Prognostic significance of stem cell/ epithelial-mesenchymal transition markers in periampullary/pancreatic cancers: FGFR1 is a promising prognostic marker.

abstract：BACKGROUND:In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas and from areas of disadvantage. We have a limited understanding of how individual and area-level facto...

journal_title：BMC cancer

authors： Youl PH,Baade PD,Aitken JF,Chambers SK,Turrell G,Pyke C,Dunn J

更新日期：2011-09-28 00:00:00

abstract：BACKGROUND:There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). METHODS:Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a ...

journal_title：BMC cancer

authors： Gremel G,Djureinovic D,Niinivirta M,Laird A,Ljungqvist O,Johannesson H,Bergman J,Edqvist PH,Navani S,Khan N,Patil T,Sivertsson Å,Uhlén M,Harrison DJ,Ullenhag GJ,Stewart GD,Pontén F

更新日期：2017-01-04 00:00:00

abstract：BACKGROUND:BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signaling pathways. Evidence that BAG-1 expression is frequently altered in human cancers, in particular in...

journal_title：BMC cancer

authors： Götz R,Kramer BW,Camarero G,Rapp UR

更新日期：2004-11-24 00:00:00

abstract：BACKGROUND:Neuroendocrine tumors (NETs) of the esophagus are extremely rare, and few cases have been reported worldwide. Thus, a comprehensive nationwide study is needed to understand the characteristics of and treatment strategy for esophageal NETs. METHODS:We collected data on esophageal NET patients from 25 hospita...

journal_title：BMC cancer

authors： Lee CG,Lim YJ,Park SJ,Jang BI,Choi SR,Kim JK,Kim YT,Cho JY,Yang CH,Chun HJ,Song SY,Neuroendocrine tumor study group.

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor that contributes to tumour aggressiveness and correlates with poor prognosis and resistance to conventional therapy. Therefore, identifying hypoxic environments within tumours is extremely useful for understanding cancer biology and developing novel therapeutic strategies. Seve...

journal_title：BMC cancer

authors： Takei N,Yoneda A,Kosaka M,Sakai-Sawada K,Tamura Y

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evalua...

journal_title：BMC cancer

authors： Palma DA,Olson R,Harrow S,Correa RJM,Schneiders F,Haasbeek CJA,Rodrigues GB,Lock M,Yaremko BP,Bauman GS,Ahmad B,Schellenberg D,Liu M,Gaede S,Laba J,Mulroy L,Senthi S,Louie AV,Swaminath A,Chalmers A,Warner A,Slot

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in distinct cancer entities can be determined by a comprehensive expression analysis of the 13 human AQPs....

journal_title：BMC cancer

authors： Warth A,Muley T,Meister M,Herpel E,Pathil A,Hoffmann H,Schnabel PA,Bender C,Buness A,Schirmacher P,Kuner R

更新日期：2011-05-06 00:00:00

abstract：BACKGROUND:Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several signaling pathways, including NF-κB, are altered in TNBC, and the complexity of this disease implies ...

journal_title：BMC cancer

authors： House CD,Grajales V,Ozaki M,Jordan E,Wubneh H,Kimble DC,James JM,Kim MK,Annunziata CM

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvir...

journal_title：BMC cancer

authors： Simon PS,Sharman SK,Lu C,Yang D,Paschall AV,Tulachan SS,Liu K

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Despite the excellent results obtained with hormone therapy, the long treatment period and the side effects associated with its use make patient adherence difficult. Moreover, certain aspects of health care can mitigate or exacerbate non-adherence. This study aimed to identify the factors associated with adh...

journal_title：BMC cancer

authors： Brito C,Portela MC,de Vasconcellos MT

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:Durvalumab is a standard drug used during maintenance therapy after chemoradiotherapy in patients with locally advanced non-small cell lung cancer (LA-NSCLC). However, little is known about the clinical benefits of durvalumab after chemoradiotherapy in patients with LA-NSCLC with a performance status (PS) of...

journal_title：BMC cancer

authors： Kaira K,Mouri A,Kato S,Yoshimura K,Kagamu H,Kobayashi K

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derived growth factor-receptors, inhibiting development of new blood vessels. There are currently no predi...

journal_title：BMC cancer

authors： Niinivirta M,Georganaki M,Enblad G,Lindskog C,Dimberg A,Ullenhag GJ

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...

journal_title：BMC cancer

authors： Fiteni F,Ray IL,Ousmen A,Isambert N,Anota A,Bonnetain F

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen rec...

journal_title：BMC cancer

authors： Zekas E,Prossnitz ER

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer susceptibility.The aim of this study was to evaluate if polymorphisms in genes codifying for the di...

journal_title：BMC cancer

authors： Rodrigues P,de Marco G,Furriol J,Mansego ML,Pineda-Alonso M,Gonzalez-Neira A,Martin-Escudero JC,Benitez J,Lluch A,Chaves FJ,Eroles P

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and novel therap...

journal_title：BMC cancer

authors： Choi J,Topouza DG,Tarnouskaya A,Nesdoly S,Koti M,Duan QL

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:To compare the survival outcomes and acute toxicities of concurrent chemoradiotherapy (CCRT), induction chemotherapy (IC) plus radiotherapy (RT), and IC plus CCRT in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated using intensity-modulated radiotherapy (IMRT). METHODS:Patients w...

journal_title：BMC cancer

authors： Li WF,Li YQ,Chen L,Zhang Y,Guo R,Zhang F,Peng H,Sun Y,Ma J

更新日期：2015-10-27 00:00:00

abstract：BACKGROUND:Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as tho...

journal_title：BMC cancer

authors： Kothandaraman N,Bajic VB,Brendan PN,Huak CY,Keow PB,Razvi K,Salto-Tellez M,Choolani M

更新日期：2010-02-24 00:00:00

abstract：BACKGROUND:Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to deve...

journal_title：BMC cancer

authors： Luo J,Liu P,Wang L,Huang Y,Wang Y,Geng W,Chen D,Bai Y,Yang Z

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer...

journal_title：BMC cancer

authors： Wang R,Chen S,Li C,Ng KT,Kong CW,Cheng J,Cheng SH,Li RA,Lo CM,Man K,Sun D

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of n...

journal_title：BMC cancer

authors： Hoeppner J,Lordick F,Brunner T,Glatz T,Bronsert P,Röthling N,Schmoor C,Lorenz D,Ell C,Hopt UT,Siewert JR

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma. METHODS:Of the entire cohort (N = 216), 108 patients were assigned to a test group and 108 patients to a validation group. In the test group, nine pre-trea...

journal_title：BMC cancer

authors： Douglas S,Schild SE,Rades D

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...

journal_title：BMC cancer

authors： Isakova J,Talaibekova E,Aldasheva N,Vinnikov D,Aldashev A

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...

journal_title：BMC cancer

authors： Yanes T,Meiser B,Young MA,Kaur R,Mitchell G,Barlow-Stewart K,Roscioli T,Halliday J,James P

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:The effect of current therapies in improving the survival of lung cancer patients remains far from satisfactory. It is consequently desirable to find more appropriate therapeutic opportunities based on informed insights. A molecular pharmacological analysis was undertaken to design an improved chemotherapeut...

journal_title：BMC cancer

authors： Gemma A,Li C,Sugiyama Y,Matsuda K,Seike Y,Kosaihira S,Minegishi Y,Noro R,Nara M,Seike M,Yoshimura A,Shionoya A,Kawakami A,Ogawa N,Uesaka H,Kudoh S

更新日期：2006-06-30 00:00:00

abstract：BACKGROUND:Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood. METHODS:Expression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological character...

journal_title：BMC cancer

authors： An Y,Wang S,Li S,Zhang L,Wang D,Wang H,Zhu S,Zhu W,Li Y,Chen W,Ji S,Guo X

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to ...

journal_title：BMC cancer

authors： Thumallapally N,Meshref A,Mousa M,Terjanian T

更新日期：2017-01-05 00:00:00

abstract：:It has been highlighted that the original manuscript [1] contains a typesetting error in the surname of Jesson Butcon. This was incorrectly captured as Jessica Butcon in the original manuscript which has since been updated. ...

journal_title：BMC cancer

authors： Chan RJ,Yates P,Li Q,Komatsu H,Lopez V,Thandar M,Chacko ST,So WKW,Pongthavornkamol K,Yi M,Pittayapan P,Butcon J,Wyld D,Molassiotis A,STEP study collaborators.

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the...

journal_title：BMC cancer

authors： Niu S,Huang J,Li J,Liu X,Wang D,Zhang R,Wang Y,Shen H,Qi M,Xiao Y,Guan M,Liu H,Li D,Liu F,Wang X,Xiong Y,Gao S,Wang X,Zhu J

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of ...

journal_title：BMC cancer

authors： Folyovich A,Varga V,Várallyay G,Kozák L,Bakos M,Scheidl E,Béres-Molnár KA,Kajdácsi Z,Bereczki D

更新日期：2018-10-03 00:00:00