Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis.

abstract：BACKGROUND:Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is supported by the short PR isofor...

journal_title：BMC cancer

authors： Rosati R,Oppat K,Huang Y,Kim S,Ratnam M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX). METHODS:Genomic DNA was isolated from who...

journal_title：BMC cancer

authors： Oh SY,Kwon HC,Kim SH,Lee S,Lee JH,Hwang JA,Hong SH,Graves CA,Camphausen K,Kim HJ,Lee YS

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...

journal_title：BMC cancer

authors： Jeong S,Lee K,Wen X,Kim Y,Cho NY,Jang JJ,Kang GH

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The sex hormone-binding globulin (SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of ...

journal_title：BMC cancer

authors： Garcia-Closas M,Brinton LA,Lissowska J,Richesson D,Sherman ME,Szeszenia-Dabrowska N,Peplonska B,Welch R,Yeager M,Zatonski W,Chanock SJ

更新日期：2007-04-05 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...

journal_title：BMC cancer

authors： Lichthardt S,Wagner J,Löb S,Matthes N,Kastner C,Anger F,Germer CT,Wiegering A

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were...

journal_title：BMC cancer

authors： Mizoo T,Taira N,Nishiyama K,Nogami T,Iwamoto T,Motoki T,Shien T,Matsuoka J,Doihara H,Ishihara S,Kawai H,Kawasaki K,Ishibe Y,Ogasawara Y,Komoike Y,Miyoshi S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival rates of only 50-60%. Neo-adjuvant and adjuvant chemotherapy (CTX) has been applied to achieve pre-...

journal_title：BMC cancer

authors： Schmitt T,Lehner B,Kasper B,Bischof M,Roeder F,Dietrich S,Dimitrakopoulou-Strauss A,Strauss LG,Mechtersheimer G,Wuchter P,Ho AD,Egerer G

更新日期：2011-12-07 00:00:00

abstract：BACKGROUND:The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. ...

journal_title：BMC cancer

authors： Martowicz A,Spizzo G,Gastl G,Untergasser G

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangiogenic polypeptide. Sustained enhanced expression of Vastatin was shown to inhibit tumour growth and ...

journal_title：BMC cancer

authors： Li Y,Li J,Woo YM,Shen Z,Yao H,Cai Y,Lin MC,Poon WS

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death and upregulation of 78-kDa glucose-regulated protein (GRP78). We hypothesized that chemotherapy induc...

journal_title：BMC cancer

authors： Raiter A,Lipovetzki J,Lubin I,Yerushalmi R

更新日期：2020-04-19 00:00:00

abstract：BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...

journal_title：BMC cancer

authors： Rief H,Omlor G,Akbar M,Welzel T,Bruckner T,Rieken S,Haefner MF,Schlampp I,Gioules A,Habermehl D,von Nettelbladt F,Debus J

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This stu...

journal_title：BMC cancer

authors： Zhu Q,Gong L,Wang J,Tu Q,Yao L,Zhang JR,Han XJ,Zhu SJ,Wang SM,Li YH,Zhang W

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...

journal_title：BMC cancer

authors： Ventrucci G,de Mello MA,Gomes-Marcondes MC

更新日期：2002-04-15 00:00:00

abstract：BACKGROUND:Evasion of immune surveillance and suppression of the immune system are important hallmarks of tumorigenesis. The goal of this study was to establish distinct patterns that reflect a rectal tumors' immune-phenotype and to determine their relation to patient outcome. METHODS:The study population consisted of...

journal_title：BMC cancer

authors： Reimers MS,Engels CC,Putter H,Morreau H,Liefers GJ,van de Velde CJ,Kuppen PJ

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...

journal_title：BMC cancer

authors： Borch KB,Braaten T,Lund E,Weiderpass E

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily ...

journal_title：BMC cancer

authors： Chu D,Wei L

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...

journal_title：BMC cancer

authors： Yu L,Wang H,Milijkovic D,Huang X,Jiang Q

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...

journal_title：BMC cancer

authors： Netland IA,Førde HE,Sleire L,Leiss L,Rahman MA,Skeie BS,Gjerde CH,Enger PØ,Goplen D

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Venous thromboembolic events (VTE) are common in cancer patients and associated with higher mortality. In vivo thrombosis and anticoagulation might be involved in tumor growth and progression. We studied the association of warfarin and other anticoagulant use as antithrombotic medication and prostate cancer ...

journal_title：BMC cancer

authors： Kinnunen PTT,Murtola TJ,Talala K,Taari K,Tammela TLJ,Auvinen A

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...

journal_title：BMC cancer

authors： Ordás J,Millán Y,Dios R,Reymundo C,de Las Mulas JM

更新日期：2007-09-20 00:00:00

abstract：BACKGROUND:In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and no evidence of its effectiveness in Japanese adult women in particular. This study aims to evaluate t...

journal_title：BMC cancer

authors： Kurokawa T,Yamamoto M,Onuma T,Tsuyoshi H,Shinagawa A,Chino Y,Yoshida Y

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is a benign lymphoid proliferation or malignant lymphoma in patients who have been treated with MTX. MTX withdrawal and observation for a short period should be considered in the initial management of patients who develop LPD while on MTX therapy...

journal_title：BMC cancer

authors： Watanabe S,Manabe O,Hirata K,Oyama-Manabe N,Hattori N,Kikuchi Y,Kobayashi K,Toyonaga T,Tamaki N

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...

journal_title：BMC cancer

authors： Osipov V,Ho KC,Krouwer HG,Meyer G,Shidham VB

更新日期：2002-12-03 00:00:00

abstract：BACKGROUND:Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to induce oncolytic cell death in a variety of cancer cells of diverse origins. However, whether oncolyti...

journal_title：BMC cancer

authors： Jiang K,Song C,Kong L,Hu L,Lin G,Ye T,Yao G,Wang Y,Chen H,Cheng W,Barr MP,Liu Q,Zhang G,Ding C,Meng S

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the preferred surgical approach worldwide. However, this procedure is associated with considerable morbidity. Several meta-analyses have shown an advantage in ...

journal_title：BMC cancer

authors： Haverkamp L,Brenkman HJ,Seesing MF,Gisbertz SS,van Berge Henegouwen MI,Luyer MD,Nieuwenhuijzen GA,Wijnhoven BP,van Lanschot JJ,de Steur WO,Hartgrink HH,Stoot JH,Hulsewé KW,Spillenaar Bilgen EJ,Rütter JE,Kouwenhoven EA,van

更新日期：2015-07-29 00:00:00

abstract：OBJECTIVE:Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this study was to explore the efficacy of crizotinib in advanced non-small-cell lung cancer (NSCLC) with c...

journal_title：BMC cancer

authors： Chen RL,Zhao J,Zhang XC,Lou NN,Chen HJ,Yang X,Su J,Xie Z,Zhou Q,Tu HY,Zhong WZ,Yan HH,Guo WB,Wu YL,Yang JJ

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

journal_title：BMC cancer

authors： Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Kv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multiforme (GBM) are lacking. METHODS:We analyzed the expression of Kv10.1 by immunohistochemistry in the...

journal_title：BMC cancer

authors： Martínez R,Stühmer W,Martin S,Schell J,Reichmann A,Rohde V,Pardo L

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...

journal_title：BMC cancer

authors： Falkenius J,Johansson H,Tuominen R,Frostvik Stolt M,Hansson J,Egyhazi Brage S

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for this population, and compare its performance to a widely used overseas model, the Nottingham Prognosti...

journal_title：BMC cancer

authors： Elwood JM,Tawfiq E,TinTin S,Marshall RJ,Phung TM,Campbell I,Harvey V,Lawrenson R

更新日期：2018-09-17 00:00:00