当前位置： SCI文献检索 > BMC CANCER期刊下所有文献 > Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis.

Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis.

Abstract：

BACKGROUND:Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic review and meta-analysis of the prevalence of HPV infection in head and neck cancers, focusing on data for European populations. METHODS:MEDLINE, Embase and grey literature sources were systematically searched for primary studies that were published in English between July 2002 and July 2012, and which reported on the prevalence of HPV infection in head and neck cancers in European populations. Studies on non-European populations, those not published in English, and those assessing patients co-infected with human immunodeficiency virus were excluded. Eligible studies were combined in a meta-analysis. In addition, the potential statistical association between the head and neck cancers and certain HPV types was investigated. RESULTS:Thirty-nine publications met the inclusion criteria. The prevalence of HPV of any type in 3,649 patients with head and neck cancers was 40.0% (95% confidence interval, 34.6% to 45.5%), and was highest in tonsillar cancer (66.4%) and lowest in pharyngeal (15.3%) and tongue (25.7%) cancers. There were no statistically significant associations between the HPV types analysed and the geographical setting, type of sample analysed or type of primer used to analyse samples in head and neck cancers. CONCLUSIONS:The prevalence of HPV infection in European patients with head and neck cancers is high but varies between the different anatomical sites of these malignancies. There appears to be no association between HPV type and geographical setting, type of samples analysed or type of primer used to analyse samples in such cancers.

journal_name

BMC Cancer

journal_title

BMC cancer

authors

Abogunrin S,Di Tanna GL,Keeping S,Carroll S,Iheanacho I

doi

10.1186/1471-2407-14-968

subject

Has Abstract

pub_date

2014-12-17 00:00:00

pages

968

issn

1471-2407

pii

1471-2407-14-968

journal_volume

pub_type

杂志文章,meta分析,评审

在线工具

Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis.