Abstract:
BACKGROUND:The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its role in non-small cell lung cancer (NSCLC) is unknown. The aim of the present study was to examine the expression pattern of HOTAIR in NSCLC and to evaluate its biological role and clinical significance in tumor progression. METHODS:Expression of HOTAIR was analyzed in 42 NSCLC tissues and four NSCLC cell lines by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Over-expression and RNA interference (RNAi) approaches were used to investigate the biological functions of HOTAIR. The effect of HOTAIR on proliferation was evaluated by MTT and colony formation assays, and cell migration and invasion were evaluated by transwell assays. Tail vein injection of cells was used to study metastasis in nude mice. Protein levels of HOTAIR targets were determined by western blot analysis. Differences between groups were tested for significance using Student's t-test (two-tailed). RESULTS:HOTAIR was highly expressed both in NSCLC samples and cell lines compared with corresponding normal counterparts. HOTAIR upregulation was correlated with NSCLC advanced pathological stage and lymph-node metastasis. Moreover, patients with high levels of HOTAIR expression had a relatively poor prognosis. Inhibition of HOTAIR by RNAi decreased the migration and invasion of NSCLC cells in vitro and impeded cell metastasis in vivo. HOXA5 levels were affected by HOTAIR knockdown or over-expression in vitro. CONCLUSIONS:Our findings indicate that HOTAIR is significantly up-regulated in NSCLC tissues, and regulates NSCLC cell invasion and metastasis, partially via the down-regulation of HOXA5. Thus, HOTAIR may represent a new marker of poor prognosis and is a potential therapeutic target for NSCLC intervention.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Liu XH,Liu ZL,Sun M,Liu J,Wang ZX,De Wdoi
10.1186/1471-2407-13-464subject
Has Abstractpub_date
2013-10-08 00:00:00pages
464issn
1471-2407pii
1471-2407-13-464journal_volume
13pub_type
杂志文章相关文献
BMC CANCER文献大全abstract::Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...
journal_title:BMC cancer
pub_type: 评论,杂志文章
doi:10.1186/s12885-017-3656-z
更新日期:2017-11-07 00:00:00
abstract:BACKGROUND:Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of the CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 gene polymorphisms and tobacco smok...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4342-5
更新日期:2018-05-03 00:00:00
abstract::Following publication of the original article [1], the authors notified us of a misleading data presentation in Table 4. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-5029-7
更新日期:2018-11-30 00:00:00
abstract:BACKGROUND:The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy. METHODS:Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-102
更新日期:2010-03-18 00:00:00
abstract:BACKGROUND:There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be explained by racial/ethnic differences in long-term adherence to adjuvant endocrine therapy (AET). ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5121-z
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery. METHODS:567 patients who were performed curative intent between 1980 and 2003 were enrolled. 187 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-308
更新日期:2010-06-20 00:00:00
abstract:BACKGROUND:XELOX (capecitabine + oxaliplatin) and FOLFOX 4 (5-FU + folinic acid + oxaliplatin) have shown similar improvements in survival in patients with metastatic colorectal cancer (MCRC). A US cost-minimization study found that the two regimens had similar costs from a healthcare provider perspective but XELOX had...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-11-288
更新日期:2011-07-09 00:00:00
abstract:BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07350-x
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:BCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCOR mutation in lymphoid malignancies is unknown. METHODS:Lymphoma patient samples were analyzed to i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07806-8
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:The use of computerized systems to support evidence-based practice is commonplace in contemporary medicine. Despite the prolific use of electronic support systems there has been relatively little research on the uptake of web-based systems in the oncology setting. Our objective was to examine the uptake of a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-112
更新日期:2013-03-12 00:00:00
abstract:BACKGROUND:The purpose of our study was to investigate the immunohistochemical expression of TGF-beta1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We also aimed to evaluate the expression of TGF-beta1 and p27 in the context of other cell cycle an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-98
更新日期:2005-08-08 00:00:00
abstract:BACKGROUND:The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic significance in patients with breast cancer. METHODS:PubMed,...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-015-1742-7
更新日期:2015-10-17 00:00:00
abstract:BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-455
更新日期:2011-10-20 00:00:00
abstract:BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07442-8
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial r...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-95
更新日期:2006-04-18 00:00:00
abstract:BACKGROUND:Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging has been reported for evaluating irradiated parotid damage. However, the changes of IVIM p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2900-2
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:Extrahepatic biliary duct cancers (EBDC) are uncommon malignancies characterized by a poor prognosis with high rate of loco-regional recurrence. The purpose of the present study is to assess the feasibility and the potential impact of adjuvant radiotherapy (RT) in a series of patients treated in one institut...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-267
更新日期:2011-06-24 00:00:00
abstract:BACKGROUND:The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The patients are at risk of developing sexual hormone deficiency and impaired fertility. This prospective c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3593-x
更新日期:2017-09-06 00:00:00
abstract:BACKGROUND:The role of serine/threonine kinase 33 (STK33) gene in tumorigenesis is still controversial. This study was aimed to investigate whether STK33 had the effect on hypopharyngeal squamous cell carcinoma (HSCC) and relevant genes, as well as the potential relation to ERK1/2 pathway. METHODS:Immunohistochemistry...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1009-3
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion of lung cancer patients (~ 30%). Once diagnosed, patients have a poor prognosis surviving typically ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06808-2
更新日期:2020-04-07 00:00:00
abstract:BACKGROUND:The cholesterol biosynthesis pathway is typically upregulated in breast cancer. The role of NAD(P)-dependent steroid dehydrogenase-like (NSDHL) gene, which is involved in cholesterol biosynthesis, in breast cancer remains unknown. This study aimed to uncover the role of NSDHL in the growth and metastasis of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06840-2
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1007-5
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to identify the magnitude of delayed diagnosis and its associated factors in women with breast cancer in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-141
更新日期:2011-04-17 00:00:00
abstract:BACKGROUND:Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective. Thus, there is an urgent need to identify new alterna...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-918
更新日期:2014-12-05 00:00:00
abstract:BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5340-y
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2712-4
更新日期:2016-08-19 00:00:00
abstract:BACKGROUND:Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has not been studied in detail. METHODS:Here, we introduce an analogue...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-677
更新日期:2010-12-12 00:00:00
abstract:BACKGROUND:Liver resection had been regarded as a standard treatment for primary hepatocellular carcinoma (HCC). However, early mortality and recurrence after surgery were still of major concern. RAM (Risk Assessment for early Mortality) scoring system is a newly developed tool for assessing early mortality after hepat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3748-9
更新日期:2017-11-09 00:00:00
abstract:BACKGROUND:While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma patients, relatively little is known about brain-specific therapeutic response and adverse events in...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-4470-y
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/HER2- breast cancer. METHODS:We conducted a cohort study of breast cancer patients initiating palbociclib and fulvestrant from February 2015 to September 2017 using the HealthCore Integrated Research Database (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07790-z
更新日期:2021-01-25 00:00:00