Comparison of different therapeutic strategies for complete hydatidiform mole in women at least 40 years old: a retrospective cohort study.

abstract：BACKGROUND:Ectopic TSH-secreting pituitary adenoma (TSH-oma) is a very unusual disorder. To date, there are only four cases reported. It is difficult to distinguish ectopic cases from both regular TSH-omas and resistance to thyroid hormone (RTH). CASE PRESENTATION:A newly identified case of ectopic TSH-oma arising fro...

journal_title：BMC cancer

authors： Song M,Wang H,Song L,Tian H,Ge Q,Li J,Zhu Y,Li J,Zhao R,Ji HL

更新日期：2014-07-28 00:00:00

abstract：OBJECTIVE:Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this study was to explore the efficacy of crizotinib in advanced non-small-cell lung cancer (NSCLC) with c...

journal_title：BMC cancer

authors： Chen RL,Zhao J,Zhang XC,Lou NN,Chen HJ,Yang X,Su J,Xie Z,Zhou Q,Tu HY,Zhong WZ,Yan HH,Guo WB,Wu YL,Yang JJ

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is ...

journal_title：BMC cancer

authors： Al Sarakbi W,Sasi W,Jiang WG,Roberts T,Newbold RF,Mokbel K

更新日期：2009-08-21 00:00:00

abstract：BACKGROUND:This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively radioresistant tumors such as malignant melanoma, renal cell carcinoma, and colorectal cancer. Additionally, a potential benefit from escalating the radiation...

journal_title：BMC cancer

authors： Meyners T,Heisterkamp C,Kueter JD,Veninga T,Stalpers LJ,Schild SE,Rades D

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Resilience has been linked to psychological adaptation to many challenging life events. The present study aims to explore the level of resilience in oral cancer patients and the key factors associated with resilience, and to evaluate the relationship between resilience and anxiety. METHODS:A multiple center...

journal_title：BMC cancer

authors： Gao Y,Yuan L,Pan B,Wang L

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...

journal_title：BMC cancer

authors： Ma Q,Shilkrut M,Zhao Z,Li M,Batty N,Barber B

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remains largely unknown. Here, we investigated the functions of HOXB-AS3, a lncRNA locate...

journal_title：BMC cancer

authors： Huang HH,Chen FY,Chou WC,Hou HA,Ko BS,Lin CT,Tang JL,Li CC,Yao M,Tsay W,Hsu SC,Wu SJ,Chen CY,Huang SY,Tseng MH,Tien HF,Chen RH

更新日期：2019-06-24 00:00:00

abstract：BACKGROUNDS:There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic review about the diagnostic accuracy of serum GP73 versus alpha-fetoprotein (AFP) for HCC. METHODS:Afte...

journal_title：BMC cancer

authors： Zhou Y,Yin X,Ying J,Zhang B

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic significance in patients with breast cancer. METHODS:PubMed,...

journal_title：BMC cancer

authors： Jiang D,Gao Z,Cai Z,Wang M,He J

更新日期：2015-10-17 00:00:00

abstract：BACKGROUND:Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. METHODS:We collected retrospectively patients with NEBC ...

journal_title：BMC cancer

authors： Roininen N,Takala S,Haapasaari KM,Jukkola-Vuorinen A,Mattson J,Heikkilä P,Karihtala P

更新日期：2017-01-24 00:00:00

abstract：BACKGROUND:The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant cells is still controversial, and the cell subsets and the mechanisms involved are poorly investiga...

journal_title：BMC cancer

authors： Estrela-Lima A,Araújo MS,Costa-Neto JM,Teixeira-Carvalho A,Barrouin-Melo SM,Cardoso SV,Martins-Filho OA,Serakides R,Cassali GD

更新日期：2010-06-04 00:00:00

abstract：BACKGROUND:Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is optimal. This study aimed to assess the outcome and failure patterns in tonsil cancer patients treated ...

journal_title：BMC cancer

authors： Song S,Wu HG,Lee CG,Keum KC,Kim MS,Ahn YC,Oh D,Park HJ,Lee SW,Park G,Moon SH,Cho KH,Kim YS,Won Y,Oh YT,Kim WT,Jeong JU

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...

journal_title：BMC cancer

authors： Rot S,Kaune T,Taubert H,Greither T,Kotrba J,Güttler A,Wichmann H,Bilkenroth U,Wienke A,Al-Nawas B,Bache M,Vordermark D,Wickenhauser C,Bethmann D,Eckert AW,Kappler M

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:First-line treatment with FOLFOXIRI plus bevacizumab (BEV) is highly effective and regarded as one of the standards-of-care for patients with metastatic colorectal cancer (mCRC), despite the high incidence of neutropenia and diarrhea as side effects. AXEPT, an Asian phase III study, showed that modified CAPI...

journal_title：BMC cancer

authors： Miyo M,Kato T,Yoshino T,Yamanaka T,Bando H,Satake H,Yamazaki K,Taniguchi H,Oki E,Kotaka M,Oba K,Miyata Y,Muro K,Komatsu Y,Baba H,Tsuji A

更新日期：2020-07-23 00:00:00

abstract：BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...

journal_title：BMC cancer

authors： Dai SD,Wang Y,Miao Y,Zhao Y,Zhang Y,Jiang GY,Zhang PX,Yang ZQ,Wang EH

更新日期：2009-06-09 00:00:00

abstract：BACKGROUND:Novel biomarkers are required to discern between breast tumors that should be targeted for treatment from those that would never become clinically apparent and/or life threatening for patients. Moreover, therapeutics that specifically target breast cancer (BC) cells with tumor-initiating capacity to prevent ...

journal_title：BMC cancer

authors： Hagerling C,Owyong M,Sitarama V,Wang CY,Lin C,van den Bijgaart RJE,Koopman CD,Brenot A,Nanjaraj A,Wärnberg F,Jirström K,Klein OD,Werb Z,Plaks V

更新日期：2020-06-10 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely unknown. An Imaging-Genomics analysis was performed to reveal the mechanistic associations between MR...

journal_title：BMC cancer

authors： Grossmann P,Gutman DA,Dunn WD Jr,Holder CA,Aerts HJ

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Despite the excellent results obtained with hormone therapy, the long treatment period and the side effects associated with its use make patient adherence difficult. Moreover, certain aspects of health care can mitigate or exacerbate non-adherence. This study aimed to identify the factors associated with adh...

journal_title：BMC cancer

authors： Brito C,Portela MC,de Vasconcellos MT

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...

journal_title：BMC cancer

authors： Jiang H,Xu S,Chen C

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20-25% of new female cancer incidents. This study aimed to describe the temporal trend of breast cancer and interpret the potential effects on the observed secular trends. METHODS:Cancer incident ...

journal_title：BMC cancer

authors： Wang F,Tse LA,Chan WC,Kwok CC,Leung SL,Wu C,Mang OW,Ngan RK,Li M,Yu WC,Tsang KH,Law SH,Miao X,Wu C,Zheng Y,Wu F,Yang XR,Yu IT

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor signaling cascades are kn...

journal_title：BMC cancer

authors： Pignochino Y,Dell'Aglio C,Inghilleri S,Zorzetto M,Basiricò M,Capozzi F,Canta M,Piloni D,Cemmi F,Sangiolo D,Gammaitoni L,Soster M,Marchiò S,Pozzi E,Morbini P,Luisetti M,Aglietta M,Grignani G,Stella GM

更新日期：2015-05-08 00:00:00

abstract：BACKGROUND:Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual's susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development. METHO...

journal_title：BMC cancer

authors： Zhao P,Zou P,Zhao L,Yan W,Kang C,Jiang T,You Y

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...

journal_title：BMC cancer

authors： Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JH

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal carcinoma (IDC). The prognosis of IMPC compared with that of IDC remains controversial; we conducted a meta-analysis to evaluate the prognostic difference between IMPC and IDC. METHODS:We searched the PubMed, Cochran...

journal_title：BMC cancer

authors： Wu Y,Zhang N,Yang Q

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:Interpretation of comparative health-related quality of life (HRQOL) studies following different prostate cancer treatments is often difficult due to differing patient ages. Furthermore, age-related changes can hardly be discriminated from therapy-related changes. The evaluation of age-and comorbidity-relate...

journal_title：BMC cancer

authors： Pinkawa M,Fischedick K,Gagel B,Piroth MD,Asadpour B,Klotz J,Borchers H,Jakse G,Eble MJ

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, little is known about the contribution of environmental tobacco smoke (ETS) to RCC incidence. This study...

journal_title：BMC cancer

authors： Theis RP,Dolwick Grieb SM,Burr D,Siddiqui T,Asal NR

更新日期：2008-12-24 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptiv...

journal_title：BMC cancer

authors： González-Reyes S,Marín L,González L,González LO,del Casar JM,Lamelas ML,González-Quintana JM,Vizoso FJ

更新日期：2010-12-03 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00