Identification of recurrence marker associated with immune infiltration in prostate cancer with radical resection and build prognostic nomogram.

Abstract:

BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostate cancer. METHODS:Prostate cancer RNA-seq data and clinical information were downloaded from the TCGA database and GEO database. The infiltration of 24 immune cells in tissues was quantified by ssGSEA. Univariate Cox regression analysis was used to screen for immune cell types associated with tumor recurrence, weighted gene co-expression network analysis (WGCNA) and LASSO were used to identify hub genes which regulate prognosis in patients through immune infiltration. Then, the nomogram was constructed based on the hub gene to predict the recurrence of prostate cancer, and the decision curve analysis (DCA) was used to compare the accuracy with the PSA and Gleason prediction models. RESULT:Analysis showed that Th2 cells and Tcm related to prostate cancer recurrence after radical prostatectomy, and they are independent protective factors for recurrence. Through WGCNA and Lasso, we identified that NDUFA13, UQCR11, and USP34 involved in the infiltration of Th2 cells and Tcm in tumor tissues, and the expression of genes is related to the recurrence of patients. Based on the above findings, we constructed a clinical prediction model and mapped a nomogram, which has better sensitivity and specificity for prostate cancer recurrence prediction, and performed better in comparison with PSA and Gleason's predictions. CONCLUSION:The immune cells Th2 cells and Tcm are associated with recurrence of PCa. Moreover, the genes NDUFA13, UQCR11, and USP34 may affect the recurrence of PCa by affecting the infiltration of Th2 cells and Tcm. Moreover, nomogram can make prediction effectively.

journal_name

BMC Cancer

journal_title

BMC cancer

authors

Rui X,Shao S,Wang L,Leng J

doi

10.1186/s12885-019-6391-9

subject

Has Abstract

pub_date

2019-12-03 00:00:00

pages

1179

issue

1

issn

1471-2407

pii

10.1186/s12885-019-6391-9

journal_volume

19

pub_type

杂志文章
  • LEIGC long non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition.

    abstract:BACKGROUND:Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown. METHODS:The differential expression of lncRNAs in gastric cancer and paired non-cancerous tissues were identified by microarray and valida...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-14-932

    authors: Han Y,Ye J,Wu D,Wu P,Chen Z,Chen J,Gao S,Huang J

    更新日期:2014-12-11 00:00:00

  • COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer.

    abstract:BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-015-1151-y

    authors: Ouyang M,Wang H,Ma J,Lü W,Li J,Yao C,Chang G,Bi J,Wang S,Wang W

    更新日期:2015-03-15 00:00:00

  • Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis.

    abstract:BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-12-597

    authors: Serce NB,Boesl A,Klaman I,von Serényi S,Noetzel E,Press MF,Dimmler A,Hartmann A,Sehouli J,Knuechel R,Beckmann MW,Fasching PA,Dahl E

    更新日期:2012-12-13 00:00:00

  • Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer.

    abstract:BACKGROUND:A disintegrin and metalloprotease 8 (ADAM8) has been reported to be associated with various malignancies. However, no studies have examined ADAM8 association in colorectal cancer (CRC). The aim of this study was to investigate the expression and function of ADAM8 in CRC. METHODS:Expression level of ADAM8 in...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-14-568

    authors: Yang Z,Bai Y,Huo L,Chen H,Huang J,Li J,Fan X,Yang Z,Wang L,Wang J

    更新日期:2014-08-07 00:00:00

  • Study design: two long-term observational studies of the biosimilar filgrastim Nivestim™ (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia.

    abstract:BACKGROUND:Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 and 3 clinical trials where its efficacy and safety was found to be similar to its reference product...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-13-547

    authors: Kamioner D,Fruehauf S,Maloisel F,Cals L,Lepretre S,Berthou C

    更新日期:2013-11-16 00:00:00

  • Cancer incidence in Arkhangelskaja Oblast in northwestern Russia. The Arkhangelsk Cancer Registry.

    abstract:BACKGROUND:Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Europe. The oncological hospital in Arkhangelsk, in co-operation with Universitetet i Tromsø (Norway),...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-5-82

    authors: Vaktskjold A,Lebedintseva JA,Korotov DS,Tkatsjov AV,Podjakova TS,Lund E

    更新日期:2005-07-19 00:00:00

  • ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly.

    abstract:BACKGROUND:ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS:We used cell death assays, size exclusion chromatography, Co-Immunoprecipitation, shRNA lentivectors and glioma neural stem cells ...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-015-1388-5

    authors: Selmi T,Alecci C,dell' Aquila M,Montorsi L,Martello A,Guizzetti F,Volpi N,Parenti S,Ferrari S,Salomoni P,Grande A,Zanocco-Marani T

    更新日期:2015-05-06 00:00:00

  • Association between the Cytotoxic T-lymphocyte antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis.

    abstract:BACKGROUND:As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer ri...

    journal_title:BMC cancer

    pub_type: 杂志文章,meta分析

    doi:10.1186/1471-2407-10-522

    authors: Zheng J,Yu X,Jiang L,Xiao M,Bai B,Lu J,Zhou Y

    更新日期:2010-10-04 00:00:00

  • Investigating the performance and cost-effectiveness of the simple ultrasound-based rules compared to the risk of malignancy index in the diagnosis of ovarian cancer (SUBSONiC-study): protocol of a prospective multicenter cohort study in the Netherlands.

    abstract:BACKGROUND:Estimating the risk of malignancy is essential in the management of adnexal masses. An accurate differential diagnosis between benign and malignant masses will reduce morbidity and costs due to unnecessary operations, and will improve referral to a gynecologic oncologist for specialized cancer care, which im...

    journal_title:BMC cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/s12885-015-1319-5

    authors: Meys EM,Rutten IJ,Kruitwagen RF,Slangen BF,Bergmans MG,Mertens HJ,Nolting E,Boskamp D,Beets-Tan RG,van Gorp T

    更新日期:2015-06-26 00:00:00

  • Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker.

    abstract:BACKGROUND:Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovar...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-14-80

    authors: Vilming Elgaaen B,Olstad OK,Haug KB,Brusletto B,Sandvik L,Staff AC,Gautvik KM,Davidson B

    更新日期:2014-02-11 00:00:00

  • Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.

    abstract:BACKGROUND:Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. Attaining these objectives will be facilitated in preclinical studies using our newly discovered CNOB-GDEPT, consisting of the produrg...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-016-2508-6

    authors: Wang JH,Endsley AN,Green CE,Matin AC

    更新日期:2016-07-25 00:00:00

  • Health profiles of 996 melanoma survivors: the M. D. Anderson experience.

    abstract:BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial r...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-6-95

    authors: Stava C,Beck M,Weiss LT,Lopez A,Vassilopoulou-Sellin R

    更新日期:2006-04-18 00:00:00

  • Pemetrexed single agent chemotherapy in previously treated patients with locally advanced or metastatic non-small cell lung cancer.

    abstract:BACKGROUND:The main objective of this study was to evaluate the safety of second-line pemetrexed in Stage IIIB or IV NSCLC. METHODS:Overall, 95 patients received pemetrexed 500 mg/m2 i.v. over Day 1 of a 21-day cycle. Patients also received oral dexamethasone, oral folic acid and i.m. vitamin B12 supplementation to re...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-8-216

    authors: Russo F,Bearz A,Pampaloni G,Investigators of Italian Pemetrexed Monotherapy of NSCLC Group.

    更新日期:2008-07-31 00:00:00

  • Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models.

    abstract:BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-016-2712-4

    authors: Netland IA,Førde HE,Sleire L,Leiss L,Rahman MA,Skeie BS,Gjerde CH,Enger PØ,Goplen D

    更新日期:2016-08-19 00:00:00

  • Bioinformatic identification of FGF, p38-MAPK, and calcium signalling pathways associated with carcinoma in situ in the urinary bladder.

    abstract:BACKGROUND:Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive. METHODS:We developed a pathway based classifier approach to predict pr...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-8-37

    authors: Herbsleb M,Christensen OF,Thykjaer T,Wiuf C,Borre M,Orntoft TF,Dyrskjøt L

    更新日期:2008-01-31 00:00:00

  • Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts.

    abstract:BACKGROUND:Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mitogenic and angiogenic factor, which is expressed at an increased level in human prostate tumours an...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-10-596

    authors: Tuomela J,Grönroos TJ,Valta MP,Sandholm J,Schrey A,Seppänen J,Marjamäki P,Forsback S,Kinnunen I,Solin O,Minn H,Härkönen PL

    更新日期:2010-10-30 00:00:00

  • Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases.

    abstract:BACKGROUND:Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-018-5217-5

    authors: Zhao J,Hu C,Wang C,Yu W,Guo Y,Shi M,Shui Y,Wei Q

    更新日期:2018-12-27 00:00:00

  • Plasma omega-3 polyunsaturated fatty acids and recurrence of endometrial cancer.

    abstract:BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. METHOD:Women diagnosed with en...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-020-07035-5

    authors: Li P,Shan B,Jia K,Hu F,Xiao Y,Zheng J,Gao YT,Wang H,Gao Y

    更新日期:2020-06-20 00:00:00

  • Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells.

    abstract:BACKGROUND:Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is impo...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-020-06903-4

    authors: Gil-Kulik P,Dudzińska E,Radzikowska-Büchner E,Wawer J,Jojczuk M,Nogalski A,Wawer GA,Feldo M,Kocki W,Cioch M,Bogucka-Kocka A,Rahnama M,Kocki J

    更新日期:2020-05-18 00:00:00

  • Prognostic significance of stem cell/ epithelial-mesenchymal transition markers in periampullary/pancreatic cancers: FGFR1 is a promising prognostic marker.

    abstract:BACKGROUND:Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to canc...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-020-6673-2

    authors: Chong Y,Thakur N,Paik KY,Lee EJ,Kang CS

    更新日期:2020-03-14 00:00:00

  • Transcatheter arterial chemoembolization plus sorafenib versus transcatheter arterial chemoembolization alone to treat advanced hepatocellular carcinoma: a meta-analysis.

    abstract:BACKGROUND:Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advan...

    journal_title:BMC cancer

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12885-017-3707-5

    authors: Cai R,Song R,Pang P,Yan Y,Liao Y,Zhou C,Wang S,Zhou X,Wang H,Zhang H,Sun H,Ma H

    更新日期:2017-11-06 00:00:00

  • The release of tryptase from mast cells promote tumor cell metastasis via exosomes.

    abstract:BACKGROUND:Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. METHOD:Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow ...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-019-6203-2

    authors: Xiao H,He M,Xie G,Liu Y,Zhao Y,Ye X,Li X,Zhang M

    更新日期:2019-10-29 00:00:00

  • Precision medicine approaches to lung adenocarcinoma with concomitant MET and HER2 amplification.

    abstract:BACKGROUND:Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine strategy that integrates genomic profiling and preclinical drug-screening platforms, in order to persona...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-017-3525-9

    authors: Oh DY,Jung K,Song JY,Kim S,Shin S,Kwon YJ,Oh E,Park WY,Song SY,Choi YL

    更新日期:2017-08-10 00:00:00

  • Impact of chromosomal instability on colorectal cancer progression and outcome.

    abstract:BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-14-121

    authors: Orsetti B,Selves J,Bascoul-Mollevi C,Lasorsa L,Gordien K,Bibeau F,Massemin B,Paraf F,Soubeyran I,Hostein I,Dapremont V,Guimbaud R,Cazaux C,Longy M,Theillet C

    更新日期:2014-02-22 00:00:00

  • Magnitude and associated factors of VIA positive test results for cervical cancer screening among refugee women aged 25-49 years in North Ethiopia.

    abstract:BACKGROUND:Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Th...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-020-07344-9

    authors: Hailemariam G,Gebreyesus H,Wubayehu T,Gebregyorgis T,Gebrecherkos K,Teweldemedhin M,Kifle M

    更新日期:2020-09-07 00:00:00

  • The study protocol of the evaluation for the preventive efficacy of the HPV vaccine for persistent HPV16/18 infection in Japanese adult women: the HAKUOH study.

    abstract:BACKGROUND:In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and no evidence of its effectiveness in Japanese adult women in particular. This study aims to evaluate t...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/s12885-020-07563-0

    authors: Kurokawa T,Yamamoto M,Onuma T,Tsuyoshi H,Shinagawa A,Chino Y,Yoshida Y

    更新日期:2020-11-03 00:00:00

  • Diffuse large B cell lymphoma derived from nodular lymphocyte predominant Hodgkin lymphoma presents with variable histopathology.

    abstract:BACKGROUND:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) usually presents in middle aged men and shows an indolent clinical behavior. However, up to 30% of the patients present a secondary transformation into aggressive diffuse large B cell lymphoma (DLBCL). The aim of the present study was to characterize mo...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-14-332

    authors: Hartmann S,Eray M,Döring C,Lehtinen T,Brunnberg U,Kujala P,Vornanen M,Hansmann ML

    更新日期:2014-05-13 00:00:00

  • FLT3 mutations in canine acute lymphocytic leukemia.

    abstract:BACKGROUND:FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apoptotic cell death, an...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-11-38

    authors: Suter SE,Small GW,Seiser EL,Thomas R,Breen M,Richards KL

    更新日期:2011-01-27 00:00:00

  • Prognostic impact of MGMT promoter methylation and MGMT and CD133 expression in colorectal adenocarcinoma.

    abstract:BACKGROUND:New biomarkers are needed for the prognosis of advanced colorectal cancer, which remains incurable by conventional treatments. O6-methylguanine DNA methyltransferase (MGMT) methylation and protein expression have been related to colorectal cancer treatment failure and tumor progression. Moreover, the presenc...

    journal_title:BMC cancer

    pub_type: 杂志文章

    doi:10.1186/1471-2407-14-511

    authors: Oliver JA,Ortiz R,Melguizo C,Alvarez PJ,Gómez-Millán J,Prados J

    更新日期:2014-07-11 00:00:00

  • Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery vs. primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA- a randomized multicenter phase III study (NCT01900327, DRKS00003893, ISRCTN82191749).

    abstract:BACKGROUND:Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritoneum, lungs), or both. Observational and autopsy series report local recurrence rates of up to 87% eve...

    journal_title:BMC cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2407-14-411

    authors: Tachezy M,Gebauer F,Petersen C,Arnold D,Trepel M,Wegscheider K,Schafhausen P,Bockhorn M,Izbicki JR,Yekebas E

    更新日期:2014-06-07 00:00:00