern, and secondarily to examine what potential impact reproducibility ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1256-3
更新日期:2015-04-12 00:00:00
abstract:BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-10
更新日期:2002-05-03 00:00:00
abstract:BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-311
更新日期:2010-06-21 00:00:00
abstract:BACKGROUND:Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor microenvironment. Such models are urgently needed. Mutations of the tumor p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07212-6
更新日期:2020-08-08 00:00:00
abstract:BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-432
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as effective antineoplastic drugs for several malignant tumors. We hypothesized that Selumetinib might be ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2773-4
更新日期:2016-10-21 00:00:00
abstract:BACKGROUND:Brain metastases (BM) represent one of the most frequent complications related to cancer, and their treatment continues to evolve. We have evaluated the activity, toxicity and the impact on Quality of Life (QoL) of a concomitant treatment with whole brain radiotherapy (WBRT) and Temozolomide (TMZ) in patient...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-18
更新日期:2007-01-25 00:00:00
abstract:BACKGROUND:Utilisation of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) for diagnosis and staging of lung cancer is gaining popularity, however, its impact on clinical practice is unclear. This study aimed to determine the impact of the introduction of endobronc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2081-z
更新日期:2016-01-28 00:00:00