FLT3 mutations in canine acute lymphocytic leukemia.

abstract：BACKGROUND:Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors. We consider this case of interest as treatment with catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect in a patient w...

journal_title：BMC cancer

authors： Bezan A,Hohla F,Meissnitzer T,Greil R

更新日期：2013-12-31 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy. METHODS:A total of 124 patients with rectal cancer treated with neoadjuvant chemoradiotherapy and consecutive surge...

journal_title：BMC cancer

authors： Trotsyuk I,Sparschuh H,Müller AJ,Neumann K,Kruschewski M,Horst D,Elezkurtaj S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastrointestinal (GI) NETs with 177Lu-Dotatate resulted in a significant improvement in progression-free su...

journal_title：BMC cancer

authors： Smith-Palmer J,Leeuwenkamp OR,Virk J,Reed N

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:XELOX (capecitabine + oxaliplatin) and FOLFOX 4 (5-FU + folinic acid + oxaliplatin) have shown similar improvements in survival in patients with metastatic colorectal cancer (MCRC). A US cost-minimization study found that the two regimens had similar costs from a healthcare provider perspective but XELOX had...

journal_title：BMC cancer

authors： Tse VC,Ng WT,Lee V,Lee AW,Chua DT,Chau J,McGhee SM

更新日期：2011-07-09 00:00:00

abstract：BACKGROUND:Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway inhibitory genes are silenced by CpG hypermethylation, and other studies have suggested that genistein...

journal_title：BMC cancer

authors： Phillip CJ,Giardina CK,Bilir B,Cutler DJ,Lai YH,Kucuk O,Moreno CS

更新日期：2012-04-11 00:00:00

abstract：BACKGROUND:Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/...

journal_title：BMC cancer

authors： Sinilnikova OM,Dondon MG,Eon-Marchais S,Damiola F,Barjhoux L,Marcou M,Verny-Pierre C,Sornin V,Toulemonde L,Beauvallet J,Le Gal D,Mebirouk N,Belotti M,Caron O,Gauthier-Villars M,Coupier I,Buecher B,Lortholary A,Dugast

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor microenvironment. Such models are urgently needed. Mutations of the tumor p...

journal_title：BMC cancer

authors： Ramelow J,Brooks CD,Gao L,Almiman AA,Williams TM,Villalona-Calero MA,Duan W

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classify...

journal_title：BMC cancer

authors： Garrido-Estepa M,Ruiz-Perales F,Miranda J,Ascunce N,González-Román I,Sánchez-Contador C,Santamariña C,Moreo P,Vidal C,Peris M,Moreno MP,Váquez-Carrete JA,Collado-García F,Casanova F,Ederra M,Salas D,Pollán M,DDM-Spain.

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these int...

journal_title：BMC cancer

authors： Vilaprinyo E,Rué M,Marcos-Gragera R,Martínez-Alonso M

更新日期：2009-03-30 00:00:00

abstract：BACKGROUND:There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA...

journal_title：BMC cancer

authors： Powell AA,Akare S,Qi W,Herzer P,Jean-Louis S,Feldman RA,Martinez JD

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...

journal_title：BMC cancer

authors： Lovitt CJ,Shelper TB,Avery VM

更新日期：2018-01-06 00:00:00

abstract：BACKGROUND:There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer. METHODS:We sought to inves...

journal_title：BMC cancer

authors： James FR,Jiminez-Linan M,Alsop J,Mack M,Song H,Brenton JD,Pharoah PDP,Ali HR

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...

journal_title：BMC cancer

authors： Oberste M,Schaffrath N,Schmidt K,Bloch W,Jäger E,Steindorf K,Hartig P,Joisten N,Zimmer P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Previous studies on bladder cancer have shown nodal involvement to be an independent indicator of prognosis and survival. This study aimed at developing an objective method for detection of nodal metastasis from molecular profiles of primary urothelial carcinoma tissues. METHODS:The study included primary b...

journal_title：BMC cancer

authors： Mitra AP,Almal AA,George B,Fry DW,Lenehan PF,Pagliarulo V,Cote RJ,Datar RH,Worzel WP

更新日期：2006-06-16 00:00:00

abstract：BACKGROUND:It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, little is known about the prognostic relevance of the OPN mRNA splice variants. METHODS:We analyzed ...

journal_title：BMC cancer

authors： Hahnel A,Wichmann H,Greither T,Kappler M,Würl P,Kotzsch M,Taubert H,Vordermark D,Bache M

更新日期：2012-04-02 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c. ...

journal_title：BMC cancer

authors： Nilsson G,Kannius-Janson M

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...

journal_title：BMC cancer

authors： Flamant L,Roegiers E,Pierre M,Hayez A,Sterpin C,De Backer O,Arnould T,Poumay Y,Michiels C

更新日期：2012-09-06 00:00:00

abstract：BACKGROUND:Forkhead box P3(FOXP3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity. However, the research on the prognostic significance of tumor-infiltrating FOXP3+ Tregs in breast cancer is still limited and the ...

journal_title：BMC cancer

authors： Shou J,Zhang Z,Lai Y,Chen Z,Huang J

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:The influence of the tumor microenvironment and tumor-stromal interactions on the heterogeneity of response within breast cancer subtypes have just begun to be explored. This study focuses on patients with estrogen receptor-positive/human epidermal growth factor receptor 2-positive (ER+/HER2+) breast cancer ...

journal_title：BMC cancer

authors： Brodsky AS,Xiong J,Yang D,Schorl C,Fenton MA,Graves TA,Sikov WM,Resnick MB,Wang Y

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...

journal_title：BMC cancer

authors： Hwang-Bo J,Bae MG,Park JH,Chung IS

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...

journal_title：BMC cancer

authors： Ai L,Mu S,Wang Y,Wang H,Cai L,Li W,Hu Y

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:Medical oncologists continue to use performance status as a proxy for quality of life (QOL) measures, as completion of QOL instruments is perceived as time consuming, may measure aspects of QOL not affected by cancer therapy, and interpretation may be unclear. The pulse oximeter is widely used in clinical pr...

journal_title：BMC cancer

authors： Martins SJ,Ho N,Cavamura SO,Harada CM,Yamamoto CA,Takagaki TY

更新日期：2005-07-06 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to determine the correlation of AREG and EREG expression between primary colorectal cancer and corresp...

journal_title：BMC cancer

authors： Kuramochi H,Nakajima G,Kaneko Y,Nakamura A,Inoue Y,Yamamoto M,Hayashi K

更新日期：2012-03-13 00:00:00

abstract：BACKGROUND:Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second ...

journal_title：BMC cancer

authors： Brasseur M,Heurgué-Berlot A,Barbe C,Brami C,Rey JB,Vella-Boucaud J,Dabouz F,Deslée G,Grange F,Volet J,Bouché O

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...

journal_title：BMC cancer

authors： Wu CT,Chen WC,Lin PY,Liao SK,Chen MF

更新日期：2009-03-25 00:00:00

abstract：BACKGROUND:The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the popu...

journal_title：BMC cancer

authors： Yoshimura A,Yamada T,Okura N,Takeda T,Furutani W,Kubota Y,Shiotsu S,Hiranuma O,Nishioka N,Chihara Y,Tamiya N,Kaneko Y,Uchino J,Takayama K

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...

journal_title：BMC cancer

authors： Jiang Q,Wei H,Tian Z

更新日期：2008-01-17 00:00:00

abstract：BACKGROUND:Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS:Comparative...

journal_title：BMC cancer

authors： Huang XY,Gan RH,Xie J,She L,Zhao Y,Ding LC,Su BH,Zheng DL,Lu YG

更新日期：2018-04-17 00:00:00