Antagonism of sorafenib and regorafenib actions by platelet factors in hepatocellular carcinoma cell lines.

abstract：BACKGROUND:Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer. METHODS:Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review...

journal_title：BMC cancer

authors： Mazzone PJ,Rai H,Beukemann M,Xu M,Jain A,Sasidhar M

更新日期：2012-09-14 00:00:00

abstract：BACKGROUND:This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially young patients. The flatness filter has been described as main source of photon scatter. MATERIAL ...

journal_title：BMC cancer

authors： Treutwein M,Steger F,Loeschel R,Koelbl O,Dobler B

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:The use of high-dose chemotherapy combined with autologous stem cell transplantation has improved the outcome of hematologic malignancies. Nevertheless, this treatment can cause persistent fatigue and a reduced global quality of life, role and physical function. Physical exercise interventions may be benefic...

journal_title：BMC cancer

authors： Persoon S,Kersten MJ,Chinapaw MJ,Buffart LM,Burghout H,Schep G,Brug J,Nollet F

更新日期：2010-12-06 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the safety and efficacy of fractionated stereotactic radiotherapy (SRT) in combination with systemic therapies (ST) for brain metastases (BM). METHODS:Ninety-nine patients (171 BM) received SRT and concurrent ST (group 1) and 95 patients (131 BM) received SRT alone wit...

journal_title：BMC cancer

authors： Guénolé M,Lucia F,Bourbonne V,Dissaux G,Reygagne E,Goasduff G,Pradier O,Schick U

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and a good prognostic indicator for lung adenocarcinoma. However, its good prognostic ability might be due to epidermal growth factor receptor (EGFR)-sensitizing mutations as shown by the positive correlation between TTF-1 expression and ...

journal_title：BMC cancer

authors： Park JY,Jang SH,Kim HI,Kim JH,Park S,Hwang YI,Jung KS,Seo J,Lee CY,Ko Y,Park YB

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. METHODS:We collected retrospectively patients with NEBC ...

journal_title：BMC cancer

authors： Roininen N,Takala S,Haapasaari KM,Jukkola-Vuorinen A,Mattson J,Heikkilä P,Karihtala P

更新日期：2017-01-24 00:00:00

abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...

journal_title：BMC cancer

authors： Chen YH,Lu HI,Lo CM,Wang YM,Chou SY,Hsiao CC,Huang CC,Shih LH,Chen SW,Li SH

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Venous thromboembolic events (VTE) are common in cancer patients and associated with higher mortality. In vivo thrombosis and anticoagulation might be involved in tumor growth and progression. We studied the association of warfarin and other anticoagulant use as antithrombotic medication and prostate cancer ...

journal_title：BMC cancer

authors： Kinnunen PTT,Murtola TJ,Talala K,Taari K,Tammela TLJ,Auvinen A

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide, and CD133 is a popular cancer stem cell (CSC) marker for HCC. CD133(+) CSCs have been reported to resist conventional chemo- and radiotherapy, but little is known about their response to immune surveillance. Interferon-gamma (IFN...

journal_title：BMC cancer

authors： Li J,Chen JN,Zeng TT,He F,Chen SP,Ma S,Bi J,Zhu XF,Guan XY

更新日期：2016-01-13 00:00:00

abstract：BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...

journal_title：BMC cancer

authors： Rief H,Omlor G,Akbar M,Welzel T,Bruckner T,Rieken S,Haefner MF,Schlampp I,Gioules A,Habermehl D,von Nettelbladt F,Debus J

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Glioblastoma is the most common and most aggressive form of malignant glioma and is very difficult to treat. Controlling tumour cell invasion and angiogenesis is essential to improve the prognosis of glioblastoma patients. Since constitutive activation of nuclear factor-κB (NF-κB) is necessary for tumour pro...

journal_title：BMC cancer

authors： Nakabayashi H,Shimizu K

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer. METHODS:We sought to inves...

journal_title：BMC cancer

authors： James FR,Jiminez-Linan M,Alsop J,Mack M,Song H,Brenton JD,Pharoah PDP,Ali HR

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...

journal_title：BMC cancer

authors： Matsushita J,Okamura K,Nakabayashi K,Suzuki T,Horibe Y,Kawai T,Sakurai T,Yamashita S,Higami Y,Ichihara G,Hata K,Nohara K

更新日期：2018-03-22 00:00:00

abstract：BACKGROUND:CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 expression in tumors has been discussed, but hepatocellular carcinoma (HCC) has not been included in these ...

journal_title：BMC cancer

authors： Chen YL,Lin PY,Ming YZ,Huang WC,Chen RF,Chen PM,Chu PY

更新日期：2017-07-07 00:00:00

abstract：BACKGROUND:Treatment of locally advanced non-small-cell lung cancer is based on a combined approach. To study the impact of trimodal therapy for stage III-N2 NSCLC a single centre retrospective evaluation focusing on survival and therapy-related toxicity was performed. METHODS:71 patients diagnosed between March 2001 ...

journal_title：BMC cancer

authors： Askoxylakis V,Tanner J,Kappes J,Hoffmann H,Nicolay NH,Rief H,Debus J,Thomas M,Bischof M

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:The incidence of thyroid cancer and the number of patients who die from this disease are increasing globally. Differentiated thyroid cancer (DTC) is the histologic subtype present in most patients and is primarily responsible for the increased overall incidence of thyroid cancer. Sorafenib is a multikinase i...

journal_title：BMC cancer

authors： Brose MS,Nutting CM,Sherman SI,Shong YK,Smit JW,Reike G,Chung J,Kalmus J,Kappeler C,Schlumberger M

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity and resistance. In dividing cells, traditional metrics derived from dose-response curves such as IC...

journal_title：BMC cancer

authors： Clark NA,Hafner M,Kouril M,Williams EH,Muhlich JL,Pilarczyk M,Niepel M,Sorger PK,Medvedovic M

更新日期：2017-10-24 00:00:00

abstract：BACKGROUND:Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of cancer incidence of a number of solid tumours, including prostate cancer (PCa). However, the underl...

journal_title：BMC cancer

authors： Crawley D,Chandra A,Loda M,Gillett C,Cathcart P,Challacombe B,Cook G,Cahill D,Santa Olalla A,Cahill F,George G,Rudman S,Van Hemelrijck M

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:The glycosylphosphatidylinositol-anchored extracellular membrane serine protease prostasin is expressed in normal bladder urothelial cells. Bladder inflammation reduces prostasin expression and a loss of prostasin expression is associated with epithelial-mesenchymal transition (EMT) in human bladder transiti...

journal_title：BMC cancer

authors： Chai AC,Robinson AL,Chai KX,Chen LM

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mortality. The Sept9 DNA-methylation assay is among the most well studied blood-based screening markers...

journal_title：BMC cancer

authors： Ørntoft MB,Nielsen HJ,Ørntoft TF,Andersen CL,Danish Study Group on Early Detection of Colorectal Cancer.

更新日期：2015-10-29 00:00:00

abstract：BACKGROUND:The origin and development of breast cancer remain complex and obscure. Recently, microRNA (miRNA) has been identified as an important regulator of the initiation and progression of breast cancer, and some studies have shown the essential role of miR-124-3p as a tumor suppressor in breast tumorigenesis. Howe...

journal_title：BMC cancer

authors： Wang Y,Chen L,Wu Z,Wang M,Jin F,Wang N,Hu X,Liu Z,Zhang CY,Zen K,Chen J,Liang H,Zhang Y,Chen X

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...

journal_title：BMC cancer

authors： Inari H,Teruya N,Kishi M,Horii R,Akiyama F,Takahashi S,Ito Y,Ueno T,Iwase T,Ohno S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Axonal sensory peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Omega-3 fatty acids have beneficial effects on neurological disorders from their effects on neurons cells and inhibition of the formation of proinflammatory cytokines involved in peripheral neuropathy. METHODS:This stu...

journal_title：BMC cancer

authors： Ghoreishi Z,Esfahani A,Djazayeri A,Djalali M,Golestan B,Ayromlou H,Hashemzade S,Asghari Jafarabadi M,Montazeri V,Keshavarz SA,Darabi M

更新日期：2012-08-15 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the severity of pain and its impact on the quality of life (QoL) in untreated patients with head and neck squamous cell carcinoma (HNSCC). METHODS:A study group of 127 patients with HNSCC were interviewed before antineoplastic treatment. The severity of pain was measured ...

journal_title：BMC cancer

authors： Oliveira KG,von Zeidler SV,Podestá JR,Sena A,Souza ED,Lenzi J,Bissoli NS,Gouvea SA

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...

journal_title：BMC cancer

authors： Marrer É,Jolly D,Arveux P,Lejeune C,Woronoff-Lemsi MC,Jégu J,Guillemin F,Velten M

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Several GI peptides linked to intestinal barrier function could be involved in the modification of intestinal permeability and the onset of diarrhea during adjuvant chemotherapy. The aim of the study was to evaluate the circulating levels of zonulin, glucagon-like peptide-2 (GLP-2), epidermal growth factor (...

journal_title：BMC cancer

authors： Russo F,Linsalata M,Clemente C,D'Attoma B,Orlando A,Campanella G,Giotta F,Riezzo G

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors on endothelial cells and their counter-receptors on cancer cells. Notably, E-selectin, a major endot...

journal_title：BMC cancer

authors： Porquet N,Poirier A,Houle F,Pin AL,Gout S,Tremblay PL,Paquet ER,Klinck R,Auger FA,Huot J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in p...

journal_title：BMC cancer

authors： Pérez-Saldivar ML,Fajardo-Gutiérrez A,Bernáldez-Ríos R,Martínez-Avalos A,Medina-Sanson A,Espinosa-Hernández L,Flores-Chapa Jde D,Amador-Sánchez R,Peñaloza-González JG,Alvarez-Rodríguez FJ,Bolea-Murga V,Flores-Lujano J,Rodríguez-Z

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:Breast cancer survivors have an elevated risk of cognitive impairment compared to age-matched women without cancer. Causes of this impairment are complex, including both treatment and psychological factors. Mindfulness-based interventions, which have been shown to improve cognitive function in the general po...

journal_title：BMC cancer

authors： Cifu G,Power MC,Shomstein S,Arem H

更新日期：2018-11-26 00:00:00