Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma.

abstract：BACKGROUND:Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were...

journal_title：BMC cancer

authors： Mizoo T,Taira N,Nishiyama K,Nogami T,Iwamoto T,Motoki T,Shien T,Matsuoka J,Doihara H,Ishihara S,Kawai H,Kawasaki K,Ishibe Y,Ogasawara Y,Komoike Y,Miyoshi S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin ...

journal_title：BMC cancer

authors： Bifulco G,Mandato VD,Piccoli R,Giampaolino P,Mignogna C,Mignogna MD,Costagliola L,Nappi C

更新日期：2010-06-23 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...

journal_title：BMC cancer

authors： Call J,Walentas CD,Eickhoff JC,Scherzer N

更新日期：2012-03-19 00:00:00

abstract：BACKGROUND:TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling. METHODS:To test the importance of TGFβ signaling to...

journal_title：BMC cancer

authors： Simms NA,Rajput A,Sharratt EA,Ongchin M,Teggart CA,Wang J,Brattain MG

更新日期：2012-06-06 00:00:00

abstract：BACKGROUND:There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer. METHODS:We sought to inves...

journal_title：BMC cancer

authors： James FR,Jiminez-Linan M,Alsop J,Mack M,Song H,Brenton JD,Pharoah PDP,Ali HR

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. METHODS:The clinicopatholo...

journal_title：BMC cancer

authors： An YZ,Cho E,Ling J,Zhang X

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:pressurized intraperitoneal aerosol chemotherapy (PIPAC), with or without electrostatic precipitation (ePIPAC), was recently introduced in the treatment of peritoneal metastases (PM) from ovarian cancer (OC). Preliminary clinical data are promising, but several methodological issues as well the anticancer ef...

journal_title：BMC cancer

authors： Van de Sande L,Willaert W,Cosyns S,De Clercq K,Shariati M,Remaut K,Ceelen W

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsR...

journal_title：BMC cancer

authors： Rodriguez BL,Yu Z,Chung WG,Weiss R,Cui Z

更新日期：2011-03-28 00:00:00

abstract：BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...

journal_title：BMC cancer

authors： Havre PA,Dang LH,Ohnuma K,Iwata S,Morimoto C,Dang NH

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). METHODS:All eligible studies were found by searching PubMed, Web of Science and EMBASE, and survival resu...

journal_title：BMC cancer

authors： Chen YL,Liu XL,Li L

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progression of hormone-naïve, organ-confined tumors. In localized prostate c...

journal_title：BMC cancer

authors： Hsiao JJ,Ng BH,Smits MM,Wang J,Jasavala RJ,Martinez HD,Lee J,Alston JJ,Misonou H,Trimmer JS,Wright ME

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...

journal_title：BMC cancer

authors： Rief H,Omlor G,Akbar M,Welzel T,Bruckner T,Rieken S,Haefner MF,Schlampp I,Gioules A,Habermehl D,von Nettelbladt F,Debus J

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...

journal_title：BMC cancer

authors： Orsetti B,Selves J,Bascoul-Mollevi C,Lasorsa L,Gordien K,Bibeau F,Massemin B,Paraf F,Soubeyran I,Hostein I,Dapremont V,Guimbaud R,Cazaux C,Longy M,Theillet C

更新日期：2014-02-22 00:00:00

abstract：BACKGROUND:Cyclo-oxygenase-2 (COX-2), the key enzyme in the conversion of arachidonic acid to prostaglandins, is involved in critical steps of tumor onset and progression, and is a strong predictor of chemotherapy resistance and poor outcome in advanced ovarian cancer. To our knowledge, no data has been reported until ...

journal_title：BMC cancer

authors： Ferrandina G,Ranelletti FO,Martinelli E,Paglia A,Zannoni GF,Scambia G

更新日期：2006-07-11 00:00:00

abstract：BACKGROUND:The length of interval between successive childbirths (birth interval) might influence the incidence of breast cancer, either by stimulating or by inhibiting the factors that are responsible for the initiation of breast cancer or its early development. METHODS:This is a case-control study nested in a cohort...

journal_title：BMC cancer

authors： Katuwal S,Tapanainen JS,Pukkala E,Kauppila A

更新日期：2019-03-04 00:00:00

abstract：BACKGROUND:Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that independently arising neoplasms in an individual patient would exhibit measurable genomic variation, en...

journal_title：BMC cancer

authors： Shen C,Xu H,Liu L,Zhou Y,Chen D,Du H,Han Z,Che G

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...

journal_title：BMC cancer

authors： Ouyang M,Wang H,Ma J,Lü W,Li J,Yao C,Chang G,Bi J,Wang S,Wang W

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...

journal_title：BMC cancer

authors： Ai L,Mu S,Wang Y,Wang H,Cai L,Li W,Hu Y

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERC...

journal_title：BMC cancer

authors： Zhang E,Cui Z,Xu Z,Duan W,Huang S,Tan X,Yin Z,Sun C,Lu L

更新日期：2013-12-12 00:00:00

abstract：BACKGROUND:Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this moment, there are no specific treatment recommendations for patients with limited nodal recurrences a...

journal_title：BMC cancer

authors： De Bruycker A,Spiessens A,Dirix P,Koutsouvelis N,Semac I,Liefhooghe N,Gomez-Iturriaga A,Everaerts W,Otte F,Papachristofilou A,Scorsetti M,Shelan M,Siva S,Ameye F,Guckenberger M,Heikkilä R,Putora PM,Zapatero A,Conde-Mo

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...

journal_title：BMC cancer

authors： Rot S,Kaune T,Taubert H,Greither T,Kotrba J,Güttler A,Wichmann H,Bilkenroth U,Wienke A,Al-Nawas B,Bache M,Vordermark D,Wickenhauser C,Bethmann D,Eckert AW,Kappler M

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earl...

journal_title：BMC cancer

authors： Sullivan FM,Farmer E,Mair FS,Treweek S,Kendrick D,Jackson C,Robertson C,Briggs A,McCowan C,Bedford L,Young B,Vedhara K,Gallant S,Littleford R,Robertson J,Sewell H,Dorward A,Sarvesvaran J,Schembri S

更新日期：2017-03-11 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). The cardiotoxic effects of sorafenib and sunitinib may cause hypertension, left ventricular ejection fraction (LVEF) dysfunction and/or congestive heart failure (CHF), and arterial thrombo-em...

journal_title：BMC cancer

authors： Pantaleo MA,Mandrioli A,Saponara M,Nannini M,Erente G,Lolli C,Biasco G

更新日期：2012-06-11 00:00:00

abstract：BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...

journal_title：BMC cancer

authors： Jensen H,Tørring ML,Olesen F,Overgaard J,Fenger-Grøn M,Vedsted P

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeasures against IBD-associated neoplasia are crucial. The purpose of this study is to develop a new dia...

journal_title：BMC cancer

authors： Kinugasa H,Hiraoka S,Nouso K,Yamamoto S,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Takahara M,Harada K,Tanaka T,Okada H

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a subset of breast cancer with different biologic behaviour. We investigated the clinicopathologic charac...

journal_title：BMC cancer

authors： Rhee J,Han SW,Oh DY,Kim JH,Im SA,Han W,Park IA,Noh DY,Bang YJ,Kim TY

更新日期：2008-10-23 00:00:00

abstract：BACKGROUND:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS:We here investigated a represent...

journal_title：BMC cancer

authors： Deichmann M,Thome M,Benner A,Kirschner M,Hassanzadeh J,Kurzen H

更新日期：2005-06-03 00:00:00

abstract：BACKGROUND:BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in the breast cancer-associated chromosomal region 11q13. The EMSY gene encodes a BRCA2-interacting protein that has been implic...

journal_title：BMC cancer

authors： Määttä KM,Nurminen R,Kankuri-Tammilehto M,Kallioniemi A,Laasanen SL,Schleutker J

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. METHOD:Women diagnosed with en...

journal_title：BMC cancer

authors： Li P,Shan B,Jia K,Hu F,Xiao Y,Zheng J,Gao YT,Wang H,Gao Y

更新日期：2020-06-20 00:00:00

abstract：BACKGROUND:Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey. METHODS:A qualitative interview study with thematic analysis, conducted with 36 patients. RESULTS:There is no clear patte...

journal_title：BMC cancer

authors： Ng CWQ,Lim JNW,Liu J,Hartman M

更新日期：2020-11-10 00:00:00