Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis.

abstract：BACKGROUND:Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of the CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 gene polymorphisms and tobacco smok...

journal_title：BMC cancer

authors： Ezzeldin N,El-Lebedy D,Darwish A,El Bastawisy A,Abd Elaziz SH,Hassan MM,Saad-Hussein A

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in patients with metastatic/relapsed STS following failure of prior chemotherapy by examining data colle...

journal_title：BMC cancer

authors： Wagner MJ,Amodu LI,Duh MS,Korves C,Solleza F,Manson SC,Diaz J,Neary MP,Demetri GD

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs) play a role in the regulation of the tumor cell response to hypoxia, however, not much is known ab...

journal_title：BMC cancer

authors： Gits CM,van Kuijk PF,de Rijck JC,Muskens N,Jonkers MB,van IJcken WF,Mathijssen RH,Verweij J,Sleijfer S,Wiemer EA

更新日期：2014-06-13 00:00:00

abstract：BACKGROUND:Soft tissue metastases, in particular intraneural metastasis, from any carcinomas seldom occur. To our knowledge, no case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma is reported in the literature. CASE PRESENTATION:A case is reported of a 82-year old woman with sciatic nerve pa...

journal_title：BMC cancer

authors： Ichikawa J,Matsumoto S,Shimoji T,Tanizawa T,Gokita T,Hayakawa K,Aoki K,Ina S,Kanda H

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive. METHODS:We developed a pathway based classifier approach to predict pr...

journal_title：BMC cancer

authors： Herbsleb M,Christensen OF,Thykjaer T,Wiuf C,Borre M,Orntoft TF,Dyrskjøt L

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy. The anticipated consequence of all therapies is induction of tumor apoptosis. The highly resistance nature of PDACs to all therapies sugges...

journal_title：BMC cancer

authors： Lu C,Yang D,Sabbatini ME,Colby AH,Grinstaff MW,Oberlies NH,Pearce C,Liu K

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial...

journal_title：BMC cancer

authors： Ploos van Amstel FK,Prins JB,van der Graaf WT,Peters ME,Ottevanger PB

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:The prognostic value of rectal invasion is still unclear in stage IVA cervical cancer. The objective of this study is to evaluate patient outcome and prognostic factors in stage IVA cervical cancer treated with radiation therapy. METHODS:A retrospective review of the medical records of patients treated with...

journal_title：BMC cancer

authors： Wakatsuki M,Kato S,Kiyohara H,Ohno T,Karasawa K,Tamaki T,Ando K,Shiba S,Kamada T,Nakano T

更新日期：2016-03-23 00:00:00

abstract：BACKGROUND:Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 and 3 clinical trials where its efficacy and safety was found to be similar to its reference product...

journal_title：BMC cancer

authors： Kamioner D,Fruehauf S,Maloisel F,Cals L,Lepretre S,Berthou C

更新日期：2013-11-16 00:00:00

abstract：BACKGROUND:Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a subset of breast cancer with different biologic behaviour. We investigated the clinicopathologic charac...

journal_title：BMC cancer

authors： Rhee J,Han SW,Oh DY,Kim JH,Im SA,Han W,Park IA,Noh DY,Bang YJ,Kim TY

更新日期：2008-10-23 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies in breast cancer suggest that some anti-tumor therapy regimens generate stimulation of the immune system that accounts for tumor clinical responses, however, demonstration of the immunostimulatory power of these therapies on cancer patients continues to be a formida...

journal_title：BMC cancer

authors： Bernal-Estévez D,Sánchez R,Tejada RE,Parra-López C

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...

journal_title：BMC cancer

authors： Jiang Q,Wei H,Tian Z

更新日期：2008-01-17 00:00:00

abstract：BACKGROUND:Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen in white males above the age of 40 years. Here we report a case of paraneoplastic acrokeratosis in a...

journal_title：BMC cancer

authors： Hempen A,Samartzis EP,Kamarachev J,Fink D,Dedes KJ

更新日期：2015-07-08 00:00:00

abstract：BACKGROUND:Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer...

journal_title：BMC cancer

authors： Wang R,Chen S,Li C,Ng KT,Kong CW,Cheng J,Cheng SH,Li RA,Lo CM,Man K,Sun D

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer ri...

journal_title：BMC cancer

authors： Zheng J,Yu X,Jiang L,Xiao M,Bai B,Lu J,Zhou Y

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:There is no consensus regarding resection of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastatic colorectal cancer (CRC). A potential benefit of resection of the primary tumour is to prevent complications of the primary tumour in later stages of the disease. We...

journal_title：BMC cancer

authors： 't Lam-Boer J,Mol L,Verhoef C,de Haan AF,Yilmaz M,Punt CJ,de Wilt JH,Koopman M

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:To date, there is no report in the international literature of an oligodendroglioma of the ciliary body, nor is there an analysis of the possible origins of this lesion. CASE PRESENTATION:Here we report on a 52-year-old man admitted to our hospital with a ciliary body tumor revealed by clinical examination ...

journal_title：BMC cancer

authors： Guo Q,Hao J,Sun Sb,Xu Sp,Yang Q,Guo Ql,Cui Gd

更新日期：2010-10-23 00:00:00

abstract：BACKGROUND:Wilms' tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms' tumor. MiRNAs play important roles in this tumorigenic process. In the present study, we aimed to investigate the role of m...

journal_title：BMC cancer

authors： Liu Z,He F,OuYang S,Li Y,Ma F,Chang H,Cao D,Wu J

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect reproductive function. This paper describes the design and encountered methodological challenges of ...

journal_title：BMC cancer

authors： Overbeek A,van den Berg MH,Kremer LC,van den Heuvel-Eibrink MM,Tissing WJ,Loonen JJ,Versluys B,Bresters D,Kaspers GJ,Lambalk CB,van Leeuwen FE,van Dulmen-den Broeder E,DCOG LATER-VEVO study group.

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect varies substantially among ...

journal_title：BMC cancer

authors： Tranberg M,Bech BH,Blaakær J,Jensen JS,Svanholm H,Andersen B

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy. METHODS:A total of 124 patients with rectal cancer treated with neoadjuvant chemoradiotherapy and consecutive surge...

journal_title：BMC cancer

authors： Trotsyuk I,Sparschuh H,Müller AJ,Neumann K,Kruschewski M,Horst D,Elezkurtaj S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell surv...

journal_title：BMC cancer

authors： Koschny R,Brost S,Hinz U,Sykora J,Batke EM,Singer S,Breuhahn K,Stremmel W,Walczak H,Schemmer P,Schirmacher P,Ganten TM

更新日期：2013-11-09 00:00:00

abstract：BACKGROUND:Total mesorectal excision is the standard surgical treatment for mid- and low-rectal cancer. Laparoscopy represents a clear leap forward in the management of rectal cancer patients, offering significant improvements in post-operative measures such as pain, first bowel movement, and hospital length of stay. H...

journal_title：BMC cancer

authors： Lelong B,de Chaisemartin C,Meillat H,Cournier S,Boher JM,Genre D,Karoui M,Tuech JJ,Delpero JR,French Research Group of Rectal Cancer Surgery (GRECCAR).

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...

journal_title：BMC cancer

authors： Wang L,Wang R,Pan Y,Sun Y,Zhang J,Chen H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Cytokines are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play key role in tumor dissemination and are an independent survival predictor in breast cancer patients. The aim of this study was to assess correlation between CTCs and plasma cytokines in primary breast cancer (PBC) p...

journal_title：BMC cancer

authors： Mego M,Cholujova D,Minarik G,Sedlackova T,Gronesova P,Karaba M,Benca J,Cingelova S,Cierna Z,Manasova D,Pindak D,Sufliarsky J,Cristofanilli M,Reuben JM,Mardiak J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...

journal_title：BMC cancer

authors： Bond CE,Bettington ML,Pearson SA,McKeone DM,Leggett BA,Whitehall VL

更新日期：2015-01-23 00:00:00

abstract：BACKGROUND:Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the chemokine receptor CXCR4, which is known to enable CRC metastasis, as well as the cancer-initiating ...

journal_title：BMC cancer

authors： Cutler MJ,Lowthers EL,Richard CL,Hajducek DM,Spagnuolo PA,Blay J

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic revi...

journal_title：BMC cancer

authors： Abogunrin S,Di Tanna GL,Keeping S,Carroll S,Iheanacho I

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma patients, relatively little is known about brain-specific therapeutic response and adverse events in...

journal_title：BMC cancer

authors： McDonald MA,Sanghvi P,Bykowski J,Daniels GA

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...

journal_title：BMC cancer

authors： Miwa K,Oki E,Enomoto M,Ihara K,Ando K,Fujita F,Tominaga M,Mori S,Nakayama G,Shimokawa M,Saeki H,Baba H,Mori M,Akagi Y

更新日期：2021-01-05 00:00:00