miR-23b and miR-27b are oncogenic microRNAs in breast cancer: evidence from a CRISPR/Cas9 deletion study.

abstract：BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...

journal_title：BMC cancer

authors： Elkiran ET,Mar N,Aygen B,Gursu F,Karaoglu A,Koca S

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:The incidence and survival rates for colorectal cancer in Australia are among the highest in the world. With population growth and ageing there are increasing numbers of colorectal cancer survivors in the community, yet little is known of their ongoing follow up and survivorship care experiences. This study ...

journal_title：BMC cancer

authors： Young JM,Durcinoska I,DeLoyde K,Solomon MJ

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast cancer to achieve a better prognosis for individuals suffering from breast cancer. MicroRNAs (miRNAs) h...

journal_title：BMC cancer

authors： Xia L,Li F,Qiu J,Feng Z,Xu Z,Chen Z,Sun J

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. METHODS:The clinicopatholo...

journal_title：BMC cancer

authors： An YZ,Cho E,Ling J,Zhang X

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:This study was performed to design a predictive tool that allows the estimation of overall survival (OS) of elderly myeloma patients (aged ≥ 65 years) presenting with myeloma-induced spinal cord compression (SCC). METHODS:One-hundred-and-sixteen patients irradiated for motor deficits of the legs due to myel...

journal_title：BMC cancer

authors： Rades D,Conde-Moreno AJ,Cacicedo J,Veninga T,Gebauer N,Bartscht T,Schild SE

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...

journal_title：BMC cancer

authors： Khaddour K,Singh V,Shayuk M

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...

journal_title：BMC cancer

authors： Bissey PA,Teng M,Law JH,Shi W,Bruce JP,Petit V,Tsao SW,Yip KW,Liu FF

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In this study, which examined the value of serum TRAP concentrations as ...

journal_title：BMC cancer

authors： Honig A,Rieger L,Kapp M,Krockenberger M,Eck M,Dietl J,Kämmerer U

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...

journal_title：BMC cancer

authors： Korja M,Jokilammi A,Salmi TT,Kalimo H,Pelliniemi TT,Isola J,Rantala I,Haapasalo H,Finne J

更新日期：2009-02-17 00:00:00

abstract：BACKGROUND:Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection (RET), inducing anti-angiogenic and pro-apoptotic actions in a wide range of solid tumors. A side e...

journal_title：BMC cancer

authors： Schneider TC,Kapiteijn E,van Wezel T,Smit JWA,van der Hoeven JJM,Morreau H

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:The increasing number of individuals living with cancer has led to a focus on the quality of life of survivors, and their families. Sexual wellbeing is a central component of quality of life, with a growing body of research demonstrating the association between cancer and changes to sexuality and intimacy. H...

journal_title：BMC cancer

authors： Perz J,Ussher JM,Gilbert E

更新日期：2013-05-31 00:00:00

abstract：BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...

journal_title：BMC cancer

authors： Cong J,Gong J,Yang C,Xia Z,Zhang H

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...

journal_title：BMC cancer

authors： Wang L,Wang R,Pan Y,Sun Y,Zhang J,Chen H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Fos-related antigen 1 (FRA-1) is an immediate early gene encoding a member of AP-1 family of transcription factors involved in cell proliferation, differentiation, apoptosis, and other biological processes. fra-1 gene overexpression has an important role in the process of cellular transformation, and our pre...

journal_title：BMC cancer

authors： Chiappetta G,Ferraro A,Botti G,Monaco M,Pasquinelli R,Vuttariello E,Arnaldi L,Di Bonito M,D'Aiuto G,Pierantoni GM,Fusco A

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS:This multicenter, randomized phase III trial com...

journal_title：BMC cancer

authors： Rochlitz C,Bigler M,von Moos R,Bernhard J,Matter-Walstra K,Wicki A,Zaman K,Anchisi S,Küng M,Na KJ,Bärtschi D,Borner M,Rordorf T,Rauch D,Müller A,Ruhstaller T,Vetter M,Trojan A,Hasler-Strub U,Cathomas R,Winterhalde

更新日期：2016-10-10 00:00:00

abstract：BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

journal_title：BMC cancer

authors： Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...

journal_title：BMC cancer

authors： Klenke S,Akdeli N,Stelmach P,Heukamp L,Schulte JH,Bachmann HS

更新日期：2019-03-18 00:00:00

abstract：:Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published. ...

journal_title：BMC cancer

authors： Doma V,Kárpáti S,Rásó E,Barbai T,Tímár J

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...

journal_title：BMC cancer

authors： Kelly-Morland C,Rudman S,Nathan P,Mallett S,Montana G,Cook G,Goh V

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escalation trea...

journal_title：BMC cancer

authors： Nopmaneepaisarn T,Tangjaturonrasme N,Rawangban W,Vinayanuwattikun C,Keelawat S,Bychkov A

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:Primary treatment of carcinoma of the oro-/hypopharynx or larynx may consist of combined platinum-containing chemoradiotherapy. In order to improve clinical outcome (i.e. local control/overall survival), combined therapy is intensified by the addition of the EGFR inhibitor cetuximab (Erbitux®). Radiation the...

journal_title：BMC cancer

authors： Habl G,Jensen AD,Potthoff K,Uhl M,Hof H,Hajda J,Simon C,Debus J,Krempien R,Münter MW

更新日期：2010-11-26 00:00:00

abstract：BACKGROUND:The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these b...

journal_title：BMC cancer

authors： Rud AK,Lund-Iversen M,Berge G,Brustugun OT,Solberg SK,Mælandsmo GM,Boye K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism o...

journal_title：BMC cancer

authors： Kong X,Xu P,Cai WJ,Wang HG,Li BB,Huang GL,He ZW,Chen G,Ye CG

更新日期：2018-04-13 00:00:00

abstract：BACKGROUND:Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that...

journal_title：BMC cancer

authors： Hayashi T,Yamashita T,Terashima T,Suda T,Okada H,Asahina Y,Hayashi T,Hara Y,Nio K,Sunagozaka H,Takatori H,Arai K,Sakai Y,Yamashita T,Mizukoshi E,Honda M,Kaneko S

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast cancer. The current study evaluated the prognostic impact of TOP2A protein on luminal breast cancer....

journal_title：BMC cancer

authors： An X,Xu F,Luo R,Zheng Q,Lu J,Yang Y,Qin T,Yuan Z,Shi Y,Jiang W,Wang S

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been reported to promote tumorigenesis and progression in several human malignancies. The purpose of this study was to explore the function of BDNF in lung squamous cell carcinoma (SCC) and adenocarcinoma (ADC). METHODS:The expression of BDNF was examined in 110 ...

journal_title：BMC cancer

authors： Zhang SY,Hui LP,Li CY,Gao J,Cui ZS,Qiu XS

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of ...

journal_title：BMC cancer

authors： Folyovich A,Varga V,Várallyay G,Kozák L,Bakos M,Scheidl E,Béres-Molnár KA,Kajdácsi Z,Bereczki D

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is supported by the short PR isofor...

journal_title：BMC cancer

authors： Rosati R,Oppat K,Huang Y,Kim S,Ratnam M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy. METHODS:A total of 124 patients with rectal cancer treated with neoadjuvant chemoradiotherapy and consecutive surge...

journal_title：BMC cancer

authors： Trotsyuk I,Sparschuh H,Müller AJ,Neumann K,Kruschewski M,Horst D,Elezkurtaj S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, is linked to hereditary nonpolyposis colorectal cancer (HNPCC). Because not all MLH1 alterations result in loss of MMR function, accurate characterization of variants and their classification in terms of their effect on M...

journal_title：BMC cancer

authors： Vogelsang M,Comino A,Zupanec N,Hudler P,Komel R

更新日期：2009-10-28 00:00:00