Characterization of three new serous epithelial ovarian cancer cell lines.

abstract：BACKGROUND:We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival (OS) in an expanded access cohort of trastuzumab-treated HER2-positive patients with metastatic brea...

journal_title：BMC cancer

authors： Toi M,Sperinde J,Huang W,Saji S,Winslow J,Jin X,Tan Y,Ohno S,Nakamura S,Iwata H,Masuda N,Aogi K,Morita S,Petropoulos C,Bates M

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

journal_title：BMC cancer

authors： Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear. METHODS:We investigated the biological and clinical significance of the presence of KIT exon 10 variant (c.1621 A > C), KIT (L541), in a transfected cell lin...

journal_title：BMC cancer

authors： Brahmi M,Alberti L,Dufresne A,Ray-Coquard I,Cassier P,Meeus P,Decouvelaere AV,Ranchère-Vince D,Blay JY

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...

journal_title：BMC cancer

authors： Nielsen K,Binderup T,Langer SW,Kjaer A,Knigge P,Grøndahl V,Melchior L,Federspiel B,Knigge U

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the degradation of ECM macromolecules. The MMPs and their nat...

journal_title：BMC cancer

authors： Balducci C,Lilli C,Stabellini G,Marinucci L,Giustozzi G,Becchetti A,Cagini L,Locci P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Cancer survivors and their caregivers may have various unmet needs that are medically difficult to solve. Previous studies have suggested the relations between individuals' backgrounds and their unmet needs. We conducted a large-scale analysis to clarify the influence of individuals' backgrounds, primarily c...

journal_title：BMC cancer

authors： Watanabe K,Katayama K,Yoshioka T,Narimatsu H

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC. METHODS:We employed 2 human ESCC cell lines, Eca109 and TE-1, as the model system. The effect of miR-203 and ΔNp63 on cell proliferati...

journal_title：BMC cancer

authors： Yuan Y,Zeng ZY,Liu XH,Gong DJ,Tao J,Cheng HZ,Huang SD

更新日期：2011-02-07 00:00:00

abstract：BACKGROUND:Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs of the two drugs among patients with mRCC/advanced RCC (aRCC). MATERIALS AND METHODS:PubMed, Scien...

journal_title：BMC cancer

authors： Deng H,Huang Y,Hong Z,Yuan X,Cao Z,Wei Y,Zhang W

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:The development and evaluation of new therapeutic approaches for malignant mesothelioma has been sparse due, in part, to lack of suitable tumor models. METHODS:We established primary mesothelioma cultures from pleural and ascitic fluids of five patients with advanced mesothelioma. Electron microscopy and im...

journal_title：BMC cancer

authors： Kalra N,Zhang J,Thomas A,Xi L,Cheung M,Talarchek J,Burkett S,Tsokos MG,Chen Y,Raffeld M,Miettinen M,Pastan I,Testa JR,Hassan R

更新日期：2015-05-08 00:00:00

abstract：BACKGROUND:Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to investigate the association between metformin use and risk and prognosis of patients with EC. METHODS:...

journal_title：BMC cancer

authors： Chu D,Wu J,Wang K,Zhao M,Wang C,Li L,Guo R

更新日期：2018-04-18 00:00:00

abstract：BACKGROUND:Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regime...

journal_title：BMC cancer

authors： Jensen AD,Krauss J,Potthoff K,Desta A,Habl G,Mavtratzas A,Windemuth-Kiesselbach C,Debus J,Münter MW

更新日期：2011-05-19 00:00:00

abstract：BACKGROUND:Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to identify the magnitude of delayed diagnosis and its associated factors in women with breast cancer in...

journal_title：BMC cancer

authors： Norsa'adah B,Rampal KG,Rahmah MA,Naing NN,Biswal BM

更新日期：2011-04-17 00:00:00

abstract：BACKGROUND:Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. However, the mechanisms underlying its cell-death-inducing activity a...

journal_title：BMC cancer

authors： Han B,Wang TD,Shen SM,Yu Y,Mao C,Yao ZJ,Wang LS

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, particularly in Asian melanoma. METHODS:We retrospectively reviewed 49 melanoma patients undergoing...

journal_title：BMC cancer

authors： Wu CE,Yang CK,Peng MT,Huang PW,Chang CF,Yeh KY,Chen CB,Wang CL,Hsu CW,Chen IW,Lin CT,Ueng SH,Lin G,Lin YF,Cheng CY,Chang JW

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Modeling the relationship between age and mortality for breast cancer patients may have important prognostic and therapeutic implications. METHODS:Data from 9 registries of the Surveillance, Epidemiology, and End Results Program (SEER) of the United States were used. This study employed proportional hazards...

journal_title：BMC cancer

authors： Tai P,Cserni G,Van De Steene J,Vlastos G,Voordeckers M,Royce M,Lee SJ,Vinh-Hung V,Storme G

更新日期：2005-10-08 00:00:00

abstract：BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...

journal_title：BMC cancer

authors： Yasuta S,Kobayashi T,Aizawa H,Takahashi S,Ikeda M,Konishi M,Kojima M,Kuno H,Uesaka K,Morinaga S,Miyamoto A,Toyama H,Takakura N,Sugimachi K,Takayama W

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor in human. Research has shown that HPV status HNSCC is a unique prognosis factor, which may due to its immune infiltration landscape. But the underlying mechanism is unclear. METHODS:In this study, we used a combination of several b...

journal_title：BMC cancer

authors： Zeng H,Song X,Ji J,Chen L,Liao Q,Ma X

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Abnormal glucose and lipids levels may impact survival after breast cancer (BC) diagnosis, but their association to other causes of mortality such as cardiovascular (CV) disease may result in a competing risk problem. METHODS:We assessed serum glucose, triglycerides (TG) and total cholesterol (TC) measured ...

journal_title：BMC cancer

authors： Wulaningsih W,Vahdaninia M,Rowley M,Holmberg L,Garmo H,Malmstrom H,Lambe M,Hammar N,Walldius G,Jungner I,Coolen AC,Van Hemelrijck M

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Diabetes is related with increased cancer mortality across multiple cancer types. Its role in lung cancer mortality is still unclear. We aim to determine the prognostic value of fasting plasma glucose (FPG) and diabetes mellitus in patients with locally advanced non-small cell lung cancer (NSCLC) treated wit...

journal_title：BMC cancer

authors： Bergamino M,Rullan AJ,Saigí M,Peiró I,Montanya E,Palmero R,Ruffinelli JC,Navarro A,Arnaiz MD,Brao I,Aso S,Padrones S,Cardenal F,Nadal E

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the an...

journal_title：BMC cancer

authors： Yue T,Zheng X,Dou Y,Zheng X,Sun R,Tian Z,Wei H

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Europe. The oncological hospital in Arkhangelsk, in co-operation with Universitetet i Tromsø (Norway),...

journal_title：BMC cancer

authors： Vaktskjold A,Lebedintseva JA,Korotov DS,Tkatsjov AV,Podjakova TS,Lund E

更新日期：2005-07-19 00:00:00

abstract：BACKGROUND:An understanding of growth dynamics of tumors is important in understanding progression of cancer and designing appropriate treatment strategies. We perform a comparative study of the hyperbolastic growth models with the Weibull and Gompertz models, which are prevalently used in the field of tumor growth. M...

journal_title：BMC cancer

authors： Eby WM,Tabatabai MA,Bursac Z

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1...

journal_title：BMC cancer

authors： Michael IP,Orebrand M,Lima M,Pereira B,Volpert O,Quaggin SE,Jeansson M

更新日期：2017-08-11 00:00:00

abstract：BACKGROUND:The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether th...

journal_title：BMC cancer

authors： Liu C,Lu P,Lu Y,Xu H,Wang S,Chen J

更新日期：2007-10-24 00:00:00

abstract：BACKGROUND:There is no consensus regarding resection of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastatic colorectal cancer (CRC). A potential benefit of resection of the primary tumour is to prevent complications of the primary tumour in later stages of the disease. We...

journal_title：BMC cancer

authors： 't Lam-Boer J,Mol L,Verhoef C,de Haan AF,Yilmaz M,Punt CJ,de Wilt JH,Koopman M

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publicatio...

journal_title：BMC cancer

authors： Wang L,Yu X,Li J,Zhang Z,Hou J,Li F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...

journal_title：BMC cancer

authors： Isakova J,Talaibekova E,Aldasheva N,Vinnikov D,Aldashev A

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is a plausible candidate. CHEK2 encodes a checkpoint...

journal_title：BMC cancer

authors： Rashid MU,Muhammad N,Faisal S,Amin A,Hamann U

更新日期：2013-06-27 00:00:00