Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis.

abstract：BACKGROUNDS:Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows phenotypic changes (population changes) upon differentiation of CSC during culture and can be used for s...

journal_title：BMC cancer

authors： Yamada T,Abei M,Danjoh I,Shirota R,Yamashita T,Hyodo I,Nakamura Y

更新日期：2015-04-11 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist...

journal_title：BMC cancer

authors： Huang J,Zhang YL,Teng XM,Lin Y,Zheng DL,Yang PY,Han ZG

更新日期：2007-07-12 00:00:00

abstract：BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...

journal_title：BMC cancer

authors： Zhou P,Wang C,Hu Z,Chen W,Qi W,Li A

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling. METHODS:To test the importance of TGFβ signaling to...

journal_title：BMC cancer

authors： Simms NA,Rajput A,Sharratt EA,Ongchin M,Teggart CA,Wang J,Brattain MG

更新日期：2012-06-06 00:00:00

abstract：BACKGROUND:Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown. METHODS:The differential expression of lncRNAs in gastric cancer and paired non-cancerous tissues were identified by microarray and valida...

journal_title：BMC cancer

authors： Han Y,Ye J,Wu D,Wu P,Chen Z,Chen J,Gao S,Huang J

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Abnormal glucose and lipids levels may impact survival after breast cancer (BC) diagnosis, but their association to other causes of mortality such as cardiovascular (CV) disease may result in a competing risk problem. METHODS:We assessed serum glucose, triglycerides (TG) and total cholesterol (TC) measured ...

journal_title：BMC cancer

authors： Wulaningsih W,Vahdaninia M,Rowley M,Holmberg L,Garmo H,Malmstrom H,Lambe M,Hammar N,Walldius G,Jungner I,Coolen AC,Van Hemelrijck M

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors, notably ASF/SF2. The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in ...

journal_title：BMC cancer

authors： Boukakis G,Patrinou-Georgoula M,Lekarakou M,Valavanis C,Guialis A

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:The bone scan index (BSI) using a computer-aided diagnosis system for bone scans is expected to be an objective and quantitative clinical tool for evaluating bone metastatic prostate cancer. This study aimed to evaluate the pretreatment BSI as a prognostic factor in hormone-naive prostate cancer patients wit...

journal_title：BMC cancer

authors： Miyoshi Y,Yoneyama S,Kawahara T,Hattori Y,Teranishi J,Kondo K,Moriyama M,Takebayashi S,Yokomizo Y,Yao M,Uemura H,Noguchi K

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:High-risk Human Papillomavirus (HPV) testing is replacing cytology in cervical cancer screening as it is more sensitive for preinvasive cervical lesions. However, the bottleneck of HPV testing is the many false positive test results (positive tests without cervical lesions). Here, we evaluated to what extent...

journal_title：BMC cancer

authors： Preisler S,Rebolj M,Ejegod DM,Lynge E,Rygaard C,Bonde J

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...

journal_title：BMC cancer

authors： Young JM,Walsh J,Butow PN,Solomon MJ,Shaw J

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC. METHODS:We employed 2 human ESCC cell lines, Eca109 and TE-1, as the model system. The effect of miR-203 and ΔNp63 on cell proliferati...

journal_title：BMC cancer

authors： Yuan Y,Zeng ZY,Liu XH,Gong DJ,Tao J,Cheng HZ,Huang SD

更新日期：2011-02-07 00:00:00

abstract：BACKGROUND:A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and novel therap...

journal_title：BMC cancer

authors： Choi J,Topouza DG,Tarnouskaya A,Nesdoly S,Koti M,Duan QL

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERC...

journal_title：BMC cancer

authors： Zhang E,Cui Z,Xu Z,Duan W,Huang S,Tan X,Yin Z,Sun C,Lu L

更新日期：2013-12-12 00:00:00

abstract：BACKGROUND:Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer. METHODS:Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review...

journal_title：BMC cancer

authors： Mazzone PJ,Rai H,Beukemann M,Xu M,Jain A,Sasidhar M

更新日期：2012-09-14 00:00:00

abstract：BACKGROUND:There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escalation trea...

journal_title：BMC cancer

authors： Nopmaneepaisarn T,Tangjaturonrasme N,Rawangban W,Vinayanuwattikun C,Keelawat S,Bychkov A

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancer...

journal_title：BMC cancer

authors： Naguib A,Cooke JC,Happerfield L,Kerr L,Gay LJ,Luben RN,Ball RY,Mitrou PN,McTaggart A,Arends MJ

更新日期：2011-04-07 00:00:00

abstract：BACKGROUND:Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinoma and poorly differentiated, less treatable non-adenocarcinoma including small cell carcinoma, and t...

journal_title：BMC cancer

authors： Kanan AD,Corey E,Vêncio RZN,Ishwar A,Liu AY

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...

journal_title：BMC cancer

authors： Kim J,Roh M,Abdulkadir SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and...

journal_title：BMC cancer

authors： Olsson Möller U,Rydén L,Malmström M

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear. METHODS:We investigated the biological and clinical significance of the presence of KIT exon 10 variant (c.1621 A > C), KIT (L541), in a transfected cell lin...

journal_title：BMC cancer

authors： Brahmi M,Alberti L,Dufresne A,Ray-Coquard I,Cassier P,Meeus P,Decouvelaere AV,Ranchère-Vince D,Blay JY

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. Here we followed-up on our previous observation that inhibition of ...

journal_title：BMC cancer

authors： Hackl C,Lang SA,Moser C,Mori A,Fichtner-Feigl S,Hellerbrand C,Dietmeier W,Schlitt HJ,Geissler EK,Stoeltzing O

更新日期：2010-12-03 00:00:00

abstract：BACKGROUND:During the last two decades the use of laparoscopic resection and a multimodal approach known as an enhanced recovery programme, have been major changes in colorectal perioperative care. Clinical outcome improves using laparoscopic surgery to resect colorectal cancer but until recently no multicentre trial e...

journal_title：BMC cancer

authors： Kennedy RH,Francis A,Dutton S,Love S,Pearson S,Blazeby JM,Quirke P,Franks PJ,Kerr DJ

更新日期：2012-05-16 00:00:00

abstract：BACKGROUND:The fecal immunochemical test (FIT) is easier to use and more sensitive than the guaiac fecal occult blood test, but it is unclear how to optimize FIT performance. We compared the sensitivity and specificity for detecting advanced colorectal neoplasia between single-sample (1-FIT) and two-sample (2-FIT) FIT ...

journal_title：BMC cancer

authors： Liles EG,Perrin N,Rosales AG,Smith DH,Feldstein AC,Mosen DM,Levin TR

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:It is well known that estrogen receptor α (ERα) participates in the pathogenic progress of breast cancer, hepatocellular carcinoma and head and neck squamous cell carcinoma. In neuroblastoma cells and related cancer clinical specimens, moreover, the ectopic expression of ERα has been identified. However, the...

journal_title：BMC cancer

authors： Cao P,Feng F,Dong G,Yu C,Feng S,Song E,Shi G,Liang Y,Liang G

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) shows a 5-year survival rate below 10%, demonstrating the urgency in improving its treatment. Alterations in epidermal growth factor receptors are closely related to malignancy transformation in a number of tumors and recent successful targeted therapies have been di...

journal_title：BMC cancer

authors： Gonzaga IM,Soares-Lima SC,de Santos PT,Blanco TC,de Reis BS,Quintella DC,de Oliveira IM,de Faria PA,Kruel CD,Andreollo NA,de Simão TA,Pinto LF

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:For most patients, pancreatic adenocarcinoma responds poorly to treatment, and novel therapeutic approaches are needed. Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of the apoptosis antagonist SMAC (second mitochondria-derived activator of caspases), exerts synergisti...

journal_title：BMC cancer

authors： Niu J,Wang X,Qu J,Mager DE,Straubinger RM

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangemen...

journal_title：BMC cancer

authors： Wang L,Sun Y,Sun Y,Meng L,Xu X

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients. METHODS:In total, 90 participants including 60 PTC patients (15 males and 45 fe...

journal_title：BMC cancer

authors： Zarkesh M,Zadeh-Vakili A,Akbarzadeh M,Fanaei SA,Hedayati M,Azizi F

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection (RET), inducing anti-angiogenic and pro-apoptotic actions in a wide range of solid tumors. A side e...

journal_title：BMC cancer

authors： Schneider TC,Kapiteijn E,van Wezel T,Smit JWA,van der Hoeven JJM,Morreau H

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 protein overexpression, a second line gene amplification test is generally deemed necessary for cases ...

journal_title：BMC cancer

authors： Moelans CB,de Weger RA,Ezendam C,van Diest PJ

更新日期：2009-01-05 00:00:00