Abstract:
BACKGROUND:Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as effective antineoplastic drugs for several malignant tumors. We hypothesized that Selumetinib might be potential drug for TNBC and explore the mechanism. METHODS:After treated with Selumetinib, the viability and mobility of HCC1937 and MDA-MB-231 were detected by MTT, tunnel, wound-healing assay, transwell assay and FCM methods. MiR array was used to analysis the change of miRs. We predicted and verified CUL1 is the target of miR-302a using Luciferase reporter assay. We also silenced the CUL1 by siRNA, to clarify whether CUL1 take part in the cell proliferation, migration and regulated its substrate TIMP1 and TRAF2. Moreover, after transfection, the antagomir of miR-302a and CUL1 over-expressed plasmid into HCC1937 and MDA-MB-231 cell accompanied with the Selumetinib treatment, we detected the proliferation and migration again. RESULTS:Selumetinib reduce the proliferation, migration, triggered apoptosis and G1 arrest in TNBC cell lines. In this process, the miR-302a was up-regulated and inhibited the CUL1 expression. The later negatively regulated the TIMP1 and TRAF2. As soon as we knockdown miR-302a and over-expression CUL1 in TNBC cells, the cytotoxicity of Selumetinib was reversed. CONCLUSIONS:MiR-302a targeted regulated the CUL1 expression and mediated the Selumetinib-induced cytotoxicity of triple-negative breast cancer.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Zhou Y,Lin S,Tseng KF,Han K,Wang Y,Gan ZH,Min DL,Hu HYdoi
10.1186/s12885-016-2773-4subject
Has Abstractpub_date
2016-10-21 00:00:00pages
818issue
1issn
1471-2407pii
10.1186/s12885-016-2773-4journal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:To assess the diagnostic value of retrospective PET-MRI fusion and to compare the results with side-by-side analysis and single modality use of PET and of MRI alone for locoregional tumour and nodal staging of head-and-neck cancer. METHODS:Thirty-three patients with head-and-neck cancer underwent preoperati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-846
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6175-2
更新日期:2019-10-31 00:00:00
abstract:BACKGROUND:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). METHODS:Between 2002 and 2007, a population-based case-contro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-344
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated oligometastasized PC patients receiving stereotactic body radiotherapy (SBRT) to bone metastases. METHODS:In this retrospective study, 15 oligometastasized...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3341-2
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and JAK2 are critical for inflamm...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-018-5045-7
更新日期:2018-11-19 00:00:00
abstract:BACKGROUND:Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to canc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6673-2
更新日期:2020-03-14 00:00:00
abstract:BACKGROUND:Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinoma and poorly differentiated, less treatable non-adenocarcinoma including small cell carcinoma, and t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5680-7
更新日期:2019-05-30 00:00:00
abstract:BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-016-2844-6
更新日期:2016-10-14 00:00:00
abstract:BACKGROUND:The main objective of this study was to evaluate the safety of second-line pemetrexed in Stage IIIB or IV NSCLC. METHODS:Overall, 95 patients received pemetrexed 500 mg/m2 i.v. over Day 1 of a 21-day cycle. Patients also received oral dexamethasone, oral folic acid and i.m. vitamin B12 supplementation to re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-216
更新日期:2008-07-31 00:00:00
abstract:BACKGROUND:Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regime...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-182
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Platelets are frequently altered in hepatocellular carcinoma (HCC) patients. Platelet lysates (hPL) can enhance HCC cell growth and decrease apoptosis. The aims were to evaluate whether hPL can modulate the actions of sorafenib or regorafenib, two clinical HCC multikinase antagonists. METHODS:Several human ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-351
更新日期:2014-05-21 00:00:00
abstract:BACKGROUND:Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA (protein) Napsin A was described to promote resistance to cisplatin by degradation of the tumor sup...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-524
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-214
更新日期:2007-11-19 00:00:00
abstract:BACKGROUND:Thymosin β10 (Tβ10) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of Tβ10 in liver fluke-associated cholangiocarcinoma (CCA) are not fully understood. In this study, we investigated the expression of Tβ10 in CCA tumor tissues and cell lines as well as mo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-430
更新日期:2013-09-23 00:00:00
abstract::Following publication of the original article [1], the authors notified us of a misleading data presentation in Table 4. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-5029-7
更新日期:2018-11-30 00:00:00
abstract:BACKGROUND:The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations. METHODS:Subjects with biopsy confirmed untreated lung cancer, and others at risk for developing lung cancer, provided a urine sample. A colorimetric sens...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1996-0
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3709-3
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-464
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) in patients with resectable thoracic esophageal squamo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2696-0
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:We sought to determine the comparative diagnostic performance of standard b-value (800-1000 s/mm2) versus low b-value (400-500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC). METHOD:After a systematic review of the available literature, studies w...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-843
更新日期:2014-11-18 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-92
更新日期:2009-03-25 00:00:00
abstract:BACKGROUND:Tobacco smoke exposure may be associated with increased breast cancer risk, although the evidence supporting the association is inconclusive. We conducted a case-control study in Delaware, incorporating detailed exposure assessment for active and secondhand smoke at home and in the workplace. METHODS:Primar...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-157
更新日期:2008-06-02 00:00:00
abstract:BACKGROUND:Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of n...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-016-2564-y
更新日期:2016-07-19 00:00:00
abstract:BACKGROUND:Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G), as well as the matched ascites for one case (OV-1946). METHODS:In addition to growth parameters,...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-152
更新日期:2008-05-28 00:00:00
abstract:BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-432
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Resistance to 5-fluorouracil (5-FU) in patients with colorectal cancer prevents effective treatment and leads to unnecessary and burdensome chemotherapy. Therefore, prediction of 5-FU resistance is imperative. METHODS:To identify the proteins linked to 5-FU resistance, two-dimensional gel electrophoresis-ba...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-160
更新日期:2014-03-06 00:00:00
abstract:BACKGROUND:HOXA family genes were crucial transcription factors involving cell proliferation and apoptosis. While few studies have focused on HOXA10 in AML. We aimed to investigate the prognostic significance of HOXA10. METHODS:We downloaded datasets from GEO and BeatAML database, to compare HOXA expression level betw...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07088-6
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. METHODS:The clinicopatholo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07495-9
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-019-5799-6
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction and increased physical activity may suppress hormonal, energy-sensing, and inflammatory factor...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-016-2075-x
更新日期:2016-02-05 00:00:00