Androgen deprivation modulates the inflammatory response induced by irradiation.

abstract：BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with ...

journal_title：BMC cancer

authors： Kawahara T,Yokomizo Y,Ito Y,Ito H,Ishiguro H,Teranishi J,Makiyama K,Miyoshi Y,Miyamoto H,Yao M,Uemura H

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a p...

journal_title：BMC cancer

authors： Hofmann JN,Liao LM,Strickland PT,Shu XO,Yang G,Ji BT,Li HL,Rothman N,Kamangar F,Gao YT,Zheng W,Chow WH

更新日期：2013-06-11 00:00:00

abstract：BACKGROUND:The increasing number of individuals living with cancer has led to a focus on the quality of life of survivors, and their families. Sexual wellbeing is a central component of quality of life, with a growing body of research demonstrating the association between cancer and changes to sexuality and intimacy. H...

journal_title：BMC cancer

authors： Perz J,Ussher JM,Gilbert E

更新日期：2013-05-31 00:00:00

abstract：BACKGROUND:Diabetes is related with increased cancer mortality across multiple cancer types. Its role in lung cancer mortality is still unclear. We aim to determine the prognostic value of fasting plasma glucose (FPG) and diabetes mellitus in patients with locally advanced non-small cell lung cancer (NSCLC) treated wit...

journal_title：BMC cancer

authors： Bergamino M,Rullan AJ,Saigí M,Peiró I,Montanya E,Palmero R,Ruffinelli JC,Navarro A,Arnaiz MD,Brao I,Aso S,Padrones S,Cardenal F,Nadal E

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...

journal_title：BMC cancer

authors： Saka B,Akakpo SA,Teclessou JN,Gnossike P,Adam S,Mahamadou G,Kassang P,Elegbede Y,Mouhari-Toure A,Darre T,Kombate K,Pitché P

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus. In our previous studies, we have shown that TTC9A was a hormonally-regulated gene in breast cancer cells. In this study, we found that TTC9A was over-ex...

journal_title：BMC cancer

authors： Cao S,Ho GH,Lin VC

更新日期：2008-08-12 00:00:00

abstract：BACKGROUND:The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expressi...

journal_title：BMC cancer

authors： Huang Y,Dong W,Li J,Zhang H,Shan Z,Teng W

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：BACKGROUND:Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS:LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy...

journal_title：BMC cancer

authors： Takei K,Ikeda S,Arai T,Tanaka N,Muramatsu M,Sawabe M

更新日期：2008-08-13 00:00:00

abstract：PURPOSE:Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practitioners is not well known. METHODS:Two nationwide observational telephone surveys were conducted in early ...

journal_title：BMC cancer

authors： Eisinger F,Cals L,Calazel-Benque A,Blay JY,Coscas Y,Dolbeault S,Namer M,Pivot X,Rixe O,Serin D,Roussel C,Morère JF,EDIFICE committee.

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...

journal_title：BMC cancer

authors： Tanimoto K,Sekiguchi N,Yokota Y,Kaneko A,Watanabe T,Maeshima AM,Matsuno Y,Harada M,Tobinai K,Kobayashi Y

更新日期：2006-10-20 00:00:00

abstract：BACKGROUND:Increased level of serum S100B can serve as a marker of metastatic spread in patients with cutaneous melanoma (CM). In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and planning treatment.The aims of this study were to det...

journal_title：BMC cancer

authors： Peric B,Zagar I,Novakovic S,Zgajnar J,Hocevar M

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS:At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-i...

journal_title：BMC cancer

authors： Liu Z,Qi L,Li Y,Zhao X,Sun B

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...

journal_title：BMC cancer

authors： Lapin M,Tjensvoll K,Oltedal S,Javle M,Smaaland R,Gilje B,Nordgård O

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:The incidence of thyroid cancer and the number of patients who die from this disease are increasing globally. Differentiated thyroid cancer (DTC) is the histologic subtype present in most patients and is primarily responsible for the increased overall incidence of thyroid cancer. Sorafenib is a multikinase i...

journal_title：BMC cancer

authors： Brose MS,Nutting CM,Sherman SI,Shong YK,Smit JW,Reike G,Chung J,Kalmus J,Kappeler C,Schlumberger M

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma. METHODS:Of the entire cohort (N = 216), 108 patients were assigned to a test group and 108 patients to a validation group. In the test group, nine pre-trea...

journal_title：BMC cancer

authors： Douglas S,Schild SE,Rades D

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging has been reported for evaluating irradiated parotid damage. However, the changes of IVIM p...

journal_title：BMC cancer

authors： Zhou N,Chu C,Dou X,Li M,Liu S,Zhu L,Liu B,Guo T,Chen W,He J,Yan J,Zhou Z,Yang X,Liu T

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:Kv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multiforme (GBM) are lacking. METHODS:We analyzed the expression of Kv10.1 by immunohistochemistry in the...

journal_title：BMC cancer

authors： Martínez R,Stühmer W,Martin S,Schell J,Reichmann A,Rohde V,Pardo L

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005. METHODS:Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS wa...

journal_title：BMC cancer

authors： Hamidou Z,Causeret S,Dabakuyo TS,Gentil J,Arnould L,Roignot P,Altwegg T,Poillot ML,Bonnetain F,Arveux P

更新日期：2010-11-10 00:00:00

abstract：BACKGROUND:Overweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain over the lifetime in postmenopausal breast cancer is not well documented. METHODS:We conducted a pop...

journal_title：BMC cancer

authors： Cordina-Duverger E,Truong T,Anger A,Sanchez M,Arveux P,Kerbrat P,Guénel P

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in human pancreatic carcinomas. METHODS:In this study, we established a MBD1-knock-down pancreatic cancer ...

journal_title：BMC cancer

authors： Liu C,Chen Y,Yu X,Jin C,Xu J,Long J,Ni Q,Fu D,Jin H,Bai C

更新日期：2008-04-29 00:00:00

abstract：BACKGROUND:The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to date. Broadly speaking, the CTAs can be divided into two groups: the CTX antigens that are encoded ...

journal_title：BMC cancer

authors： Kim R,Kulkarni P,Hannenhalli S

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...

journal_title：BMC cancer

authors： Zhang D,Chen X,Xia H,Wang L,Zhao H,Xu B,Zhang A,Zhang W

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism o...

journal_title：BMC cancer

authors： Kong X,Xu P,Cai WJ,Wang HG,Li BB,Huang GL,He ZW,Chen G,Ye CG

更新日期：2018-04-13 00:00:00

abstract：BACKGROUND:The high complication rates of surgically implanted port catheter systems (SIPCS) represents a major drawback in the treatment of isolated liver neoplasms by hepatic arterial infusion (HAI) of chemotherapy. Interventionally implanted port catheter systems (IIPCS) have evolved into a promising alternative tha...

journal_title：BMC cancer

authors： Hildebrandt B,Pech M,Nicolaou A,Langrehr JM,Kurcz J,Bartels B,Miersch A,Felix R,Neuhaus P,Riess H,Dörken B,Ricke J

更新日期：2007-04-24 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies. This study aimed to identify the key prognosis impacting genes and relevant subtypes for LUAD. ME...

journal_title：BMC cancer

authors： Lv Z,Lei T

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...

journal_title：BMC cancer

authors： Xu H,Xu Y,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a downstram molecule of the pathway, in predicting chemotherapy response in breast cancer. METHODS:The...

journal_title：BMC cancer

authors： Moon HG,Yi JK,Kim HS,Lee HY,Lee KM,Yi M,Ahn S,Shin HC,Ju JH,Shin I,Han W,Noh DY

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:In Brazil, the rate of cervical cancer remains high despite the availability of screening programs. With ongoing vaccine development and implementation, information on the prevalence of specific HPV types is needed, particularly among high-risk populations, such as HIV-infected women. METHODS:We performed a...

journal_title：BMC cancer

authors： Castilho JL,Levi JE,Luz PM,Cambou MC,Vanni T,de Andrade A,Derrico M,Veloso VG,Grinsztejn B,Friedman RK

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:We sought to determine the comparative diagnostic performance of standard b-value (800-1000 s/mm2) versus low b-value (400-500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC). METHOD:After a systematic review of the available literature, studies w...

journal_title：BMC cancer

authors： Tang Y,Zhou Y,Du W,Liu N,Zhang C,Ouyang T,Hu J

更新日期：2014-11-18 00:00:00