Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.

abstract：BACKGROUND:The transient receptor potential, subfamily V, member 6 (TRPV6) is a Ca(2+) selective cation channel. Several studies have shown that TRPV6 transcripts are expressed in locally advanced prostatic adenocarcinoma, metastatic and androgen-insensitive prostatic lesions but are undetectable in healthy prostate ti...

journal_title：BMC cancer

authors： Kessler T,Wissenbach U,Grobholz R,Flockerzi V

更新日期：2009-10-26 00:00:00

abstract：BACKGROUND:Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS:Comparative...

journal_title：BMC cancer

authors： Huang XY,Gan RH,Xie J,She L,Zhao Y,Ding LC,Su BH,Zheng DL,Lu YG

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Significant progress in treatment of metastatic castration resistant prostate cancer (mCRPC) has been made. Biomarkers to tailor therapy are scarce. To facilitate decision-making we evaluated dynamic changes of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and prostate specific antigen (PSA) under ...

journal_title：BMC cancer

authors： Mikah P,Krabbe LM,Eminaga O,Herrmann E,Papavassilis P,Hinkelammert R,Semjonow A,Schrader AJ,Boegemann M

更新日期：2016-03-14 00:00:00

abstract：BACKGROUND:New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health. This paper reports on trends in the geographical mortality patterns of the most frequent cancers in Spain, over a period of 2...

journal_title：BMC cancer

authors： López-Abente G,Aragonés N,Pérez-Gómez B,Pollán M,García-Pérez J,Ramis R,Fernández-Navarro P

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Deaf people represent 0.1% of the French population and their access to public health campaigns is limited due to their frequent illiteracy and the infrequent use of sign language in campaigns. There is also a lack of general health knowledge in spite of the existence of French Deaf Care Units (UASS). The ai...

journal_title：BMC cancer

authors： Druel V,Hayet H,Esman L,Clavel M,Rougé Bugat ME

更新日期：2018-01-23 00:00:00

abstract：BACKGROUND:New biomarkers are needed for the prognosis of advanced colorectal cancer, which remains incurable by conventional treatments. O6-methylguanine DNA methyltransferase (MGMT) methylation and protein expression have been related to colorectal cancer treatment failure and tumor progression. Moreover, the presenc...

journal_title：BMC cancer

authors： Oliver JA,Ortiz R,Melguizo C,Alvarez PJ,Gómez-Millán J,Prados J

更新日期：2014-07-11 00:00:00

abstract：BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangemen...

journal_title：BMC cancer

authors： Wang L,Sun Y,Sun Y,Meng L,Xu X

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism. METHODS:The expre...

journal_title：BMC cancer

authors： Tu XP,Li H,Chen LS,Luo XN,Lu ZM,Zhang SY,Chen SH

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS:In a candid...

journal_title：BMC cancer

authors： Desjardins S,Beauparlant JC,Labrie Y,Ouellette G,Durocher F,INHERIT BRCAs.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...

journal_title：BMC cancer

authors： Zoni E,Minoli M,Bovet C,Wehrhan A,Piscuoglio S,Ng CKY,Gray PC,Spahn M,Thalmann GN,Kruithof-de Julio M

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...

journal_title：BMC cancer

authors： Kijima H,Sawada T,Tomosugi N,Kubota K

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. METHODS:We used high-throughp...

journal_title：BMC cancer

authors： Celestino R,Nome T,Pestana A,Hoff AM,Gonçalves AP,Pereira L,Cavadas B,Eloy C,Bjøro T,Sobrinho-Simões M,Skotheim RI,Soares P

更新日期：2018-01-10 00:00:00

abstract：BACKGROUND:Febrile neutropenia (FN) is common in breast cancer patients undergoing chemotherapy. Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This study aimed to evaluate the predictive value of patient-related, chemotherapy-related, and genetic risk...

journal_title：BMC cancer

authors： Pfeil AM,Vulsteke C,Paridaens R,Dieudonné AS,Pettengell R,Hatse S,Neven P,Lambrechts D,Szucs TD,Schwenkglenks M,Wildiers H

更新日期：2014-03-19 00:00:00

abstract：CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Wang X,Chen J,Wang J,Yu F,Zhao S,Zhang Y,Tang H,Peng Z

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. However, inherent heterogeneity and treatment-induced adaptation to drugs c...

journal_title：BMC cancer

authors： Shahi Thakuri P,Gupta M,Singh S,Joshi R,Glasgow E,Lekan A,Agarwal S,Luker GD,Tavana H

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make compliance with protocol-driven treatment challenging in low- and...

journal_title：BMC cancer

authors： Vasudevan L,Schroeder K,Raveendran Y,Goel K,Makarushka C,Masalu N,Zullig LL

更新日期：2020-03-29 00:00:00

abstract：BACKGROUND:H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there is also an overexpression of CXCR4 and an obvious involvement in gastric cancer metastasis. The aim o...

journal_title：BMC cancer

authors： Zhao C,Lu X,Bu X,Zhang N,Wang W

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...

journal_title：BMC cancer

authors： Lovitt CJ,Shelper TB,Avery VM

更新日期：2018-01-06 00:00:00

abstract：BACKGROUND:There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). METHODS:Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a ...

journal_title：BMC cancer

authors： Gremel G,Djureinovic D,Niinivirta M,Laird A,Ljungqvist O,Johannesson H,Bergman J,Edqvist PH,Navani S,Khan N,Patil T,Sivertsson Å,Uhlén M,Harrison DJ,Ullenhag GJ,Stewart GD,Pontén F

更新日期：2017-01-04 00:00:00

abstract：BACKGROUND:The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist surgical pathways for several cancers including prostate, bladder, kidney, and oesophago-gastric ...

journal_title：BMC cancer

authors： Melnychuk M,Vindrola-Padros C,Aitchison M,Clarke CS,Fulop NJ,Levermore C,Maddineni SB,Moore CM,Mughal MM,Perry C,Pritchard-Jones K,Ramsay AIG,Shackley D,Vickers J,Morris S

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the abov...

journal_title：BMC cancer

authors： Zhao P,Chen Q,Lu W

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...

journal_title：BMC cancer

authors： Pignochino Y,Sarotto I,Peraldo-Neia C,Penachioni JY,Cavalloni G,Migliardi G,Casorzo L,Chiorino G,Risio M,Bardelli A,Aglietta M,Leone F

更新日期：2010-11-18 00:00:00

abstract：BACKGROUND:Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classify...

journal_title：BMC cancer

authors： Garrido-Estepa M,Ruiz-Perales F,Miranda J,Ascunce N,González-Román I,Sánchez-Contador C,Santamariña C,Moreo P,Vidal C,Peris M,Moreno MP,Váquez-Carrete JA,Collado-García F,Casanova F,Ederra M,Salas D,Pollán M,DDM-Spain.

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...

journal_title：BMC cancer

authors： Klenke S,Akdeli N,Stelmach P,Heukamp L,Schulte JH,Bachmann HS

更新日期：2019-03-18 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer. METHODS:Circulating cells were identified by reverse transcription-polymerase chain reaction (RT-PCR) to detect p503S, p504S and p510...

journal_title：BMC cancer

authors： Cardillo MR,Gentile V,Ceccariello A,Giacomelli L,Messinetti S,Di Silverio F

更新日期：2005-09-05 00:00:00

abstract：BACKGROUND:Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is optimal. This study aimed to assess the outcome and failure patterns in tonsil cancer patients treated ...

journal_title：BMC cancer

authors： Song S,Wu HG,Lee CG,Keum KC,Kim MS,Ahn YC,Oh D,Park HJ,Lee SW,Park G,Moon SH,Cho KH,Kim YS,Won Y,Oh YT,Kim WT,Jeong JU

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide, and CD133 is a popular cancer stem cell (CSC) marker for HCC. CD133(+) CSCs have been reported to resist conventional chemo- and radiotherapy, but little is known about their response to immune surveillance. Interferon-gamma (IFN...

journal_title：BMC cancer

authors： Li J,Chen JN,Zeng TT,He F,Chen SP,Ma S,Bi J,Zhu XF,Guan XY

更新日期：2016-01-13 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. METHODS:The in vitro antineoplastic effect and mechanism of action of Casiopei...

journal_title：BMC cancer

authors： Trejo-Solís C,Jimenez-Farfan D,Rodriguez-Enriquez S,Fernandez-Valverde F,Cruz-Salgado A,Ruiz-Azuara L,Sotelo J

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular m...

journal_title：BMC cancer

authors： Lanz HL,Saleh A,Kramer B,Cairns J,Ng CP,Yu J,Trietsch SJ,Hankemeier T,Joore J,Vulto P,Weinshilboum R,Wang L

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection in the current clinical practice. METHODS:Stage I-II NSCLC patients (surgery 55 patients, SBRT 29 patients, median age 68)...

journal_title：BMC cancer

authors： Mokhles S,Nuyttens JJME,de Mol M,Aerts JGJV,Maat APWM,Birim Ö,Bogers AJJC,Takkenberg JJM

更新日期：2018-01-15 00:00:00