Abstract：
BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial responses were analyzed and compared with those of the survivors from other cancers. RESULTS:The melanoma survivors were 44.8 +/- 12.8 years of age at diagnosis (significantly younger than the survivors of other cancers) and 63.7 +/- 12.8 years at survey. Melanoma survivors were less likely to report that cancer had affected their health than survivors of other cancers (15.8% vs. 34.9%). The 577 individuals treated with surgery alone reported arthritis/osteoporosis, cataracts, and heart problems most frequently (less often than survivors of other cancers). The 391 individuals who had undergone combined treatments reported circulation problems and kidney problems generally as often as survivors of other cancers. Health problems were not associated with number of decades since diagnosis but with age at diagnosis, treatment modality, and family relationships. CONCLUSION:We present information from a large cohort of long-term survivors of melanoma. As a group, they were less likely to report that cancer had affected their overall health than survivors of other cancers; a number of disease related and psychosocial factors appear to influence their health profiles.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Stava C,Beck M,Weiss LT,Lopez A,Vassilopoulou-Sellin Rdoi
10.1186/1471-2407-6-95subject
Has Abstractpub_date
2006-04-18 00:00:00pages
95issn
1471-2407pii
1471-2407-6-95journal_volume
6pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-4
更新日期：2008-01-13 00:00:00
abstract：BACKGROUND:Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas. METHODS:Plasmids containing either MMP-2 siRNA or tissue inhibitor of metalloproteinase-2 (TIMP-2) cDNA were...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-182
更新日期：2008-06-30 00:00:00
abstract：BACKGROUND:Cancer has a lot of consequences on patients' quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients' partners and their relationship, such as distress and communication difficulties. These consequences are undertreated, and interventions based on hy...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-5046-6
更新日期：2018-11-15 00:00:00
abstract：BACKGROUND:Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone receptor statu...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-06756-x
更新日期：2020-04-07 00:00:00
abstract：BACKGROUND:Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on smoking sta...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-778
更新日期：2014-10-24 00:00:00
abstract：BACKGROUND:Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mortality. The Sept9 DNA-methylation assay is among the most well studied blood-based screening markers...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1832-6
更新日期：2015-10-29 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differen...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4639-4
更新日期：2018-07-20 00:00:00
abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-6-251
更新日期：2006-10-23 00:00:00
abstract：BACKGROUND:Angiogenesis is a proliferative process resulting in the development of new blood vessels from existing endothelial cells and is considered crucial for tumor growth and metastasis. Tumor angiogenesis can be quantified by microvascular density (MVD), which is evaluated in highly vascularized tumor areas (hot ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-72
更新日期：2014-02-07 00:00:00
abstract：BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1512-6
更新日期：2015-07-04 00:00:00
abstract：BACKGROUND:Primary treatment of carcinoma of the oro-/hypopharynx or larynx may consist of combined platinum-containing chemoradiotherapy. In order to improve clinical outcome (i.e. local control/overall survival), combined therapy is intensified by the addition of the EGFR inhibitor cetuximab (Erbitux®). Radiation the...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2407-10-651
更新日期：2010-11-26 00:00:00
abstract：BACKGROUND:Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Th...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07344-9
更新日期：2020-09-07 00:00:00
abstract：BACKGROUND:To determine the safety and efficacy of transarterial chemoembolization (TACE) combined with radiofrequency ablation (hereafter, TACE-RFA) in treating Barcelona Clinic Liver Cancer (BCLC) Stage A or B (hereafter, BCLC A/B) hepatocellular carcinoma (HCC) patients, and to explore the range of tumor sizes suita...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6237-5
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostat...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6391-9
更新日期：2019-12-03 00:00:00
abstract：BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-365
更新日期：2008-12-11 00:00:00
abstract：BACKGROUND:There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be explained by racial/ethnic differences in long-term adherence to adjuvant endocrine therapy (AET). ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-5121-z
更新日期：2018-12-04 00:00:00
abstract：BACKGROUND:The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-501
更新日期：2012-10-30 00:00:00
abstract：BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-121
更新日期：2014-02-22 00:00:00
abstract：BACKGROUND:Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic activity across human cancers, including breast cancer. METHODS:To clarify this dichotomous role in bre...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5839-2
更新日期：2019-06-28 00:00:00
abstract：BACKGROUND:There is no biological or epidemiological data on the association between NOS3 promoter polymorphisms and prostate cancer. The polymorphisms in the promoter region of NOS3 gene may be responsible for variations in the plasma NO, which may promote cancer progression by providing a selective growth advantage t...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-273
更新日期：2008-09-29 00:00:00
abstract：BACKGROUND:Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with clinically different phenotypes. However, such data is still rare for important patient subgroups, s...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1471-2407-7-89
更新日期：2007-05-25 00:00:00
abstract：BACKGROUND:Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of smoking on breast cancer characteristics is limited. We evaluated the impact of smoking on breast ca...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3611-z
更新日期：2017-09-06 00:00:00
abstract：BACKGROUND:Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluated a well-established hepatic tumor cell line, HepG2, and an adul...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-402
更新日期：2012-09-10 00:00:00
abstract：BACKGROUND:Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma (PMBCL). However, their CNA-based profile and clinical impact still remain unc...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07293-3
更新日期：2020-08-27 00:00:00
abstract：BACKGROUND:Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-218
更新日期：2012-06-06 00:00:00
abstract：BACKGROUND:The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, particularly in Asian melanoma. METHODS:We retrospectively reviewed 49 melanoma patients undergoing...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07508-7
更新日期：2020-10-21 00:00:00
abstract：BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1151-y
更新日期：2015-03-15 00:00:00
abstract：BACKGROUND:Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus. In our previous studies, we have shown that TTC9A was a hormonally-regulated gene in breast cancer cells. In this study, we found that TTC9A was over-ex...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-231
更新日期：2008-08-12 00:00:00
abstract：BACKGROUND:The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic th...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1648-4
更新日期：2015-09-22 00:00:00
abstract：BACKGROUND:Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major ro...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-4
更新日期：2013-01-03 00:00:00
