Abstract:
BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL patients from 2006 to 2017. The log-rank test, univariate analysis, and Cox regression analysis were applied to evaluate the relationship between ESR and survival. An ESR of more than 37.5 mm/hour was found to be the optimal threshold value for predicting prognosis. RESULTS:ESR was associated with more frequent advanced Ann Arbor stage, poorer performance status, elevated lactate dehydrogenase level, the presence of B symptoms, high-risk International Prognostic Index (IPI 3-5), more extranodal involvement (ENI ≥2), non-germinal-center B-cell (non-GCB) subtypes, and more frequent Myc protein positivity. Shorter overall survival (OS) and progression-free survival (PFS) were found for patients with higher ESRs. Multivariate analysis demonstrated that ESR level is an independent prognostic factor of both OS and PFS. In addition, dynamic changes in ESR are valuable in assessing curative effect and predicting disease recurrence. CONCLUSION:High ESR in DLBCL patients indicated unfavorable prognosis that may require alternative treatment regimens.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wu S,Zhou Y,Hua HY,Zhang Y,Zhu WY,Wang ZQ,Li J,Gao HQ,Wu XH,Lu TX,Hua Ddoi
10.1186/s12885-018-4914-4subject
Has Abstractpub_date
2018-10-19 00:00:00pages
997issue
1issn
1471-2407pii
10.1186/s12885-018-4914-4journal_volume
18pub_type
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