Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis.


BACKGROUND:Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptive immune system. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4 and 9 in breast cancer. METHODS:The expression levels of TLR3, TLR4 and TLR9 were analyzed on tumors from 74 patients with breast cancer. The analysis was performed by immunohistochemistry. RESULTS:Samples of carcinomas with recurrence exhibited a significant increase in the mRNA levels of TLR3, TLR4 and TLR9. Tumors showed high expression of TLRs expression levels by cancer cells, especially TLR4 and 9. Nevertheless, a significant percentage of tumors also showed TLR4 expression by mononuclear inflammatory cells (21.6%) and TLR9 expression by fibroblast-like cells (57.5%). Tumors with high TLR3 expression by tumor cell or with high TLR4 expression by mononuclear inflammatory cells were significantly associated with higher probability of metastasis. However, tumours with high TLR9 expression by fibroblast-like cells were associated with low probability of metastasis. CONCLUSIONS:The expression levels of TLR3, TLR4 and TLR9 have clinical interest as indicators of tumor aggressiveness in breast cancer. TLRs may represent therapeutic targets in breast cancer.


BMC Cancer


BMC cancer


González-Reyes S,Marín L,González L,González LO,del Casar JM,Lamelas ML,González-Quintana JM,Vizoso FJ




Has Abstract


2010-12-03 00:00:00










  • Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis.

    abstract:BACKGROUND:Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERC...

    journal_title:BMC cancer

    pub_type: 杂志文章,meta分析


    authors: Zhang E,Cui Z,Xu Z,Duan W,Huang S,Tan X,Yin Z,Sun C,Lu L

    更新日期:2013-12-12 00:00:00

  • Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer.

    abstract:BACKGROUND:The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour ...

    journal_title:BMC cancer

    pub_type: 杂志文章,多中心研究


    authors: Diessner J,Wischnewsky M,Stüber T,Stein R,Krockenberger M,Häusler S,Janni W,Kreienberg R,Blettner M,Schwentner L,Wöckel A,Bartmann C

    更新日期:2016-05-12 00:00:00

  • miR-10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 (CSMD1).

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This stu...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Zhu Q,Gong L,Wang J,Tu Q,Yao L,Zhang JR,Han XJ,Zhu SJ,Wang SM,Li YH,Zhang W

    更新日期:2016-10-18 00:00:00

  • Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients.

    abstract:BACKGROUND:The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy. METHODS:Medical notes of 174 NPC patients a...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Luo R,Wu VWC,He B,Gao X,Xu Z,Wang D,Yang Z,Li M,Lin Z

    更新日期:2018-05-18 00:00:00

  • IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts.

    abstract:BACKGROUND:Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several signaling pathways, including NF-κB, are altered in TNBC, and the complexity of this disease implies ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: House CD,Grajales V,Ozaki M,Jordan E,Wubneh H,Kimble DC,James JM,Kim MK,Annunziata CM

    更新日期:2018-05-25 00:00:00

  • Different protein expression associated with chemotherapy response in oropharyngeal cancer according to HPV status.

    abstract:BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Kim MJ,Ki MS,Kim K,Shim HJ,Hwang JE,Bae WK,Chung IJ,Lee DH,Lee JK,Yoon TM,Lim SC,Chung WK,Jeong JU,Lim HS,Choi YD,Cho SH

    更新日期:2014-11-07 00:00:00

  • Impact of organised programs on colorectal cancer screening.

    abstract:PURPOSE:Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practitioners is not well known. METHODS:Two nationwide observational telephone surveys were conducted in early ...

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    pub_type: 杂志文章


    authors: Eisinger F,Cals L,Calazel-Benque A,Blay JY,Coscas Y,Dolbeault S,Namer M,Pivot X,Rixe O,Serin D,Roussel C,Morère JF,EDIFICE committee.

    更新日期:2008-04-15 00:00:00

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    abstract:BACKGROUND:The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast cancer. The reporting recommendations for tumor marker prognostic studies (REMARK) guideline...

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    pub_type: 杂志文章


    authors: Schillaci R,Guzmán P,Cayrol F,Beguelin W,Díaz Flaqué MC,Proietti CJ,Pineda V,Palazzi J,Frahm I,Charreau EH,Maronna E,Roa JC,Elizalde PV

    更新日期:2012-02-22 00:00:00

  • Estrogen receptor, progesterone receptor, interleukin-6 and interleukin-8 are variable in breast cancer and benign stem/progenitor cell populations.

    abstract:BACKGROUND:Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. Interleukin-6 (IL-6) and interleukin-8 (IL-8) may i...

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    pub_type: 杂志文章


    authors: Schillace RV,Skinner AM,Pommier RF,O'Neill S,Muller PJ,Naik AM,Hansen JE,Pommier SJ

    更新日期:2014-09-30 00:00:00

  • Meta-analysis of quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesions.

    abstract:BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...

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    pub_type: 杂志文章,meta分析


    authors: Chen X,Li WL,Zhang YL,Wu Q,Guo YM,Bai ZL

    更新日期:2010-12-29 00:00:00

  • Projecting productivity losses for cancer-related mortality 2011 - 2030.

    abstract:BACKGROUND:When individuals stop working due to cancer this represents a loss to society - the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from all adult cancers and from the 20 highest mortality adult cancers in Ireland in 2011, and project the...

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    authors: Pearce A,Bradley C,Hanly P,O'Neill C,Thomas AA,Molcho M,Sharp L

    更新日期:2016-10-18 00:00:00

  • Replicase-based plasmid DNA shows anti-tumor activity.

    abstract:BACKGROUND:Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsR...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Rodriguez BL,Yu Z,Chung WG,Weiss R,Cui Z

    更新日期:2011-03-28 00:00:00

  • Correction to: Relationship between tumor biomarkers and efficacy in MARIANNE, a phase III study of trastuzumab emtansine ± pertuzumab versus trastuzumab plus taxane in HER2-positive advanced breast cancer.

    abstract::Following publication of the original article [1], the authors reported the following errors in the article. ...

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    pub_type: 杂志文章,已发布勘误


    authors: Perez EA,de Haas SL,Eiermann W,Barrios CH,Toi M,Im YH,Conte PF,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Stanzel S,Patre M,Ellis PA

    更新日期:2019-06-24 00:00:00

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    abstract:BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cleary CM,White KM,Young RM,Hawkes AL,Leske S,Starfelt LC,Wihardjo K

    更新日期:2014-03-07 00:00:00

  • Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis.

    abstract:BACKGROUND:cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and pro...

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    authors: Figueiredo JC,Knight JA,Cho S,Savas S,Onay UV,Briollais L,Goodwin PJ,McLaughlin JR,Andrulis IL,Ozcelik H

    更新日期:2007-06-14 00:00:00

  • A case-control study of occupation/industry and renal cell carcinoma risk.

    abstract:BACKGROUND:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). METHODS:Between 2002 and 2007, a population-based case-contro...

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    authors: Karami S,Colt JS,Schwartz K,Davis FG,Ruterbusch JJ,Munuo SS,Wacholder S,Stewart PA,Graubard BI,Rothman N,Chow WH,Purdue MP

    更新日期:2012-08-08 00:00:00

  • Precision medicine approaches to lung adenocarcinoma with concomitant MET and HER2 amplification.

    abstract:BACKGROUND:Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine strategy that integrates genomic profiling and preclinical drug-screening platforms, in order to persona...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Oh DY,Jung K,Song JY,Kim S,Shin S,Kwon YJ,Oh E,Park WY,Song SY,Choi YL

    更新日期:2017-08-10 00:00:00

  • Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-κB/slug/E-cadherin pathway.

    abstract:BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Zhou P,Wang C,Hu Z,Chen W,Qi W,Li A

    更新日期:2017-12-04 00:00:00

  • Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma.

    abstract:BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Korja M,Jokilammi A,Salmi TT,Kalimo H,Pelliniemi TT,Isola J,Rantala I,Haapasalo H,Finne J

    更新日期:2009-02-17 00:00:00

  • Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses.

    abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the p...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Yang Y,Im SA,Keam B,Lee KH,Kim TY,Suh KJ,Ryu HS,Moon HG,Han SW,Oh DY,Han W,Kim TY,Park IA,Noh DY

    更新日期:2016-07-21 00:00:00

  • Ruxolitinib in GvHD (RIG) study: a multicenter, randomized phase 2 trial to determine the response rate of Ruxolitinib and best available treatment (BAT) versus BAT in steroid-refractory acute graft-versus-host disease (aGvHD) (NCT02396628).

    abstract:BACKGROUND:Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and JAK2 are critical for inflamm...

    journal_title:BMC cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: von Bubnoff N,Ihorst G,Grishina O,Röthling N,Bertz H,Duyster J,Finke J,Zeiser R

    更新日期:2018-11-19 00:00:00

  • Confocal microscopy of unfixed breast needle core biopsies: a comparison to fixed and stained sections.

    abstract:BACKGROUND:Needle core biopsy, often in conjunction with ultrasonic or stereotactic guided techniques, is frequently used to diagnose breast carcinoma in women. Confocal scanning laser microscopy (CSLM) is a technology that provides real-time digital images of tissues with cellular resolution. This paper reports the pr...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Schiffhauer LM,Boger JN,Bonfiglio TA,Zavislan JM,Zuley M,Fox CA

    更新日期:2009-08-03 00:00:00

  • An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1.

    abstract:BACKGROUND:Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate processes such as replication, transcription, DNA repair and maintenance of epigeneti...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Patel M,Patel D,Datta S,Singh U

    更新日期:2020-10-20 00:00:00

  • Clinical significance of peripheral blood and tumor tissue lymphocyte subsets in cervical cancer patients.

    abstract:BACKGROUND:Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluate...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Wu Y,Ye S,Goswami S,Pei X,Xiang L,Zhang X,Yang H

    更新日期:2020-03-04 00:00:00

  • Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma.

    abstract:BACKGROUND:The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablating metastatic lesions and may play a synergistic role with immunotherapy. The purpose of this study ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Bahig H,Aubin F,Stagg J,Gologan O,Ballivy O,Bissada E,Nguyen-Tan FP,Soulières D,Guertin L,Filion E,Christopoulos A,Lambert L,Tehfe M,Ayad T,Charpentier D,Jamal R,Wong P

    更新日期:2019-01-14 00:00:00

  • The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies.

    abstract:BACKGROUND:The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K ...

    journal_title:BMC cancer

    pub_type: 历史文章,杂志文章,评审


    authors: Krone B,Kölmel KF,Grange JM

    更新日期:2014-08-16 00:00:00

  • The role of major duct excision and microdochectomy in the detection of breast carcinoma.

    abstract:BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

    更新日期:2006-06-23 00:00:00

  • A microRNA molecular modeling extension for prediction of colorectal cancer treatment.

    abstract:BACKGROUND:Several studies show that the regulatory impact of microRNAs (miRNAs) is an essential contribution to the pathogenesis of colorectal cancer (CRC). The expression levels of diverse miRNAs are associated with specific clinical diagnoses and prognoses of CRC. However, this association reveals very little action...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Li J,Mansmann UR

    更新日期:2015-06-18 00:00:00

  • Cancer incidence and mortality in Serbia 1999-2009.

    abstract:BACKGROUND:Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are a...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Mihajlović J,Pechlivanoglou P,Miladinov-Mikov M,Zivković S,Postma MJ

    更新日期:2013-01-15 00:00:00

  • Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies.

    abstract:BACKGROUND:The development of non-small cell lung carcinoma proceeds through a series of well-defined pathological steps before the appearance of invasive lung carcinoma. The molecular changes that correspond with pathology changes are not well defined and identification of the molecular events may provide clues on the...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Tichelaar JW,Zhang Y,leRiche JC,Biddinger PW,Lam S,Anderson MW

    更新日期:2005-12-06 00:00:00